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Aliases for ALG2 Gene

Aliases for ALG2 Gene

  • ALG2, Alpha-1,3/1,6-Mannosyltransferase 2 3
  • Asparagine-Linked Glycosylation 2 Homolog (Yeast, Alpha-1,3-Mannosyltransferase) 2 3
  • GDP-Man:Man(1)GlcNAc(2)-PP-Dol Alpha-1,3-Mannosyltransferase 3 4
  • GDP-Man:Man(2)GlcNAc(2)-PP-Dol Alpha-1,6-Mannosyltransferase 3 4
  • GDP-Man:Man(1)GlcNAc(2)-PP-Dolichol Mannosyltransferase 3 4
  • Asparagine-Linked Glycosylation Protein 2 Homolog 3 4
  • CDGIi 3 6
  • Asparagine-Linked Glycosylation 2, Alpha-1,3-Mannosyltransferase Homolog (S. Cerevisiae) 2
  • Asparagine-Linked Glycosylation 2 Homolog (S. Cerevisiae, Alpha-1,3-Mannosyltransferase) 3
  • Asparagine-Linked Glycosylation 2, Alpha-1,3-Mannosyltransferase Homolog 3
  • Alpha-1,3/1,6-Mannosyltransferase ALG2 3
  • Alpha-1,3-Mannosyltransferase ALG2 3
  • Homolog Of Yeast ALG2 3
  • EC 4
  • EC 4
  • EC 2.4.1 63
  • CMSTA3 3
  • HALPG2 3
  • NET38 3

External Ids for ALG2 Gene

Previous GeneCards Identifiers for ALG2 Gene

  • GC09M095436
  • GC09M097359
  • GC09M097358
  • GC09M099058
  • GC09M101018
  • GC09M101978
  • GC09M071577

Summaries for ALG2 Gene

Entrez Gene Summary for ALG2 Gene

  • This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

GeneCards Summary for ALG2 Gene

ALG2 (ALG2, Alpha-1,3/1,6-Mannosyltransferase) is a Protein Coding gene. Diseases associated with ALG2 include congenital disorder of glycosylation, type ii and congenital myasthenic syndromes with glycosylation defect. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include protein heterodimerization activity and calcium-dependent protein binding.

UniProtKB/Swiss-Prot for ALG2 Gene

  • Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.

Gene Wiki entry for ALG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALG2 Gene

Genomics for ALG2 Gene

Regulatory Elements for ALG2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ALG2 Gene

99,216,425 bp from pter
99,221,964 bp from pter
5,540 bases
Minus strand

Genomic View for ALG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALG2 Gene

Proteins for ALG2 Gene

  • Protein details for ALG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-1,3/1,6-mannosyltransferase ALG2
    Protein Accession:
    Secondary Accessions:
    • A2A2Y0
    • Q8NBX2
    • Q8NC39

    Protein attributes for ALG2 Gene

    416 amino acids
    Molecular mass:
    47092 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ALG2 Gene


neXtProt entry for ALG2 Gene

Proteomics data for ALG2 Gene at MOPED

Selected DME Specific Peptides for ALG2 Gene

Post-translational modifications for ALG2 Gene

  • Ubiquitination at Lys48
  • Modification sites at PhosphoSitePlus

Other Protein References for ALG2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for ALG2 Gene

Gene Families for ALG2 Gene

  • GLT1 :Glycosyltransferase group 1 domain containing

Protein Domains for ALG2 Gene

Suggested Antigen Peptide Sequences for ALG2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9H553
  • Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
genes like me logo Genes that share domains with ALG2: view

Function for ALG2 Gene

Molecular function for ALG2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
GDP-D-mannose + D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-GlcNAc-diphosphodolichol
UniProtKB/Swiss-Prot CatalyticActivity:
GDP-D-mannose + D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
UniProtKB/Swiss-Prot Function:
Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.

Enzyme Numbers (IUBMB) for ALG2 Gene

Gene Ontology (GO) - Molecular Function for ALG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000033 alpha-1,3-mannosyltransferase activity IDA 12684507
GO:0004378 GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity IEA --
GO:0005515 protein binding IPI 11883939
GO:0033164 glycolipid 6-alpha-mannosyltransferase activity IEA --
GO:0043495 protein anchor --
genes like me logo Genes that share ontologies with ALG2: view

Phenotypes for ALG2 Gene

GenomeRNAi human phenotypes for ALG2:
genes like me logo Genes that share phenotypes with ALG2: view

Animal Model Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ALG2 Gene

Localization for ALG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALG2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ALG2 Gene COMPARTMENTS Subcellular localization image for ALG2 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4
cytoskeleton 1
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ALG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11278427
GO:0005737 cytoplasm IDA 11278427
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA 16996505
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ALG2: view

Pathways for ALG2 Gene

genes like me logo Genes that share pathways with ALG2: view

UniProtKB/Swiss-Prot Q9H553-ALG2_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for ALG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0009058 biosynthetic process --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0033577 protein glycosylation in endoplasmic reticulum IGI 12684507
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ALG2: view

Compounds for ALG2 Gene

(3) HMDB Compounds for ALG2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Dolichol (C100)
Guanosine diphosphate
  • 5'-GDP
Guanosine diphosphate mannose
  • GDP mannose
genes like me logo Genes that share compounds with ALG2: view

Transcripts for ALG2 Gene

mRNA/cDNA for ALG2 Gene

Unigene Clusters for ALG2 Gene

ALG2, alpha-1,3/1,6-mannosyltransferase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALG2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALG2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP3: - -

Relevant External Links for ALG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALG2 Gene

mRNA expression in normal human tissues for ALG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ALG2 Gene

This gene is overexpressed in Stomach (15.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ALG2 Gene

SOURCE GeneReport for Unigene cluster for ALG2 Gene Hs.40919

genes like me logo Genes that share expressions with ALG2: view

Expression partners for ALG2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ALG2 Gene

Orthologs for ALG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ALG2 35
  • 88.54 (n)
  • 89.18 (a)
ALG2 36
  • 89 (a)
(Canis familiaris)
Mammalia ALG2 35
  • 89.98 (n)
  • 90.38 (a)
ALG2 36
  • 90 (a)
(Mus musculus)
Mammalia Alg2 35
  • 82.49 (n)
  • 80.72 (a)
Alg2 16
Alg2 36
  • 81 (a)
(Pan troglodytes)
Mammalia ALG2 35
  • 99.36 (n)
  • 99.76 (a)
ALG2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Alg2 35
  • 81.85 (n)
  • 81.45 (a)
(Monodelphis domestica)
Mammalia ALG2 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia ALG2 36
  • 73 (a)
(Gallus gallus)
Aves ALG2 35
  • 70.86 (n)
  • 72.19 (a)
ALG2 36
  • 72 (a)
(Anolis carolinensis)
Reptilia ALG2 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia alg2 35
  • 66.58 (n)
  • 68.42 (a)
(Danio rerio)
Actinopterygii alg2 35
  • 64.3 (n)
  • 68.35 (a)
Dr.18620 35
alg2 36
  • 59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001232 35
  • 56.99 (n)
  • 55.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1291 35
  • 55.78 (n)
  • 53.42 (a)
CG1291 36
  • 50 (a)
(Caenorhabditis elegans)
Secernentea F09E5.2 35
  • 51.31 (n)
  • 48.09 (a)
bus-8 36
  • 27 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL098W 35
  • 49.83 (n)
  • 42.78 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02420g 35
  • 49.43 (n)
  • 45.69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALG2 35
  • 49.28 (n)
  • 43.73 (a)
ALG2 36
  • 34 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G78800 35
  • 51.91 (n)
  • 50.38 (a)
(Oryza sativa)
Liliopsida Os04g0589600 35
  • 52.49 (n)
  • 50.13 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03503 35
  • 50.59 (n)
  • 44.22 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes alg2 35
  • 48.16 (n)
  • 41.96 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2651 36
  • 52 (a)
Species with no ortholog for ALG2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALG2 Gene

Gene Tree for ALG2 (if available)
Gene Tree for ALG2 (if available)

Paralogs for ALG2 Gene

No data available for Paralogs for ALG2 Gene

Variants for ALG2 Gene

Sequence variations from dbSNP and Humsavar for ALG2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs13283030 -- 99,217,692(+) CATGG(A/T)ATGAC utr-variant-3-prime, nc-transcript-variant
rs34382969 -- 99,218,204(+) ATGCC(A/G)AAGTG synonymous-codon, reference, nc-transcript-variant
rs34630037 -- 99,219,975(+) AAATA(-/C)CAAAT intron-variant
rs34736268 -- 99,215,932(+) TACCA(-/G)GAATT downstream-variant-500B
rs35149914 -- 99,219,035(+) GTGCT(-/A)AAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALG2 Gene

Variant ID Type Subtype PubMed ID
nsv831666 CNV Gain 17160897

Relevant External Links for ALG2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALG2 Gene

Disorders for ALG2 Gene

(1) OMIM Diseases for ALG2 Gene (607905)


  • Congenital disorder of glycosylation 1I (CDG1I) [MIM:607906]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. {ECO:0000269 PubMed:12684507}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for ALG2 Gene

Relevant External Links for ALG2

genes like me logo Genes that share disorders with ALG2: view

No data available for Novoseek inferred disease relationships and Genatlas for ALG2 Gene

Publications for ALG2 Gene

  1. A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis. (PMID: 12684507) Thiel C. … Koerner C. (J. Biol. Chem. 2003) 2 3 4
  2. The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability. (PMID: 19383317) la Cour J.M. … Berchtold M.W. (Mol Oncol 2008) 3 23
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4

Products for ALG2 Gene

Sources for ALG2 Gene

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