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Aliases for MMP23B Gene

Aliases for MMP23B Gene

  • Matrix Metallopeptidase 23B 2 3
  • Femalysin 2 3 4
  • MMP22 3 4 6
  • Matrix Metalloproteinase In The Female Reproductive Tract 2 3
  • Matrix Metalloproteinase 23B 2 3
  • Matrix Metalloproteinase-21 3 4
  • Matrix Metalloproteinase 22 2 3
  • Matrix Metalloproteinase-22 3 4
  • MMP-21 3 4
  • MIFR-1 3 4
  • MMP-22 3 4
  • MMP-23 3 4
  • Matrix Metalloproteinase-23 3
  • MMP23A MMP23B 4
  • EC 3.4.24.- 4
  • MMP23A 3
  • MMP21 4
  • MIFR 3

External Ids for MMP23B Gene

Previous HGNC Symbols for MMP23B Gene

  • MMP22

Previous GeneCards Identifiers for MMP23B Gene

  • GC01P001188
  • GC01P001437
  • GC01P001500
  • GC01P001580
  • GC01P9N0048
  • GC01P001558
  • GC01P001559
  • GC01P000843
  • GC01P001567

Summaries for MMP23B Gene

Entrez Gene Summary for MMP23B Gene

  • This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the more telomeric copy of the duplicated region. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP23B Gene

MMP23B (Matrix Metallopeptidase 23B) is a Protein Coding gene. Diseases associated with MMP23B include transient hypogammaglobulinemia and choanal atresia. Among its related pathways are GPCR Pathway and Integrin Pathway. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is MMP2.

UniProtKB/Swiss-Prot for MMP23B Gene

  • Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).

Tocris Summary for MMP23B Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been identified in humans, which can be organized into six groups based on domain organization and substrate preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and -11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others (MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP23B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP23B Gene

Genomics for MMP23B Gene

Regulatory Elements for MMP23B Gene

Genomic Location for MMP23B Gene

Start:
1,631,681 bp from pter
End:
1,701,810 bp from pter
Size:
70,130 bases
Orientation:
Plus strand

Genomic View for MMP23B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMP23B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP23B Gene

Proteins for MMP23B Gene

  • Protein details for MMP23B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75900-MMP23_HUMAN
    Recommended name:
    Matrix metalloproteinase-23
    Protein Accession:
    O75900
    Secondary Accessions:
    • A2AGN0
    • A2AGN1
    • O75894
    • O75895
    • Q5QPQ8
    • Q76P96
    • Q7LDM6
    • Q7LDM7
    • Q9UBR9
    • Q9UJK8

    Protein attributes for MMP23B Gene

    Size:
    390 amino acids
    Molecular mass:
    43935 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MMP23B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MMP23B Gene

Proteomics data for MMP23B Gene at MOPED

Post-translational modifications for MMP23B Gene

No data available for DME Specific Peptides for MMP23B Gene

Domains for MMP23B Gene

Gene Families for MMP23B Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for MMP23B Gene

Graphical View of Domain Structure for InterPro Entry

O75900

UniProtKB/Swiss-Prot:

MMP23_HUMAN :
  • O75900
Domain:
  • The ShKT domain associates with, and blocks several potassium channels in the nanomolar to low micromolar range. The relative affinity is Kv1.6 > Kv1.3 > Kv1.1 = Kv3.2 > Kv1.4 (By similarity).
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 ShKT domain.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP23B: view

Function for MMP23B Gene

Molecular function for MMP23B Gene

GENATLAS Biochemistry: matrix metalloproteinase 23B,regulator in matrix remodeling,with three alternatively spliced isoforms A,B,C,expressed in ovary,testis,prostate
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by TIMP2.
UniProtKB/Swiss-Prot Function: Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).

Enzyme Numbers (IUBMB) for MMP23B Gene

Gene Ontology (GO) - Molecular Function for MMP23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity NAS 9740677
GO:0005515 protein binding --
GO:0008237 metallopeptidase activity NAS 9740677
GO:0008270 zinc ion binding NAS 9988691
genes like me logo Genes that share ontologies with MMP23B: view

miRNA for MMP23B Gene

miRTarBase miRNAs that target MMP23B

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MMP23B Gene

Localization for MMP23B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP23B Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Membrane; Single-pass type II membrane protein. Note=A secreted form produced by proteolytic cleavage may also exist. {ECO:0000305}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP23B Gene COMPARTMENTS Subcellular localization image for MMP23B gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for MMP23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix NAS 9740677
GO:0005622 intracellular NAS 9988691
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MMP23B: view

Pathways for MMP23B Gene

genes like me logo Genes that share pathways with MMP23B: view

Pathways by source for MMP23B Gene

Interacting Proteins for MMP23B Gene

Gene Ontology (GO) - Biological Process for MMP23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000003 reproduction IEP 9988691
GO:0006508 proteolysis IDA 9988691
genes like me logo Genes that share ontologies with MMP23B: view

Compounds for MMP23B Gene

(5) Tocris Compounds for MMP23B Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
GI 254023X Selective ADAM10 metalloprotease inhibitor [260264-93-5]
GM 6001 Broad spectrum MMP inhibitor [142880-36-2]
Ro 32-3555 Potent, collagenase-selective MMP inhibitor [190648-49-8]
WAY 170523 Potent and selective inhibitor of MMP-13 [307002-73-9]
genes like me logo Genes that share compounds with MMP23B: view

Transcripts for MMP23B Gene

Unigene Clusters for MMP23B Gene

Matrix metallopeptidase 23B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMP23B Gene

No ASD Table

Relevant External Links for MMP23B Gene

GeneLoc Exon Structure for
MMP23B
ECgene alternative splicing isoforms for
MMP23B

Expression for MMP23B Gene

mRNA expression in normal human tissues for MMP23B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP23B Gene

This gene is overexpressed in Ovary (6.2), Artery - Aorta (4.7), and Artery - Coronary (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MMP23B Gene

SOURCE GeneReport for Unigene cluster for MMP23B Gene Hs.192316

mRNA Expression by UniProt/SwissProt for MMP23B Gene

O75900-MMP23_HUMAN
Tissue specificity: Predominantly expressed in ovary, testis and prostate.
genes like me logo Genes that share expressions with MMP23B: view

Orthologs for MMP23B Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP23B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP23B 35
  • 98.99 (n)
  • 98.65 (a)
MMP23B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MMP23B 35
  • 87.92 (n)
  • 88.17 (a)
MMP23B 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP23B 35
  • 85.9 (n)
  • 89.49 (a)
MMP23B 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp23 35
  • 80.12 (n)
  • 84.32 (a)
Mmp23 16
Mmp23 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MMP23B 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP23B 36
  • 32 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp23 35
  • 80.28 (n)
  • 84.5 (a)
chicken
(Gallus gallus)
Aves MMP23B 35
  • 66.19 (n)
  • 71.92 (a)
MMP23B 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMP23B 36
  • 1 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp23b 35
  • 64.09 (n)
  • 68.42 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101882601 35
  • 69.84 (n)
  • 71.43 (a)
MMP23B 36
  • 67 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea H19M22.3 36
  • 14 (a)
ManyToMany
zmp-1 36
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
OneToOne
Species with no ortholog for MMP23B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP23B Gene

ENSEMBL:
Gene Tree for MMP23B (if available)
TreeFam:
Gene Tree for MMP23B (if available)

Paralogs for MMP23B Gene

Paralogs for MMP23B Gene

Selected SIMAP similar genes for MMP23B Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for MMP23B Gene

genes like me logo Genes that share paralogs with MMP23B: view

Variants for MMP23B Gene

Sequence variations from dbSNP and Humsavar for MMP23B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2235535 -- 1,634,663(+) CTCCT(C/G)GCTCA downstream-variant-500B
rs28362023 -- 1,631,524(+) CCCTT(C/T)CCGGC upstream-variant-2KB
rs28445304 -- 1,631,603(+) ACCCA(C/T)GCACC upstream-variant-2KB
rs28451771 -- 1,631,710(+) GCGTC(C/T)CCTGC upstream-variant-2KB, utr-variant-5-prime
rs28456011 -- 1,631,827(+) CAGCA(A/G)TGGGG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MMP23B Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv10n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
nsv871837 CNV Loss 21882294
nsv871690 CNV Gain 21882294
dgv9e1 CNV Complex 17122850
dgv43n71 CNV Loss 21882294
dgv44n71 CNV Gain+Loss 21882294
nsv871954 CNV Loss 21882294
nsv871540 CNV Gain 21882294
dgv45n71 CNV Loss 21882294
nsv870847 CNV Loss 21882294
nsv871940 CNV Loss 21882294
dgv46n71 CNV Loss 21882294
esv2661270 CNV Deletion 23128226
esv2659399 CNV Deletion 23128226
dgv47n71 CNV Loss 21882294
nsv871583 CNV Loss 21882294
esv27786 CNV Gain 19812545

Relevant External Links for MMP23B Gene

HapMap Linkage Disequilibrium report
MMP23B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP23B Gene

Disorders for MMP23B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for MMP23B Gene including...

Search for MMP23B Gene in MalaCards »

(2) University of Copenhagen DISEASES for MMP23B Gene

genes like me logo Genes that share disorders with MMP23B: view

No data available for UniProtKB/Swiss-Prot for MMP23B Gene

Publications for MMP23B Gene

  1. Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3. (PMID: 9740677) Gururajan R. … Kidd V.J. (Genomics 1998) 2 3 4 23
  2. Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2. (PMID: 9750192) Gururajan R. … Kidd V.J. (Genome Res. 1998) 2 3
  3. Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members. (PMID: 9988691) Velasco G. … Lopez-Otin C. (J. Biol. Chem. 1999) 3 4
  4. Cloning and characterization of a rat ortholog of MMP-23 (matrix metalloproteinase-23), a unique type of membrane-anchored matrix metalloproteinase and conditioned switching of its expression during the ovarian follicular development. (PMID: 11328856) Ohnishi J. … Takahashi T. (Mol. Endocrinol. 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MMP23B Gene

Sources for MMP23B Gene

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