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Aliases for TEAD2 Gene

Aliases for TEAD2 Gene

  • TEA Domain Family Member 2 2 3 4
  • TEF4 3 4 6
  • TEAD-2 3 4
  • Transcriptional Enhancer Factor TEF-4 3
  • TEF-4 3
  • ETF 3

External Ids for TEAD2 Gene

Summaries for TEAD2 Gene

GeneCards Summary for TEAD2 Gene

TEAD2 (TEA Domain Family Member 2) is a Protein Coding gene. Among its related pathways are Hippo signaling pathway and Metabolism. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TEAD1.

UniProtKB/Swiss-Prot for TEAD2 Gene

  • Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC enhansons (5-GTGGAATGT-3). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.

Gene Wiki entry for TEAD2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEAD2 Gene

Genomics for TEAD2 Gene

Genomic Location for TEAD2 Gene

Start:
49,340,595 bp from pter
End:
49,362,457 bp from pter
Size:
21,863 bases
Orientation:
Minus strand

Genomic View for TEAD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TEAD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEAD2 Gene

Regulatory Elements for TEAD2 Gene

Proteins for TEAD2 Gene

  • Protein details for TEAD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15562-TEAD2_HUMAN
    Recommended name:
    Transcriptional enhancer factor TEF-4
    Protein Accession:
    Q15562
    Secondary Accessions:
    • B4DTJ6
    • M0R1T9
    • Q8NA25
    • Q96IG3

    Protein attributes for TEAD2 Gene

    Size:
    447 amino acids
    Molecular mass:
    49243 Da
    Quaternary structure:
    • Interacts with YAP1 and WWTR1/TAZ.

    Three dimensional structures from OCA and Proteopedia for TEAD2 Gene

    Alternative splice isoforms for TEAD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEAD2 Gene

Proteomics data for TEAD2 Gene at MOPED

Post-translational modifications for TEAD2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys75

No data available for DME Specific Peptides for TEAD2 Gene

Domains for TEAD2 Gene

Protein Domains for TEAD2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TEAD2_HUMAN
Domain:
  • Contains 1 TEA DNA-binding domain.:
    • Q15562
genes like me logo Genes that share domains with TEAD2: view

No data available for Gene Families for TEAD2 Gene

Function for TEAD2 Gene

Molecular function for TEAD2 Gene

GENATLAS Biochemistry: SV40-transcriptional enhancer factor 4 (TEF4),expressed throughout the embryo from the onset of gene expression,required for cardiac muscle and skeletal muscle specific genes
UniProtKB/Swiss-Prot Function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC enhansons (5-GTGGAATGT-3). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.

Gene Ontology (GO) - Molecular Function for TEAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 8702974
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 18579750
genes like me logo Genes that share ontologies with TEAD2: view
genes like me logo Genes that share phenotypes with TEAD2: view

Animal Models for TEAD2 Gene

MGI Knock Outs for TEAD2:

miRNA for TEAD2 Gene

miRTarBase miRNAs that target TEAD2
Targeting motifs for TEAD2 Gene
HOMER Transcription Factor Regulatory Elements motif TEAD2
  • Consensus sequence: CCWGGAATGY Submotif: canonical Cell Type: Py2T GeoId: GSE55709

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for TEAD2 Gene

Localization for TEAD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEAD2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEAD2 Gene COMPARTMENTS Subcellular localization image for TEAD2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for TEAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 8702974
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with TEAD2: view

Pathways for TEAD2 Gene

genes like me logo Genes that share pathways with TEAD2: view

Gene Ontology (GO) - Biological Process for TEAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IEA --
GO:0001843 neural tube closure IEA --
GO:0003143 embryonic heart tube morphogenesis IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 8702974
GO:0006366 transcription from RNA polymerase II promoter --
genes like me logo Genes that share ontologies with TEAD2: view

Transcripts for TEAD2 Gene

Unigene Clusters for TEAD2 Gene

TEA domain family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TEAD2 Gene

No ASD Table

Relevant External Links for TEAD2 Gene

GeneLoc Exon Structure for
TEAD2
ECgene alternative splicing isoforms for
TEAD2

Expression for TEAD2 Gene

mRNA expression in normal human tissues for TEAD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for TEAD2 Gene Hs.515534

genes like me logo Genes that share expressions with TEAD2: view

Orthologs for TEAD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TEAD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEAD2 36
  • 96.3 (n)
  • 95.33 (a)
TEAD2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TEAD2 36
  • 91.17 (n)
  • 96.88 (a)
TEAD2 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TEAD2 36
  • 91.52 (n)
  • 97.54 (a)
TEAD2 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tead2 36
  • 86.14 (n)
  • 93.71 (a)
Tead2 16
Tead2 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEAD2 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tead2 36
  • 86.67 (n)
  • 93.93 (a)
lizard
(Anolis carolinensis)
Reptilia TEAD2 37
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sd 37
  • 39 (a)
OneToMany
sd 38
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea egl-44 37
  • 36 (a)
OneToMany
egl-44 38
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TEC1 39
Species with no ortholog for TEAD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TEAD2 Gene

ENSEMBL:
Gene Tree for TEAD2 (if available)
TreeFam:
Gene Tree for TEAD2 (if available)

Paralogs for TEAD2 Gene

Paralogs for TEAD2 Gene

Selected SIMAP similar genes for TEAD2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TEAD2: view

Variants for TEAD2 Gene

Sequence variations from dbSNP and Humsavar for TEAD2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs30002 -- 49,341,987(-) CTTGA(A/T)CTCCG intron-variant
rs30003 -- 49,343,141(+) CTCCA(C/T)GCATA intron-variant
rs30004 -- 49,343,700(-) agtgc(A/G)atggt intron-variant
rs30005 -- 49,343,854(+) ttttt(G/T)ggggg intron-variant
rs30006 -- 49,344,659(+) TTACT(C/T)CTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEAD2 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv52n68 CNV Loss 17160897
nsv912261 CNV Loss 21882294

Relevant External Links for TEAD2 Gene

HapMap Linkage Disequilibrium report
TEAD2

Disorders for TEAD2 Gene

Relevant External Links for TEAD2

Genetic Association Database (GAD)
TEAD2
Human Genome Epidemiology (HuGE) Navigator
TEAD2
genes like me logo Genes that share disorders with TEAD2: view

No data available for UniProtKB/Swiss-Prot for TEAD2 Gene

Publications for TEAD2 Gene

  1. A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain. (PMID: 8702974) Jacquemin P. … Davidson I. (J. Biol. Chem. 1996) 2 3 4
  2. Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis. (PMID: 9889009) Jacquemin P. … Davidson I. (Genomics 1999) 2 3 23
  3. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. (PMID: 19324877) Zhang H. … Guan K.L. (J. Biol. Chem. 2009) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TEAD2 Gene

  • Addgene plasmids for TEAD2

Sources for TEAD2 Gene

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