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Aliases for TRIM5 Gene

Aliases for TRIM5 Gene

  • Tripartite Motif Containing 5 2 3
  • RNF88 3 4 6
  • Tripartite Motif Protein TRIM5 2 3
  • Tripartite Motif Containing 5 Transcript Variant Kappa 3
  • Tripartite Motif Containing 5 Transcript Variant Iota 3
  • Tripartite Motif-Containing Protein 5 3
  • Tripartite Motif Protein TRIM 2
  • Tripartite Motif-Containing 5 2
  • Ring Finger Protein 88 3
  • RING Finger Protein 88 4
  • TRIM5alpha 3
  • EC 6.3.2.- 4
  • EC 6.3.2 63

External Ids for TRIM5 Gene

Summaries for TRIM5 Gene

Entrez Gene Summary for TRIM5 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for TRIM5 Gene

TRIM5 (Tripartite Motif Containing 5) is a Protein Coding gene. Diseases associated with TRIM5 include hiv-1. GO annotations related to this gene include protein homodimerization activity and ubiquitin-protein transferase activity. An important paralog of this gene is TRIM58.

UniProtKB/Swiss-Prot for TRIM5 Gene

  • Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates Lys-63-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV) and equine infectious anemia virus (EIAV).

Gene Wiki entry for TRIM5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM5 Gene

Genomics for TRIM5 Gene

Genomic Location for TRIM5 Gene

Start:
5,663,195 bp from pter
End:
5,938,619 bp from pter
Size:
275,425 bases
Orientation:
Minus strand

Genomic View for TRIM5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM5 Gene

Regulatory Elements for TRIM5 Gene

Proteins for TRIM5 Gene

  • Protein details for TRIM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C035-TRIM5_HUMAN
    Recommended name:
    Tripartite motif-containing protein 5
    Protein Accession:
    Q9C035
    Secondary Accessions:
    • A6NGQ1
    • A8WFA8
    • D3DQS8
    • D3DQS9
    • G3GJY1
    • Q2MLV4
    • Q2MLV8
    • Q2MLV9
    • Q2MLW1
    • Q2MLW3
    • Q2MLW4
    • Q2MLW6
    • Q2MLW7
    • Q2MLX1
    • Q2MLX2
    • Q2MLX3
    • Q2MLX5
    • Q2MLY3
    • Q2MLY4
    • Q2V6Q6
    • Q6GX26
    • Q8WU46
    • Q96SR5
    • Q9C031
    • Q9C032
    • Q9C033
    • Q9C034

    Protein attributes for TRIM5 Gene

    Size:
    493 amino acids
    Molecular mass:
    56338 Da
    Quaternary structure:
    • Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Isoform Delta interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70 (By similarity). Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, SQSTM1, MAP3K7/TAK1, TAB2 and TAB3.

    Three dimensional structures from OCA and Proteopedia for TRIM5 Gene

    Alternative splice isoforms for TRIM5 Gene

neXtProt entry for TRIM5 Gene

Proteomics data for TRIM5 Gene at MOPED

Post-translational modifications for TRIM5 Gene

  • Autoubiquitinated in a RING finger- and UBE2D2-dependent manner. Monoubiquitinated by TRIM21. Deubiquitinated by Yersinia YopJ. Ubiquitination may not lead to proteasomal degradation.
  • Degraded in a proteasome-independent fashion in the absence of viral infection but in a proteasome-dependent fashion following exposure to restriction sensitive virus
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys50, Lys91, Lys111, Lys255, Lys282, Lys324, and Lys481

Domains for TRIM5 Gene

Gene Families for TRIM5 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Graphical View of Domain Structure for InterPro Entry

Q9C035

UniProtKB/Swiss-Prot:

TRIM5_HUMAN
Domain:
  • The B box-type zinc finger domain and the coiled-coil domain contribute to the higher and low order multimerization respectively which is essential for restriction activity.:
    • Q9C035
  • The B30.2/SPRY domain acts as a capsid recognition domain. Polymorphisms in this domain explain the observed species-specific differences among orthologs (PubMed:22482711).:
    • Q9C035
  • The RING-type zinc finger domain confers E3 ubiquitin ligase activity and is essential for retrovirus restriction activity, autoubiquitination and higher-order multimerization.:
    • Q9C035
  • Contains 1 B30.2/SPRY domain.:
    • Q9C035
Family:
  • Belongs to the TRIM/RBCC family.:
    • Q9C035
Similarity:
  • Contains 1 B box-type zinc finger.:
    • Q9C035
  • Contains 1 RING-type zinc finger.:
    • Q9C035
genes like me logo Genes that share domains with TRIM5: view

Function for TRIM5 Gene

Molecular function for TRIM5 Gene

UniProtKB/Swiss-Prot Function: Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates Lys-63-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV) and equine infectious anemia virus (EIAV).

Enzyme Numbers (IUBMB) for TRIM5 Gene

Gene Ontology (GO) - Molecular Function for TRIM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 21512573
GO:0005515 protein binding IPI 12878161
GO:0008270 zinc ion binding IEA --
GO:0008329 signaling pattern recognition receptor activity IDA 21512573
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRIM5: view

miRNA for TRIM5 Gene

miRTarBase miRNAs that target TRIM5

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIM5 Gene

Localization for TRIM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM5 Gene

Cytoplasm, P-body. Note=Closely associates with proteasomal subunits in cytoplasmic bodies (By similarity). Colocalizes with SQSTM1 in cytoplasmic bodies. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM5 Gene COMPARTMENTS Subcellular localization image for TRIM5 gene
Compartment Confidence
golgi apparatus 4
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for TRIM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IDA 12878161
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm IDA 11331580
GO:0005794 Golgi apparatus --
genes like me logo Genes that share ontologies with TRIM5: view

Pathways for TRIM5 Gene

SuperPathways for TRIM5 Gene

No Data Available

UniProtKB/Swiss-Prot Q9C035-TRIM5_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002218 activation of innate immune response IDA 21512573
GO:0002221 pattern recognition receptor signaling pathway IDA 21512573
GO:0016032 viral process IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway IMP 21512573
genes like me logo Genes that share ontologies with TRIM5: view

No data available for Pathways by source for TRIM5 Gene

Compounds for TRIM5 Gene

(4) HMDB Compounds for TRIM5 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(2) Novoseek inferred chemical compound relationships for TRIM5 Gene

Compound -log(P) Hits PubMed IDs
arsenite 43.3 1
cyclosporin a 31.2 3
genes like me logo Genes that share compounds with TRIM5: view

Transcripts for TRIM5 Gene

Unigene Clusters for TRIM5 Gene

Tripartite motif containing 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - -
SP2: - -
SP3:
SP4:

Relevant External Links for TRIM5 Gene

GeneLoc Exon Structure for
TRIM5
ECgene alternative splicing isoforms for
TRIM5

Expression for TRIM5 Gene

mRNA expression in normal human tissues for TRIM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM5 Gene

SOURCE GeneReport for Unigene cluster for TRIM5 Gene Hs.125300

genes like me logo Genes that share expressions with TRIM5: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRIM5 Gene

Orthologs for TRIM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM5 35
  • 99.05 (n)
  • 97.77 (a)
TRIM5 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 50 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
LOC616948 35
  • 74.55 (n)
  • 62.03 (a)
TRIM5 36
  • 59 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TRIM34 36
  • 31 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Trim12a 36
  • 53 (a)
OneToMany
Trim12c 36
  • 49 (a)
OneToMany
Trim30a 36
  • 46 (a)
OneToMany
Trim30b 36
  • 47 (a)
OneToMany
Trim30c 36
  • 44 (a)
OneToMany
Trim30d 36
  • 45 (a)
OneToMany
Trim5 35
  • 66.25 (n)
  • 53.33 (a)
Trim5 16
Trim5 36
  • 50 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Trim5 35
  • 67.01 (n)
  • 53.72 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 29 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 29 (a)
OneToMany
Species with no ortholog for TRIM5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM5 Gene

ENSEMBL:
Gene Tree for TRIM5 (if available)
TreeFam:
Gene Tree for TRIM5 (if available)

Paralogs for TRIM5 Gene

Pseudogenes.org Pseudogenes for TRIM5 Gene

genes like me logo Genes that share paralogs with TRIM5: view

Variants for TRIM5 Gene

Sequence variations from dbSNP and Humsavar for TRIM5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs904375 -- 5,670,750(+) ATATT(C/T)GAGAT intron-variant
rs937446 -- 5,684,260(+) tcccc(A/G)tactc intron-variant
rs1566281 -- 5,663,187(+) TTACC(A/C)CTTAC downstream-variant-500B
rs1566282 -- 5,663,545(+) AGATC(A/G)AGACA utr-variant-3-prime, downstream-variant-500B
rs1814720 -- 5,684,077(+) aggaa(C/G)aaact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM5 Gene

Variant ID Type Subtype PubMed ID
nsv896939 CNV Loss 21882294
nsv896948 CNV Loss 21882294
esv22319 CNV Loss 19812545

Relevant External Links for TRIM5 Gene

HapMap Linkage Disequilibrium report
TRIM5
Human Gene Mutation Database (HGMD)
TRIM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM5 Gene

Disorders for TRIM5 Gene

(1) MalaCards Diseases for TRIM5 Gene

Search for TRIM5 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TRIM5 Gene

(5) Novoseek inferred disease relationships for TRIM5 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 68.1 25
retrovirus infections 66.7 1
leukemia 46.8 7
virus infection 22.4 2
aids 0 1

Relevant External Links for TRIM5

Genetic Association Database (GAD)
TRIM5
Human Genome Epidemiology (HuGE) Navigator
TRIM5
genes like me logo Genes that share disorders with TRIM5: view

No data available for UniProtKB/Swiss-Prot for TRIM5 Gene

Publications for TRIM5 Gene

  1. Trim5alpha protein restricts both HIV-1 and murine leukemia virus. (PMID: 15249690) Yap M.W. … Stoye J.P. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 23
  2. Retroviral restriction factors Fv1 and TRIM5alpha act independently and can compete for incoming virus before reverse transcription. (PMID: 16474118) Passerini L.D. … Towers G.J. (J. Virol. 2006) 3 4 23
  3. High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans. (PMID: 16401428) Sawyer S.L. … Malik H.S. (Curr. Biol. 2006) 3 4 23
  4. The effect of Trim5 polymorphisms on the clinical course of HIV-1 infection. (PMID: 18248091) van Manen D. … Kootstra N.A. (PLoS Pathog. 2008) 3 23 48
  5. p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha. (PMID: 20357094) O'Connor C. … Campbell E.M. (J. Virol. 2010) 3 4 23

Products for TRIM5 Gene

Sources for TRIM5 Gene

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