Aliases for MYLK2 Gene
External Ids for MYLK2 Gene
Previous GeneCards Identifiers for MYLK2 Gene
This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle. [provided by RefSeq, Jul 2008]
GeneCards Summary for MYLK2 Gene
MYLK2 (Myosin Light Chain Kinase 2) is a Protein Coding gene. Diseases associated with MYLK2 include cardiomyopathy, familial hypertrophic and cardiomyopathy. Among its related pathways are Regulation of actin cytoskeleton and Aquaporin-mediated transport. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MYLK4.
UniProtKB/Swiss-Prot for MYLK2 Gene
Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.
Myosin Light Chain Kinases (MLCKs) are a group of protein serine/threonine kinases that are currently divided into two subtypes. MLCK1 is found in smooth muscle and phosphorylates myosin II regulatory light chains at Ser19. MLCK2 is located in the striated muscle.