External Ids for PKP4 Gene
Previous GeneCards Identifiers for PKP4 Gene
Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]
GeneCards Summary for PKP4 Gene
PKP4 (Plakophilin 4) is a Protein Coding gene. Among its related pathways are Cell adhesion_Endothelial cell contacts by junctional mechanisms. GO annotations related to this gene include binding. An important paralog of this gene is PKP3.
UniProtKB/Swiss-Prot for PKP4 Gene
Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.