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Aliases for RIOX2 Gene

Aliases for RIOX2 Gene

  • Ribosomal Oxygenase 2 2 3 5
  • 60S Ribosomal Protein L27a Histidine Hydroxylase 3 4
  • Histone Lysine Demethylase MINA 3 4
  • MYC Induced Nuclear Antigen 2 3
  • Ribosomal Oxygenase MINA 3 4
  • Nucleolar Protein 52 3 4
  • MINA53 3 4
  • MDIG 3 4
  • NO52 3 4
  • ROX 3 4
  • Bifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase MINA 3
  • Myc-Induced Nuclear Antigen, 53 KDa 3
  • Mineral Dust Induced Gene Protein 3
  • Mineral Dust-Induced Gene Protein 4
  • MYC-Induced Nuclear Antigen 4
  • EC 1.14.11.- 4
  • JMJD10 3
  • MINA 3

External Ids for RIOX2 Gene

Previous HGNC Symbols for RIOX2 Gene

  • MINA

Summaries for RIOX2 Gene

Entrez Gene Summary for RIOX2 Gene

  • MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]

GeneCards Summary for RIOX2 Gene

RIOX2 (Ribosomal Oxygenase 2) is a Protein Coding gene. Diseases associated with RIOX2 include Lung Cancer. Among its related pathways are Validated targets of C-MYC transcriptional activation and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. An important paralog of this gene is RIOX1.

UniProtKB/Swiss-Prot for RIOX2 Gene

  • Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated Lys-9 on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on His-39. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.

Gene Wiki entry for RIOX2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIOX2 Gene

Genomics for RIOX2 Gene

Regulatory Elements for RIOX2 Gene

Enhancers for RIOX2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G097882 0.9 Ensembl ENCODE 15.1 +89.5 89467 0.8 NFIB FEZF1 JUND GATA3 NFIC GATA2 SMARCA4 HMBOX1 EZH2 RIOX2 LOC105373994
GH03G097820 1.2 ENCODE dbSUPER 10.5 +150.0 149978 3.1 SIN3A DMAP1 ZNF48 YY1 ZNF143 KLF7 ZNF263 SP3 REST CBX8 RIOX2 CRYBG3 LOC105373994
GH03G097910 1.1 Ensembl ENCODE 11.4 +61.4 61386 1.7 HDAC1 PKNOX1 ATF1 FOXA2 TBL1XR1 ARNT NFRKB TCF12 ZNF766 GATA2 RIOX2 CRYBG3 LOC105373994
GH03G098013 0.7 ENCODE 10.9 -41.2 -41175 0.2 PKNOX1 FOXA2 JUN CEBPB EP300 ZNF843 JUND PRDM6 STAT3 FOS RIOX2 ARL6 GABRR3
GH03G097793 0.6 ENCODE 10.2 +178.8 178816 0.1 CTCF ZNF654 ZNF511 TRIM22 REST RAD21 ZNF316 SMC3 ZNF143 MAFK ARL6 RIOX2 GC03M097791 GC03M097742
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RIOX2 on UCSC Golden Path with GeneCards custom track

Promoters for RIOX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000155329 257 1601 HDGF CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 YY1 CBX5

Genomic Location for RIOX2 Gene

Chromosome:
3
Start:
97,941,817 bp from pter
End:
97,972,457 bp from pter
Size:
30,641 bases
Orientation:
Minus strand

Genomic View for RIOX2 Gene

Genes around RIOX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIOX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIOX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIOX2 Gene

Proteins for RIOX2 Gene

  • Protein details for RIOX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUF8-MINA_HUMAN
    Recommended name:
    Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA
    Protein Accession:
    Q8IUF8
    Secondary Accessions:
    • D3DN35
    • Q6AHW4
    • Q6SKS0
    • Q8IU69
    • Q8IUF6
    • Q8IUF7
    • Q96C17
    • Q96KB0

    Protein attributes for RIOX2 Gene

    Size:
    465 amino acids
    Molecular mass:
    52800 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH10679.1; Type=Erroneous termination; Positions=431; Note=Translated as Trp.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RIOX2 Gene

    Alternative splice isoforms for RIOX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIOX2 Gene

Post-translational modifications for RIOX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RIOX2 Gene

Domains & Families for RIOX2 Gene

Protein Domains for RIOX2 Gene

Suggested Antigen Peptide Sequences for RIOX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUF8

UniProtKB/Swiss-Prot:

MINA_HUMAN :
  • Belongs to the ROX family. MINA53 subfamily.
Family:
  • Belongs to the ROX family. MINA53 subfamily.
genes like me logo Genes that share domains with RIOX2: view

No data available for Gene Families for RIOX2 Gene

Function for RIOX2 Gene

Molecular function for RIOX2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
L-histidine-[60S ribosomal protein L27a] + 2-oxoglutarate + O(2) = (3S)-3-hydroxy-L-histidine-[60S ribosomal protein L27a] + succinate + CO(2).
UniProtKB/Swiss-Prot Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated Lys-9 on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on His-39. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to MYC, in alveolar macrophages from coal miners and in silica particle-treated A549 lung cancer cells.

Enzyme Numbers (IUBMB) for RIOX2 Gene

Gene Ontology (GO) - Molecular Function for RIOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0032452 histone demethylase activity TAS --
GO:0032453 histone demethylase activity (H3-K4 specific) IBA --
GO:0042802 identical protein binding IPI 16189514
genes like me logo Genes that share ontologies with RIOX2: view
genes like me logo Genes that share phenotypes with RIOX2: view

Animal Models for RIOX2 Gene

MGI Knock Outs for RIOX2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RIOX2 Gene

Localization for RIOX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIOX2 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIOX2 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for RIOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005730 nucleolus IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with RIOX2: view

Pathways & Interactions for RIOX2 Gene

genes like me logo Genes that share pathways with RIOX2: view

Pathways by source for RIOX2 Gene

Gene Ontology (GO) - Biological Process for RIOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006338 chromatin remodeling IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016577 histone demethylation IEA --
genes like me logo Genes that share ontologies with RIOX2: view

No data available for SIGNOR curated interactions for RIOX2 Gene

Drugs & Compounds for RIOX2 Gene

(2) Drugs for RIOX2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Succinic acid Approved Nutra Full agonist, Agonist 0

(1) Additional Compounds for RIOX2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Oxoglutaric acid
  • 2-Ketoglutarate
  • 2-Ketoglutaric acid
  • 2-Oxo-1,5-pentanedioate
  • 2-Oxo-1,5-pentanedioic acid
  • 2-Oxoglutarate
328-50-7
genes like me logo Genes that share compounds with RIOX2: view

Transcripts for RIOX2 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIOX2 Gene

No ASD Table

Relevant External Links for RIOX2 Gene

GeneLoc Exon Structure for
RIOX2
ECgene alternative splicing isoforms for
RIOX2

Expression for RIOX2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RIOX2 Gene:

RIOX2

mRNA Expression by UniProt/SwissProt for RIOX2 Gene:

Q8IUF8-MINA_HUMAN
Tissue specificity: Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines.

Evidence on tissue expression from TISSUES for RIOX2 Gene

  • Nervous system(2.9)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIOX2 Gene

Orthologs for RIOX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RIOX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MINA 34 35
  • 99.43 (n)
cow
(Bos Taurus)
Mammalia MINA 34 35
  • 85.76 (n)
rat
(Rattus norvegicus)
Mammalia Mina 34
  • 82.15 (n)
mouse
(Mus musculus)
Mammalia Mina 34 35
  • 80.93 (n)
Riox2 16
dog
(Canis familiaris)
Mammalia MINA 34 35
  • 80.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MINA 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MINA 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves MINA 34 35
  • 70.78 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 64 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mina 34
  • 59.19 (n)
Str.7087 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14893 34
zebrafish
(Danio rerio)
Actinopterygii minal 34 35
  • 59.7 (n)
zgc63873 34
fruit fly
(Drosophila melanogaster)
Insecta CG2982 35
  • 18 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea jmjc-1 35
  • 17 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8544 35
  • 36 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10438 34
Species where no ortholog for RIOX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIOX2 Gene

ENSEMBL:
Gene Tree for RIOX2 (if available)
TreeFam:
Gene Tree for RIOX2 (if available)

Paralogs for RIOX2 Gene

Paralogs for RIOX2 Gene

genes like me logo Genes that share paralogs with RIOX2: view

Variants for RIOX2 Gene

Sequence variations from dbSNP and Humsavar for RIOX2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000068386 -- 97,973,544(+) AACAA(G/T)ATTAG upstream-variant-2KB
rs1000069027 -- 97,944,780(+) TCATT(A/T)TAAAA nc-transcript-variant, utr-variant-3-prime
rs1000323736 -- 97,950,088(+) GTAGA(C/T)TGCAA intron-variant
rs1000490114 -- 97,971,281(+) GGGCC(C/T)TCATC intron-variant
rs1000843127 -- 97,965,609(+) GAGCC(C/T)AGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIOX2 Gene

Variant ID Type Subtype PubMed ID
nsv1012322 CNV gain 25217958
nsv1013060 CNV gain 25217958
nsv520553 CNV gain 19592680

Variation tolerance for RIOX2 Gene

Residual Variation Intolerance Score: 87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.87; 93.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIOX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIOX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIOX2 Gene

Disorders for RIOX2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RIOX2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, protection against
- elite association - COSMIC cancer census association via MalaCards
Search RIOX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RIOX2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIOX2
genes like me logo Genes that share disorders with RIOX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RIOX2 Gene

Publications for RIOX2 Gene

  1. A novel myc target gene, mina53, that is involved in cell proliferation. (PMID: 12091391) Tsuneoka M. … Kimura H. (J. Biol. Chem. 2002) 2 3 4 22 64
  2. Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3. (PMID: 19502796) Lu Y. … Chen F. (Cell Cycle 2009) 3 4 64
  3. Protein NO52 -- a constitutive nucleolar component sharing high sequence homologies to protein NO66. (PMID: 15819408) Eilbracht J. … Schmidt-Zachmann M.S. (Eur. J. Cell Biol. 2005) 3 4 64
  4. The human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer. (PMID: 15897898) Zhang Y. … Chen F. (Oncogene 2005) 3 4 64
  5. Increased expression of a Myc target gene Mina53 in human colon cancer. (PMID: 14695334) Teye K. … Kimura H. (Am. J. Pathol. 2004) 3 4 64

Products for RIOX2 Gene

Sources for RIOX2 Gene

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