Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CUL4A Gene

Aliases for CUL4A Gene

  • Cullin 4A 2 3 5
  • CUL-4A 3 4

External Ids for CUL4A Gene

Previous GeneCards Identifiers for CUL4A Gene

  • GC13P112473
  • GC13P108500
  • GC13P112949
  • GC13P111811
  • GC13P112911
  • GC13P113863
  • GC13P094301

Summaries for CUL4A Gene

Entrez Gene Summary for CUL4A Gene

  • CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009]

GeneCards Summary for CUL4A Gene

CUL4A (Cullin 4A) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Transcription-Coupled Nucleotide Excision Repair (TC-NER). GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is CUL1.

UniProtKB/Swiss-Prot for CUL4A Gene

  • Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL.

Gene Wiki entry for CUL4A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUL4A Gene

Genomics for CUL4A Gene

Regulatory Elements for CUL4A Gene

Promoters for CUL4A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CUL4A on UCSC Golden Path with GeneCards custom track

Genomic Location for CUL4A Gene

Chromosome:
13
Start:
113,208,193 bp from pter
End:
113,267,108 bp from pter
Size:
58,916 bases
Orientation:
Plus strand

Genomic View for CUL4A Gene

Genes around CUL4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUL4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUL4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUL4A Gene

Proteins for CUL4A Gene

  • Protein details for CUL4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13619-CUL4A_HUMAN
    Recommended name:
    Cullin-4A
    Protein Accession:
    Q13619
    Secondary Accessions:
    • A2A2W2
    • O75834
    • Q589T6
    • Q5TC62
    • Q6UP08
    • Q9UP17

    Protein attributes for CUL4A Gene

    Size:
    759 amino acids
    Molecular mass:
    87680 Da
    Quaternary structure:
    • Component of multiple DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes that seem to consist of DDB1, CUL4A or CUL4B, RBX1 and a variable substrate recognition component which seems to belong to a protein family described as DCAF (Ddb1- and Cul4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins. Component of the CSA complex (DCX(ERCC8) complex) containing ERCC8, RBX1, DDB1 and CUL4A; the CSA complex interacts with RNA polymerase II; upon UV irradiation it interacts with the COP9 signalosome and preferentially with the hyperphosphorylated form of RNA polymerase II. Component of the DCX(DET1-COP1) complex with the substrate recognition component DET1 and COP1. Component of the DCX(DDB2) complex with the substrate recognition component DDB2. Component of the DCX(DTL) complex with the putative substrate recognition component DTL. Interacts with DDB1, RBX1, RNF7, CTD1, TIP120A/CAND1, SKP2, CDKN1B, MDM2, TP53 and HOXA9. Interacts with DDB2; the interactions with DDB2 and CAND1 are mutually exclusive. Interacts with VPRBP, DTL, DDA1, DCAF6, DCAF4, DCAF16, DCAF17, DET1, WDTC1, DCAF5, DCAF11, WDR24A, RFWD2, PAFAH1B1, ERCC8, GRWD1, FBXW5, RBBP7, GNB2, WSB1, WSB2, NUP43, PWP1, FBXW8, ATG16L1, KATNB1, RBBP4, RBBP5, LRWD1 and DCAF8. May interact with WDR26, WDR51B, SNRNP40, WDR61, WDR76, WDR5. Can self-associate. Interacts with Epstein-Barr virus BPLF1.

    Three dimensional structures from OCA and Proteopedia for CUL4A Gene

    Alternative splice isoforms for CUL4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CUL4A Gene

Proteomics data for CUL4A Gene at MOPED

Post-translational modifications for CUL4A Gene

  • Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (By similarity). Deneddylated by Epstein-Barr virus BPLF1 leading to a S-phase-like environment that is required for efficient replication of the viral genome.
  • Ubiquitination at Lys 33 and Lys 104
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CUL4A (CUL4A)

No data available for DME Specific Peptides for CUL4A Gene

Domains & Families for CUL4A Gene

Gene Families for CUL4A Gene

Suggested Antigen Peptide Sequences for CUL4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13619

UniProtKB/Swiss-Prot:

CUL4A_HUMAN :
  • Belongs to the cullin family.
Family:
  • Belongs to the cullin family.
genes like me logo Genes that share domains with CUL4A: view

Function for CUL4A Gene

Molecular function for CUL4A Gene

UniProtKB/Swiss-Prot Function:
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL.
genes like me logo Genes that share phenotypes with CUL4A: view

Animal Models for CUL4A Gene

MGI Knock Outs for CUL4A:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CUL4A Gene

Localization for CUL4A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CUL4A Gene COMPARTMENTS Subcellular localization image for CUL4A gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CUL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CUL4A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CUL4A Gene

Pathways & Interactions for CUL4A Gene

genes like me logo Genes that share pathways with CUL4A: view

UniProtKB/Swiss-Prot Q13619-CUL4A_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for CUL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS 8681378
GO:0000715 nucleotide-excision repair, DNA damage recognition TAS --
GO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS --
GO:0001701 in utero embryonic development IEA --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
genes like me logo Genes that share ontologies with CUL4A: view

No data available for SIGNOR curated interactions for CUL4A Gene

Drugs & Compounds for CUL4A Gene

No Compound Related Data Available

Transcripts for CUL4A Gene

Unigene Clusters for CUL4A Gene

Cullin 4A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CUL4A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a ·
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - -
SP6: - - - -
SP7:
SP8: - - - - - -
SP9: - - - - -
SP10: - - -
SP11: - - -
SP12: - - - -
SP13: -

ExUns: 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b · 26c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for CUL4A Gene

GeneLoc Exon Structure for
CUL4A
ECgene alternative splicing isoforms for
CUL4A

Expression for CUL4A Gene

mRNA expression in normal human tissues for CUL4A Gene

mRNA differential expression in normal tissues according to GTEx for CUL4A Gene

This gene is overexpressed in Muscle - Skeletal (x5.2).

Protein differential expression in normal tissues from HIPED for CUL4A Gene

This gene is overexpressed in Lymph node (11.3) and Peripheral blood mononuclear cells (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CUL4A Gene



SOURCE GeneReport for Unigene cluster for CUL4A Gene Hs.339735

genes like me logo Genes that share expression patterns with CUL4A: view

Protein tissue co-expression partners for CUL4A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CUL4A Gene

Orthologs for CUL4A Gene

This gene was present in the common ancestor of animals.

Orthologs for CUL4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CUL4A 36
  • 100 (a)
OneToOne
CUL4A 35
  • 99.65 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CUL4A 36
  • 94 (a)
OneToOne
CUL4A 35
  • 83.88 (n)
  • 92.68 (a)
dog
(Canis familiaris)
Mammalia CUL4A 35
  • 87.83 (n)
  • 95.13 (a)
CUL4A 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cul4a 16
Cul4a 35
  • 86.21 (n)
  • 95.13 (a)
Cul4a 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CUL4A 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CUL4A 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cul4a 35
  • 86.17 (n)
  • 94.99 (a)
chicken
(Gallus gallus)
Aves CUL4A 35
  • 80.68 (n)
  • 91.04 (a)
CUL4A 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CUL4A 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cul4a 35
  • 75.08 (n)
  • 84.2 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6469 35
zebrafish
(Danio rerio)
Actinopterygii cul4a 36
  • 79 (a)
OneToOne
zgc64071 35
fruit fly
(Drosophila melanogaster)
Insecta cul-4 37
  • 68 (a)
Cul-4 36
  • 60 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cul-4 36
  • 29 (a)
OneToMany
cul-4 37
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9784 36
  • 54 (a)
OneToMany
Species with no ortholog for CUL4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CUL4A Gene

ENSEMBL:
Gene Tree for CUL4A (if available)
TreeFam:
Gene Tree for CUL4A (if available)

Paralogs for CUL4A Gene

Paralogs for CUL4A Gene

(4) SIMAP similar genes for CUL4A Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CUL4A Gene

genes like me logo Genes that share paralogs with CUL4A: view

Variants for CUL4A Gene

Sequence variations from dbSNP and Humsavar for CUL4A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs2302757 - 113,255,025(+) TCCCA(A/G)AGGAA reference, missense
rs9994 -- 113,229,987(+) AGGGG(C/T)TCTGG intron-variant
rs912012 -- 113,231,838(-) GGCCT(C/T)TCCTG intron-variant
rs1535598 -- 113,232,806(-) CCTCC(C/T)GCCAC intron-variant
rs2287245 -- 113,232,967(+) AGGAA(C/T)GTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CUL4A Gene

Variant ID Type Subtype PubMed ID
nsv901039 CNV Loss 21882294
dgv1797n71 CNV Loss 21882294
nsv901049 CNV Loss 21882294
nsv518044 CNV Gain 19592680
esv25141 CNV Loss 19812545
esv2748266 CNV Deletion 23290073
esv2748267 CNV Deletion 23290073
nsv509520 CNV Insertion 20534489
esv2748268 CNV Deletion 23290073
esv1282521 CNV Insertion 17803354
esv2748269 CNV Deletion 23290073
esv2748270 CNV Deletion 23290073
esv1654591 CNV Insertion 17803354
esv2748271 CNV Deletion 23290073
nsv1194 CNV Insertion 18451855
dgv1802n71 CNV Loss 21882294
esv1087624 CNV Insertion 17803354
esv1574408 CNV Insertion 17803354

Variation tolerance for CUL4A Gene

Residual Variation Intolerance Score: 10.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.85; 83.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CUL4A Gene

HapMap Linkage Disequilibrium report
CUL4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUL4A Gene

Disorders for CUL4A Gene

Relevant External Links for CUL4A

Genetic Association Database (GAD)
CUL4A
Human Genome Epidemiology (HuGE) Navigator
CUL4A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CUL4A

No disorders were found for CUL4A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CUL4A Gene

Publications for CUL4A Gene

  1. cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. (PMID: 8681378) Kipreos E.T. … Hedgecock E.M. (Cell 1996) 2 3 4 67
  2. DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA. (PMID: 20368362) Takedachi A. … Tanaka K. (Mol. Cell. Biol. 2010) 3 23
  3. Identification of a primary target of thalidomide teratogenicity. (PMID: 20223979) Ito T. … Handa H. (Science 2010) 3 23
  4. HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response. (PMID: 19798433) Ward J. … Barker E. (PLoS Pathog. 2009) 3 23
  5. WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. (PMID: 18381890) Hu J. … Xiong Y. (Genes Dev. 2008) 3 23

Products for CUL4A Gene

Sources for CUL4A Gene

Back to Top

Content