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Aliases for PPFIA1 Gene

Aliases for PPFIA1 Gene

  • Protein Tyrosine Phosphatase, Receptor Type, F Polypeptide (PTPRF), Interacting Protein (Liprin), Alpha 1 2 3
  • LIP1 3 4 6
  • Protein Tyrosine Phosphatase Receptor Type F Polypeptide-Interacting Protein Alpha-1 3 4
  • PTPRF-Interacting Protein Alpha-1 3 4
  • LAR-Interacting Protein 1 3 4
  • Liprin-Alpha1 2 3
  • LIP-1 3 4
  • Liprin-Alpha-1 3
  • LIPRIN 3
  • LIP.1 3

External Ids for PPFIA1 Gene

Previous GeneCards Identifiers for PPFIA1 Gene

  • GC11P072448
  • GC11P071639
  • GC11P070339
  • GC11P069843
  • GC11P069794
  • GC11P070116
  • GC11P066374

Summaries for PPFIA1 Gene

Entrez Gene Summary for PPFIA1 Gene

  • The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPFIA1 Gene

PPFIA1 (Protein Tyrosine Phosphatase, Receptor Type, F Polypeptide (PTPRF), Interacting Protein (Liprin), Alpha 1) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is KAZN.

UniProtKB/Swiss-Prot for PPFIA1 Gene

  • May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.

Gene Wiki entry for PPFIA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPFIA1 Gene

Genomics for PPFIA1 Gene

Regulatory Elements for PPFIA1 Gene

Genomic Location for PPFIA1 Gene

Start:
70,270,682 bp from pter
End:
70,384,501 bp from pter
Size:
113,820 bases
Orientation:
Plus strand

Genomic View for PPFIA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPFIA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPFIA1 Gene

Proteins for PPFIA1 Gene

  • Protein details for PPFIA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13136-LIPA1_HUMAN
    Recommended name:
    Liprin-alpha-1
    Protein Accession:
    Q13136
    Secondary Accessions:
    • A6NLE3
    • Q13135
    • Q14567
    • Q8N4I2

    Protein attributes for PPFIA1 Gene

    Size:
    1202 amino acids
    Molecular mass:
    135779 Da
    Quaternary structure:
    • Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS. Interacts with GIT1, KIF1A and GRIP1 (By similarity).
    SequenceCaution:
    • Sequence=BAA08353.1; Type=Frameshift; Positions=1033, 1041, 1045, 1067, 1113; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PPFIA1 Gene

    Alternative splice isoforms for PPFIA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPFIA1 Gene

Proteomics data for PPFIA1 Gene at MOPED

Post-translational modifications for PPFIA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPFIA1 Gene

Domains for PPFIA1 Gene

Gene Families for PPFIA1 Gene

HGNC:
  • SAMD :Sterile alpha motif (SAM) domain containing

Suggested Antigen Peptide Sequences for PPFIA1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13136

UniProtKB/Swiss-Prot:

LIPA1_HUMAN :
  • Q13136
Domain:
  • The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS
  • Contains 3 SAM (sterile alpha motif) domains.
Family:
  • Belongs to the liprin family. Liprin-alpha subfamily.
genes like me logo Genes that share domains with PPFIA1: view

Function for PPFIA1 Gene

Molecular function for PPFIA1 Gene

UniProtKB/Swiss-Prot Function: May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.

Gene Ontology (GO) - Molecular Function for PPFIA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 7796809
GO:0005515 protein binding IPI 11931740
genes like me logo Genes that share ontologies with PPFIA1: view

Phenotypes for PPFIA1 Gene

GenomeRNAi human phenotypes for PPFIA1:
genes like me logo Genes that share phenotypes with PPFIA1: view

miRNA for PPFIA1 Gene

miRTarBase miRNAs that target PPFIA1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPFIA1 Gene

Localization for PPFIA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPFIA1 Gene

Cytoplasm. Note=Colocalizes with PTPRF at the ends of focal adhesions most proximal to the cell nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPFIA1 Gene COMPARTMENTS Subcellular localization image for PPFIA1 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PPFIA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA --
GO:0048786 presynaptic active zone TAS 15217342
genes like me logo Genes that share ontologies with PPFIA1: view

Pathways for PPFIA1 Gene

SuperPathways for PPFIA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPFIA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007160 cell-matrix adhesion TAS 7796809
GO:0007165 signal transduction TAS 7796809
GO:0007268 synaptic transmission TAS --
GO:0007269 neurotransmitter secretion TAS --
GO:0014047 glutamate secretion TAS --
genes like me logo Genes that share ontologies with PPFIA1: view

No data available for Pathways by source for PPFIA1 Gene

Transcripts for PPFIA1 Gene

Unigene Clusters for PPFIA1 Gene

Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPFIA1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c · 20d ^
SP1:
SP2:
SP3: -
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10: - - - -
SP11: - - -
SP12: - - - - -
SP13:
SP14: -
SP15:
SP16:
SP17:
SP18:

ExUns: 21 ^ 22a · 22b · 22c · 22d ^ 23 ^ 24 ^ 25a · 25b · 25c ^ 26a · 26b · 26c ^ 27 ^ 28 ^ 29a · 29b · 29c ^ 30 ^ 31 ^ 32 ^ 33a · 33b · 33c ^ 34 ^ 35a ·
SP1: - -
SP2: -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8: - - -
SP9:
SP10: -
SP11: - - - -
SP12: - - - -
SP13: - - -
SP14: -
SP15: - - - -
SP16: -
SP17:
SP18: - -

Relevant External Links for PPFIA1 Gene

GeneLoc Exon Structure for
PPFIA1
ECgene alternative splicing isoforms for
PPFIA1

Expression for PPFIA1 Gene

mRNA expression in normal human tissues for PPFIA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPFIA1 Gene

SOURCE GeneReport for Unigene cluster for PPFIA1 Gene Hs.530749

mRNA Expression by UniProt/SwissProt for PPFIA1 Gene

Q13136-LIPA1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with PPFIA1: view

No data available for mRNA differential expression in normal tissues for PPFIA1 Gene

Orthologs for PPFIA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPFIA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPFIA1 35
  • 98.91 (n)
  • 98.74 (a)
PPFIA1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPFIA1 35
  • 84.36 (n)
  • 94.09 (a)
PPFIA1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPFIA1 35
  • 86.97 (n)
  • 94.26 (a)
PPFIA1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppfia1 35
  • 85.96 (n)
  • 95.92 (a)
Ppfia1 16
Ppfia1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPFIA1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPFIA1 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppfia1 35
  • 85.73 (n)
  • 96.28 (a)
chicken
(Gallus gallus)
Aves PPFIA1 35
  • 81.41 (n)
  • 92.89 (a)
PPFIA1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPFIA1 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11800 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ppfia1 35
  • 76.57 (n)
  • 87.19 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.196 35
zebrafish
(Danio rerio)
Actinopterygii PPFIA1 36
  • 77 (a)
OneToOne
zgc:171298 35
  • 68.13 (n)
  • 76.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta Liprin-alpha 36
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea syd-2 36
  • 48 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToMany
Species with no ortholog for PPFIA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPFIA1 Gene

ENSEMBL:
Gene Tree for PPFIA1 (if available)
TreeFam:
Gene Tree for PPFIA1 (if available)

Paralogs for PPFIA1 Gene

Paralogs for PPFIA1 Gene

Pseudogenes.org Pseudogenes for PPFIA1 Gene

genes like me logo Genes that share paralogs with PPFIA1: view

Variants for PPFIA1 Gene

Sequence variations from dbSNP and Humsavar for PPFIA1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs12829 -- 70,362,298(+) GGTTG(G/T)GATGC reference, missense, nc-transcript-variant
rs13365 -- 70,384,019(-) ACAAA(A/C)AAATG utr-variant-3-prime, nc-transcript-variant
rs470972 -- 70,340,731(+) TGACT(A/G)TTGGT intron-variant
rs470973 -- 70,340,739(+) GGTGT(A/G)GAACA intron-variant
rs470975 -- 70,340,828(+) cagga(C/T)agtcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPFIA1 Gene

Variant ID Type Subtype PubMed ID
nsv379 CNV Insertion 18451855
dgv163e201 CNV Deletion 23290073
esv2744713 CNV Deletion 23290073
nsv509426 CNV Insertion 20534489
esv989281 CNV Insertion 20482838
esv2440471 CNV Deletion 19546169
esv9603 CNV Gain 19470904
esv1376217 CNV Insertion 17803354
nsv825984 CNV Gain 20364138

Relevant External Links for PPFIA1 Gene

HapMap Linkage Disequilibrium report
PPFIA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPFIA1 Gene

Disorders for PPFIA1 Gene

No disorders were found for PPFIA1 Gene.

No data available for UniProtKB/Swiss-Prot for PPFIA1 Gene

Publications for PPFIA1 Gene

  1. The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions. (PMID: 7796809) Serra-Pages C. … Streuli M. (EMBO J. 1995) 2 3 4
  2. Liprins, a family of LAR transmembrane protein-tyrosine phosphatase- interacting proteins. (PMID: 9624153) Serra-Pages C. … Streuli M. (J. Biol. Chem. 1998) 2 3 4
  3. The LAR/PTP delta/PTP sigma subfamily of transmembrane protein- tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1. (PMID: 8524829) Pulido R. … Streuli M. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 4 23
  4. PPFIA1 and CCND1 are frequently coamplified in breast cancer. (PMID: 19787783) Dancau A.M. … Simon R. (Genes Chromosomes Cancer 2010) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PPFIA1 Gene

  • antibodies-online peptides for PPFIA1
  • antibodies-online antibodies for PPFIA1
  • antibodies-online kits for PPFIA1

Sources for PPFIA1 Gene

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