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Aliases for SLC35B4 Gene

Aliases for SLC35B4 Gene

  • Solute Carrier Family 35 Member B4 2 3 4
  • Solute Carrier Family 35 (UDP-Xylose/UDP-N-Acetylglucosamine Transporter), Member B4 2 3 5
  • Solute Carrier Family 35, Member B4 2 3
  • YEA4 Homolog 3 4
  • YEA4 3 4
  • UDP-Xylose/N-Acetylglucosamine Transporter 3
  • YEA 3

External Ids for SLC35B4 Gene

Previous GeneCards Identifiers for SLC35B4 Gene

  • GC07M133377
  • GC07M133394
  • GC07M133435
  • GC07M133624
  • GC07M133974
  • GC07M128275

Summaries for SLC35B4 Gene

Entrez Gene Summary for SLC35B4 Gene

  • Glycosyltransferases, such as SLC35B4, transport nucleotide sugars from the cytoplasm where they are synthesized, to the Golgi apparatus where they are utilized in the synthesis of glycoproteins, glycolipids, and proteoglycans (Ashikov et al., 2005 [PubMed 15911612]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC35B4 Gene

SLC35B4 (Solute Carrier Family 35 Member B4) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of vitamins, nucleosides, and related molecules. GO annotations related to this gene include UDP-N-acetylglucosamine transmembrane transporter activity and UDP-xylose transmembrane transporter activity.

UniProtKB/Swiss-Prot for SLC35B4 Gene

  • Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.

Gene Wiki entry for SLC35B4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35B4 Gene

Genomics for SLC35B4 Gene

Regulatory Elements for SLC35B4 Gene

Genomic Location for SLC35B4 Gene

Chromosome:
7
Start:
134,289,332 bp from pter
End:
134,320,314 bp from pter
Size:
30,983 bases
Orientation:
Minus strand

Genomic View for SLC35B4 Gene

Genes around SLC35B4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35B4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35B4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35B4 Gene

Proteins for SLC35B4 Gene

  • Protein details for SLC35B4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969S0-S35B4_HUMAN
    Recommended name:
    UDP-xylose and UDP-N-acetylglucosamine transporter
    Protein Accession:
    Q969S0
    Secondary Accessions:
    • A4D1P3
    • A6NNS4
    • Q53GQ7
    • Q8TCU7
    • Q96K33

    Protein attributes for SLC35B4 Gene

    Size:
    331 amino acids
    Molecular mass:
    37424 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55325.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC35B4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35B4 Gene

Proteomics data for SLC35B4 Gene at MOPED

Post-translational modifications for SLC35B4 Gene

No Post-translational modifications

Other Protein References for SLC35B4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC35B4 Gene

Domains & Families for SLC35B4 Gene

Gene Families for SLC35B4 Gene

HGNC:
IUPHAR :

Protein Domains for SLC35B4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35B4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969S0

UniProtKB/Swiss-Prot:

S35B4_HUMAN :
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
Family:
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
genes like me logo Genes that share domains with SLC35B4: view

Function for SLC35B4 Gene

Molecular function for SLC35B4 Gene

UniProtKB/Swiss-Prot Function:
Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.

Gene Ontology (GO) - Molecular Function for SLC35B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SLC35B4: view
genes like me logo Genes that share phenotypes with SLC35B4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35B4

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35B4 Gene

Localization for SLC35B4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35B4 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC35B4 Gene COMPARTMENTS Subcellular localization image for SLC35B4 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 3
nucleus 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SLC35B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0030176 integral component of endoplasmic reticulum membrane IBA --
genes like me logo Genes that share ontologies with SLC35B4: view

Pathways & Interactions for SLC35B4 Gene

genes like me logo Genes that share pathways with SLC35B4: view

Interacting Proteins for SLC35B4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000367770%0d%0a9606.ENSP00000434939%0d%0a9606.ENSP00000439467%0d%0a
Selected Interacting proteins: Q969S0-S35B4_HUMAN ENSP00000367770 for SLC35B4 Gene via I2D UniProtKB STRING

Gene Ontology (GO) - Biological Process for SLC35B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015783 GDP-fucose transport IBA --
GO:0015790 UDP-xylose transport IDA 15911612
GO:0055085 transmembrane transport IEA --
GO:1990569 UDP-N-acetylglucosamine transmembrane transport IDA,TAS --
genes like me logo Genes that share ontologies with SLC35B4: view

No data available for SIGNOR curated interactions for SLC35B4 Gene

Drugs & Compounds for SLC35B4 Gene

No Compound Related Data Available

Transcripts for SLC35B4 Gene

Unigene Clusters for SLC35B4 Gene

Solute carrier family 35, member B4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35B4 Gene

No ASD Table

Relevant External Links for SLC35B4 Gene

GeneLoc Exon Structure for
SLC35B4
ECgene alternative splicing isoforms for
SLC35B4

Expression for SLC35B4 Gene

mRNA expression in normal human tissues for SLC35B4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35B4 Gene

This gene is overexpressed in Fetal Brain (21.3), Retina (21.1), Testis (14.0), and Ovary (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC35B4 Gene



SOURCE GeneReport for Unigene cluster for SLC35B4 Gene Hs.490181

genes like me logo Genes that share expression patterns with SLC35B4: view

Protein tissue co-expression partners for SLC35B4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC35B4 Gene

Orthologs for SLC35B4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC35B4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC35B4 35
  • 92.15 (n)
  • 93.96 (a)
SLC35B4 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC35B4 35
  • 90.61 (n)
  • 94.24 (a)
SLC35B4 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35b4 35
  • 88.92 (n)
  • 90.94 (a)
Slc35b4 16
Slc35b4 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC35B4 35
  • 99.5 (n)
  • 100 (a)
SLC35B4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc35b4 35
  • 89.22 (n)
  • 91.54 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC35B4 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35B4 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35B4 35
  • 76.54 (n)
  • 81.27 (a)
SLC35B4 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC35B4 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35b4 35
  • 73.01 (n)
  • 79.15 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.2187 35
slc35b4 35
  • 68.29 (n)
  • 73.56 (a)
slc35b4 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011493 35
  • 60.14 (n)
  • 60.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta Efr 35
  • 57.62 (n)
  • 53.66 (a)
CG14511 36
  • 50 (a)
OneToMany
Efr 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nstp-2 35
  • 51.12 (n)
  • 43.45 (a)
nstp-1 36
  • 36 (a)
OneToMany
nstp-2 36
  • 42 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B03157g 35
  • 45.44 (n)
  • 32.48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YEA4 35
  • 43.92 (n)
  • 31.43 (a)
YEA4 36
  • 28 (a)
OneToOne
YEA4 38
bread mold
(Neurospora crassa)
Ascomycetes NCU02980 35
  • 46.64 (n)
  • 38.59 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1734.09 35
  • 46.32 (n)
  • 37.01 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
Species with no ortholog for SLC35B4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35B4 Gene

ENSEMBL:
Gene Tree for SLC35B4 (if available)
TreeFam:
Gene Tree for SLC35B4 (if available)

Paralogs for SLC35B4 Gene

No data available for Paralogs for SLC35B4 Gene

Variants for SLC35B4 Gene

Sequence variations from dbSNP and Humsavar for SLC35B4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2504 -- 134,294,793(-) GAGGG(A/T)GGGAC utr-variant-3-prime
rs2505 -- 134,294,800(-) TCGTC(A/G)TGAGG utr-variant-3-prime
rs7486 -- 134,290,431(-) TGTTA(A/C/T)GTGAA utr-variant-3-prime
rs8134 -- 134,289,767(-) ATAGA(C/T)GACTC utr-variant-3-prime
rs14624 -- 134,289,897(+) CCTCA(C/G)TTGAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC35B4 Gene

Variant ID Type Subtype PubMed ID
nsv831145 CNV Gain 17160897

Variation tolerance for SLC35B4 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35B4 Gene

HapMap Linkage Disequilibrium report
SLC35B4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35B4 Gene

Disorders for SLC35B4 Gene

Relevant External Links for SLC35B4

Genetic Association Database (GAD)
SLC35B4
Human Genome Epidemiology (HuGE) Navigator
SLC35B4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35B4

No disorders were found for SLC35B4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35B4 Gene

Publications for SLC35B4 Gene

  1. The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP- N-acetylglucosamine. (PMID: 15911612) Ashikov A. … Bakker H. (J. Biol. Chem. 2005) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis. (PMID: 21507882) Yazbek S.N. … Nadeau J.H. (Genome Res. 2011) 3
  5. Subcellular localization of UDP-GlcNAc, UDP-Gal and SLC35B4 transporters. (PMID: 21918738) Maszczak-Seneczko D. … Olczak M. (Acta Biochim. Pol. 2011) 3

Products for SLC35B4 Gene

Sources for SLC35B4 Gene

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