Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DCTN5 Gene

Aliases for DCTN5 Gene

  • Dynactin 5 (P25) 2 3
  • Dynactin Subunit P25 4
  • P25 6

External Ids for DCTN5 Gene

Previous GeneCards Identifiers for DCTN5 Gene

  • GC16P023561
  • GC16P021742

Summaries for DCTN5 Gene

Entrez Gene Summary for DCTN5 Gene

  • This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for DCTN5 Gene

DCTN5 (Dynactin 5 (P25)) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Alzheimers Disease Pathway.

Gene Wiki entry for DCTN5 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTN5 Gene

Genomics for DCTN5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCTN5 Gene

Start:
23,641,366 bp from pter
End:
23,677,455 bp from pter
Size:
36,090 bases
Orientation:
Plus strand

Genomic View for DCTN5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCTN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTN5 Gene

Proteins for DCTN5 Gene

  • Protein details for DCTN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTE1-DCTN5_HUMAN
    Recommended name:
    Dynactin subunit 5
    Protein Accession:
    Q9BTE1
    Secondary Accessions:
    • A8K9X8
    • H3BN51
    • H3BQA4

    Protein attributes for DCTN5 Gene

    Size:
    182 amino acids
    Molecular mass:
    20127 Da
    Quaternary structure:
    • Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10. Within the complex DCTN6 forms a heterodimer with DCTN5.

    Alternative splice isoforms for DCTN5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCTN5 Gene

Proteomics data for DCTN5 Gene at MOPED

Post-translational modifications for DCTN5 Gene

  • Ubiquitination at Lys175
  • Modification sites at PhosphoSitePlus

Other Protein References for DCTN5 Gene

No data available for DME Specific Peptides for DCTN5 Gene

Domains for DCTN5 Gene

Protein Domains for DCTN5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCTN5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTE1

UniProtKB/Swiss-Prot:

DCTN5_HUMAN :
  • Q9BTE1
Family:
  • Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
genes like me logo Genes that share domains with DCTN5: view

No data available for Gene Families for DCTN5 Gene

Function for DCTN5 Gene

Gene Ontology (GO) - Molecular Function for DCTN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DCTN5: view

Phenotypes for DCTN5 Gene

genes like me logo Genes that share phenotypes with DCTN5: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCTN5

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCTN5 Gene

Localization for DCTN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTN5 Gene

Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCTN5 Gene COMPARTMENTS Subcellular localization image for DCTN5 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
extracellular 2
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for DCTN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DCTN5: view

Pathways for DCTN5 Gene

genes like me logo Genes that share pathways with DCTN5: view

Pathways by source for DCTN5 Gene

1 Qiagen pathway for DCTN5 Gene
2 Reactome pathways for DCTN5 Gene

Gene Ontology (GO) - Biological Process for DCTN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with DCTN5: view

Transcripts for DCTN5 Gene

Unigene Clusters for DCTN5 Gene

Dynactin 5 (p25):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCTN5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DCTN5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCTN5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: -
SP7:

Relevant External Links for DCTN5 Gene

GeneLoc Exon Structure for
DCTN5
ECgene alternative splicing isoforms for
DCTN5

Expression for DCTN5 Gene

mRNA expression in normal human tissues for DCTN5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCTN5 Gene

SOURCE GeneReport for Unigene cluster for DCTN5 Gene Hs.435941

genes like me logo Genes that share expressions with DCTN5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCTN5 Gene

Orthologs for DCTN5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCTN5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCTN5 35
  • 99.63 (n)
  • 100 (a)
DCTN5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCTN5 35
  • 93.04 (n)
  • 99.45 (a)
MGC3248 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCTN5 35
  • 93.04 (n)
  • 100 (a)
DCTN5 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dctn5 35
  • 92.12 (n)
  • 99.45 (a)
Dctn5 16
Dctn5 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCTN5 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCTN5 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dctn5 35
  • 92.45 (n)
  • 99.45 (a)
chicken
(Gallus gallus)
Aves DCTN5 35
  • 81.32 (n)
  • 98.35 (a)
DCTN5 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCTN5 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dctn5 35
  • 79.49 (n)
  • 96.15 (a)
Str.13717 35
zebrafish
(Danio rerio)
Actinopterygii dctn5 35
  • 78.94 (n)
  • 95.05 (a)
dctn5 36
  • 96 (a)
OneToOne
Dr.12983 35
fruit fly
(Drosophila melanogaster)
Insecta dyn-p25 35
  • 59.51 (n)
  • 60.45 (a)
dyn-p25 36
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dnc-5 35
  • 53.56 (n)
  • 44.38 (a)
dnc-5 36
  • 43 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU07196 35
  • 54.33 (n)
  • 46.75 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7368 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 78 (a)
OneToOne
Species with no ortholog for DCTN5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCTN5 Gene

ENSEMBL:
Gene Tree for DCTN5 (if available)
TreeFam:
Gene Tree for DCTN5 (if available)

Paralogs for DCTN5 Gene

Pseudogenes.org Pseudogenes for DCTN5 Gene

genes like me logo Genes that share paralogs with DCTN5: view

No data available for Paralogs for DCTN5 Gene

Variants for DCTN5 Gene

Sequence variations from dbSNP and Humsavar for DCTN5 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs7588 -- 23,669,844(+) ATAAA(A/G)AACCA utr-variant-3-prime, nc-transcript-variant
rs26760 -- 23,668,965(-) TCCCA(C/T)CACCT utr-variant-3-prime, nc-transcript-variant, intron-variant
rs34513 -- 23,660,671(-) AGAGA(C/G)AGAAC intron-variant
rs34514 -- 23,659,276(-) TTATT(C/T)CCACT intron-variant
rs35585 -- 23,665,790(-) TTTTG(C/T)GATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCTN5 Gene

Variant ID Type Subtype PubMed ID
esv2660866 CNV Deletion 23128226
esv2714093 CNV Deletion 23290073
nsv827603 CNV Loss 20364138
nsv819151 CNV Loss 19587683

Relevant External Links for DCTN5 Gene

HapMap Linkage Disequilibrium report
DCTN5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTN5 Gene

Disorders for DCTN5 Gene

Relevant External Links for DCTN5

Genetic Association Database (GAD)
DCTN5
Human Genome Epidemiology (HuGE) Navigator
DCTN5
genes like me logo Genes that share disorders with DCTN5: view

No data available for UniProtKB/Swiss-Prot for DCTN5 Gene

Publications for DCTN5 Gene

  1. Dynactins p25 and p27 are predicted to adopt the LbetaH fold. (PMID: 15043994) Parisi G. … Echave J. (FEBS Lett. 2004) 2 3 23
  2. Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end. (PMID: 10525537) Eckley D.M. … Schroer T.A. (J. Cell Biol. 1999) 2 3
  3. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PMID: 17554300) (Nature 2007) 3 48
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DCTN5 Gene

Sources for DCTN5 Gene

Back to Top

Content