Aliases for MINA Gene
External Ids for MINA Gene
Previous GeneCards Identifiers for MINA Gene
MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]
GeneCards Summary for MINA Gene
MINA (MYC Induced Nuclear Antigen) is a Protein Coding gene. Diseases associated with MINA include lung cancer. Among its related pathways are Validated targets of C-MYC transcriptional activation. GO annotations related to this gene include dioxygenase activity and transcriptional repressor activity, RNA polymerase II transcription factor binding. An important paralog of this gene is C14orf169.
UniProtKB/Swiss-Prot for MINA Gene
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated Lys-9 on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on His-39. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.