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Aliases for GPAT3 Gene

Aliases for GPAT3 Gene

  • Glycerol-3-Phosphate Acyltransferase 3 2 3 5
  • 1-Acyl-Sn-Glycerol-3-Phosphate O-Acyltransferase 10 3 4
  • 1-Acyl-Sn-Glycerol-3-Phosphate O-Acyltransferase 9 3 4
  • Acyl-CoA:Glycerol-3-Phosphate Acyltransferase 3 3 4
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 9 2 3
  • Lung Cancer Metastasis-Associated Protein 1 3 4
  • Lysophosphatidic Acid Acyltransferase Theta 3 4
  • 1-AGP Acyltransferase 9 3 4
  • LPAAT-Theta 3 4
  • EC 2.3.1.15 4 61
  • 1-AGPAT 9 3 4
  • AGPAT 10 3 4
  • AGPAT9 3 4
  • GPAT-3 3 4
  • HGPAT3 3 4
  • MAG-1 3 4
  • MAG1 3 4
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 9 (Lysophosphatidic Acid Acyltransferase, Theta) 2
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 8 3
  • Testis Secretory Sperm-Binding Protein Li 213e 3
  • Lysophosphatidic Acid Acyltransferase, Theta 2
  • Endoplasmic Reticulum Associated GPAT 3
  • EC 2.3.1.51 4
  • HMFN0839 3
  • AGPAT10 3
  • AGPAT8 3

External Ids for GPAT3 Gene

Previous HGNC Symbols for GPAT3 Gene

  • AGPAT9

Summaries for GPAT3 Gene

Entrez Gene Summary for GPAT3 Gene

  • This gene encodes a member of the lysophosphatidic acid acyltransferase protein family. The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]

GeneCards Summary for GPAT3 Gene

GPAT3 (Glycerol-3-Phosphate Acyltransferase 3) is a Protein Coding gene. Among its related pathways are Fatty Acyl-CoA Biosynthesis and Acyl chain remodelling of PC. An important paralog of this gene is GPAT4.

UniProtKB/Swiss-Prot for GPAT3 Gene

  • May transfer the acyl-group from acyl-coA to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Also transfers the acyl-group from acyl-coA to the sn-2 position of 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, or LPA), forming 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid, or PA).

Gene Wiki entry for GPAT3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPAT3 Gene

Genomics for GPAT3 Gene

Regulatory Elements for GPAT3 Gene

Enhancers for GPAT3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around GPAT3 on UCSC Golden Path with GeneCards custom track

Promoters for GPAT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for GPAT3 Gene

Chromosome:
4
Start:
83,535,914 bp from pter
End:
83,605,875 bp from pter
Size:
69,962 bases
Orientation:
Plus strand

Genomic View for GPAT3 Gene

Genes around GPAT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPAT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPAT3 Gene

Proteins for GPAT3 Gene

  • Protein details for GPAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53EU6-GPAT3_HUMAN
    Recommended name:
    Glycerol-3-phosphate acyltransferase 3
    Protein Accession:
    Q53EU6
    Secondary Accessions:
    • Q68CJ4
    • Q6GPI6
    • Q96NA3

    Protein attributes for GPAT3 Gene

    Size:
    434 amino acids
    Molecular mass:
    48705 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPAT3 Gene

Post-translational modifications for GPAT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPAT3 Gene

Domains & Families for GPAT3 Gene

Protein Domains for GPAT3 Gene

Suggested Antigen Peptide Sequences for GPAT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53EU6

UniProtKB/Swiss-Prot:

GPAT3_HUMAN :
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Domain:
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Family:
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
genes like me logo Genes that share domains with GPAT3: view

Function for GPAT3 Gene

Molecular function for GPAT3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-ethylmaleimide (NEM).
UniProtKB/Swiss-Prot Function:
May transfer the acyl-group from acyl-coA to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Also transfers the acyl-group from acyl-coA to the sn-2 position of 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, or LPA), forming 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid, or PA).

Enzyme Numbers (IUBMB) for GPAT3 Gene

Gene Ontology (GO) - Molecular Function for GPAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity TAS --
GO:0004366 glycerol-3-phosphate O-acyltransferase activity IEA,IDA 17170135
genes like me logo Genes that share ontologies with GPAT3: view
genes like me logo Genes that share phenotypes with GPAT3: view

Animal Models for GPAT3 Gene

MGI Knock Outs for GPAT3:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPAT3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPAT3 Gene

Localization for GPAT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPAT3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for GPAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 17170135
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPAT3: view

No data available for Subcellular locations from COMPARTMENTS for GPAT3 Gene

Pathways & Interactions for GPAT3 Gene

genes like me logo Genes that share pathways with GPAT3: view

UniProtKB/Swiss-Prot Q53EU6-GPAT3_HUMAN

  • Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis.
  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.

Gene Ontology (GO) - Biological Process for GPAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0016024 CDP-diacylglycerol biosynthetic process IEA --
GO:0019432 triglyceride biosynthetic process TAS --
GO:0032006 regulation of TOR signaling IDA 17002884
genes like me logo Genes that share ontologies with GPAT3: view

No data available for SIGNOR curated interactions for GPAT3 Gene

Drugs & Compounds for GPAT3 Gene

(2) Drugs for GPAT3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0
Coenzyme A Nutra 0

(45) Additional Compounds for GPAT3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with GPAT3: view

Transcripts for GPAT3 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPAT3 Gene

No ASD Table

Relevant External Links for GPAT3 Gene

GeneLoc Exon Structure for
GPAT3
ECgene alternative splicing isoforms for
GPAT3

Expression for GPAT3 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPAT3 Gene:

GPAT3

mRNA Expression by UniProt/SwissProt for GPAT3 Gene:

Q53EU6-GPAT3_HUMAN
Tissue specificity: Widely expressed. Expressed in liver, kidney, testis, brain, heart, skeletal muscle, thyroid, prostate, thymus and placenta. Also expressed lung and adipose tissue.

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPAT3 Gene

Orthologs for GPAT3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPAT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AGPAT9 34
  • 90.76 (n)
  • 91.92 (a)
AGPAT9 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agpat9 16
Agpat9 35
  • 93 (a)
OneToOne
Agpat9 34
  • 88.27 (n)
  • 94.68 (a)
dog
(Canis familiaris)
Mammalia AGPAT9 35
  • 98 (a)
OneToOne
AGPAT9 34
  • 94.07 (n)
  • 97.92 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 91 (a)
OneToMany
-- 35
  • 91 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia AGPAT9 35
  • 100 (a)
OneToOne
AGPAT9 34
  • 99.69 (n)
  • 99.77 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia AGPAT9 35
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agpat9 34
  • 87.33 (n)
  • 92.4 (a)
chicken
(Gallus gallus)
Aves AGPAT9 35
  • 77 (a)
OneToOne
AGPAT9 34
  • 76.02 (n)
  • 80.05 (a)
lizard
(Anolis carolinensis)
Reptilia AGPAT9 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485787 34
  • 74 (n)
  • 78.69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11126 34
zebrafish
(Danio rerio)
Actinopterygii agpat9l 35
  • 71 (a)
OneToMany
agpat9 35
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG15450 35
  • 38 (a)
ManyToMany
CG3209 35
  • 44 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea acl-4 35
  • 35 (a)
ManyToMany
acl-5 35
  • 37 (a)
ManyToMany
M79.2 35
  • 25 (a)
ManyToMany
corn
(Zea mays)
Liliopsida Zm.35 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1550 35
  • 43 (a)
OneToMany
Species where no ortholog for GPAT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPAT3 Gene

ENSEMBL:
Gene Tree for GPAT3 (if available)
TreeFam:
Gene Tree for GPAT3 (if available)

Paralogs for GPAT3 Gene

Paralogs for GPAT3 Gene

genes like me logo Genes that share paralogs with GPAT3: view

Variants for GPAT3 Gene

Sequence variations from dbSNP and Humsavar for GPAT3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs483676 -- 83,564,463(+) ggagg(A/C)tgagg intron-variant
rs501368 -- 83,547,538(+) tgagc(C/T)actgc intron-variant
rs501522 -- 83,547,479(+) GATCT(C/T)CTGAC intron-variant
rs502384 -- 83,547,397(-) cgggc(A/G)cctgt intron-variant
rs536293 -- 83,541,584(-) TAGCT(C/T)TAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPAT3 Gene

Variant ID Type Subtype PubMed ID
esv2676861 CNV deletion 23128226
esv2727904 CNV deletion 23290073
esv3601200 CNV loss 21293372
nsv1010009 CNV gain 25217958
nsv1123814 CNV deletion 24896259
nsv829994 CNV loss 17160897
nsv829995 CNV loss 17160897

Variation tolerance for GPAT3 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPAT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPAT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPAT3 Gene

Disorders for GPAT3 Gene

Relevant External Links for GPAT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPAT3

No disorders were found for GPAT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPAT3 Gene

Publications for GPAT3 Gene

  1. Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis. (PMID: 17170135) Cao J. … Gimeno R.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3 4 65
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 65
  3. Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway. (PMID: 17002884) Tang W. … Yu L. (J. Biochem. Mol. Biol. 2006) 3 4 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S. … Nakagawara A. (Oncogene 2004) 3 4 65

Products for GPAT3 Gene

Sources for GPAT3 Gene

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