Aliases for CYP4F2 Gene
- Cytochrome P450, Family 4, Subfamily F, Polypeptide 2 2 3
- Cytochrome P450, Subfamily IVF, Polypeptide 2 2 3
- 20-Hydroxyeicosatetraenoic Acid Synthase 3 4
- Leukotriene-B(4) Omega-Hydroxylase 1 3 4
- Leukotriene-B(4) 20-Monooxygenase 1 3 4
- Arachidonic Acid Omega-Hydroxylase 3 4
- Cytochrome P450-LTB-Omega 3 4
- Cytochrome P450 4F2 3 4
External Ids for CYP4F2 Gene
Previous GeneCards Identifiers for CYP4F2 Gene
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008]
GeneCards Summary for CYP4F2 Gene
CYP4F2 (Cytochrome P450, Family 4, Subfamily F, Polypeptide 2) is a Protein Coding gene. Diseases associated with CYP4F2 include cyp4f2-related altered drug metabolism and vitamin k antagonists toxicity or dose selection. Among its related pathways are Metabolism and Linoleic acid metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F12.
UniProtKB/Swiss-Prot for CYP4F2 Gene
Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:19297519, PubMed:24138531). Also shows arachidonic acid omega-hydroxylase activity in kidney, by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), possibly influencing blood pressure control (PubMed:10660572, PubMed:17341693, PubMed:18574070). Also acts as a leukotriene-B(4) omega-hydroxylase by mediating conversion of leukotriene-B(4) (LTB4) to its omega-hydroxylated metabolite 20-hydroxyleukotriene-B(4) (20-OH LTB4) (PubMed:8026587, PubMed:9799565).