Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TEAD2 Gene

Aliases for TEAD2 Gene

  • TEA Domain Transcription Factor 2 2 3 5
  • TEA Domain Family Member 2 2 3 4
  • TEAD-2 3 4
  • TEF4 3 4
  • Transcriptional Enhancer Factor TEF-4 3
  • TEF-4 3
  • ETF 3

External Ids for TEAD2 Gene

Previous GeneCards Identifiers for TEAD2 Gene

  • GC19M050502
  • GC19M050211
  • GC19M054519
  • GC19M054535
  • GC19M049843
  • GC19M046220

Summaries for TEAD2 Gene

GeneCards Summary for TEAD2 Gene

TEAD2 (TEA Domain Transcription Factor 2) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway and Gene Expression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. An important paralog of this gene is TEAD1.

UniProtKB/Swiss-Prot for TEAD2 Gene

  • Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC enhansons (5-GTGGAATGT-3). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.

Gene Wiki entry for TEAD2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEAD2 Gene

Genomics for TEAD2 Gene

Regulatory Elements for TEAD2 Gene

Enhancers for TEAD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G048880 1.5 Ensembl ENCODE dbSUPER 10.1 +480.9 480932 1.8 ATF1 CREB3L1 ETS1 ZNF121 ZNF766 ELK1 ZNF143 KLF13 CAVIN1 ZNF592 RRAS TULP2 PRR12 EMP3 NUCB1 FLT3LG TEAD2 ENSG00000268157 IRF3 GC19M048876
GH19G049987 1.2 ENCODE 10.1 -624.8 -624842 0.2 MLX CREB3L1 ZFP64 DMAP1 SLC30A9 ZNF143 ZNF263 NFYC TBX21 MEF2D VRK3 PRR12 FLT3LG RRAS NR1H2 ENSG00000268047 ENSG00000221125 ZNF473 CLEC11A TEAD2
GH19G049359 1.4 ENCODE dbSUPER 0.7 +0.1 126 4.8 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 DKKL1 CCDC155 NUP62 GRWD1 AKT1S1 SNORD35A PRR12 KDELR1 PIH1D1 PTOV1-AS2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TEAD2 on UCSC Golden Path with GeneCards custom track

Promoters for TEAD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110881 457 2001 HDGF ARID4B SIN3A ZNF48 YY1 GLIS2 SP3 SP5 YY2 NFYC
ENSR00000288872 -1143 801 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for TEAD2 Gene

Chromosome:
19
Start:
49,340,595 bp from pter
End:
49,362,457 bp from pter
Size:
21,863 bases
Orientation:
Minus strand

Genomic View for TEAD2 Gene

Genes around TEAD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEAD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEAD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEAD2 Gene

Proteins for TEAD2 Gene

  • Protein details for TEAD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15562-TEAD2_HUMAN
    Recommended name:
    Transcriptional enhancer factor TEF-4
    Protein Accession:
    Q15562
    Secondary Accessions:
    • B4DTJ6
    • M0R1T9
    • Q8NA25
    • Q96IG3

    Protein attributes for TEAD2 Gene

    Size:
    447 amino acids
    Molecular mass:
    49243 Da
    Quaternary structure:
    • Interacts with YAP1 and WWTR1/TAZ.

    Three dimensional structures from OCA and Proteopedia for TEAD2 Gene

    Alternative splice isoforms for TEAD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEAD2 Gene

Post-translational modifications for TEAD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TEAD2 (TEAD2)

No data available for DME Specific Peptides for TEAD2 Gene

Domains & Families for TEAD2 Gene

Gene Families for TEAD2 Gene

Protein Domains for TEAD2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TEAD2: view

No data available for UniProtKB/Swiss-Prot for TEAD2 Gene

Function for TEAD2 Gene

Molecular function for TEAD2 Gene

GENATLAS Biochemistry:
SV40-transcriptional enhancer factor 4 (TEF4),expressed throughout the embryo from the onset of gene expression,required for cardiac muscle and skeletal muscle specific genes
UniProtKB/Swiss-Prot Function:
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC enhansons (5-GTGGAATGT-3). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.

Gene Ontology (GO) - Molecular Function for TEAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001085 RNA polymerase II transcription factor binding IBA --
GO:0001134 transcription factor activity, transcription factor recruiting IMP 20368466
GO:0001223 transcription coactivator binding IPI 20368466
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 8702974
genes like me logo Genes that share ontologies with TEAD2: view
genes like me logo Genes that share phenotypes with TEAD2: view

Animal Models for TEAD2 Gene

MGI Knock Outs for TEAD2:

Animal Model Products

CRISPR Products

miRNA for TEAD2 Gene

miRTarBase miRNAs that target TEAD2
Targeted motifs for TEAD2 Gene
HOMER Transcription Factor Regulatory Elements motif TEAD2
  • Consensus sequence: CCWGGAATGY Submotif: canonical Cell Type: Py2T GEO ID: GSE55709

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for TEAD2 Gene

Localization for TEAD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEAD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEAD2 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for TEAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 8702974
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IBA --
GO:0005829 cytosol IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with TEAD2: view

Pathways & Interactions for TEAD2 Gene

genes like me logo Genes that share pathways with TEAD2: view

Pathways by source for TEAD2 Gene

SIGNOR curated interactions for TEAD2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TEAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IEA --
GO:0001843 neural tube closure IEA --
GO:0003143 embryonic heart tube morphogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 8702974
genes like me logo Genes that share ontologies with TEAD2: view

Transcripts for TEAD2 Gene

Unigene Clusters for TEAD2 Gene

TEA domain family member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEAD2 Gene

No ASD Table

Relevant External Links for TEAD2 Gene

GeneLoc Exon Structure for
TEAD2
ECgene alternative splicing isoforms for
TEAD2

Expression for TEAD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TEAD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TEAD2 Gene:

TEAD2

SOURCE GeneReport for Unigene cluster for TEAD2 Gene:

Hs.515534

Evidence on tissue expression from TISSUES for TEAD2 Gene

  • Nervous system(4.2)
  • Skin(4.1)
  • Eye(4)
genes like me logo Genes that share expression patterns with TEAD2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEAD2 Gene

Orthologs for TEAD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TEAD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEAD2 34 35
  • 96.3 (n)
dog
(Canis familiaris)
Mammalia TEAD2 34 35
  • 91.52 (n)
cow
(Bos Taurus)
Mammalia TEAD2 34 35
  • 91.17 (n)
rat
(Rattus norvegicus)
Mammalia Tead2 34
  • 86.67 (n)
mouse
(Mus musculus)
Mammalia Tead2 34 16 35
  • 86.14 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TEAD2 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TEAD2 35
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sd 36 35
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea egl-44 36 35
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TEC1 37
Species where no ortholog for TEAD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TEAD2 Gene

ENSEMBL:
Gene Tree for TEAD2 (if available)
TreeFam:
Gene Tree for TEAD2 (if available)

Paralogs for TEAD2 Gene

Paralogs for TEAD2 Gene

(3) SIMAP similar genes for TEAD2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TEAD2: view

Variants for TEAD2 Gene

Sequence variations from dbSNP and Humsavar for TEAD2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000023181 -- 49,354,717(+) AATAG(A/T)GGCTG intron-variant
rs1000136176 -- 49,354,288(+) CACTT(C/G)AGCCC intron-variant
rs1000290461 -- 49,353,965(+) TTTTT(C/G/T)TTTTT intron-variant
rs1000323766 -- 49,349,018(+) GACGT(C/T)AGGGG intron-variant, reference, missense, utr-variant-5-prime
rs1000419828 -- 49,341,816(+) CCATA(C/T)CATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEAD2 Gene

Variant ID Type Subtype PubMed ID
dgv52n68 CNV loss 17160897
nsv1138716 CNV deletion 24896259
nsv476353 CNV novel sequence insertion 20440878
nsv9739 CNV gain+loss 18304495

Variation tolerance for TEAD2 Gene

Residual Variation Intolerance Score: 23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEAD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEAD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEAD2 Gene

Disorders for TEAD2 Gene

Relevant External Links for TEAD2

Genetic Association Database (GAD)
TEAD2
Human Genome Epidemiology (HuGE) Navigator
TEAD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEAD2

No disorders were found for TEAD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEAD2 Gene

Publications for TEAD2 Gene

  1. Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis. (PMID: 9889009) Jacquemin P. … Davidson I. (Genomics 1999) 2 3 22 64
  2. A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain. (PMID: 8702974) Jacquemin P. … Davidson I. (J. Biol. Chem. 1996) 2 3 4 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. (PMID: 19324877) Zhang H. … Guan K.L. (J. Biol. Chem. 2009) 3 4 64
  5. TEAD mediates YAP-dependent gene induction and growth control. (PMID: 18579750) Zhao B. … Guan K.L. (Genes Dev. 2008) 3 4 64

Products for TEAD2 Gene

Sources for TEAD2 Gene

Content
Loading form....