Aliases for PIK3R3 Gene
External Ids for PIK3R3 Gene
GeneCards Summary for PIK3R3 Gene
PIK3R3 (Phosphoinositide-3-Kinase, Regulatory Subunit 3 (Gamma)) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include 1-phosphatidylinositol-3-kinase activity and phosphatidylinositol 3-kinase regulator activity. An important paralog of this gene is PIK3R1.
UniProtKB/Swiss-Prot for PIK3R3 Gene
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1
PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the 3OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes (C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI 3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.