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Aliases for API5 Gene

Aliases for API5 Gene

  • Apoptosis Inhibitor 5 2 3 5
  • Fibroblast Growth Factor 2-Interacting Factor 2 2 3
  • Cell Migration-Inducing Gene 8 Protein 3 4
  • Migration-Inducing Protein MIG8 2 3
  • Antiapoptosis Clone 11 Protein 3 4
  • AAC-11 3 4
  • FIF 3 4
  • Fibroblast Growth Factor 2-Interacting Factor 4
  • Protein XAGL 4
  • API5-Like 1 2
  • AAC11 3
  • API-5 4

External Ids for API5 Gene

Previous GeneCards Identifiers for API5 Gene

  • GC11M045153
  • GC11P044016
  • GC11P043372
  • GC11P043297
  • GC11P043290
  • GC11P043043

Summaries for API5 Gene

Entrez Gene Summary for API5 Gene

  • This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

GeneCards Summary for API5 Gene

API5 (Apoptosis Inhibitor 5) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and fibroblast growth factor binding.

UniProtKB/Swiss-Prot for API5 Gene

  • Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.

Gene Wiki entry for API5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for API5 Gene

Genomics for API5 Gene

Regulatory Elements for API5 Gene

Promoters for API5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around API5 on UCSC Golden Path with GeneCards custom track

Genomic Location for API5 Gene

Chromosome:
11
Start:
43,311,955 bp from pter
End:
43,344,530 bp from pter
Size:
32,576 bases
Orientation:
Plus strand

Genomic View for API5 Gene

Genes around API5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
API5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for API5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for API5 Gene

Proteins for API5 Gene

  • Protein details for API5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZZ5-API5_HUMAN
    Recommended name:
    Apoptosis inhibitor 5
    Protein Accession:
    Q9BZZ5
    Secondary Accessions:
    • B4DGR0
    • B4DRJ2
    • B4E283
    • D3DR21
    • O15441
    • Q9Y4J7

    Protein attributes for API5 Gene

    Size:
    524 amino acids
    Molecular mass:
    59005 Da
    Quaternary structure:
    • Monomer. Interacts with FGF2 and ACIN1.
    SequenceCaution:
    • Sequence=AAB86528.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAB86528.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for API5 Gene

    Alternative splice isoforms for API5 Gene

neXtProt entry for API5 Gene

Proteomics data for API5 Gene at MOPED

Post-translational modifications for API5 Gene

  • Acetylation at Lys-251 impairs antiapoptotic function.
  • Ubiquitination at Lys 12, Lys 51, and Lys 487
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for API5 Gene

Domains & Families for API5 Gene

Protein Domains for API5 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BZZ5

UniProtKB/Swiss-Prot:

API5_HUMAN :
  • Two regions, an N-terminal (aa 96-107) and a C-terminal (aa 274-311) are required for binding FGF2.
  • Belongs to the API5 family.
Domain:
  • Two regions, an N-terminal (aa 96-107) and a C-terminal (aa 274-311) are required for binding FGF2.
Family:
  • Belongs to the API5 family.
genes like me logo Genes that share domains with API5: view

No data available for Gene Families for API5 Gene

Function for API5 Gene

Molecular function for API5 Gene

GENATLAS Biochemistry:
antiapoptosis 5,inhibiting apoptosis after growth factor withdrawal,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
genes like me logo Genes that share phenotypes with API5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for API5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for API5 Gene

Localization for API5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for API5 Gene

Nucleus. Cytoplasm. Note=Mainly nuclear. Can also be cytoplasmic.
Isoform 3: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for API5 Gene COMPARTMENTS Subcellular localization image for API5 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for API5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 11075807
genes like me logo Genes that share ontologies with API5: view

Pathways & Interactions for API5 Gene

SuperPathways for API5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for API5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for API5 Gene

Drugs & Compounds for API5 Gene

No Compound Related Data Available

Transcripts for API5 Gene

Unigene Clusters for API5 Gene

Apoptosis inhibitor 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for API5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - -
SP2: -
SP3:
SP4: -

Relevant External Links for API5 Gene

GeneLoc Exon Structure for
API5
ECgene alternative splicing isoforms for
API5

Expression for API5 Gene

mRNA expression in normal human tissues for API5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for API5 Gene

This gene is overexpressed in Lymph node (10.3) and Peripheral blood mononuclear cells (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for API5 Gene



SOURCE GeneReport for Unigene cluster for API5 Gene Hs.435771

mRNA Expression by UniProt/SwissProt for API5 Gene

Q9BZZ5-API5_HUMAN
Tissue specificity: Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer.
genes like me logo Genes that share expression patterns with API5: view

Protein tissue co-expression partners for API5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for API5 Gene

Orthologs for API5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for API5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia API5 36
  • 100 (a)
OneToOne
API5 35
  • 99.87 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia API5 35
  • 93.39 (n)
  • 98.6 (a)
API5 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia API5 36
  • 99 (a)
OneToOne
API5 35
  • 93.64 (n)
  • 98.85 (a)
mouse
(Mus musculus)
Mammalia Api5 16
Api5 36
  • 97 (a)
OneToOne
Api5 35
  • 89.85 (n)
  • 98.2 (a)
oppossum
(Monodelphis domestica)
Mammalia API5 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia API5 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Api5 35
  • 90.51 (n)
  • 98.6 (a)
chicken
(Gallus gallus)
Aves API5 35
  • 81.63 (n)
  • 95.19 (a)
API5 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia API5 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia srnyz021-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia api5 35
  • 74.42 (n)
  • 86.17 (a)
Str.5903 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6581 35
zebrafish
(Danio rerio)
Actinopterygii api5 35
  • 73.05 (n)
  • 84.07 (a)
srnyz021 35
api5 36
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009645 35
  • 53.79 (n)
  • 52.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta Aac11 37
  • 46 (a)
Aac11 35
  • 52.82 (n)
  • 48.68 (a)
Aac11 36
  • 45 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G29030 35
  • 49.13 (n)
  • 37.02 (a)
rice
(Oryza sativa)
Liliopsida Os02g0313400 35
  • 43.7 (n)
  • 31.1 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for API5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for API5 Gene

ENSEMBL:
Gene Tree for API5 (if available)
TreeFam:
Gene Tree for API5 (if available)

Paralogs for API5 Gene

Pseudogenes.org Pseudogenes for API5 Gene

genes like me logo Genes that share paralogs with API5: view

No data available for Paralogs for API5 Gene

Variants for API5 Gene

Sequence variations from dbSNP and Humsavar for API5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_021519 -
rs5743240 - 43,327,831(+) GTGAC(A/G)TGGAA nc-transcript-variant, reference, missense
VAR_021521 -
rs14754 -- 43,344,358(+) CCCTT(C/T)CCCTT nc-transcript-variant, utr-variant-3-prime
rs1143463 -- 43,320,874(-) CGAGG(A/G)AGGTT nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for API5 Gene

Variant ID Type Subtype PubMed ID
esv270488 CNV Insertion 20981092

Variation tolerance for API5 Gene

Residual Variation Intolerance Score: 18.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for API5 Gene

HapMap Linkage Disequilibrium report
API5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for API5 Gene

Disorders for API5 Gene

Relevant External Links for API5

Genetic Association Database (GAD)
API5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
API5

No disorders were found for API5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for API5 Gene

Publications for API5 Gene

  1. AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal. (PMID: 9307294) Tewari M. … Rubin R. (Cancer Res. 1997) 2 3 4 67
  2. Tumor suppressors miR-143 and miR-145 and predicted target proteins API5, ERK5, K-RAS, and IRS-1 are differentially expressed in proximal and distal colon. (PMID: 25477374) Pekow J. … Bissonnette M. (Am. J. Physiol. Gastrointest. Liver Physiol. 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. MicroRNA-1 promotes apoptosis of hepatocarcinoma cells by targeting apoptosis inhibitor-5 (API-5). (PMID: 25433291) Li D. … Zhang T. (FEBS Lett. 2015) 3

Products for API5 Gene

Sources for API5 Gene

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