Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC7A3 Gene

Aliases for SLC7A3 Gene

  • Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 3 2 3
  • CAT3 3 4 6
  • ATRC3 3 4
  • CAT-3 3 4
  • Cationic Amino Acid Transporter Y+ 4
  • Cationic Amino Acid Transporter 3 3
  • Solute Carrier Family 7 Member 3 4

External Ids for SLC7A3 Gene

Summaries for SLC7A3 Gene

Entrez Gene Summary for SLC7A3 Gene

  • This gene encodes a member of the solute carrier family 7. The encoded protein is a sodium-independent cationic amino acid transporter. Alternate splicing results in multiple transcripts that encoded the same protein.[provided by RefSeq, May 2010]

GeneCards Summary for SLC7A3 Gene

SLC7A3 (Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 3) is a Protein Coding gene. Diseases associated with SLC7A3 include allan-herndon-dudley syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include arginine transmembrane transporter activity. An important paralog of this gene is SLC7A14.

UniProtKB/Swiss-Prot for SLC7A3 Gene

  • Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.

Gene Wiki entry for SLC7A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC7A3 Gene

Genomics for SLC7A3 Gene

Genomic Location for SLC7A3 Gene

Start:
70,925,579 bp from pter
End:
70,931,125 bp from pter
Size:
5,547 bases
Orientation:
Minus strand

Genomic View for SLC7A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC7A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC7A3 Gene

Regulatory Elements for SLC7A3 Gene

Proteins for SLC7A3 Gene

  • Protein details for SLC7A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WY07-CTR3_HUMAN
    Recommended name:
    Cationic amino acid transporter 3
    Protein Accession:
    Q8WY07
    Secondary Accessions:
    • D3DVU7
    • Q5JQR2
    • Q8N185
    • Q8NCA7
    • Q96SZ7

    Protein attributes for SLC7A3 Gene

    Size:
    619 amino acids
    Molecular mass:
    67169 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55118.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC7A3 Gene

Proteomics data for SLC7A3 Gene at MOPED

Post-translational modifications for SLC7A3 Gene

Other Protein References for SLC7A3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC7A3 Gene

Domains for SLC7A3 Gene

Gene Families for SLC7A3 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC7A3 Gene

UniProtKB/Swiss-Prot:

CTR3_HUMAN
Family:
  • Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.:
    • Q8WY07
genes like me logo Genes that share domains with SLC7A3: view

Function for SLC7A3 Gene

Molecular function for SLC7A3 Gene

UniProtKB/Swiss-Prot Function: Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.

Gene Ontology (GO) - Molecular Function for SLC7A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000064 L-ornithine transmembrane transporter activity IBA --
GO:0015171 amino acid transmembrane transporter activity --
GO:0015174 basic amino acid transmembrane transporter activity --
GO:0015181 arginine transmembrane transporter activity IBA --
GO:0015189 L-lysine transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC7A3: view

Phenotypes for SLC7A3 Gene

GenomeRNAi human phenotypes for SLC7A3:
genes like me logo Genes that share phenotypes with SLC7A3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC7A3 Gene

Localization for SLC7A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC7A3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC7A3 Gene COMPARTMENTS Subcellular localization image for SLC7A3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC7A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC7A3: view

Pathways for SLC7A3 Gene

genes like me logo Genes that share pathways with SLC7A3: view

Interacting Proteins for SLC7A3 Gene

Gene Ontology (GO) - Biological Process for SLC7A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport --
GO:0006810 transport --
GO:0006811 ion transport TAS --
GO:0006865 amino acid transport TAS --
GO:0015809 arginine transport --
genes like me logo Genes that share ontologies with SLC7A3: view

Compounds for SLC7A3 Gene

(1) HMDB Compounds for SLC7A3 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5

(3) Drugbank Compounds for SLC7A3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Arginine
  • (S)-2-Amino-5-guanidinovaleric acid
74-79-3 target
L-Lysine
  • (S)-2,6-diaminohexanoic acid
56-87-1 target
L-Ornithine
  • (S)-2,5-Diaminopentanoate
70-26-8 target
genes like me logo Genes that share compounds with SLC7A3: view

Transcripts for SLC7A3 Gene

mRNA/cDNA for SLC7A3 Gene

Unigene Clusters for SLC7A3 Gene

Solute carrier family 7 (cationic amino acid transporter, y+ system), member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - - -
SP3: - - -
SP4:
SP5:

Relevant External Links for SLC7A3 Gene

GeneLoc Exon Structure for
SLC7A3
ECgene alternative splicing isoforms for
SLC7A3

Expression for SLC7A3 Gene

mRNA expression in normal human tissues for SLC7A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC7A3 Gene

This gene is overexpressed in Uterus (9.4), Brain - Hypothalamus (7.1), and Stomach (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC7A3 Gene

SOURCE GeneReport for Unigene cluster for SLC7A3 Gene Hs.175220

mRNA Expression by UniProt/SwissProt for SLC7A3 Gene

Q8WY07-CTR3_HUMAN
Tissue specificity: Highly expressed in thymus, uterus and testis. Detected at lower levels in brain, mammary gland, prostate, salivary gland and fetal spleen. In brain, highest expression in thalamus, hippocampus and amygdala.
genes like me logo Genes that share expressions with SLC7A3: view

Orthologs for SLC7A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC7A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC7A3 36
  • 99.35 (n)
  • 98.87 (a)
SLC7A3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC7A3 36
  • 88.37 (n)
  • 87.4 (a)
SLC7A3 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 67 (a)
OneToMany
-- 37
  • 67 (a)
OneToMany
-- 37
  • 60 (a)
OneToMany
-- 37
  • 60 (a)
OneToMany
-- 37
  • 68 (a)
OneToMany
-- 37
  • 65 (a)
OneToMany
-- 37
  • 66 (a)
OneToMany
-- 37
  • 60 (a)
OneToMany
-- 37
  • 89 (a)
OneToMany
SLC7A3 36
  • 88.49 (n)
  • 87.84 (a)
mouse
(Mus musculus)
Mammalia Slc7a3 36
  • 83.58 (n)
  • 82.17 (a)
Slc7a3 16
Slc7a3 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 72 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 55 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Slc7a3 36
  • 83.87 (n)
  • 83.66 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 61 (a)
OneToMany
SLC7A3 36
  • 65.89 (n)
  • 66.28 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 64 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia slc7a3-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10160 36
zebrafish
(Danio rerio)
Actinopterygii CT573152.3 37
  • 60 (a)
ManyToMany
slc7a3a 36
  • 65.25 (n)
  • 68.64 (a)
slc7a3a 37
  • 62 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG13248 38
  • 40 (a)
CG11128 38
  • 48 (a)
CG7255 38
  • 45 (a)
CG5535 38
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea F23F1.6 38
  • 36 (a)
C50D2.2 38
  • 39 (a)
B0454.6 38
  • 37 (a)
rice
(Oryza sativa)
Liliopsida Os10g0437100 36
  • 47.36 (n)
  • 38.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 49 (a)
OneToMany
Species with no ortholog for SLC7A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC7A3 Gene

ENSEMBL:
Gene Tree for SLC7A3 (if available)
TreeFam:
Gene Tree for SLC7A3 (if available)

Paralogs for SLC7A3 Gene

Paralogs for SLC7A3 Gene

Selected SIMAP similar genes for SLC7A3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SLC7A3 Gene

genes like me logo Genes that share paralogs with SLC7A3: view

Variants for SLC7A3 Gene

Sequence variations from dbSNP and Humsavar for SLC7A3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs4844280 -- 70,932,122(+) CATTG(A/G)GTCAG upstream-variant-2KB
rs4993078 -- 70,931,232(+) ACACA(A/C)AACAC upstream-variant-2KB
rs5936604 -- 70,928,740(+) TCACC(C/T)CCCTT intron-variant
rs5936605 -- 70,929,077(+) CTGCC(A/T)TTTTC intron-variant
rs5936606 -- 70,929,510(+) AACCC(A/G)CACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC7A3 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
esv33082 CNV Loss 17666407
nsv510931 CNV Complex 20534489

Relevant External Links for SLC7A3 Gene

HapMap Linkage Disequilibrium report
SLC7A3
Locus Specific Mutation Databases (LSDB)
SLC7A3

Disorders for SLC7A3 Gene

(1) University of Copenhagen DISEASES for SLC7A3 Gene

genes like me logo Genes that share disorders with SLC7A3: view

No data available for UniProtKB/Swiss-Prot for SLC7A3 Gene

Publications for SLC7A3 Gene

  1. Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues. (PMID: 11591158) Vekony N. … Closs E.I. (Biochemistry 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Activation of classical protein kinase C decreases transport via systems y+ and y+L. (PMID: 17329401) Rotmann A. … Closs E.I. (Am. J. Physiol. 2007) 23 25
  5. Monovalent cation conductance in Xenopus laevis oocytes expressing hCAT-3. (PMID: 15737334) Gilles W. … Nawrath H. (Biochim. Biophys. Acta 2005) 3

Products for SLC7A3 Gene

Sources for SLC7A3 Gene

Back to Top

Content