Aliases for CDK10 Gene
Aliases for CDK10 Gene
External Ids for CDK10 Gene
- HGNC: 1770
- Entrez Gene: 8558
- Ensembl: ENSG00000185324
- OMIM: 603464
- UniProtKB: Q15131
Previous GeneCards Identifiers for CDK10 Gene
- GC16P081075
- GC16P090742
- GC16P089455
- GC16P089496
- GC16P088280
- GC16P089753
- GC16P075448
Summaries for CDK10 Gene
-
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
GeneCards Summary for CDK10 Gene
CDK10 (Cyclin Dependent Kinase 10) is a Protein Coding gene. Diseases associated with CDK10 include Al Kaissi Syndrome and Tick Infestation. Among its related pathways are DNA Damage and Cell Cycle Control of Chromosomal Replication. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK11A.
UniProtKB/Swiss-Prot for CDK10 Gene
-
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells).
Additional gene information for CDK10 Gene
- Monarch Initiative
- Search for CDK10 at DataMed
- Search for CDK10 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK10 Gene
Genomics for CDK10 Gene
GeneHancer (GH) Regulatory Elements for CDK10 Gene
Promoters and enhancers for CDK10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CDK10 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CDK10 Gene
Genomic Locations for CDK10 Gene
- chr16:89,672,247-89,696,364
- (GRCh38/hg38)
- Size:
- 24,118 bases
- Orientation:
- Plus strand
- chr16:89,747,145-89,762,772
- (GRCh37/hg19)
Genomic View for CDK10 Gene
Genes around CDK10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q24.3 by Ensembl
- 16q24.3 by Entrez Gene
- 16q24.3 by HGNC
CDK10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CDK10 Gene
Proteins for CDK10 Gene
-
Protein details for CDK10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15131-CDK10_HUMAN
- Recommended name:
- Cyclin-dependent kinase 10
- Protein Accession:
- Q15131
- A8K370
- A8K8I6
- A8MXU6
- B3KQJ3
- B7Z420
- D3DX82
- D3DX83
- Q0VGZ7
- Q15130
- Q6PJC0
Protein attributes for CDK10 Gene
- Size:
- 360 amino acids
- Molecular mass:
- 41038 Da
- Quaternary structure:
-
- Heterodimer with CCNQ, the interaction is required for kinase activity. Interacts with ETS2.
Protein Expression for CDK10 Gene
Selected DME Specific Peptides for CDK10 Gene
- Q15131:
-
- TDEIVALK
- DFGLARA
- TDEIVALKKVRMDKEKDG
- QYSLRKQPYNNLKHKFPWLSEAGLRL
- VVTLWYR
- DLIVQLLGTPSENIWPGFS
- LQVLRGLQYLHR
- YRAPELLL
- IGEGTYG
Post-translational modifications for CDK10 Gene
- Ubiquitination at posLast=7676
Other Protein References for CDK10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001092003.2
- NP_001153839.1
- NP_443713.2
- NP_443714.3
- XP_006721371.1
- XP_006721373.1
- XP_011521707.1
- XP_011521708.1
- XP_011521709.1
- XP_011521710.1
- XP_011521712.1
- XP_011521713.1
- XP_011521714.1
- XP_011521715.1
- XP_011521716.1
- XP_011521717.1
- XP_011521718.1
- XP_011521719.1
- XP_016879295.1
- XP_016879296.1
- XP_016879297.1
- XP_016879298.1
- XP_016879299.1
Antibody Products
- Cell Signaling Technology (CST) Antibodies for CDK10 (CDK10)
-
Custom Antibody ServicesOriGene Antibodies for CDK10
- Novus Biologicals Antibodies for CDK10
-
Abcam antibodies for CDK10
- Invitrogen Antibodies for CDK10
- GeneTex CDK10 antibody for CDK10
Protein Products
-
OriGene Purified Proteins for CDK10
- Search Origene for MassSpec and Protein Over-expression Lysates for CDK10
- Origene Custom Protein Services for CDK10
- antibodies-online: Search results for 6 available CDK10 Proteins ranked by validation data
- Compare Top CDK10 Proteins
-
Quality Products:
- Search GeneTex for Proteins for CDK10
-
Abcam proteins for CDK10
Assay Products
- antibodies-online: Search results for 1 available CDK10 Elisa Kits ranked by validation data
- Compare Top CDK10 Elisa Kits
-
Quality Products:
Domains & Families for CDK10 Gene
Gene Families for CDK10 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for CDK10 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CDK10 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ78380, highly similar to Homo sapiens cyclin-dependent kinase (CDC2-like) 10, mRNA (A8K8I6_HUMAN)
- cDNA FLJ90555 fis, clone OVARC1000916, highly similar to Cell division protein kinase 10 (EC 2.7.11.22) (B3KQJ3_HUMAN)
- Serine/threonine-protein kinase PISSLRE (CDK10_HUMAN)
- Cyclin-dependent kinase related protein (Q9UHL7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q15131UniProtKB/Swiss-Prot:
CDK10_HUMAN :- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Function for CDK10 Gene
Molecular function for CDK10 Gene
- GENATLAS Biochemistry:
- cyclin dependent kinase (CDC2-like) related protein kinase,with several isoforms resulting from complex splicing,acting in G2 phase of the cell cycle,not deleted in sporadic breast carcinoma
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot Function:
- Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells).
Enzyme Numbers (IUBMB) for CDK10 Gene
Phenotypes From GWAS Catalog for CDK10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA,IDA | 27104747 |
| GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | IBA,TAS | -- |
| GO:0005515 | protein binding | IPI | 18242510 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for CDK10 Gene
- GenomeRNAi human phenotypes for CDK10:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- Decreased substrate adherent cell growth
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased cell viability after pRB stimulation
- Decreased cell proliferation
- Increased viability with 4OH tamoxifen
- Paclitaxel antagonistic effect
- Decreased viability in Von Hippel-Lindau (VHL) (-/-) cell line
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CDK10
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CDK10 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK10 gene
- Search ViGene Biosciences for CDK10
CRISPR Products
-
OriGene CRISPR knockouts for CDK10
- genomics-online: gRNA clones - Search results for 184 available CDK10 gene related products
- Overview of 184 available CDK10 gene related products
-
Recommended
- Applied Biological Materials CRISPR for CDK10
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK10
- GenScript: Design CRISPR guide RNA sequences for CDK10
miRNA for CDK10 Gene
- miRTarBase miRNAs that target CDK10
miRNA Products
- Search ViGene Biosciences for CDK10
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CDK10
- Browse OriGene Inhibitory RNA Products For CDK10
- genomics-online: shRNA clones - Search results for 184 available CDK10 gene related products
- Overview of 184 available CDK10 gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK10 gene
Clone Products
- Sino Biological Human cDNA Clone for CDK10
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CDK10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CDK10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CDK10
- genomics-online: cdna clones - Search results for 184 available CDK10 gene related products
- Overview of 184 available CDK10 gene related products
-
Recommended
- orf clones - Search results for 184 available CDK10 gene related products
- Overview of 184 available CDK10 gene related products
-
Recommended
- Applied Biological Materials Clones for CDK10
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CDK10
-
ViGene Biosciences adenoviral particle packaged cDNA for CDK10 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CDK10 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK10 gene
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK10 Gene
Localization for CDK10 Gene
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 4 |
| cytosol | 2 |
| mitochondrion | 1 |
- Nucleoplasm (3)
- Midbody (2)
- Midbody ring (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016592 | mediator complex | IBA | -- |
| GO:0036064 | ciliary basal body | IDA | 27104747 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDK10 Gene
Pathways & Interactions for CDK10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | DNA Damage | ||
| 2 | Cell Cycle Control of Chromosomal Replication | ||
| 3 | GADD45 Pathway | ||
Pathways by source for CDK10 Gene
1 GeneTex pathway for CDK10 Gene
1 Cell Signaling Technology pathway for CDK10 Gene
2 Qiagen pathways for CDK10 Gene
Interacting Proteins for CDK10 Gene
Selected Interacting proteins:
ENSP00000338673
Q15131-CDK10_HUMAN
for CDK10 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IBA | -- |
| GO:0007089 | traversing start control point of mitotic cell cycle | TAS | 8208557 |
| GO:0008285 | negative regulation of cell proliferation | TAS | 8208557 |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0018107 | peptidyl-threonine phosphorylation | IDA | 27104747 |
No data available for SIGNOR curated interactions for CDK10 Gene
Drugs & Compounds for CDK10 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for CDK10 Gene
mRNA/cDNA for CDK10 Gene
- (24) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (255) Selected AceView cDNA sequences:
- (22) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CDK10 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CDK10
- genomics-online: gRNA clones - Search results for 184 available CDK10 gene related products
- Overview of 184 available CDK10 gene related products
-
Recommended
- Applied Biological Materials CRISPR for CDK10
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK10
- GenScript: Design CRISPR guide RNA sequences for CDK10
miRNA Products
- Search ViGene Biosciences for CDK10
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CDK10
- Browse OriGene Inhibitory RNA Products For CDK10
- genomics-online: shRNA clones - Search results for 184 available CDK10 gene related products
- Overview of 184 available CDK10 gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK10 gene
Clone Products
- Sino Biological Human cDNA Clone for CDK10
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CDK10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CDK10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CDK10
- genomics-online: cdna clones - Search results for 184 available CDK10 gene related products
- Overview of 184 available CDK10 gene related products
-
Recommended
- orf clones - Search results for 184 available CDK10 gene related products
- Overview of 184 available CDK10 gene related products
-
Recommended
- Applied Biological Materials Clones for CDK10
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: |
| ExUns: | 11c | · | 11d | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | · | 15c | · | 15d | · | 15e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||
| SP15: | - | - | - | - | - | ||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||
| SP17: | - | - | - | ||||||||||||||||||||||
| SP18: |
Expression for CDK10 Gene
This gene is overexpressed in Bone marrow mesenchymal stem cell (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDK10 Gene
NURSA nuclear receptor signaling pathways regulating expression of CDK10 Gene:
CDK10SOURCE GeneReport for Unigene cluster for CDK10 Gene:
Hs.699177Evidence on tissue expression from TISSUES for CDK10 Gene
- Nervous system(4.6)
- Lung(4.4)
- Intestine(4.3)
Primer Products
-
OriGene qPCR primer pairs for CDK10
- genomics-online: primer clones - Search results for 184 available CDK10 gene related products
- Overview of 184 available CDK10 gene related products
-
Recommended
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK10 Gene
Orthologs for CDK10 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CDK10 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CDK10 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CDK10 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CDK10 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cdk10 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Cdk10 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CDK10 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CDK10 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CDK10 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cdk10 33 |
|
||
| Str.19111 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.12757 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cdk10 33 34 |
|
||
| Dr.16835 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10159 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | cdc2rk 35 33 34 |
|
||
| CG6800 35 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005851 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | H01G02.2 35 |
|
|
|
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CTK1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.13995 33 |
|
- Species where no ortholog for CDK10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CDK10 Gene
(126) SIMAP similar genes for CDK10 Gene using alignment to 10 proteins:
- pp12301
- EIF3G
- PPP5D1
- ADCK1
- PFKFB3
- NELFA
- ZNF66
- NDC80
- ARIH1
- VPS33A
- IRF2
- C12orf76
- FLJ00047
- RRM2B
- EEF1E1
- SLC35E3
- NLRC5
- HINFP
- TNNT1
- RARS
- SPG7
- RPGRIP1L
- EIF3K
- CDK11B
- CDK11A
- COQ5
- ZNF799
- ZNF28
- IDNK
- CDC2L1
- ABI2
- SEC14L3
- RQCD1
- GALK2
- PPP2R5C
- NAE1
- MRPL45
- DOCK8
- ASCC1
- ATF1
- ZNF554
- NUP93
- CDC2L2
- TUBA1C
- SUV420H1
- FRG1
- DYNC2LI1
- AAMDC
- PHKG2
- NLN
- DYRK4
- RPS13
- ZNF180
- ZNF114
- TMX3
- CDK3
- TXK
- CDK1
- CDC2
- C21orf37
- LSM12
- CDK17
- CDK16
- CDK12
- TM2D1
- SLC16A3
- PCTK1
- CCRK
- MST132
- CDK5
- CDK18
- STK25
- DPP9
- DKFZp686L20222
- CDK15
- BEAN1
- CDK4
- CDK7
- CDK20
- PCTK3
- MAPK8
- ZNF429
- ZNF257
- PTPN22
- CDK6
- CDK2
- MAP4K2
- ICK
- CDK14
- CDKL3
- CDKL2
- CDK19
- SIPA1L3
- MAPK15
- CDK9
- CDKL4
- DKFZp434M058
- CDKL5
- CDK8
- MAPK7
- MAK
- MAP4K5
- TBCK
- DKFZp313C1916
- ZNF85
- PLK4
- NLK
- MAPK3
- CDKL1
- STK11
- DKFZp564L2416
- MAPK1
- STK36
- DKFZp686O0215
- MAPK4
- MAP4K1
- HUNK
- MOK
- MAPK14
- NEK9
- FLT4
- MAPK12
- MAPK11
- CAMK1
- MAPK13
- PUS1
Variants for CDK10 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1060499745 | likely-pathogenic, Abnormality of brain morphology | 89,694,721(+) | C/G/T | coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
| rs767176610 | pathogenic, AL KAISSI SYNDROME | 89,694,172(+) | G/A | splice_acceptor_variant | |
| rs771066826 | pathogenic, AL KAISSI SYNDROME | 89,693,468(+) | G/A/T | splice_donor_variant | |
| rs772157816 | likely-pathogenic, Abnormality of brain morphology | 89,695,679(+) | G/A | coding_sequence_variant, genic_downstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant | |
| rs1000199180 | -- | 89,687,994(+) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2762221 | CNV | gain+loss | 21179565 |
| esv3639592 | CNV | gain | 21293372 |
| nsv1057351 | CNV | loss | 25217958 |
| nsv428331 | CNV | gain+loss | 18775914 |
| nsv457623 | CNV | gain | 19166990 |
| nsv482951 | CNV | loss | 15286789 |
| nsv509639 | CNV | insertion | 20534489 |
| nsv516241 | CNV | loss | 19592680 |
| nsv573739 | CNV | gain | 21841781 |
| nsv573743 | CNV | gain | 21841781 |
| nsv833330 | CNV | loss | 17160897 |
| nsv952079 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.03;
37.31% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CDK10 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK10 Gene
Disorders for CDK10 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| al kaissi syndrome |
|
|
| tick infestation |
|
|
Search CDK10 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CDK10
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CDK10 Gene
Publications for CDK10 Gene
- Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases. (PMID: 8084611) Brambilla R … Draetta G (Oncogene 1994) 2 3 4 58
- PISSLRE, a human novel CDC2-related protein kinase. (PMID: 8208557) Graña X … Giordano A (Oncogene 1994) 2 3 4 58
- CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. (PMID: 24218572) Guen VJ … Colas P (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 4 58
- Genome-wide association study identifies three new melanoma susceptibility loci. (PMID: 21983787) Barrett JH … GenoMEL Consortium (Nature genetics 2011) 3 44 58
- A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation. (PMID: 18483556) Han J … Hunter DJ (PLoS genetics 2008) 3 44 58
Products for CDK10 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CDK10
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CDK10
- Search Origene for MassSpec and Protein Over-expression Lysates for CDK10
- Origene Custom Protein Services for CDK10
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDK10
- Browse OriGene Inhibitory RNA Products For CDK10
- OriGene qPCR primer pairs for CDK10
- OriGene CRISPR knockouts for CDK10
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CDK10
- GenScript: Next-day shipping of latest version cDNA ORF clones for CDK10 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CDK10
- GenScript Custom Assay Services for CDK10
- GenScript Custom overexpressing Cell Line Services for CDK10
- GenScript: Design CRISPR guide RNA sequences for CDK10
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CDK10
- Cell Signaling Technology (CST) Antibodies for CDK10 (CDK10)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for CDK10
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CDK10
- Novus Biologicals proteins and lysates for CDK10
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CDK10
- Abcam proteins for CDK10
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for CDK10
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for CDK10
- VectorBuilder custom plasmid, inducible vectors for CDK10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CDK10
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CDK10
- antibodies-online: Search results for 91 available CDK10 Antibodies ranked by validation data
- Compare Top CDK10 Antibodies
- antibodies-online: Search results for 1 available CDK10 Elisa Kits ranked by validation data
- Compare Top CDK10 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 6 available CDK10 Proteins ranked by validation data
- Compare Top CDK10 Proteins
- Quality Products:
- GeneTex CDK10 antibody for CDK10
- Search GeneTex for Proteins for CDK10
- ViGene Biosciences adenoviral particle packaged cDNA for CDK10 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CDK10 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CDK10 gene
- Search ViGene Biosciences for CDK10
- Horizon Cell Lines for CDK10
- genomics-online: cdna clones - Search results for 184 available CDK10 gene related products
- Overview of 184 available CDK10 gene related products
- Recommended
- orf clones - Search results for 184 available CDK10 gene related products
- Overview of 184 available CDK10 gene related products
- Recommended
- genomics-online: gRNA clones - Search results for 184 available CDK10 gene related products
- Overview of 184 available CDK10 gene related products
- Recommended
- genomics-online: primer clones - Search results for 184 available CDK10 gene related products
- Overview of 184 available CDK10 gene related products
- Recommended
- genomics-online: shRNA clones - Search results for 184 available CDK10 gene related products
- Overview of 184 available CDK10 gene related products
- Recommended
Sources for CDK10 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew