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Aliases for MAPKAPK5 Gene

Aliases for MAPKAPK5 Gene

  • Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 2 3
  • PRAK 3 4 6
  • P38-Regulated/Activated Protein Kinase 3 4
  • MAPK-Activated Protein Kinase 5 3 4
  • MAPKAP Kinase 5 3 4
  • EC 2.7.11.1 4 63
  • MAPKAP-K5 3 4
  • MAPKAPK-5 3 4
  • MK-5 3 4
  • MK5 3 4
  • MAP Kinase-Activated Protein Kinase 5 3
  • EC 2.7.11 63

External Ids for MAPKAPK5 Gene

Previous GeneCards Identifiers for MAPKAPK5 Gene

  • GC12P111177
  • GC12P111802
  • GC12P112062
  • GC12P110692
  • GC12P110691
  • GC12P110742
  • GC12P112282
  • GC12P109293

Summaries for MAPKAPK5 Gene

Entrez Gene Summary for MAPKAPK5 Gene

  • The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]

GeneCards Summary for MAPKAPK5 Gene

MAPKAPK5 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 5) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Akt Signaling. GO annotations related to this gene include protein serine/threonine kinase activity and MAP kinase kinase activity. An important paralog of this gene is MKNK2.

UniProtKB/Swiss-Prot for MAPKAPK5 Gene

  • Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.

Gene Wiki entry for MAPKAPK5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPKAPK5 Gene

Genomics for MAPKAPK5 Gene

Regulatory Elements for MAPKAPK5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAPKAPK5 Gene

Start:
111,841,978 bp from pter
End:
111,896,539 bp from pter
Size:
54,562 bases
Orientation:
Plus strand

Genomic View for MAPKAPK5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAPKAPK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPKAPK5 Gene

Proteins for MAPKAPK5 Gene

  • Protein details for MAPKAPK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IW41-MAPK5_HUMAN
    Recommended name:
    MAP kinase-activated protein kinase 5
    Protein Accession:
    Q8IW41
    Secondary Accessions:
    • B3KVA5
    • O60491
    • Q86X46
    • Q9BVX9
    • Q9UG86

    Protein attributes for MAPKAPK5 Gene

    Size:
    473 amino acids
    Molecular mass:
    54220 Da
    Quaternary structure:
    • Interacts with ERK3/MAPK6 and ERK4/MAPK4 (via FRIEDE motif); the interaction is direct (By similarity). Interacts with YWHAE; the interaction prevents phosphorylation of HSP27/HSPB1 leading to disrupt F-actin polymerization. Interacts with SQSTM1.

    Alternative splice isoforms for MAPKAPK5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPKAPK5 Gene

Proteomics data for MAPKAPK5 Gene at MOPED

Selected DME Specific Peptides for MAPKAPK5 Gene

Post-translational modifications for MAPKAPK5 Gene

  • Phosphorylated on Thr-182 ERK3/MAPK6 or ERK4/MAPK4; which is the regulatory phosphorylation site and is located on the T-loop/loop 12, leading to activation. Phosphorylation at Thr-182 by p38-alpha/MAPK14, p38-beta/MAPK11 is subject to debate. Phosphorylated at Ser-115 by PKA/PRKACA, leading to localization to the cytoplasm. Autophosphorylated (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPKAPK5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAPKAPK5 (MAPKAPK5)

Domains for MAPKAPK5 Gene

Protein Domains for MAPKAPK5 Gene

Suggested Antigen Peptide Sequences for MAPKAPK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IW41

UniProtKB/Swiss-Prot:

MAPK5_HUMAN :
  • Q8IW41
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MAPKAPK5: view

Function for MAPKAPK5 Gene

Molecular function for MAPKAPK5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated following phosphorylation at Thr-182 by p38-alpha/MAPK14, p38-beta/MAPK11, ERK2/MAPK1, ERK3/MAPK6, and ERK4/MAPK4. Activated by stress-related extracellular stimuli; such as H(2)O(2), arsenite, anisomycin TNF alpha and also PMA and the calcium ionophore A23187; but to a lesser extent. In vitro, activated by SQSTM1. Inhibited by diterpenoid alkaloid noroxoaconitine.
UniProtKB/Swiss-Prot Function:
Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.
UniProtKB/Swiss-Prot Induction:
Directly regulated by MYC: expression is activated by MYC, suggesting the existence of a feedback regulatory loop.

Enzyme Numbers (IUBMB) for MAPKAPK5 Gene

Gene Ontology (GO) - Molecular Function for MAPKAPK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IDA 17254968
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 17254968
GO:0004683 calmodulin-dependent protein kinase activity IBA --
GO:0004708 MAP kinase kinase activity TAS 9628874
genes like me logo Genes that share ontologies with MAPKAPK5: view
genes like me logo Genes that share phenotypes with MAPKAPK5: view

Animal Models for MAPKAPK5 Gene

MGI Knock Outs for MAPKAPK5:

Animal Model Products

CRISPR Products

miRNA for MAPKAPK5 Gene

miRTarBase miRNAs that target MAPKAPK5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAPKAPK5

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for MAPKAPK5 Gene

Localization for MAPKAPK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPKAPK5 Gene

Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPKAPK5 Gene COMPARTMENTS Subcellular localization image for MAPKAPK5 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MAPKAPK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with MAPKAPK5: view

Pathways for MAPKAPK5 Gene

genes like me logo Genes that share pathways with MAPKAPK5: view

Pathways by source for MAPKAPK5 Gene

2 Qiagen pathways for MAPKAPK5 Gene
1 Cell Signaling Technology pathway for MAPKAPK5 Gene
1 KEGG pathway for MAPKAPK5 Gene
1 R&D Systems pathway for MAPKAPK5 Gene

Gene Ontology (GO) - Biological Process for MAPKAPK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS 9628874
GO:0000187 activation of MAPK activity TAS 9628874
GO:0006417 regulation of translation IDA 21329882
GO:0006468 protein phosphorylation --
GO:0007165 signal transduction TAS 9628874
genes like me logo Genes that share ontologies with MAPKAPK5: view

Compounds for MAPKAPK5 Gene

(3) HMDB Compounds for MAPKAPK5 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with MAPKAPK5: view

Transcripts for MAPKAPK5 Gene

Unigene Clusters for MAPKAPK5 Gene

Mitogen-activated protein kinase-activated protein kinase 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAPKAPK5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPKAPK5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17
SP1: -
SP2: -
SP3: -
SP4:
SP5: -
SP6: - -

Relevant External Links for MAPKAPK5 Gene

GeneLoc Exon Structure for
MAPKAPK5
ECgene alternative splicing isoforms for
MAPKAPK5

Expression for MAPKAPK5 Gene

mRNA expression in normal human tissues for MAPKAPK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MAPKAPK5 Gene

This gene is overexpressed in Lung (43.0) and Monocytes (14.6).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MAPKAPK5 Gene

SOURCE GeneReport for Unigene cluster for MAPKAPK5 Gene Hs.413901

mRNA Expression by UniProt/SwissProt for MAPKAPK5 Gene

Q8IW41-MAPK5_HUMAN
Tissue specificity: Expressed ubiquitously.
genes like me logo Genes that share expressions with MAPKAPK5: view

Expression partners for MAPKAPK5 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MAPKAPK5 Gene

Orthologs for MAPKAPK5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAPKAPK5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAPKAPK5 35
  • 93.48 (n)
  • 97.66 (a)
MAPKAPK5 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPKAPK5 35
  • 94.22 (n)
  • 98.52 (a)
MAPKAPK5 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapkapk5 35
  • 90.7 (n)
  • 97.25 (a)
Mapkapk5 16
Mapkapk5 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAPKAPK5 35
  • 99.65 (n)
  • 99.58 (a)
MAPKAPK5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapkapk5 35
  • 90.63 (n)
  • 96.41 (a)
oppossum
(Monodelphis domestica)
Mammalia MAPKAPK5 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
chicken
(Gallus gallus)
Aves MAPKAPK5 35
  • 85.88 (n)
  • 96.34 (a)
MAPKAPK5 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPKAPK5 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapkapk5 35
  • 80.24 (n)
  • 91.26 (a)
Str.17845 35
zebrafish
(Danio rerio)
Actinopterygii mapkapk5 35
  • 77.38 (n)
  • 87.66 (a)
mapkapk5 36
  • 87 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RCK1 36
  • 22 (a)
ManyToMany
RCK2 36
  • 18 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14027 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for MAPKAPK5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAPKAPK5 Gene

ENSEMBL:
Gene Tree for MAPKAPK5 (if available)
TreeFam:
Gene Tree for MAPKAPK5 (if available)

Paralogs for MAPKAPK5 Gene

Selected SIMAP similar genes for MAPKAPK5 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for MAPKAPK5 Gene

genes like me logo Genes that share paralogs with MAPKAPK5: view

Variants for MAPKAPK5 Gene

Sequence variations from dbSNP and Humsavar for MAPKAPK5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs876896 -- 111,860,453(-) TTAGA(C/T)GGGCA intron-variant
rs1080527 -- 111,870,562(-) TCAGT(A/G)TCATC intron-variant, upstream-variant-2KB
rs1811181 -- 111,865,842(+) AAAAA(A/G)AAAAA intron-variant, upstream-variant-2KB
rs1981517 -- 111,885,778(+) ATCCC(A/G)TCTGT intron-variant
rs2097701 -- 111,878,970(+) gttct(G/T)cattt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPKAPK5 Gene

Variant ID Type Subtype PubMed ID
dgv1492n71 CNV Gain 21882294
nsv455715 CNV Gain 19166990
nsv470317 CNV Gain 18288195
nsv515716 CNV Gain 19592680
esv2746359 CNV Deletion 23290073
esv6864 CNV Loss 19470904
esv2665280 CNV Deletion 23128226
esv1010936 CNV Deletion 20482838

Relevant External Links for MAPKAPK5 Gene

HapMap Linkage Disequilibrium report
MAPKAPK5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPKAPK5 Gene

Disorders for MAPKAPK5 Gene

No disorders were found for MAPKAPK5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MAPKAPK5 Gene

Publications for MAPKAPK5 Gene

  1. PRAK, a novel protein kinase regulated by the p38 MAP kinase. (PMID: 9628874) New L. … Han J. (EMBO J. 1998) 2 3 4 23
  2. Regulation of PRAK subcellular location by p38 MAP kinases. (PMID: 12808055) New L. … Han J. (Mol. Biol. Cell 2003) 3 4 23
  3. Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. (PMID: 18720373) DAclAcris P. … Meloche S. (J. Cell. Physiol. 2008) 3 23
  4. p62 functions as a p38 MAP kinase regulator. (PMID: 10708586) Sudo T. … Osada H. (Biochem. Biophys. Res. Commun. 2000) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for MAPKAPK5 Gene

Sources for MAPKAPK5 Gene

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