Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC35B4 Gene

Aliases for SLC35B4 Gene

  • Solute Carrier Family 35 Member B4 2 3 4 5
  • Solute Carrier Family 35 (UDP-Xylose/UDP-N-Acetylglucosamine Transporter), Member B4 2 3
  • YEA4 Homolog 3 4
  • YEA4 3 4
  • UDP-Xylose And UDP-N-Acetylglucosamine Transporter 3
  • UDP-Xylose/N-Acetylglucosamine Transporter 3
  • Solute Carrier Family 35, Member B4 2
  • YEA 3

External Ids for SLC35B4 Gene

Previous GeneCards Identifiers for SLC35B4 Gene

  • GC07M133377
  • GC07M133394
  • GC07M133435
  • GC07M133624
  • GC07M133974
  • GC07M128275

Summaries for SLC35B4 Gene

Entrez Gene Summary for SLC35B4 Gene

  • Glycosyltransferases, such as SLC35B4, transport nucleotide sugars from the cytoplasm where they are synthesized, to the Golgi apparatus where they are utilized in the synthesis of glycoproteins, glycolipids, and proteoglycans (Ashikov et al., 2005 [PubMed 15911612]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC35B4 Gene

SLC35B4 (Solute Carrier Family 35 Member B4) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of vitamins, nucleosides, and related molecules. GO annotations related to this gene include UDP-N-acetylglucosamine transmembrane transporter activity and UDP-xylose transmembrane transporter activity.

UniProtKB/Swiss-Prot for SLC35B4 Gene

  • Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.

Gene Wiki entry for SLC35B4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35B4 Gene

Genomics for SLC35B4 Gene

Regulatory Elements for SLC35B4 Gene

Enhancers for SLC35B4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G134292 1 ENCODE 31.2 +27.2 27167 0.9 FOXA2 ARID4B DMAP1 FEZF1 YY1 YY2 MIER2 TBX21 KAT8 MIER3 SLC35B4 PIR38208 ENSG00000231098
GH07G134315 1.1 ENCODE 25.7 +3.6 3562 2.2 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC35B4 PIR38208
GH07G134298 0.6 ENCODE 31.6 +20.9 20949 0.8 CTCF ZNF316 SMARCA4 MAFG NFE2 RAD21 EMSY SLC35B4 PIR38208
GH07G134363 1.3 Ensembl ENCODE 14 -44.9 -44856 3.6 ATF1 FOXA2 MLX YY1 TCF12 ZNF766 ELK1 FOS ZNF592 KAT8 SLC35B4 LOC105375519 AKR1B1 LOC105375518 ENSG00000229177
GH07G134561 1.5 FANTOM5 ENCODE dbSUPER 11.2 -243.5 -243456 5.1 FOXA2 SIN3A FEZF1 RAD21 YY1 ZNF121 ZNF366 FOS TBX21 ZNF843 AKR1B15 SLC35B4 AGBL3 AKR1B1 ENSG00000272941 LRGUK LOC105375520 GC07M134627
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC35B4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC35B4 Gene

Chromosome:
7
Start:
134,289,332 bp from pter
End:
134,320,314 bp from pter
Size:
30,983 bases
Orientation:
Minus strand

Genomic View for SLC35B4 Gene

Genes around SLC35B4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35B4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35B4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35B4 Gene

Proteins for SLC35B4 Gene

  • Protein details for SLC35B4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969S0-S35B4_HUMAN
    Recommended name:
    UDP-xylose and UDP-N-acetylglucosamine transporter
    Protein Accession:
    Q969S0
    Secondary Accessions:
    • A4D1P3
    • A6NNS4
    • Q53GQ7
    • Q8TCU7
    • Q96K33

    Protein attributes for SLC35B4 Gene

    Size:
    331 amino acids
    Molecular mass:
    37424 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55325.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC35B4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35B4 Gene

Post-translational modifications for SLC35B4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35B4 Gene

No data available for DME Specific Peptides for SLC35B4 Gene

Domains & Families for SLC35B4 Gene

Gene Families for SLC35B4 Gene

HGNC:
IUPHAR :

Protein Domains for SLC35B4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35B4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969S0

UniProtKB/Swiss-Prot:

S35B4_HUMAN :
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
Family:
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
genes like me logo Genes that share domains with SLC35B4: view

Function for SLC35B4 Gene

Molecular function for SLC35B4 Gene

UniProtKB/Swiss-Prot Function:
Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.

Gene Ontology (GO) - Molecular Function for SLC35B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005457 GDP-fucose transmembrane transporter activity IBA --
GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity TAS --
GO:0005464 UDP-xylose transmembrane transporter activity TAS --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SLC35B4: view
genes like me logo Genes that share phenotypes with SLC35B4: view

Animal Models for SLC35B4 Gene

MGI Knock Outs for SLC35B4:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35B4

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC35B4 Gene

Localization for SLC35B4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35B4 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35B4 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 3
nucleus 2
lysosome 1

Gene Ontology (GO) - Cellular Components for SLC35B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum IDA 21918738
GO:0005794 Golgi apparatus IEA,IDA 15911612
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35B4: view

Pathways & Interactions for SLC35B4 Gene

genes like me logo Genes that share pathways with SLC35B4: view

Interacting Proteins for SLC35B4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000367770%0d%0a9606.ENSP00000434939%0d%0a
Selected Interacting proteins: ENSP00000367770 Q969S0-S35B4_HUMAN for SLC35B4 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for SLC35B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006111 regulation of gluconeogenesis IEA --
GO:0006810 transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0015783 GDP-fucose transport IBA --
GO:0015788 UDP-N-acetylglucosamine transport IDA 15911612
genes like me logo Genes that share ontologies with SLC35B4: view

No data available for SIGNOR curated interactions for SLC35B4 Gene

Drugs & Compounds for SLC35B4 Gene

No Compound Related Data Available

Transcripts for SLC35B4 Gene

Unigene Clusters for SLC35B4 Gene

Solute carrier family 35, member B4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35B4 Gene

No ASD Table

Relevant External Links for SLC35B4 Gene

GeneLoc Exon Structure for
SLC35B4
ECgene alternative splicing isoforms for
SLC35B4

Expression for SLC35B4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35B4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35B4 Gene

This gene is overexpressed in Fetal Brain (21.3), Retina (21.1), Testis (14.0), and Ovary (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC35B4 Gene



Protein tissue co-expression partners for SLC35B4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC35B4 Gene:

SLC35B4

SOURCE GeneReport for Unigene cluster for SLC35B4 Gene:

Hs.490181

Evidence on tissue expression from TISSUES for SLC35B4 Gene

  • Liver(4.2)
  • Skin(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SLC35B4: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35B4 Gene

Orthologs for SLC35B4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC35B4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35B4 34 35
  • 99.5 (n)
cow
(Bos Taurus)
Mammalia SLC35B4 34 35
  • 92.15 (n)
dog
(Canis familiaris)
Mammalia SLC35B4 34 35
  • 90.61 (n)
rat
(Rattus norvegicus)
Mammalia Slc35b4 34
  • 89.22 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC35B4 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35B4 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35b4 34 16 35
  • 88.92 (n)
chicken
(Gallus gallus)
Aves SLC35B4 34 35
  • 76.54 (n)
lizard
(Anolis carolinensis)
Reptilia SLC35B4 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35b4 34
  • 73.01 (n)
zebrafish
(Danio rerio)
Actinopterygii slc35b4 34 35
  • 68.29 (n)
Dr.2187 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011493 34
  • 60.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta Efr 34 35
  • 57.62 (n)
CG14511 35
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nstp-2 34 35
  • 51.12 (n)
nstp-1 35
  • 36 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B03157g 34
  • 45.44 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YEA4 34 35 37
  • 43.92 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToMany
-- 35
  • 47 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU02980 34
  • 46.64 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1734.09 34
  • 46.32 (n)
Species where no ortholog for SLC35B4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35B4 Gene

ENSEMBL:
Gene Tree for SLC35B4 (if available)
TreeFam:
Gene Tree for SLC35B4 (if available)

Paralogs for SLC35B4 Gene

No data available for Paralogs for SLC35B4 Gene

Variants for SLC35B4 Gene

Sequence variations from dbSNP and Humsavar for SLC35B4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000055467 -- 134,314,811(+) TTACA(C/G)GTGTG intron-variant
rs1000061829 -- 134,308,754(+) CAATA(C/T)ACTGT intron-variant
rs1000411109 -- 134,318,157(+) CTCGT(A/T)ATCGA intron-variant, upstream-variant-2KB
rs1000559329 -- 134,319,401(+) CTGTT(C/T)ATAAG intron-variant
rs1000571595 -- 134,300,961(+) AGTGA(C/G)GCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35B4 Gene

Variant ID Type Subtype PubMed ID
esv3615084 CNV gain 21293372
esv3615093 CNV gain 21293372
nsv1020759 CNV gain 25217958
nsv608444 CNV gain 21841781
nsv831145 CNV gain 17160897

Variation tolerance for SLC35B4 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35B4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35B4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35B4 Gene

Disorders for SLC35B4 Gene

Relevant External Links for SLC35B4

Genetic Association Database (GAD)
SLC35B4
Human Genome Epidemiology (HuGE) Navigator
SLC35B4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35B4

No disorders were found for SLC35B4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35B4 Gene

Publications for SLC35B4 Gene

  1. The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP- N-acetylglucosamine. (PMID: 15911612) Ashikov A. … Bakker H. (J. Biol. Chem. 2005) 3 4 64
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64

Products for SLC35B4 Gene

Sources for SLC35B4 Gene

Content
Loading form....