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Aliases for CYP4F2 Gene

Aliases for CYP4F2 Gene

  • Cytochrome P450 Family 4 Subfamily F Member 2 2 3 5
  • Cytochrome P450, Family 4, Subfamily F, Polypeptide 2 2 3
  • Cytochrome P450, Subfamily IVF, Polypeptide 2 2 3
  • 20-Hydroxyeicosatetraenoic Acid Synthase 3 4
  • Leukotriene-B(4) Omega-Hydroxylase 1 3 4
  • Leukotriene-B(4) 20-Monooxygenase 1 3 4
  • Arachidonic Acid Omega-Hydroxylase 3 4
  • Cytochrome P450-LTB-Omega 3 4
  • Cytochrome P450 4F2 3 4
  • 20-HETE Synthase 3 4
  • CYPIVF2 3 4
  • EC 1.14.13.194 4
  • EC 1.14.13.30 4
  • EC 1.14.13.- 4
  • CPF2 3

External Ids for CYP4F2 Gene

Previous GeneCards Identifiers for CYP4F2 Gene

  • GC19M016474
  • GC19M015725
  • GC19M015849
  • GC19M015988
  • GC19M015560

Summaries for CYP4F2 Gene

Entrez Gene Summary for CYP4F2 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP4F2 Gene

CYP4F2 (Cytochrome P450 Family 4 Subfamily F Member 2) is a Protein Coding gene. Diseases associated with CYP4F2 include Cyp4f2-Related Altered Drug Metabolism and Vitamin K Antagonists Toxicity Or Dose Selection. Among its related pathways are Phase II conjugation and Arachidonic acid metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F8.

UniProtKB/Swiss-Prot for CYP4F2 Gene

  • Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:19297519, PubMed:24138531). Also shows arachidonic acid omega-hydroxylase activity in kidney, by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), possibly influencing blood pressure control (PubMed:10660572, PubMed:17341693, PubMed:18574070). Also acts as a leukotriene-B(4) omega-hydroxylase by mediating conversion of leukotriene-B(4) (LTB4) to its omega-hydroxylated metabolite 20-hydroxyleukotriene-B(4) (20-OH LTB4) (PubMed:8026587, PubMed:9799565).

Gene Wiki entry for CYP4F2 Gene

PharmGKB "VIP" Summary for CYP4F2 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4F2 Gene

Genomics for CYP4F2 Gene

Regulatory Elements for CYP4F2 Gene

Enhancers for CYP4F2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CYP4F2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP4F2 Gene

Chromosome:
19
Start:
15,878,023 bp from pter
End:
15,898,120 bp from pter
Size:
20,098 bases
Orientation:
Minus strand

Genomic View for CYP4F2 Gene

Genes around CYP4F2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP4F2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP4F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4F2 Gene

Proteins for CYP4F2 Gene

  • Protein details for CYP4F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78329-CP4F2_HUMAN
    Recommended name:
    Phylloquinone omega-hydroxylase CYP4F2
    Protein Accession:
    P78329
    Secondary Accessions:
    • A0A024R7K3
    • A8K425
    • B4DV75
    • Q16677
    • Q6NWT4
    • Q6NWT6
    • Q9NNZ0
    • Q9UIU8

    Protein attributes for CYP4F2 Gene

    Size:
    520 amino acids
    Molecular mass:
    59853 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP4F2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP4F2 Gene

Proteomics data for CYP4F2 Gene at MOPED

Post-translational modifications for CYP4F2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP4F2 Gene

No data available for DME Specific Peptides for CYP4F2 Gene

Domains & Families for CYP4F2 Gene

Gene Families for CYP4F2 Gene

Protein Domains for CYP4F2 Gene

Graphical View of Domain Structure for InterPro Entry

P78329

UniProtKB/Swiss-Prot:

CP4F2_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4F2: view

Function for CYP4F2 Gene

Molecular function for CYP4F2 Gene

GENATLAS Biochemistry:
leukotriene B4 omega-hydroxylase,involved in the degradation of LTB4,a potent mediator of inflammation
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=74.8 uM for leukotriene-B(4) {ECO:0000269 PubMed:9799565}; KM=1.7 uM for menaquinone-4 (MK-4) {ECO:0000269 PubMed:24138531}; Vmax=2.42 nmol/min/mg enzyme {ECO:0000269 PubMed:9799565}; Note=kcat is 0.067 min(-1) with menaquinone-4 (MK-4) as substrate. {ECO:0000269 PubMed:24138531};
UniProtKB/Swiss-Prot CatalyticActivity:
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + O(2) = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
Phylloquinone + NADPH + O(2) = omega-hydroxyphylloquinone + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
(5Z,8Z,11Z,14Z)-icosatetraenoate + NADPH + O(2) = (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoate + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot Function:
Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:19297519, PubMed:24138531). Also shows arachidonic acid omega-hydroxylase activity in kidney, by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), possibly influencing blood pressure control (PubMed:10660572, PubMed:17341693, PubMed:18574070). Also acts as a leukotriene-B(4) omega-hydroxylase by mediating conversion of leukotriene-B(4) (LTB4) to its omega-hydroxylated metabolite 20-hydroxyleukotriene-B(4) (20-OH LTB4) (PubMed:8026587, PubMed:9799565).

Enzyme Numbers (IUBMB) for CYP4F2 Gene

Gene Ontology (GO) - Molecular Function for CYP4F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA,TAS --
GO:0050051 leukotriene-B4 20-monooxygenase activity IDA,TAS --
GO:0097259 20-aldehyde-leukotriene B4 20-monooxygenase activity TAS --
genes like me logo Genes that share ontologies with CYP4F2: view

Phenotypes for CYP4F2 Gene

genes like me logo Genes that share phenotypes with CYP4F2: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYP4F2 Gene

Localization for CYP4F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4F2 Gene

Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP4F2 Gene COMPARTMENTS Subcellular localization image for CYP4F2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
cytoskeleton 2
extracellular 2
peroxisome 2
golgi apparatus 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CYP4F2 Gene

Pathways & Interactions for CYP4F2 Gene

genes like me logo Genes that share pathways with CYP4F2: view

Pathways by source for CYP4F2 Gene

2 KEGG pathways for CYP4F2 Gene
1 GeneGo (Thomson Reuters) pathway for CYP4F2 Gene

UniProtKB/Swiss-Prot P78329-CP4F2_HUMAN

  • Pathway: Cofactor degradation; phylloquinone degradation.

Gene Ontology (GO) - Biological Process for CYP4F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000038 very long-chain fatty acid metabolic process IDA 18433732
GO:0003091 renal water homeostasis IEP 10660572
GO:0006690 icosanoid metabolic process TAS --
GO:0006691 leukotriene metabolic process TAS --
GO:0007596 blood coagulation TAS 19297519
genes like me logo Genes that share ontologies with CYP4F2: view

No data available for SIGNOR curated interactions for CYP4F2 Gene

Drugs & Compounds for CYP4F2 Gene

(24) Drugs for CYP4F2 Gene - From: DrugBank, PharmGKB, ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Warfarin Approved Pharma 435
Fingolimod Approved, Investigational Pharma Enzyme, substrate 0
Acenocoumarol Approved Pharma 27
Aspirin Approved Pharma Channel blocker 1059
Phenprocoumon Approved Pharma 28

(12) Additional Compounds for CYP4F2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
20-Hydroxyeicosatetraenoic acid
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoate
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid
  • (all-Z)-20-hydroxy-5,8,11,14-Eicosatetraenoate
  • (all-Z)-20-hydroxy-5,8,11,14-Eicosatetraenoic acid
  • 20-HETE
79551-86-3
Leukotriene B4
  • (6z,8e,10e,14z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
  • (6z,8e,10e,14z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid
  • 5,12-DiHETE
  • 5,12-Dihydroxy-6,10-trans -8,14-cis -eicosatetraenoate
  • 5,12-Dihydroxy-6,10-trans -8,14-cis -eicosatetraenoic acid
71160-24-2
12(S)-Leukotriene B4
  • 2-Epi-LTB4
  • 5(S),12(S)-Dihydroxyeicosatetraenoate
  • 5(S),12(S)-Dihydroxyeicosatetraenoic acid
  • 5S,12S-Dihydroxy-6Z,8E,10E,14Z-eicsatetraenoate
  • 5S,12S-Dihydroxy-6Z,8E,10E,14Z-eicsatetraenoic acid
83709-73-3
12-Keto-tetrahydro-leukotriene B4
  • 12-Keto-10,11,14,15-tetrahydro-LTB4
  • 5S-Hydroxy-12-keto-6Z,8E-eicosadienoate
  • 5S-Hydroxy-12-keto-6Z,8E-eicosadienoic acid
18-Hydroxyarachidonic acid
  • (18R)-Hydroxyarachidonate
  • (18R)-Hydroxyarachidonic acid
  • 18(R)-Hydroxyeicosatetraenoate
  • 18(R)-Hydroxyeicosatetraenoic acid
  • 18-HETE
133268-58-3
genes like me logo Genes that share compounds with CYP4F2: view

Transcripts for CYP4F2 Gene

Unigene Clusters for CYP4F2 Gene

Cytochrome P450, family 4, subfamily F, polypeptide 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for CYP4F2 Gene

GeneLoc Exon Structure for
CYP4F2
ECgene alternative splicing isoforms for
CYP4F2

Expression for CYP4F2 Gene

mRNA expression in normal human tissues for CYP4F2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP4F2 Gene

This gene is overexpressed in Liver (x40.4) and Small Intestine - Terminal Ileum (x4.8).

Protein differential expression in normal tissues from HIPED for CYP4F2 Gene

This gene is overexpressed in Gallbladder (35.0), Cervix (12.8), and Liver (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYP4F2 Gene



SOURCE GeneReport for Unigene cluster for CYP4F2 Gene Hs.558423

mRNA Expression by UniProt/SwissProt for CYP4F2 Gene

P78329-CP4F2_HUMAN
Tissue specificity: Liver. Also present in kidney: specifically expressed in the S2 and S3 segments of proximal tubules in cortex and outer medulla (PubMed:10660572).
genes like me logo Genes that share expression patterns with CYP4F2: view

Protein tissue co-expression partners for CYP4F2 Gene

- Elite partner

Primer Products

Orthologs for CYP4F2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CYP4F2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYP4F2 35
  • 84.55 (n)
  • 83.27 (a)
-- 36
  • 79 (a)
ManyToMany
-- 36
  • 81 (a)
ManyToMany
-- 36
  • 82 (a)
ManyToMany
-- 36
  • 83 (a)
ManyToMany
CYP4F2 36
  • 79 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyp4f18 35
  • 78.59 (n)
  • 76.35 (a)
Cyp4f18 16
Cyp4f13 36
  • 72 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC748531 35
  • 94.36 (n)
  • 92.88 (a)
CYP4F2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp4f18 35
  • 78.78 (n)
  • 77.31 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 63 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii cyp4f3 35
  • 60.73 (n)
  • 55.14 (a)
cyp4f3 36
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp311a1 37
  • 32 (a)
Cyp312a1 37
  • 32 (a)
Cyp313a1 37
  • 25 (a)
Cyp313a3 37
  • 27 (a)
Cyp313a4 37
  • 26 (a)
Cyp313b1 37
  • 26 (a)
Cyp4aa1 37
  • 27 (a)
Cyp4ac1 37
  • 32 (a)
Cyp4ac2 37
  • 29 (a)
Cyp4ac3 37
  • 34 (a)
Cyp4ad1 37
  • 29 (a)
Cyp4ae1 37
  • 33 (a)
Cyp4c3 37
  • 36 (a)
Cyp4d1 37
  • 35 (a)
Cyp4d14 37
  • 35 (a)
Cyp4d2 37
  • 36 (a)
Cyp4d20 37
  • 34 (a)
Cyp4d21 37
  • 32 (a)
Cyp4d8 37
  • 36 (a)
Cyp4e1 37
  • 32 (a)
Cyp4e2 37
  • 32 (a)
Cyp4e3 37
  • 32 (a)
Cyp4g1 37
  • 26 (a)
Cyp4g15 37
  • 36 (a)
Cyp4p1 37
  • 35 (a)
Cyp4p2 37
  • 32 (a)
Cyp4p3 37
  • 32 (a)
Cyp4s3 37
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea B0331.1 37
  • 31 (a)
C26F1.2 37
  • 32 (a)
F01D5.9 37
  • 35 (a)
F28G4.1 37
  • 33 (a)
Y17G9B.3 37
  • 35 (a)
Y38C9B.1 37
  • 33 (a)
Y5H2B.5 37
  • 36 (a)
Y80D3A.5 37
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIT2 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
CSA.3998 36
  • 40 (a)
ManyToMany
CSA.6060 36
  • 38 (a)
ManyToMany
CSA.8060 36
  • 41 (a)
ManyToMany
Species with no ortholog for CYP4F2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CYP4F2 Gene

ENSEMBL:
Gene Tree for CYP4F2 (if available)
TreeFam:
Gene Tree for CYP4F2 (if available)

Paralogs for CYP4F2 Gene

genes like me logo Genes that share paralogs with CYP4F2: view

Variants for CYP4F2 Gene

Sequence variations from dbSNP and Humsavar for CYP4F2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3093104 - 15,897,592(-) CCTGT(A/C)CTGGC reference, missense
rs3093105 - 15,897,578(-) GCCTC(G/T)GGCCA reference, missense
rs3093153 - 15,890,405(-) AGAGG(G/T)TAGTG reference, missense
rs2108622 - 15,879,621(+) CCACA(C/T)AGCTG reference, missense
rs3093200 - 15,878,779(-) AGCCC(A/C)TGAGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CYP4F2 Gene

Variant ID Type Subtype PubMed ID
nsv911139 CNV Gain 21882294
esv2718244 CNV Deletion 23290073
nsv833766 CNV Loss 17160897
esv2671181 CNV Deletion 23128226
dgv3750n71 CNV Loss 21882294
esv2676393 CNV Deletion 23128226
esv2718247 CNV Deletion 23290073
esv1958771 CNV Deletion 18987734
esv2718248 CNV Deletion 23290073
esv2718249 CNV Deletion 23290073
esv1124839 CNV Deletion 17803354
esv2718252 CNV Deletion 23290073
nsv911150 CNV Loss 21882294
nsv911151 CNV Loss 21882294

Variation tolerance for CYP4F2 Gene

Residual Variation Intolerance Score: 97.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.59; 93.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP4F2 Gene

Human Gene Mutation Database (HGMD)
CYP4F2
The Human Cytochrome P450 Allele Nomenclature Database
CYP4F2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4F2 Gene

Disorders for CYP4F2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CYP4F2 Gene - From: GeneTests, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CP4F2_HUMAN
  • Coumarin resistance (CMRES) [MIM:122700]: A condition characterized by partial or complete resistance to warfarin or other 4-hydroxycoumarin derivatives. These drugs are used as anti-coagulants for the prevention of thromboembolic diseases in subjects with deep vein thrombosis, atrial fibrillation, or mechanical heart valve replacement. {ECO:0000269 PubMed:18250228, ECO:0000269 PubMed:19207028, ECO:0000269 PubMed:19270263, ECO:0000269 PubMed:19297519, ECO:0000269 PubMed:20555338, ECO:0000269 PubMed:23132553, ECO:0000269 PubMed:24138531}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. The variant Met-433 is associated with coumarin (the brand name of warfarin) resistance by increasing coumarin maintenance dose in patients on this anti-coagulant therapy. This is probably due to decreased activity of the phylloquinone omega-hydroxylase activity, leading to an increase in hepatic vitamin K levels that warfarin must antagonize (PubMed:24138531). {ECO:0000269 PubMed:24138531}.

Relevant External Links for CYP4F2

Genetic Association Database (GAD)
CYP4F2
Human Genome Epidemiology (HuGE) Navigator
CYP4F2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP4F2
genes like me logo Genes that share disorders with CYP4F2: view

No data available for Genatlas for CYP4F2 Gene

Publications for CYP4F2 Gene

  1. CYP4F2 is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variant. (PMID: 19297519) McDonald M.G. … Rettie A.E. (Mol. Pharmacol. 2009) 3 4 23 48 67
  2. Genetic and clinical predictors of warfarin dose requirements in African Americans. (PMID: 20072124) Cavallari L.H. … Johnson J.A. (Clin. Pharmacol. Ther. 2010) 3 23
  3. CYP4F2 gene V433M polymorphism is associated with ischemic stroke in the male Northern Chinese Han population. (PMID: 20227456) Deng S. … Zhiyi H. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2010) 3 23
  4. A genome-wide association study of acenocoumarol maintenance dosage. (PMID: 19578179) Teichert M. … Stricker B.H. (Hum. Mol. Genet. 2009) 3 23
  5. Association of a functional cytochrome P450 4F2 haplotype with urinary 20-HETE and hypertension. (PMID: 18235092) Liu H. … Lu J. (J. Am. Soc. Nephrol. 2008) 3 23

Products for CYP4F2 Gene

Sources for CYP4F2 Gene

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