Aliases for RIOX2 Gene
External Ids for RIOX2 Gene
Previous HGNC Symbols for RIOX2 Gene
MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]
GeneCards Summary for RIOX2 Gene
RIOX2 (Ribosomal Oxygenase 2) is a Protein Coding gene. Diseases associated with RIOX2 include Lung Cancer. Among its related pathways are Validated targets of C-MYC transcriptional activation and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. An important paralog of this gene is RIOX1.
UniProtKB/Swiss-Prot for RIOX2 Gene
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated Lys-9 on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on His-39. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.