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Aliases for FOXN1 Gene

Aliases for FOXN1 Gene

  • Forkhead Box N1 2 3
  • WHN 3 4 6
  • Winged-Helix Transcription Factor Nude 3 4
  • Winged-Helix Nude 2 3
  • Rowett Nude 2 3
  • RONU 3 4
  • Forkhead Box Protein N1 3
  • Winged Helix Nude 3
  • FKHL20 3

External Ids for FOXN1 Gene

Previous Symbols for FOXN1 Gene

  • WHN
  • RONU

Summaries for FOXN1 Gene

Entrez Gene Summary for FOXN1 Gene

  • Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXN1 Gene

FOXN1 (Forkhead Box N1) is a Protein Coding gene. Diseases associated with FOXN1 include t-cell immunodeficiency, congenital alopecia, and nail dystrophy and alopecia and t-cell immunodeficiency. GO annotations related to this gene include sequence-specific DNA binding and double-stranded DNA binding. An important paralog of this gene is FOXK2.

UniProtKB/Swiss-Prot for FOXN1 Gene

  • Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T cell ontogeny (PubMed:21507891).

Gene Wiki entry for FOXN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXN1 Gene

Genomics for FOXN1 Gene

Genomic Location for FOXN1 Gene

Start:
28,506,243 bp from pter
End:
28,538,896 bp from pter
Size:
32,654 bases
Orientation:
Plus strand

Genomic View for FOXN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXN1 Gene

Regulatory Elements for FOXN1 Gene

Proteins for FOXN1 Gene

  • Protein details for FOXN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15353-FOXN1_HUMAN
    Recommended name:
    Forkhead box protein N1
    Protein Accession:
    O15353
    Secondary Accessions:
    • B2R9Q7
    • O15352

    Protein attributes for FOXN1 Gene

    Size:
    648 amino acids
    Molecular mass:
    68925 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXN1 Gene

Proteomics data for FOXN1 Gene at MOPED

Post-translational modifications for FOXN1 Gene

No Post-translational modifications

Other Protein References for FOXN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXN1 Gene

Domains for FOXN1 Gene

Gene Families for FOXN1 Gene

HGNC:
  • FOX :Forkhead boxes

Protein Domains for FOXN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FOXN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15353

UniProtKB/Swiss-Prot:

FOXN1_HUMAN
Domain:
  • Contains 1 fork-head DNA-binding domain.:
    • O15353
genes like me logo Genes that share domains with FOXN1: view

Function for FOXN1 Gene

Molecular function for FOXN1 Gene

UniProtKB/Swiss-Prot Function: Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T cell ontogeny (PubMed:21507891).

Gene Ontology (GO) - Molecular Function for FOXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXN1: view
genes like me logo Genes that share phenotypes with FOXN1: view

Animal Models for FOXN1 Gene

MGI Knock Outs for FOXN1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FOXN1 Gene

Localization for FOXN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXN1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXN1 Gene COMPARTMENTS Subcellular localization image for FOXN1 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FOXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FOXN1: view

Pathways for FOXN1 Gene

SuperPathways for FOXN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001942 hair follicle development IEA --
GO:0002260 lymphocyte homeostasis IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 10767081
GO:0006366 transcription from RNA polymerase II promoter TAS 10767081
genes like me logo Genes that share ontologies with FOXN1: view

No data available for Pathways by source for FOXN1 Gene

Transcripts for FOXN1 Gene

mRNA/cDNA for FOXN1 Gene

(19) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXN1 Gene

Forkhead box N1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXN1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2:

Relevant External Links for FOXN1 Gene

GeneLoc Exon Structure for
FOXN1
ECgene alternative splicing isoforms for
FOXN1

Expression for FOXN1 Gene

mRNA expression in normal human tissues for FOXN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXN1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (18.8), Skin - Not Sun Exposed (Suprapubic) (17.1), Esophagus - Mucosa (8.0), and Vagina (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FOXN1 Gene

SOURCE GeneReport for Unigene cluster for FOXN1 Gene Hs.663679

mRNA Expression by UniProt/SwissProt for FOXN1 Gene

O15353-FOXN1_HUMAN
Tissue specificity: Expressed in thymus
genes like me logo Genes that share expressions with FOXN1: view

Orthologs for FOXN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXN1 35
  • 99.13 (n)
  • 98.15 (a)
FOXN1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FOXN1 35
  • 89.49 (n)
  • 91.77 (a)
FOXN1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXN1 35
  • 90.2 (n)
  • 91.76 (a)
FOXN1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxn1 35
  • 85.13 (n)
  • 86.11 (a)
Foxn1 16
Foxn1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXN1 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXN1 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxn1 35
  • 83.95 (n)
  • 85.96 (a)
chicken
(Gallus gallus)
Aves FOXN1 35
  • 63.57 (n)
  • 56.48 (a)
FOXN1 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXN1 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxn1 35
  • 59.5 (n)
  • 55.09 (a)
zebrafish
(Danio rerio)
Actinopterygii foxn1 35
  • 58.73 (n)
  • 54.02 (a)
foxn1 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta jumu 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FHL1 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 68 (a)
OneToMany
Species with no ortholog for FOXN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXN1 Gene

ENSEMBL:
Gene Tree for FOXN1 (if available)
TreeFam:
Gene Tree for FOXN1 (if available)

Paralogs for FOXN1 Gene

genes like me logo Genes that share paralogs with FOXN1: view

Variants for FOXN1 Gene

Sequence variations from dbSNP and Humsavar for FOXN1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs483434 -- 28,523,911(+) TCCCC(A/C)CTGGA upstream-variant-2KB, intron-variant
rs498655 -- 28,520,431(+) AGGGG(A/G)CATCA intron-variant
rs502276 -- 28,520,808(+) TGGAG(C/T)TCAGA intron-variant
rs532369 -- 28,521,778(+) CCCTC(A/C)TTTTC intron-variant
rs532648 - 28,537,284(-) CGGGG(C/G)TGCCA missense, reference

Relevant External Links for FOXN1 Gene

HapMap Linkage Disequilibrium report
FOXN1
Human Gene Mutation Database (HGMD)
FOXN1
Locus Specific Mutation Databases (LSDB)
FOXN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FOXN1 Gene

Disorders for FOXN1 Gene

(1) OMIM Diseases for FOXN1 Gene (600838)

UniProtKB/Swiss-Prot

FOXN1_HUMAN
  • T-cell immunodeficiency, congenital alopecia, and nail dystrophy (TIDAND) [MIM:601705]: A disorder characterized by the association of congenital alopecia, severe T-cell immunodeficiency, and ridging and pitting of all nails. {ECO:0000269 PubMed:10206641, ECO:0000269 PubMed:21507891}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for FOXN1 Gene

(1) Novoseek inferred disease relationships for FOXN1 Gene

Disease -log(P) Hits PubMed IDs
athymia 95.8 1

Relevant External Links for FOXN1

Genetic Association Database (GAD)
FOXN1
Human Genome Epidemiology (HuGE) Navigator
FOXN1
genes like me logo Genes that share disorders with FOXN1: view

Publications for FOXN1 Gene

  1. Characterization of mouse and human nude genes. (PMID: 9321431) Schorpp M. … Boehm T. (Immunogenetics 1997) 2 3 4 23
  2. Human clinical phenotype associated with FOXN1 mutations. (PMID: 20429426) Pignata C. … Amorosi S. (Adv. Exp. Med. Biol. 2009) 3 23
  3. Exposing the human nude phenotype. (PMID: 10206641) Frank J. … Christiano A.M. (Nature 1999) 3 4
  4. Transcription of the nude gene (WHN) in human normal organs and mediastinal and pulmonary tumors. (PMID: 10483588) GattenlAPhner S. … Marx A. (Pathol. Res. Pract. 1999) 3 23
  5. Forkhead/winged-helix transcription factor Whn regulates hair keratin gene expression: molecular analysis of the nude skin phenotype. (PMID: 10767081) Schlake T. … Boehm T. (Dev. Dyn. 2000) 3 23

Products for FOXN1 Gene

Sources for FOXN1 Gene

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