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Aliases for MAPKAPK5 Gene

Aliases for MAPKAPK5 Gene

  • Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 2 3 5
  • P38-Regulated/Activated Protein Kinase 3 4
  • MAPK-Activated Protein Kinase 5 3 4
  • MAPKAP Kinase 5 3 4
  • EC 2.7.11.1 4 61
  • MAPKAP-K5 3 4
  • MAPKAPK-5 3 4
  • MK-5 3 4
  • PRAK 3 4
  • MK5 3 4
  • MAP Kinase-Activated Protein Kinase 5 3
  • EC 2.7.11 61

External Ids for MAPKAPK5 Gene

Previous GeneCards Identifiers for MAPKAPK5 Gene

  • GC12P111177
  • GC12P111802
  • GC12P112062
  • GC12P110692
  • GC12P110691
  • GC12P110742
  • GC12P112282
  • GC12P109293

Summaries for MAPKAPK5 Gene

Entrez Gene Summary for MAPKAPK5 Gene

  • The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]

GeneCards Summary for MAPKAPK5 Gene

MAPKAPK5 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 5) is a Protein Coding gene. Among its related pathways are Regulation of TP53 Activity and Signaling mediated by p38-alpha and p38-beta. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPKAPK2.

UniProtKB/Swiss-Prot for MAPKAPK5 Gene

  • Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.

Gene Wiki entry for MAPKAPK5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPKAPK5 Gene

Genomics for MAPKAPK5 Gene

Regulatory Elements for MAPKAPK5 Gene

Enhancers for MAPKAPK5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G111055 2.7 VISTA FANTOM5 ENCODE 12 -784.8 -784787 2.9 HDGF PKNOX1 ATF1 ZNF473 NFRKB FEZF1 ZBTB40 ZNF155 EGR1 ELK1 ADAM1A CUX2 MAPKAPK5 MYL2 LINC01405 PPTC7 SH2B3 GC12M111175
GH12G112407 1.4 Ensembl ENCODE 23.1 +566.8 566756 3.0 PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 MAPKAPK5 ADAM1A SLC8B1 DDX54 TMEM116 PTPN11 HECTD4
GH12G110930 1.3 ENCODE dbSUPER 22.6 -910.5 -910501 1.9 HDGF PKNOX1 ARID4B SIN3A YY1 ZNF143 ZNF207 KLF13 SP3 SP5 MAPKAPK5 LINC01405 C12orf76 RPS2P41 MYL2
GH12G112124 1.6 Ensembl ENCODE dbSUPER 16 +286.4 286384 7.4 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 TMEM116 MAPKAPK5 ADAM1A NAA25 ERP29 TRAFD1 GC12P112151
GH12G111150 0.8 Ensembl 28.9 -691.5 -691478 0.2 ZNF493 ZFP64 ZNF140 ZNF266 ZNF101 ZNF697 ZFHX2 GLI2 ZNF354C SCRT2 MAPKAPK5 ADAM1A FAM216A NAA25 CUX2 PCNPP1 PPP1CC GC12M111175
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAPKAPK5 on UCSC Golden Path with GeneCards custom track

Promoters for MAPKAPK5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000057477 222 2801 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for MAPKAPK5 Gene

Chromosome:
12
Start:
111,841,978 bp from pter
End:
111,902,238 bp from pter
Size:
60,261 bases
Orientation:
Plus strand

Genomic View for MAPKAPK5 Gene

Genes around MAPKAPK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPKAPK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPKAPK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPKAPK5 Gene

Proteins for MAPKAPK5 Gene

  • Protein details for MAPKAPK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IW41-MAPK5_HUMAN
    Recommended name:
    MAP kinase-activated protein kinase 5
    Protein Accession:
    Q8IW41
    Secondary Accessions:
    • B3KVA5
    • O60491
    • Q86X46
    • Q9BVX9
    • Q9UG86

    Protein attributes for MAPKAPK5 Gene

    Size:
    473 amino acids
    Molecular mass:
    54220 Da
    Quaternary structure:
    • Interacts with ERK3/MAPK6 and ERK4/MAPK4 (via FRIEDE motif); the interaction is direct (By similarity). Interacts with YWHAE; the interaction prevents phosphorylation of HSP27/HSPB1 leading to disrupt F-actin polymerization. Interacts with SQSTM1.

    Alternative splice isoforms for MAPKAPK5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPKAPK5 Gene

Selected DME Specific Peptides for MAPKAPK5 Gene

Q8IW41:
  • DLWSLGV
  • LKPENLL
  • RDLKPEN
  • TPYYVAP

Post-translational modifications for MAPKAPK5 Gene

  • Phosphorylated on Thr-182 ERK3/MAPK6 or ERK4/MAPK4; which is the regulatory phosphorylation site and is located on the T-loop/loop 12, leading to activation. Phosphorylation at Thr-182 by p38-alpha/MAPK14, p38-beta/MAPK11 is subject to debate. Phosphorylated at Ser-115 by PKA/PRKACA, leading to localization to the cytoplasm. Autophosphorylated (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for MAPKAPK5 Gene

Protein Domains for MAPKAPK5 Gene

Suggested Antigen Peptide Sequences for MAPKAPK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IW41

UniProtKB/Swiss-Prot:

MAPK5_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MAPKAPK5: view

Function for MAPKAPK5 Gene

Molecular function for MAPKAPK5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated following phosphorylation at Thr-182 by p38-alpha/MAPK14, p38-beta/MAPK11, ERK2/MAPK1, ERK3/MAPK6, and ERK4/MAPK4. Activated by stress-related extracellular stimuli; such as H(2)O(2), arsenite, anisomycin TNF alpha and also PMA and the calcium ionophore A23187; but to a lesser extent. In vitro, activated by SQSTM1. Inhibited by diterpenoid alkaloid noroxoaconitine.
UniProtKB/Swiss-Prot Function:
Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.
UniProtKB/Swiss-Prot Induction:
Directly regulated by MYC: expression is activated by MYC, suggesting the existence of a feedback regulatory loop.

Enzyme Numbers (IUBMB) for MAPKAPK5 Gene

Gene Ontology (GO) - Molecular Function for MAPKAPK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0002039 p53 binding IDA 17254968
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004683 calmodulin-dependent protein kinase activity IBA --
genes like me logo Genes that share ontologies with MAPKAPK5: view
genes like me logo Genes that share phenotypes with MAPKAPK5: view

Animal Models for MAPKAPK5 Gene

MGI Knock Outs for MAPKAPK5:

Animal Model Products

CRISPR Products

miRNA for MAPKAPK5 Gene

miRTarBase miRNAs that target MAPKAPK5

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPKAPK5 Gene

Localization for MAPKAPK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPKAPK5 Gene

Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPKAPK5 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MAPKAPK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IEA,IBA --
GO:0005829 cytosol TAS,IDA --
genes like me logo Genes that share ontologies with MAPKAPK5: view

Pathways & Interactions for MAPKAPK5 Gene

genes like me logo Genes that share pathways with MAPKAPK5: view

Pathways by source for MAPKAPK5 Gene

1 Sino Biological pathway for MAPKAPK5 Gene
1 Cell Signaling Technology pathway for MAPKAPK5 Gene
1 KEGG pathway for MAPKAPK5 Gene
1 R&D Systems pathway for MAPKAPK5 Gene
2 Qiagen pathways for MAPKAPK5 Gene

SIGNOR curated interactions for MAPKAPK5 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MAPKAPK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0000187 activation of MAPK activity IEA --
GO:0006417 regulation of translation IDA 21329882
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction TAS 9628874
genes like me logo Genes that share ontologies with MAPKAPK5: view

Drugs & Compounds for MAPKAPK5 Gene

(3) Drugs for MAPKAPK5 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
GLPG0259 Pharma 0
calcium Nutra 0

(1) Additional Compounds for MAPKAPK5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MAPKAPK5: view

Transcripts for MAPKAPK5 Gene

Unigene Clusters for MAPKAPK5 Gene

Mitogen-activated protein kinase-activated protein kinase 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPKAPK5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17
SP1: -
SP2: -
SP3: -
SP4:
SP5: -
SP6: - -

Relevant External Links for MAPKAPK5 Gene

GeneLoc Exon Structure for
MAPKAPK5
ECgene alternative splicing isoforms for
MAPKAPK5

Expression for MAPKAPK5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAPKAPK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAPKAPK5 Gene

This gene is overexpressed in Lung (43.0) and Monocytes (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAPKAPK5 Gene



Protein tissue co-expression partners for MAPKAPK5 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAPKAPK5 Gene:

MAPKAPK5

SOURCE GeneReport for Unigene cluster for MAPKAPK5 Gene:

Hs.413901

mRNA Expression by UniProt/SwissProt for MAPKAPK5 Gene:

Q8IW41-MAPK5_HUMAN
Tissue specificity: Expressed ubiquitously.

Evidence on tissue expression from TISSUES for MAPKAPK5 Gene

  • Nervous system(4.6)
  • Pancreas(4.2)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with MAPKAPK5: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPKAPK5 Gene

Orthologs for MAPKAPK5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAPKAPK5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPKAPK5 34 35
  • 99.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 98 (a)
OneToMany
-- 35
  • 95 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MAPKAPK5 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPKAPK5 35 34
  • 94.22 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MAPKAPK5 35 34
  • 93.48 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mapkapk5 35 16 34
  • 90.7 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapkapk5 34
  • 90.63 (n)
chicken
(Gallus gallus)
Aves MAPKAPK5 34 35
  • 85.88 (n)
lizard
(Anolis carolinensis)
Reptilia MAPKAPK5 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapkapk5 34
  • 80.24 (n)
Str.17845 34
zebrafish
(Danio rerio)
Actinopterygii mapkapk5 34 35
  • 77.38 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RCK1 35
  • 22 (a)
ManyToMany
RCK2 35
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14027 34
Species where no ortholog for MAPKAPK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAPKAPK5 Gene

ENSEMBL:
Gene Tree for MAPKAPK5 (if available)
TreeFam:
Gene Tree for MAPKAPK5 (if available)

Paralogs for MAPKAPK5 Gene

Paralogs for MAPKAPK5 Gene

(14) SIMAP similar genes for MAPKAPK5 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for MAPKAPK5 Gene

genes like me logo Genes that share paralogs with MAPKAPK5: view

Variants for MAPKAPK5 Gene

Sequence variations from dbSNP and Humsavar for MAPKAPK5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000102324 -- 111,846,556(+) AGTGG(C/T)GTGAT intron-variant
rs1000122251 -- 111,865,630(+) CAGGA(A/G)ATGGA intron-variant
rs1000219735 -- 111,884,697(+) GCACT(A/G)CCCCT intron-variant
rs1000278909 -- 111,885,942(+) GGAGA(G/T)ACTCA reference, missense
rs1000306834 -- 111,841,570(+) GGGAG(A/C/G)ACAAA nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAPKAPK5 Gene

Variant ID Type Subtype PubMed ID
dgv1556n100 CNV gain 25217958
dgv2874n54 CNV gain 21841781
dgv304e214 CNV gain 21293372
dgv514e212 CNV gain 25503493
esv1010936 CNV deletion 20482838
esv2665280 CNV deletion 23128226
esv2746359 CNV deletion 23290073
esv2760710 CNV gain 21179565
esv3549773 CNV deletion 23714750
esv3630769 CNV loss 21293372
esv3630770 CNV gain 21293372
esv3630771 CNV loss 21293372
esv6864 CNV loss 19470904
nsv1044606 CNV gain 25217958
nsv1045488 CNV gain 25217958
nsv455715 CNV gain 19166990
nsv470317 CNV gain 18288195
nsv515716 CNV gain 19592680

Variation tolerance for MAPKAPK5 Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.75; 33.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPKAPK5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPKAPK5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPKAPK5 Gene

Disorders for MAPKAPK5 Gene

Relevant External Links for MAPKAPK5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPKAPK5

No disorders were found for MAPKAPK5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAPKAPK5 Gene

Publications for MAPKAPK5 Gene

  1. PRAK, a novel protein kinase regulated by the p38 MAP kinase. (PMID: 9628874) New L. … Han J. (EMBO J. 1998) 2 3 4 22 64
  2. Regulation of PRAK subcellular location by p38 MAP kinases. (PMID: 12808055) New L. … Han J. (Mol. Biol. Cell 2003) 3 4 22 64
  3. The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis. (PMID: 21329882) Kress T.R. … Eilers M. (Mol. Cell 2011) 3 4 64
  4. PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5. (PMID: 19166925) Kostenko S. … Moens U. (Cell. Signal. 2009) 3 4 64
  5. Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. (PMID: 18720373) DAclAcris P. … Meloche S. (J. Cell. Physiol. 2008) 3 22 64

Products for MAPKAPK5 Gene

Sources for MAPKAPK5 Gene

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