Aliases for PPFIA1 Gene
Aliases for PPFIA1 Gene
External Ids for PPFIA1 Gene
- HGNC: 9245
- Entrez Gene: 8500
- Ensembl: ENSG00000131626
- OMIM: 611054
- UniProtKB: Q13136
Previous GeneCards Identifiers for PPFIA1 Gene
- GC11P072448
- GC11P071639
- GC11P070339
- GC11P069843
- GC11P069794
- GC11P070116
- GC11P066374
Summaries for PPFIA1 Gene
-
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPFIA1 Gene
PPFIA1 (PTPRF Interacting Protein Alpha 1) is a Protein Coding gene. Among its related pathways are Neurotransmitter Release Cycle and Transmission across Chemical Synapses. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is PPFIA2.
UniProtKB/Swiss-Prot for PPFIA1 Gene
-
May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPFIA1 Gene
Genomics for PPFIA1 Gene
Regulatory Elements for PPFIA1 Gene
Enhancers for PPFIA1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH11G070396 | 1.5 | FANTOM5 ENCODE | 46.9 | +128.4 | 128392 | 4.2 | HDGF FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF766 | PPFIA1 ORAOV1 FADD CTTN ANO1 ENSG00000246889 GC11P070444 |
| GH11G070269 | 1.1 | ENCODE | 53.8 | +0.3 | 336 | 2.9 | ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 ZNF143 | PPFIA1 H2AFZP4 |
| GH11G070364 | 0.8 | Ensembl ENCODE | 59.7 | +94.5 | 94514 | 1.2 | ZNF121 MAX PRDM10 MYC | PPFIA1 ENSG00000246889 CTTN ENSG00000254604 |
| GH11G070302 | 0.5 | ENCODE | 61.6 | +32.2 | 32191 | 1.7 | ZNF263 ADNP GLIS1 ZMYM3 MAFK | PPFIA1 LOC105369373 GC11P070297 ENSG00000254484 |
| GH11G070332 | 0.6 | ENCODE | 50.7 | +62.7 | 62748 | 1.0 | ZFHX2 POLR2A BHLHE40 FOS MAFK NFE2L2 EGR2 | PPFIA1 ENSG00000254495 CTTN ENSG00000246889 GC11M070315 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around PPFIA1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PPFIA1 gene promoter:
Regulatory Element Products
Genomic Location for PPFIA1 Gene
- Chromosome:
- 11
- Start:
- 70,270,687 bp from pter
- End:
- 70,384,501 bp from pter
- Size:
- 113,815 bases
- Orientation:
- Plus strand
Genomic View for PPFIA1 Gene
Genes around PPFIA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.3 by Ensembl
- 11q13.3 by Entrez Gene
- 11q13.3 by HGNC
PPFIA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPFIA1 Gene
Proteins for PPFIA1 Gene
-
Protein details for PPFIA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13136-LIPA1_HUMAN
- Recommended name:
- Liprin-alpha-1
- Protein Accession:
- Q13136
- A6NLE3
- Q13135
- Q14567
- Q8N4I2
Protein attributes for PPFIA1 Gene
- Size:
- 1202 amino acids
- Molecular mass:
- 135779 Da
- Quaternary structure:
-
- Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS. Interacts with GIT1, KIF1A and GRIP1 (By similarity).
- SequenceCaution:
-
- Sequence=BAA08353.1; Type=Frameshift; Positions=1033, 1041, 1045, 1067, 1113; Evidence={ECO:0000305};
Protein Expression for PPFIA1 Gene
Post-translational modifications for PPFIA1 Gene
Other Protein References for PPFIA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for PPFIA1
- Novus Biologicals Antibodies for PPFIA1
-
Cloud-Clone Corp. Antibodies for PPFIA1
- Invitrogen Antibodies for PPFIA1
- antibodies-online Antibodies for PPFIA1: See all 36
- GeneTex PPFIA1 antibody for PPFIA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for PPFIA1
Protein Products
-
OriGene Purified Proteins for PPFIA1
- Search Origene for MassSpec and Protein Over-expression Lysates for PPFIA1
- Origene Custom Protein Services for PPFIA1
-
Cloud-Clone Corp. Proteins for PPFIA1
- Search GeneTex for Proteins for PPFIA1
Assay Products
No data available for DME Specific Peptides for PPFIA1 Gene
Domains & Families for PPFIA1 Gene
Gene Families for PPFIA1 Gene
Protein Domains for PPFIA1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PPFIA1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13136UniProtKB/Swiss-Prot:
LIPA1_HUMAN :- The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.
- Belongs to the liprin family. Liprin-alpha subfamily.
- Domain:
-
- The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.
- Family:
-
- Belongs to the liprin family. Liprin-alpha subfamily.
Function for PPFIA1 Gene
Molecular function for PPFIA1 Gene
- UniProtKB/Swiss-Prot Function:
- May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004871 | signal transducer activity | TAS | 7796809 |
| GO:0005515 | protein binding | IPI | 11931740 |
Phenotypes for PPFIA1 Gene
- GenomeRNAi human phenotypes for PPFIA1:
-
- Increased vaccinia virus (VACV) infection
- Synthetic lethal with Ras
- Mildly decreased CFP-tsO45G cell surface transport
- Increased transferrin (TF) endocytosis
- Strongly decreased CFP-tsO45G cell surface transport
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- Decreased shRNA abundance (Z-score < -2)
- Decreased cell migration
- Increased cell migration
- Decreased viability
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for PPFIA1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PPFIA1 gene
- Search ViGene Biosciences for PPFIA1
CRISPR Products
-
OriGene CRISPR knockouts for PPFIA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPFIA1
- GenScript: Design CRISPR guide RNA sequences for PPFIA1
miRNA for PPFIA1 Gene
- miRTarBase miRNAs that target PPFIA1
miRNA Products
- Search ViGene Biosciences for PPFIA1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PPFIA1
- Browse OriGene Inhibitory RNA Products For PPFIA1
-
ViGene Biosciences ready-to-package AAV shRNAs for PPFIA1 gene
Cell Line Products
-
Horizon Cell Lines for PPFIA1
-
ViGene Biosciences adenoviral particle packaged cDNA for PPFIA1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PPFIA1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PPFIA1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPFIA1 Gene
Localization for PPFIA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PPFIA1 Gene
- Cytoplasm. Note=Colocalizes with PTPRF at the ends of focal adhesions most proximal to the cell nucleus.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | TAS | 7796809 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005925 | focal adhesion | IDA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for PPFIA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Neurotransmitter Release Cycle | ||
| 2 | Transmission across Chemical Synapses |
.62
|
|
Pathways by source for PPFIA1 Gene
Interacting Proteins for PPFIA1 Gene
Selected Interacting proteins:
ENSP00000253925
Q13136-LIPA1_HUMAN
for PPFIA1 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007160 | cell-matrix adhesion | TAS | 7796809 |
| GO:0007165 | signal transduction | TAS | 7796809 |
| GO:0007269 | neurotransmitter secretion | TAS | -- |
| GO:0014047 | glutamate secretion | TAS | -- |
| GO:0051497 | negative regulation of stress fiber assembly | IMP | 22266902 |
No data available for SIGNOR curated interactions for PPFIA1 Gene
Transcripts for PPFIA1 Gene
mRNA/cDNA for PPFIA1 Gene
- (20) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (40) Selected AceView cDNA sequences:
- (25) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PPFIA1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PPFIA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPFIA1
- GenScript: Design CRISPR guide RNA sequences for PPFIA1
miRNA Products
- Search ViGene Biosciences for PPFIA1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PPFIA1
- Browse OriGene Inhibitory RNA Products For PPFIA1
-
ViGene Biosciences ready-to-package AAV shRNAs for PPFIA1 gene
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | · | 20c | · | 20d | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: |
| ExUns: | 21 | ^ | 22a | · | 22b | · | 22c | · | 22d | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | · | 25c | ^ | 26a | · | 26b | · | 26c | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b | · | 29c | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33a | · | 33b | · | 33c | ^ | 34 | ^ | 35a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - |
Expression for PPFIA1 Gene
This gene is overexpressed in Cardia (21.5), Lung (15.8), Colon muscle (9.2), and Platelet (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPFIA1 Gene
NURSA nuclear receptor signaling pathways regulating expression of PPFIA1 Gene:
PPFIA1SOURCE GeneReport for Unigene cluster for PPFIA1 Gene:
Hs.530749mRNA Expression by UniProt/SwissProt for PPFIA1 Gene:
Q13136-LIPA1_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for PPFIA1 Gene
- Nervous system(4.6)
- Liver(4.3)
Primer Products
-
OriGene qPCR primer pairs for PPFIA1
-
OriGene qPCR primer pairs and template standards for PPFIA1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPFIA1 Gene
Orthologs for PPFIA1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PPFIA1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | PPFIA1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Ppfia1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ppfia1 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PPFIA1 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PPFIA1 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PPFIA1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PPFIA1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PPFIA1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ppfia1 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.11800 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | PPFIA1 35 |
|
OneToOne | |
| zgc:171298 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.196 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Liprin-alpha 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | syd-2 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for PPFIA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PPFIA1 Gene
(4) SIMAP similar genes for PPFIA1 Gene using alignment to 14 proteins:
Pseudogenes.org Pseudogenes for PPFIA1 Gene
Variants for PPFIA1 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000032697 | -- | 70,377,418(+) | TTGAG(C/T)TTGAC | intron-variant | |
| rs1000040387 | -- | 70,308,638(+) | AAAAA(A/C)TTGAT | intron-variant | |
| rs1000061956 | -- | 70,292,570(+) | GTCTA(C/G/T)TGTGT | intron-variant | |
| rs1000064902 | -- | 70,334,361(+) | GAAAT(C/G)TGTAT | intron-variant | |
| rs1000076919 | -- | 70,294,423(+) | CCTTT(A/T)GACAT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv144e201 | CNV | deletion | 23290073 |
| esv1376217 | CNV | insertion | 17803354 |
| esv2440471 | CNV | deletion | 19546169 |
| esv2744713 | CNV | deletion | 23290073 |
| esv2857791 | CNV | duplication | 24192839 |
| esv3381709 | CNV | insertion | 20981092 |
| esv9603 | CNV | gain | 19470904 |
| esv989281 | CNV | insertion | 20482838 |
| nsv1118218 | CNV | deletion | 24896259 |
| nsv1140482 | CNV | tandem duplication | 24896259 |
| nsv379 | CNV | insertion | 18451855 |
| nsv472658 | CNV | novel sequence insertion | 20440878 |
| nsv480854 | CNV | novel sequence insertion | 20440878 |
| nsv481016 | CNV | novel sequence insertion | 20440878 |
| nsv509426 | CNV | insertion | 20534489 |
| nsv825984 | CNV | gain | 20364138 |
| nsv975199 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
9.24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.45;
85.70% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PPFIA1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPFIA1 Gene
Disorders for PPFIA1 Gene
Relevant External Links for PPFIA1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- PPFIA1
No disorders were found for PPFIA1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPFIA1 Gene
Publications for PPFIA1 Gene
- Liprins, a family of LAR transmembrane protein-tyrosine phosphatase- interacting proteins. (PMID: 9624153) Serra-Pages C. … Streuli M. (J. Biol. Chem. 1998) 2 3 4 64
- The LAR/PTP delta/PTP sigma subfamily of transmembrane protein- tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1. (PMID: 8524829) Pulido R. … Streuli M. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 4 22 64
- The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions. (PMID: 7796809) Serra-Pages C. … Streuli M. (EMBO J. 1995) 2 3 4 64
- PPFIA1 and CCND1 are frequently coamplified in breast cancer. (PMID: 19787783) Dancau A.M. … Simon R. (Genes Chromosomes Cancer 2010) 3 22 64
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
Products for PPFIA1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PPFIA1
- Search Origene for MassSpec and Protein Over-expression Lysates for PPFIA1
- Origene Custom Protein Services for PPFIA1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for PPFIA1
- Browse OriGene Inhibitory RNA Products For PPFIA1
- OriGene qPCR primer pairs and template standards for PPFIA1
- OriGene qPCR primer pairs for PPFIA1
- OriGene CRISPR knockouts for PPFIA1
- OriGene ORF clones in human for PPFIA1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PPFIA1
- GenScript: Next-day shipping cDNA ORF clone for PPFIA1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PPFIA1
- GenScript Custom Assay Services for PPFIA1
- GenScript Custom overexpressing Cell Line Services for PPFIA1
- GenScript: Design CRISPR guide RNA sequences for PPFIA1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PPFIA1
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for PPFIA1
- Novus Biologicals proteins and lysates for PPFIA1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for PPFIA1
- Cloud-Clone Corp. Proteins for PPFIA1
- Browse Assay Kits at Cloud-Clone Corp.
- ViGene Biosciences adenoviral particle packaged cDNA for PPFIA1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PPFIA1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PPFIA1 gene
- Search ViGene Biosciences for PPFIA1
- Santa Cruz Biotechnology (SCBT) Antibodies for PPFIA1
- Search Santa Cruz Biotechnology (SCBT) for PPFIA1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PPFIA1
- Horizon Cell Lines for PPFIA1
- Cyagen custom Knockout/knockin (KOKI) mouse models for PPFIA1
- VectorBuilder custom plasmid, inducible vectors for PPFIA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PPFIA1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for PPFIA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer