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Aliases for TRIM5 Gene

Aliases for TRIM5 Gene

  • Tripartite Motif Containing 5 2 3
  • Tripartite Motif Protein TRIM5 2 3
  • RNF88 3 4
  • Tripartite Motif Containing 5 Transcript Variant Kappa 3
  • Tripartite Motif Containing 5 Transcript Variant Iota 3
  • Tripartite Motif Protein TRIM 2
  • Tripartite Motif-Containing 5 2
  • Ring Finger Protein 88 3
  • RING Finger Protein 88 4
  • TRIM5alpha 3
  • EC 6.3.2.- 4
  • EC 6.3.2 63

External Ids for TRIM5 Gene

Previous GeneCards Identifiers for TRIM5 Gene

  • GC11M006432
  • GC11M005986
  • GC11M005643
  • GC11M005649
  • GC11M005345

Summaries for TRIM5 Gene

Entrez Gene Summary for TRIM5 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for TRIM5 Gene

TRIM5 (Tripartite Motif Containing 5) is a Protein Coding gene. Diseases associated with TRIM5 include rubella and ipex syndrome. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include protein homodimerization activity and ligase activity. An important paralog of this gene is TRIM58.

UniProtKB/Swiss-Prot for TRIM5 Gene

  • Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates Lys-63-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) (PubMed:17156811). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057).

Gene Wiki entry for TRIM5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM5 Gene

Genomics for TRIM5 Gene

Regulatory Elements for TRIM5 Gene

Genomic Location for TRIM5 Gene

Chromosome:
11
Start:
5,590,982 bp from pter
End:
5,938,619 bp from pter
Size:
347,638 bases
Orientation:
Minus strand

Genomic View for TRIM5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM5 Gene

Proteins for TRIM5 Gene

  • Protein details for TRIM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C035-TRIM5_HUMAN
    Recommended name:
    Tripartite motif-containing protein 5
    Protein Accession:
    Q9C035
    Secondary Accessions:
    • A6NGQ1
    • A8WFA8
    • D3DQS8
    • D3DQS9
    • G3GJY1
    • Q2MLV4
    • Q2MLV8
    • Q2MLV9
    • Q2MLW1
    • Q2MLW3
    • Q2MLW4
    • Q2MLW6
    • Q2MLW7
    • Q2MLX1
    • Q2MLX2
    • Q2MLX3
    • Q2MLX5
    • Q2MLY3
    • Q2MLY4
    • Q2V6Q6
    • Q6GX26
    • Q8WU46
    • Q96SR5
    • Q9C031
    • Q9C032
    • Q9C033
    • Q9C034

    Protein attributes for TRIM5 Gene

    Size:
    493 amino acids
    Molecular mass:
    56338 Da
    Quaternary structure:
    • Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Isoform Delta interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70 (By similarity). Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3 (PubMed:21512573, PubMed:22078707). Interacts with SQSTM1 (PubMed:20357094, PubMed:25127057). Interacts with TRIM6 and TRIM34 (PubMed:21680743, PubMed:17156811). Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1 (PubMed:25127057).

    Three dimensional structures from OCA and Proteopedia for TRIM5 Gene

    Alternative splice isoforms for TRIM5 Gene

neXtProt entry for TRIM5 Gene

Proteomics data for TRIM5 Gene at MOPED

Post-translational modifications for TRIM5 Gene

  • Autoubiquitinated in a RING finger- and UBE2D2-dependent manner. Monoubiquitinated by TRIM21. Deubiquitinated by Yersinia YopJ. Ubiquitination may not lead to proteasomal degradation.
  • Degraded in a proteasome-independent fashion in the absence of viral infection but in a proteasome-dependent fashion following exposure to restriction sensitive virus
  • Ubiquitination at Lys 50, Lys 91, Lys 111, Lys 255, Lys 282, Lys 324, and Lys 481
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TRIM5 (TRIM5)

Domains & Families for TRIM5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9C035

UniProtKB/Swiss-Prot:

TRIM5_HUMAN :
  • The B box-type zinc finger domain and the coiled-coil domain contribute to the higher and low order multimerization respectively which is essential for restriction activity (PubMed:22482711). The coiled coil domain is important for higher order multimerization by promoting the initial dimerization (By similarity).
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Domain:
  • The B box-type zinc finger domain and the coiled-coil domain contribute to the higher and low order multimerization respectively which is essential for restriction activity (PubMed:22482711). The coiled coil domain is important for higher order multimerization by promoting the initial dimerization (By similarity).
  • The B30.2/SPRY domain acts as a capsid recognition domain. Polymorphisms in this domain explain the observed species-specific differences among orthologs (PubMed:22482711).
  • The RING-type zinc finger domain confers E3 ubiquitin ligase activity and is essential for retrovirus restriction activity, autoubiquitination and higher-order multimerization.
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM5: view

Function for TRIM5 Gene

Molecular function for TRIM5 Gene

UniProtKB/Swiss-Prot Function:
Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates Lys-63-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) (PubMed:17156811). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057).

Enzyme Numbers (IUBMB) for TRIM5 Gene

Gene Ontology (GO) - Molecular Function for TRIM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 21512573
GO:0005515 protein binding IPI 12878161
GO:0008270 zinc ion binding IEA --
GO:0008329 signaling pattern recognition receptor activity IDA 21512573
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRIM5: view

Phenotypes for TRIM5 Gene

GenomeRNAi human phenotypes for TRIM5:
genes like me logo Genes that share phenotypes with TRIM5: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM5

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM5 Gene

Localization for TRIM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM5 Gene

Cytoplasm. Cytoplasm, P-body. Nucleus. Note=Predominantly cytoplasmic, and is only occasionally and partially localized in the nucleus (PubMed:25127057). Closely associates with proteasomal subunits in cytoplasmic bodies (By similarity). Colocalizes with SQSTM1 in cytoplasmic bodies (By similarity). {ECO:0000250 UniProtKB:Q0PF16, ECO:0000269 PubMed:25127057}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM5 Gene COMPARTMENTS Subcellular localization image for TRIM5 gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for TRIM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IDA 12878161
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 11331580
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TRIM5: view

Pathways & Interactions for TRIM5 Gene

genes like me logo Genes that share pathways with TRIM5: view

Pathways by source for TRIM5 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9C035-TRIM5_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002218 activation of innate immune response IDA 21512573
GO:0002221 pattern recognition receptor signaling pathway IDA 21512573
GO:0006914 autophagy IDA 25127057
GO:0016032 viral process IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with TRIM5: view

No data available for SIGNOR curated interactions for TRIM5 Gene

Drugs & Compounds for TRIM5 Gene

(4) Drugs for TRIM5 Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0
Cyclosporin A Pharma Inhibition, Inhibitor Immunosuppressive agent, Calcineurin inhibitor 0

(2) Additional Compounds for TRIM5 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
arsenite
  • AArsenite (AsO33-)
  • Arsenic (III) oxide
  • Arsenic (III) trioxide
  • Arsenic sesquioxide
  • Arsenic trioxide
15502-74-6
genes like me logo Genes that share compounds with TRIM5: view

Transcripts for TRIM5 Gene

Unigene Clusters for TRIM5 Gene

Tripartite motif containing 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - -
SP2: - -
SP3:
SP4:

Relevant External Links for TRIM5 Gene

GeneLoc Exon Structure for
TRIM5
ECgene alternative splicing isoforms for
TRIM5

Expression for TRIM5 Gene

mRNA expression in normal human tissues for TRIM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRIM5 Gene

This gene is overexpressed in Adrenal (43.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM5 Gene



SOURCE GeneReport for Unigene cluster for TRIM5 Gene Hs.125300

genes like me logo Genes that share expression patterns with TRIM5: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRIM5 Gene

Orthologs for TRIM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC616948 35
  • 74.55 (n)
  • 62.03 (a)
-- 36
  • 50 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
TRIM5 36
  • 59 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Trim5 35
  • 66.25 (n)
  • 53.33 (a)
Trim5 16
Trim12a 36
  • 53 (a)
OneToMany
Trim12c 36
  • 49 (a)
OneToMany
Trim30a 36
  • 46 (a)
OneToMany
Trim30b 36
  • 47 (a)
OneToMany
Trim30c 36
  • 44 (a)
OneToMany
Trim30d 36
  • 45 (a)
OneToMany
Trim5 36
  • 50 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TRIM5 35
  • 99.05 (n)
  • 97.77 (a)
TRIM5 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim5 35
  • 67.01 (n)
  • 53.72 (a)
dog
(Canis familiaris)
Mammalia TRIM34 36
  • 31 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 29 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 29 (a)
OneToMany
Species with no ortholog for TRIM5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM5 Gene

ENSEMBL:
Gene Tree for TRIM5 (if available)
TreeFam:
Gene Tree for TRIM5 (if available)

Paralogs for TRIM5 Gene

Pseudogenes.org Pseudogenes for TRIM5 Gene

genes like me logo Genes that share paralogs with TRIM5: view

Variants for TRIM5 Gene

Sequence variations from dbSNP and Humsavar for TRIM5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1976338 -- 5,663,170(+) CCCAA(C/T)ACCAT downstream-variant-500B, intron-variant
rs1976339 -- 5,663,172(+) CAACA(C/G)CATAA downstream-variant-500B, intron-variant
rs1982990 -- 5,667,378(+) atttt(G/T)gtatt intron-variant
rs1995161 -- 5,686,797(+) ACATG(A/G)TGAAA upstream-variant-2KB
rs2133256 -- 5,684,445(+) ACAGA(A/G)CTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM5 Gene

Variant ID Type Subtype PubMed ID
nsv896939 CNV Loss 21882294
nsv896948 CNV Loss 21882294
esv22319 CNV Loss 19812545

Variation tolerance for TRIM5 Gene

Residual Variation Intolerance Score: 82.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.88; 94.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM5 Gene

HapMap Linkage Disequilibrium report
TRIM5
Human Gene Mutation Database (HGMD)
TRIM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM5 Gene

Disorders for TRIM5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TRIM5 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
rubella
  • german measles
ipex syndrome
  • immunodeficiency
human immunodeficiency virus infectious disease
hiv-1
  • aids, slow progression to
- elite association
Search TRIM5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRIM5

Genetic Association Database (GAD)
TRIM5
Human Genome Epidemiology (HuGE) Navigator
TRIM5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM5
genes like me logo Genes that share disorders with TRIM5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM5 Gene

Publications for TRIM5 Gene

  1. Evolution of TRIM5alpha B30.2 (SPRY) domain in New World primates. (PMID: 19931648) Soares E.A. … SeuA!nez H.N. (Infect. Genet. Evol. 2010) 23 67
  2. Restriction of feline retroviruses: lessons from cat APOBEC3 cytidine deaminases and TRIM5alpha proteins. (PMID: 19896724) MA1nk C. … LAPchelt M. (Vet. Immunol. Immunopathol. 2010) 23 67
  3. Simian TRIM5alpha proteins reduce replication of herpes simplex virus. (PMID: 20060996) Reszka N. … Knipe D.M. (Virology 2010) 23 67
  4. p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha. (PMID: 20357094) O'Connor C. … Campbell E.M. (J. Virol. 2010) 23 67
  5. Molecular evolution of the antiretroviral TRIM5 gene. (PMID: 19238338) Johnson W.E. … Sawyer S.L. (Immunogenetics 2009) 23 67

Products for TRIM5 Gene

Sources for TRIM5 Gene

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