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Aliases for KLF11 Gene

Aliases for KLF11 Gene

  • Kruppel-Like Factor 11 2 3 5
  • Transforming Growth Factor-Beta-Inducible Early Growth Response Protein 2 3 4
  • TGFB-Inducible Early Growth Response Protein 2 3 4
  • TIEG-2 3 4
  • TIEG2 3 4
  • FKLF 3 4
  • TGFB Inducible Early Growth Response 2 2
  • FKLF1 3
  • MODY7 3
  • Tieg3 3

External Ids for KLF11 Gene

Previous HGNC Symbols for KLF11 Gene

  • TIEG2

Previous GeneCards Identifiers for KLF11 Gene

  • GC02P010135
  • GC02P010100
  • GC02P010182

Summaries for KLF11 Gene

Entrez Gene Summary for KLF11 Gene

  • The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

GeneCards Summary for KLF11 Gene

KLF11 (Kruppel-Like Factor 11) is a Protein Coding gene. Diseases associated with KLF11 include maturity-onset diabetes of the young, type vii and maturity-onset diabetes of the young. Among its related pathways are EGFR1 Signaling Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is SP4.

UniProtKB/Swiss-Prot for KLF11 Gene

  • Transcription factor (PubMed:9748269, PubMed:10207080). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity).

Gene Wiki entry for KLF11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF11 Gene

Genomics for KLF11 Gene

Regulatory Elements for KLF11 Gene

Promoters for KLF11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLF11 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLF11 Gene

Chromosome:
2
Start:
10,042,849 bp from pter
End:
10,054,836 bp from pter
Size:
11,988 bases
Orientation:
Plus strand

Genomic View for KLF11 Gene

Genes around KLF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF11 Gene

Proteins for KLF11 Gene

  • Protein details for KLF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14901-KLF11_HUMAN
    Recommended name:
    Krueppel-like factor 11
    Protein Accession:
    O14901
    Secondary Accessions:
    • B4DZE7
    • Q9EPF4

    Protein attributes for KLF11 Gene

    Size:
    512 amino acids
    Molecular mass:
    55139 Da
    Quaternary structure:
    • Interacts with SIN3A.

    Three dimensional structures from OCA and Proteopedia for KLF11 Gene

    Alternative splice isoforms for KLF11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLF11 Gene

Proteomics data for KLF11 Gene at MOPED

Post-translational modifications for KLF11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for KLF11 Gene

Domains & Families for KLF11 Gene

Protein Domains for KLF11 Gene

Graphical View of Domain Structure for InterPro Entry

O14901

UniProtKB/Swiss-Prot:

KLF11_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with KLF11: view

Function for KLF11 Gene

Molecular function for KLF11 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor (PubMed:9748269, PubMed:10207080). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity).
UniProtKB/Swiss-Prot Induction:
By TGFB1.

Gene Ontology (GO) - Molecular Function for KLF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0044212 transcription regulatory region DNA binding IDA 21171965
genes like me logo Genes that share ontologies with KLF11: view
genes like me logo Genes that share phenotypes with KLF11: view

Human Phenotype Ontology for KLF11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for KLF11 Gene

MGI Knock Outs for KLF11:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for KLF11 Gene

Localization for KLF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLF11 Gene COMPARTMENTS Subcellular localization image for KLF11 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for KLF11 Gene

Pathways & Interactions for KLF11 Gene

SuperPathways for KLF11 Gene

Superpath Contained pathways
1 EGFR1 Signaling Pathway
genes like me logo Genes that share pathways with KLF11: view

Pathways by source for KLF11 Gene

1 BioSystems pathway for KLF11 Gene

Gene Ontology (GO) - Biological Process for KLF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IDA 21171965
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 21171965
GO:0008285 negative regulation of cell proliferation IDA 21171965
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with KLF11: view

No data available for SIGNOR curated interactions for KLF11 Gene

Drugs & Compounds for KLF11 Gene

(1) Drugs for KLF11 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KLF11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLF11: view

Transcripts for KLF11 Gene

Unigene Clusters for KLF11 Gene

Kruppel-like factor 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLF11 Gene

No ASD Table

Relevant External Links for KLF11 Gene

GeneLoc Exon Structure for
KLF11
ECgene alternative splicing isoforms for
KLF11

Expression for KLF11 Gene

mRNA expression in normal human tissues for KLF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for KLF11 Gene Hs.12229

mRNA Expression by UniProt/SwissProt for KLF11 Gene

O14901-KLF11_HUMAN
Tissue specificity: Ubiquitous. Higher expression in erythroid cells.
genes like me logo Genes that share expression patterns with KLF11: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KLF11 Gene

Orthologs for KLF11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLF11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLF11 35
  • 80.81 (n)
  • 76.64 (a)
TIEG2 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLF11 35
  • 83.5 (n)
  • 78.86 (a)
KLF11 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klf11 35
  • 80.9 (n)
  • 76.85 (a)
Klf11 16
Klf11 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLF11 35
  • 99.22 (n)
  • 98.63 (a)
KLF11 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klf11 35
  • 80.93 (n)
  • 76.8 (a)
oppossum
(Monodelphis domestica)
Mammalia KLF11 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLF11 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLF11 35
  • 65.37 (n)
  • 60.94 (a)
KLF11 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLF11 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf11 35
  • 61.6 (n)
  • 61.39 (a)
Str.6240 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16840 35
zebrafish
(Danio rerio)
Actinopterygii Dr.9448 35
klf11b 35
  • 58.84 (n)
  • 54.19 (a)
klf11a 36
  • 46 (a)
OneToMany
klf11b 36
  • 49 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.975 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3473 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7373 36
  • 24 (a)
OneToMany
Species with no ortholog for KLF11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLF11 Gene

ENSEMBL:
Gene Tree for KLF11 (if available)
TreeFam:
Gene Tree for KLF11 (if available)

Paralogs for KLF11 Gene

Paralogs for KLF11 Gene

(7) SIMAP similar genes for KLF11 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KLF11: view

Variants for KLF11 Gene

Sequence variations from dbSNP and Humsavar for KLF11 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs35927125 - 10,046,292(-) CTTTC(A/C/T)GGGAT reference, missense
rs34336420 Maturity-onset diabetes of the young 7 (MODY7) 10,047,996(-) TGTCC(A/G)TGAGG reference, missense
VAR_031524 Maturity-onset diabetes of the young 7 (MODY7)
rs35476458 - 10,048,470(-) GGCTA(A/G)AGGTG reference, missense
rs2487 -- 10,051,915(+) CTGAT(C/T)GTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLF11 Gene

Variant ID Type Subtype PubMed ID
nsv828297 CNV Loss 20364138
nsv508826 CNV Insertion 20534489
nsv873633 CNV Loss 21882294
nsv828308 CNV Gain 20364138
esv2719632 CNV Deletion 23290073
esv2719633 CNV Deletion 23290073

Variation tolerance for KLF11 Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.03; 60.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLF11 Gene

HapMap Linkage Disequilibrium report
KLF11
Human Gene Mutation Database (HGMD)
KLF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF11 Gene

Disorders for KLF11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KLF11 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
maturity-onset diabetes of the young, type vii
  • maturity-onset diabetes of the young, type 7
maturity-onset diabetes of the young
  • mason-type diabetes
- elite association - COSMIC cancer census association via MalaCards
Search KLF11 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

KLF11_HUMAN
  • Maturity-onset diabetes of the young 7 (MODY7) [MIM:610508]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. {ECO:0000269 PubMed:15774581}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for KLF11

Genetic Association Database (GAD)
KLF11
Human Genome Epidemiology (HuGE) Navigator
KLF11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLF11
genes like me logo Genes that share disorders with KLF11: view

No data available for Genatlas for KLF11 Gene

Publications for KLF11 Gene

  1. Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function. (PMID: 15774581) Neve B. … Froguel P. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 23 48 67
  2. Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family. (PMID: 11087666) Scohy S. … Szpirer C. (Genomics 2000) 2 3 23
  3. Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth. (PMID: 9748269) Cook T. … Urrutia R. (J. Biol. Chem. 1998) 2 3 23
  4. Distinct role of Kruppel-like factor 11 in the regulation of prostaglandin E2 biosynthesis. (PMID: 20154088) Buttar N.S. … Urrutia R. (J. Biol. Chem. 2010) 3 23
  5. Identification of minimal promoter and genetic variants of Kruppel-like factor 11 gene and association analysis with type 2 diabetes in Japanese. (PMID: 19122346) Kuroda E. … Takeda J. (Endocr. J. 2009) 3 23

Products for KLF11 Gene

Sources for KLF11 Gene

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