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Aliases for FOXN1 Gene

Aliases for FOXN1 Gene

  • Forkhead Box N1 2 3 5
  • Winged-Helix Transcription Factor Nude 3 4
  • Winged-Helix Nude 2 3
  • Rowett Nude 2 3
  • RONU 3 4
  • WHN 3 4
  • Winged Helix Nude 3
  • FKHL20 3

External Ids for FOXN1 Gene

Previous HGNC Symbols for FOXN1 Gene

  • WHN
  • RONU

Previous GeneCards Identifiers for FOXN1 Gene

  • GC17P026702
  • GC17P026996
  • GC17P023875
  • GC17P026850
  • GC17P023059

Summaries for FOXN1 Gene

Entrez Gene Summary for FOXN1 Gene

  • Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXN1 Gene

FOXN1 (Forkhead Box N1) is a Protein Coding gene. Diseases associated with FOXN1 include T-Cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy and Alopecia And T-Cell Immunodeficiency. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXN2.

UniProtKB/Swiss-Prot for FOXN1 Gene

  • Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T cell ontogeny (PubMed:21507891).

Gene Wiki entry for FOXN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXN1 Gene

Genomics for FOXN1 Gene

Regulatory Elements for FOXN1 Gene

Enhancers for FOXN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FOXN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXN1 Gene

Chromosome:
17
Start:
28,506,229 bp from pter
End:
28,538,900 bp from pter
Size:
32,672 bases
Orientation:
Plus strand

Genomic View for FOXN1 Gene

Genes around FOXN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXN1 Gene

Proteins for FOXN1 Gene

  • Protein details for FOXN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15353-FOXN1_HUMAN
    Recommended name:
    Forkhead box protein N1
    Protein Accession:
    O15353
    Secondary Accessions:
    • B2R9Q7
    • O15352

    Protein attributes for FOXN1 Gene

    Size:
    648 amino acids
    Molecular mass:
    68925 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXN1 Gene

Proteomics data for FOXN1 Gene at MOPED

Post-translational modifications for FOXN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXN1 Gene

Domains & Families for FOXN1 Gene

Gene Families for FOXN1 Gene

Protein Domains for FOXN1 Gene

Suggested Antigen Peptide Sequences for FOXN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15353

UniProtKB/Swiss-Prot:

FOXN1_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXN1: view

Function for FOXN1 Gene

Molecular function for FOXN1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T cell ontogeny (PubMed:21507891).
genes like me logo Genes that share phenotypes with FOXN1: view

Human Phenotype Ontology for FOXN1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FOXN1 Gene

MGI Knock Outs for FOXN1:

Animal Model Products

miRNA for FOXN1 Gene

miRTarBase miRNAs that target FOXN1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for FOXN1 Gene

Localization for FOXN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXN1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXN1 Gene COMPARTMENTS Subcellular localization image for FOXN1 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for FOXN1 Gene

Pathways & Interactions for FOXN1 Gene

SuperPathways for FOXN1 Gene

No Data Available

SIGNOR curated interactions for FOXN1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FOXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001942 hair follicle development IEA --
GO:0002260 lymphocyte homeostasis IEA --
GO:0002360 T cell lineage commitment IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 10767081
genes like me logo Genes that share ontologies with FOXN1: view

No data available for Pathways by source for FOXN1 Gene

Drugs & Compounds for FOXN1 Gene

No Compound Related Data Available

Transcripts for FOXN1 Gene

mRNA/cDNA for FOXN1 Gene

(19) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXN1 Gene

Forkhead box N1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXN1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2:

Relevant External Links for FOXN1 Gene

GeneLoc Exon Structure for
FOXN1
ECgene alternative splicing isoforms for
FOXN1

Expression for FOXN1 Gene

mRNA expression in normal human tissues for FOXN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXN1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x18.8), Skin - Not Sun Exposed (Suprapubic) (x17.1), Esophagus - Mucosa (x8.0), and Vagina (x4.2).

Protein differential expression in normal tissues from HIPED for FOXN1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOXN1 Gene



SOURCE GeneReport for Unigene cluster for FOXN1 Gene Hs.663679

mRNA Expression by UniProt/SwissProt for FOXN1 Gene

O15353-FOXN1_HUMAN
Tissue specificity: Expressed in thymus.
genes like me logo Genes that share expression patterns with FOXN1: view

Protein tissue co-expression partners for FOXN1 Gene

- Elite partner

Primer Products

Orthologs for FOXN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXN1 35
  • 89.49 (n)
  • 91.77 (a)
FOXN1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXN1 35
  • 90.2 (n)
  • 91.76 (a)
FOXN1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxn1 35
  • 85.13 (n)
  • 86.11 (a)
Foxn1 16
Foxn1 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOXN1 35
  • 99.13 (n)
  • 98.15 (a)
FOXN1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxn1 35
  • 83.95 (n)
  • 85.96 (a)
oppossum
(Monodelphis domestica)
Mammalia FOXN1 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXN1 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXN1 35
  • 63.57 (n)
  • 56.48 (a)
FOXN1 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXN1 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxn1 35
  • 59.5 (n)
  • 55.09 (a)
zebrafish
(Danio rerio)
Actinopterygii foxn1 35
  • 58.73 (n)
  • 54.02 (a)
foxn1 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta jumu 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FHL1 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 68 (a)
OneToMany
Species with no ortholog for FOXN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXN1 Gene

ENSEMBL:
Gene Tree for FOXN1 (if available)
TreeFam:
Gene Tree for FOXN1 (if available)

Paralogs for FOXN1 Gene

Paralogs for FOXN1 Gene

genes like me logo Genes that share paralogs with FOXN1: view

Variants for FOXN1 Gene

Sequence variations from dbSNP and Humsavar for FOXN1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_010376 -
rs2071587 - 28,524,584(+) GCCCC(C/T)GCATT intron-variant, upstream-variant-2KB, reference, missense
rs532648 - 28,537,284(-) CGGGG(C/G)TGCCA reference, missense
rs2286520 - 28,534,802(-) GGGCC(A/G)GATGG intron-variant, reference, missense
rs483434 -- 28,523,911(+) TCCCC(A/C)CTGGA intron-variant, upstream-variant-2KB, utr-variant-5-prime

Variation tolerance for FOXN1 Gene

Residual Variation Intolerance Score: 70.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.08; 87.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXN1 Gene

Human Gene Mutation Database (HGMD)
FOXN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FOXN1 Gene

Disorders for FOXN1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for FOXN1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
t-cell immunodeficiency, congenital alopecia, and nail dystrophy
  • t-cell immunodeficiency, congenital alopecia and nail dystrophy
alopecia and t-cell immunodeficiency
alopecia
ectopic thymus
thymus gland disease
  • disease of thymus gland
- elite association - COSMIC cancer census association via MalaCards
Search FOXN1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FOXN1_HUMAN
  • T-cell immunodeficiency, congenital alopecia, and nail dystrophy (TIDAND) [MIM:601705]: A disorder characterized by the association of congenital alopecia, severe T-cell immunodeficiency, and ridging and pitting of all nails. {ECO:0000269 PubMed:10206641, ECO:0000269 PubMed:21507891}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FOXN1

Genetic Association Database (GAD)
FOXN1
Human Genome Epidemiology (HuGE) Navigator
FOXN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXN1
genes like me logo Genes that share disorders with FOXN1: view

No data available for Genatlas for FOXN1 Gene

Publications for FOXN1 Gene

  1. Characterization of mouse and human nude genes. (PMID: 9321431) Schorpp M. … Boehm T. (Immunogenetics 1997) 2 3 4 23 67
  2. Human clinical phenotype associated with FOXN1 mutations. (PMID: 20429426) Pignata C. … Amorosi S. (Adv. Exp. Med. Biol. 2009) 3 23
  3. Forkhead/winged-helix transcription factor Whn regulates hair keratin gene expression: molecular analysis of the nude skin phenotype. (PMID: 10767081) Schlake T. … Boehm T. (Dev. Dyn. 2000) 3 23
  4. Transcription of the nude gene (WHN) in human normal organs and mediastinal and pulmonary tumors. (PMID: 10483588) GattenlAPhner S. … Marx A. (Pathol. Res. Pract. 1999) 3 23
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3

Products for FOXN1 Gene

Sources for FOXN1 Gene

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