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Aliases for TSLP Gene

Aliases for TSLP Gene

  • Thymic Stromal Lymphopoietin 2 3 5

External Ids for TSLP Gene

Previous GeneCards Identifiers for TSLP Gene

  • GC05P110030
  • GC05P110853
  • GC05P110436
  • GC05P110481
  • GC05P110433
  • GC05P110435
  • GC05P110405
  • GC05P105586

Summaries for TSLP Gene

Entrez Gene Summary for TSLP Gene

  • This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for TSLP Gene

TSLP (Thymic Stromal Lymphopoietin) is a Protein Coding gene. Diseases associated with TSLP include cryoglobulinemic vasculitis and eczema herpeticum. Among its related pathways are Innate Lymphoid Cell Differentiation Pathways and PEDF Induced Signaling. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot for TSLP Gene

  • Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.

  • Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.

Gene Wiki entry for TSLP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSLP Gene

Genomics for TSLP Gene

Regulatory Elements for TSLP Gene

Promoters for TSLP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSLP on UCSC Golden Path with GeneCards custom track

Genomic Location for TSLP Gene

Chromosome:
5
Start:
111,070,062 bp from pter
End:
111,078,024 bp from pter
Size:
7,963 bases
Orientation:
Plus strand

Genomic View for TSLP Gene

Genes around TSLP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSLP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSLP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSLP Gene

Proteins for TSLP Gene

  • Protein details for TSLP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969D9-TSLP_HUMAN
    Recommended name:
    Thymic stromal lymphopoietin
    Protein Accession:
    Q969D9
    Secondary Accessions:
    • G3XAM8
    • Q8IW99
    • Q96AU7

    Protein attributes for TSLP Gene

    Size:
    159 amino acids
    Molecular mass:
    18141 Da
    Quaternary structure:
    • Interacts with a receptor composed of CRLF2 and IL7R. Binding of TSLP to CRLF2/TSLPR is a mechanistic prerequisite for recruitment of IL7R to the high-affinity ternary complex.
    SequenceCaution:
    • Sequence=AAH16720.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH22894.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TSLP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSLP Gene

Proteomics data for TSLP Gene at MOPED

Post-translational modifications for TSLP Gene

  • Glycosylation at Asn 64 and Asn 119
  • Modification sites at PhosphoSitePlus

Other Protein References for TSLP Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TSLP (TSLP)
  • Santa Cruz Biotechnology (SCBT) Antibodies for TSLP

No data available for DME Specific Peptides for TSLP Gene

Domains & Families for TSLP Gene

Protein Domains for TSLP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TSLP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TSLP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TSLP Gene

Function for TSLP Gene

Molecular function for TSLP Gene

UniProtKB/Swiss-Prot Function:
Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.
UniProtKB/Swiss-Prot Function:
Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.
UniProtKB/Swiss-Prot Induction:
Released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines.
genes like me logo Genes that share phenotypes with TSLP: view

Animal Models for TSLP Gene

MGI Knock Outs for TSLP:

Animal Model Products

  • Taconic Biosciences Mouse Models for TSLP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSLP Gene

Localization for TSLP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSLP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSLP Gene COMPARTMENTS Subcellular localization image for TSLP gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 1
endoplasmic reticulum 1
endosome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TSLP Gene

Pathways & Interactions for TSLP Gene

genes like me logo Genes that share pathways with TSLP: view

Pathways by source for TSLP Gene

1 BioSystems pathway for TSLP Gene
1 R&D Systems pathway for TSLP Gene

SIGNOR curated interactions for TSLP Gene

Activates:

Gene Ontology (GO) - Biological Process for TSLP Gene

None

Drugs & Compounds for TSLP Gene

(4) Drugs for TSLP Gene - From: Novoseek and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antibodies Pharma 4477
Antibodies, Monoclonal Pharma 2413
Immunoglobulins Pharma 4477

(3) Additional Compounds for TSLP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TSLP: view

Transcripts for TSLP Gene

Unigene Clusters for TSLP Gene

Thymic stromal lymphopoietin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSLP Gene

No ASD Table

Relevant External Links for TSLP Gene

GeneLoc Exon Structure for
TSLP
ECgene alternative splicing isoforms for
TSLP

Expression for TSLP Gene

mRNA expression in normal human tissues for TSLP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSLP Gene

This gene is overexpressed in Liver (x4.4) and Heart - Left Ventricle (x4.0).

SOURCE GeneReport for Unigene cluster for TSLP Gene Hs.389874

mRNA Expression by UniProt/SwissProt for TSLP Gene

Q969D9-TSLP_HUMAN
Tissue specificity: Isoform 1 is expressed in a number of tissues including heart, liver and prostate. Isoform 2 is the predominant form in keratinocytes of oral mucosa, skin and in salivary glands. It is secreted into saliva.
genes like me logo Genes that share expression patterns with TSLP: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TSLP Gene

Orthologs for TSLP Gene

This gene was present in the common ancestor of mammals.

Orthologs for TSLP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC617637 35
  • 67.14 (n)
  • 56.34 (a)
mouse
(Mus musculus)
Mammalia Tslp 35
  • 61.36 (n)
  • 44.7 (a)
Tslp 16
Tslp 36
  • 41 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TSLP 35
  • 99.79 (n)
  • 99.37 (a)
TSLP 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tslp 35
  • 65.92 (n)
  • 50 (a)
dog
(Canis familiaris)
Mammalia TSLP 36
  • 60 (a)
OneToOne
Species with no ortholog for TSLP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TSLP Gene

ENSEMBL:
Gene Tree for TSLP (if available)
TreeFam:
Gene Tree for TSLP (if available)

Paralogs for TSLP Gene

No data available for Paralogs for TSLP Gene

Variants for TSLP Gene

Sequence variations from dbSNP and Humsavar for TSLP Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1898671 -- 111,072,304(+) TTATG(C/T)GTCAA intron-variant, upstream-variant-2KB
rs2289276 -- 111,071,809(+) TGGCC(C/T)CTAAG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs2289277 -- 111,073,369(+) CAACC(A/C/G)TGACC intron-variant, utr-variant-5-prime
rs2289278 -- 111,073,450(+) TCTCA(C/G)CAACT intron-variant, utr-variant-5-prime
rs3806932 -- 111,069,977(+) CCTAT(A/G)TAATA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TSLP Gene

Variant ID Type Subtype PubMed ID
nsv830447 CNV Loss 17160897

Variation tolerance for TSLP Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSLP Gene

HapMap Linkage Disequilibrium report
TSLP
Human Gene Mutation Database (HGMD)
TSLP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSLP Gene

Disorders for TSLP Gene

MalaCards: The human disease database

(20) MalaCards diseases for TSLP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cryoglobulinemic vasculitis
  • essential cryoglobulinemia
eczema herpeticum
  • eczema herpeticum [ambiguous]
cryoglobulinemia
  • cryoimmunoglobulinaemia
allergic asthma
  • atopic asthma
membranoproliferative glomerulonephritis
  • chronic glomerulonephritis, lobular
- elite association - COSMIC cancer census association via MalaCards
Search TSLP in MalaCards View complete list of genes associated with diseases

Relevant External Links for TSLP

Genetic Association Database (GAD)
TSLP
Human Genome Epidemiology (HuGE) Navigator
TSLP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSLP
genes like me logo Genes that share disorders with TSLP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSLP Gene

Publications for TSLP Gene

  1. Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. (PMID: 11480573) Quentmeier H. … Lyman S.D. (Leukemia 2001) 2 3 4 23 67
  2. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. (PMID: 11418668) Reche P.A. … Bazan J.F. (J. Immunol. 2001) 2 3 23
  3. Functional role of thymic stromal lymphopoietin in chronic allergic keratoconjunctivitis. (PMID: 19741251) Matsuda A. … Murakami A. (Invest. Ophthalmol. Vis. Sci. 2010) 3 23
  4. Helicobacter pylori promotes the production of thymic stromal lymphopoietin by gastric epithelial cells and induces dendritic cell-mediated inflammatory Th2 responses. (PMID: 19841072) Kido M. … Watanabe N. (Infect. Immun. 2010) 3 23
  5. Opposing roles of IL-17A and IL-25 in the regulation of TSLP production in human nasal epithelial cells. (PMID: 19968632) Xu G. … Li H.B. (Allergy 2010) 3 23

Products for TSLP Gene

Sources for TSLP Gene

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