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Aliases for KCNAB2 Gene

Aliases for KCNAB2 Gene

  • Potassium Channel, Voltage Gated Subfamily A Regulatory Beta Subunit 2 2 3
  • KCNA2B 3 4 6
  • Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Beta Member 2 2 3
  • K(+) Channel Subunit Beta-2 3 4
  • KV-BETA-2 3 4
  • HKvbeta2 3 4
  • Voltage-Gated Potassium Channel Subunit Beta-2 3
  • Potassium Channel Shaker Chain Beta 2 3
  • K+ Channel Beta-2 Subunit 3
  • HKvbeta2.1 3
  • HKvbeta2.2 3
  • EC 1.1.1.- 4
  • AKR6A5 3
  • KCNK2 4

External Ids for KCNAB2 Gene

Previous GeneCards Identifiers for KCNAB2 Gene

  • GC01P005677
  • GC01P005909
  • GC01P005795
  • GC01P005235

Summaries for KCNAB2 Gene

Entrez Gene Summary for KCNAB2 Gene

  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]

GeneCards Summary for KCNAB2 Gene

KCNAB2 (Potassium Channel, Voltage Gated Subfamily A Regulatory Beta Subunit 2) is a Protein Coding gene. Diseases associated with KCNAB2 include 1p36 deletion syndrome. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include voltage-gated potassium channel activity and potassium channel regulator activity. An important paralog of this gene is KCNAB1.

UniProtKB/Swiss-Prot for KCNAB2 Gene

  • Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7649300, PubMed:11825900). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:7649300, PubMed:11825900). Promotes KCNA4 channel closure (PubMed:7649300, PubMed:11825900). Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity).

Tocris Summary for KCNAB2 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNAB2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNAB2 Gene

Genomics for KCNAB2 Gene

Regulatory Elements for KCNAB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCNAB2 Gene

Start:
5,991,466 bp from pter
End:
6,101,193 bp from pter
Size:
109,728 bases
Orientation:
Plus strand

Genomic View for KCNAB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNAB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNAB2 Gene

Proteins for KCNAB2 Gene

  • Protein details for KCNAB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13303-KCAB2_HUMAN
    Recommended name:
    Voltage-gated potassium channel subunit beta-2
    Protein Accession:
    Q13303
    Secondary Accessions:
    • A0AVM9
    • A8K1A4
    • B0AZR7
    • O43659
    • Q2YD85
    • Q5TG82
    • Q5TG83
    • Q6ZNE4
    • Q99411

    Protein attributes for KCNAB2 Gene

    Size:
    367 amino acids
    Molecular mass:
    41000 Da
    Quaternary structure:
    • Homotetramer (By similarity). Interaction with tetrameric potassium channel alpha subunits gives rise to a heterooctamer (By similarity). Identified in potassium channel complexes containing KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNAB1 and KCNAB2 (By similarity). Interacts with KCNA1 (PubMed:11086297). Interacts with KCNA2 (PubMed:11086297). Interacts with KCNA4 and KCND3 (By similarity). Interacts with KCNA5 (By similarity). Interacts with KCNB2 (By similarity). Interacts (in unphosphorylated form) with MAPRE1 (By similarity). Forms a ternary complex with SQSTM1 and PRKCZ (By similarity).

    Three dimensional structures from OCA and Proteopedia for KCNAB2 Gene

    Alternative splice isoforms for KCNAB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNAB2 Gene

Proteomics data for KCNAB2 Gene at MOPED

Post-translational modifications for KCNAB2 Gene

  • Phosphorylated by PRKCZ; may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1.
  • Ubiquitination at Lys268 and Lys290
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KCNAB2 Gene

Domains for KCNAB2 Gene

Gene Families for KCNAB2 Gene

HGNC:
  • AKR :Aldo-keto reductases
  • KCN :Potassium channels

Graphical View of Domain Structure for InterPro Entry

Q13303

UniProtKB/Swiss-Prot:

KCAB2_HUMAN :
  • Q13303
Domain:
  • In contrast to KCNAB1, the shorter N-terminal domain of KCNAB2 cannot mediate closure of delayed rectifier potassium channels by physically obstructing the pore.
Family:
  • Belongs to the shaker potassium channel beta subunit family.
genes like me logo Genes that share domains with KCNAB2: view

Function for KCNAB2 Gene

Molecular function for KCNAB2 Gene

GENATLAS Biochemistry: potassium voltage-gated channel,Drosophila shaker-related subfamily,mainly expressed in the brain,auxiliary beta 2 cytoplasmic peptide,co assembly in the endoplasmic reticulum with the channel forming alpha subunits,modulating the amplitude of K+ currents
UniProtKB/Swiss-Prot Function: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7649300, PubMed:11825900). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:7649300, PubMed:11825900). Promotes KCNA4 channel closure (PubMed:7649300, PubMed:11825900). Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity).

Enzyme Numbers (IUBMB) for KCNAB2 Gene

Gene Ontology (GO) - Molecular Function for KCNAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004033 aldo-keto reductase (NADP) activity ISS --
GO:0005249 voltage-gated potassium channel activity IEA --
GO:0005515 protein binding --
GO:0015459 potassium channel regulator activity IDA 7649300
genes like me logo Genes that share ontologies with KCNAB2: view
genes like me logo Genes that share phenotypes with KCNAB2: view

Animal Models for KCNAB2 Gene

MGI Knock Outs for KCNAB2:

Animal Model Products

CRISPR Products

miRNA for KCNAB2 Gene

miRTarBase miRNAs that target KCNAB2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNAB2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for KCNAB2 Gene

Localization for KCNAB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNAB2 Gene

Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, axon. Cell junction, synapse, synaptosome. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. Associates with microtubules when unphosphorylated. {ECO:0000250 UniProtKB:P62483}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNAB2 Gene COMPARTMENTS Subcellular localization image for KCNAB2 gene
Compartment Confidence
plasma membrane 4
mitochondrion 2
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol ISS --
GO:0005874 colocalizes_with microtubule ISS --
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IDA 11086297
genes like me logo Genes that share ontologies with KCNAB2: view

Pathways for KCNAB2 Gene

genes like me logo Genes that share pathways with KCNAB2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for KCNAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006813 potassium ion transport --
GO:0007268 synaptic transmission TAS --
GO:0034765 regulation of ion transmembrane transport --
GO:0051291 protein heterooligomerization IEA --
genes like me logo Genes that share ontologies with KCNAB2: view

Compounds for KCNAB2 Gene

(5) Tocris Compounds for KCNAB2 Gene

Compound Action Cas Number
4-Aminopyridine Non-selective KV channel blocker [504-24-5]
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
Margatoxin Potent KV1.3 channel blocker [145808-47-5]
MaxiPost Potassium channel modulator; exerts subtype-specific effects [187523-35-9]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents [122955-13-9]

(1) HMDB Compounds for KCNAB2 Gene

Compound Synonyms Cas Number PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
53-59-8
genes like me logo Genes that share compounds with KCNAB2: view

Transcripts for KCNAB2 Gene

Unigene Clusters for KCNAB2 Gene

Potassium voltage-gated channel, shaker-related subfamily, beta member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNAB2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNAB2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^
SP1: - - - - - - - - - - -
SP2: - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - -
SP7: - - - - - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - -
SP10: -
SP11:
SP12:
SP13:
SP14:

ExUns: 20 ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24 ^ 25a · 25b ^ 26
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:

Relevant External Links for KCNAB2 Gene

GeneLoc Exon Structure for
KCNAB2
ECgene alternative splicing isoforms for
KCNAB2

Expression for KCNAB2 Gene

mRNA expression in normal human tissues for KCNAB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNAB2 Gene

This gene is overexpressed in Brain - Cortex (5.7), Whole Blood (5.1), Brain - Frontal Cortex (BA9) (4.9), and Brain - Anterior cingulate cortex (BA24) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCNAB2 Gene

SOURCE GeneReport for Unigene cluster for KCNAB2 Gene Hs.440497

mRNA Expression by UniProt/SwissProt for KCNAB2 Gene

Q13303-KCAB2_HUMAN
Tissue specificity: Detected in myelinated nerve fibers in the spinal cord, in the juxtaparanodal region of the nodes of Ranvier, but also in the paranodal region (PubMed:11086297). Detected in hippocampus (at protein level) (PubMed:21357749). Detected in hippocampus (PubMed:7649300).
genes like me logo Genes that share expressions with KCNAB2: view

In Situ Assay Products

Orthologs for KCNAB2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KCNAB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNAB2 35
  • 92.31 (n)
  • 91.39 (a)
cow
(Bos Taurus)
Mammalia KCNAB2 35
  • 92.3 (n)
  • 99.39 (a)
KCNAB2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNAB2 35
  • 92.93 (n)
  • 99.04 (a)
KCNAB2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnab2 35
  • 90.27 (n)
  • 98.78 (a)
Kcnab2 16
Kcnab2 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNAB2 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNAB2 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnab2 35
  • 90.48 (n)
  • 98.78 (a)
chicken
(Gallus gallus)
Aves KCNAB2 35
  • 85.38 (n)
  • 93.98 (a)
KCNAB2 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNAB2 36
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1407 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnab2 35
  • 76.63 (n)
  • 93.25 (a)
zebrafish
(Danio rerio)
Actinopterygii kcnab2 35
  • 76.95 (n)
  • 87.95 (a)
KCNAB2 36
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hk 36
  • 25 (a)
OneToMany
Hk 37
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 25 (a)
OneToMany
corn
(Zea mays)
Liliopsida Zm.16963 35
wheat
(Triticum aestivum)
Liliopsida Ta.2911 35
Species with no ortholog for KCNAB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for KCNAB2 Gene

ENSEMBL:
Gene Tree for KCNAB2 (if available)
TreeFam:
Gene Tree for KCNAB2 (if available)

Paralogs for KCNAB2 Gene

Paralogs for KCNAB2 Gene

genes like me logo Genes that share paralogs with KCNAB2: view

Variants for KCNAB2 Gene

Sequence variations from dbSNP and Humsavar for KCNAB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs538 -- 6,100,898(-) AAGCG(C/G/T)CCAGC utr-variant-3-prime
rs481762 -- 6,001,588(-) TGCTC(C/T)TCAGA intron-variant
rs482158 -- 6,013,379(-) CTGCT(A/C)AAATT intron-variant
rs486823 -- 6,009,795(-) acCTG(C/G)TAAAG intron-variant
rs506117 -- 5,994,628(-) TTCAC(A/G)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNAB2 Gene

Variant ID Type Subtype PubMed ID
nsv871082 CNV Loss 21882294
nsv831314 CNV Loss 17160897
nsv870809 CNV Loss 21882294
nsv871226 CNV Loss 21882294
esv2470104 CNV Deletion 19546169
esv22772 CNV Gain+Loss 19812545
esv2738028 CNV Deletion 23290073
nsv159264 CNV Loss 16902084
nsv511675 CNV Loss 21212237
esv2738139 CNV Deletion 23290073
esv2738250 CNV Deletion 23290073
esv7234 CNV Loss 19470904
nsv511127 CNV Loss 21212237
esv2738362 CNV Deletion 23290073
esv2738473 CNV Deletion 23290073
esv2738584 CNV Deletion 23290073
esv2668412 CNV Deletion 23128226
esv2671721 CNV Deletion 23128226
esv2738695 CNV Deletion 23290073
esv2738806 CNV Deletion 23290073
esv2738917 CNV Deletion 23290073
nsv871698 CNV Loss 21882294
esv2739028 CNV Deletion 23290073
nsv461283 CNV Loss 19166990
dgv117n71 CNV Loss 21882294
dgv118n71 CNV Loss 21882294
nsv871817 CNV Loss 21882294
nsv870945 CNV Loss 21882294
nsv470689 CNV Loss 18288195
dgv119n71 CNV Loss 21882294
nsv871337 CNV Loss 21882294

Relevant External Links for KCNAB2 Gene

HapMap Linkage Disequilibrium report
KCNAB2
Human Gene Mutation Database (HGMD)
KCNAB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNAB2 Gene

Disorders for KCNAB2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for KCNAB2 Gene including...

Search for KCNAB2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for KCNAB2 Gene

genes like me logo Genes that share disorders with KCNAB2: view

No data available for UniProtKB/Swiss-Prot for KCNAB2 Gene

Publications for KCNAB2 Gene

  1. Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product. (PMID: 7649300) Mccormack K. … Stuehmer W. (FEBS Lett. 1995) 3 4 23
  2. Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B. (PMID: 8838324) Schultz D. … McCormack K. (Genomics 1996) 2 3
  3. Subunit composition and novel localization of K+ channels in spinal cord. (PMID: 11086297) Rasband M.N. … Trimmer J.S. (J. Comp. Neurol. 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

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