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Aliases for CUL4A Gene

Aliases for CUL4A Gene

  • Cullin 4A 2 3
  • CUL-4A 3 4
  • Cullin-4A 3

External Ids for CUL4A Gene

Summaries for CUL4A Gene

Entrez Gene Summary for CUL4A Gene

  • CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009]

GeneCards Summary for CUL4A Gene

CUL4A (Cullin 4A) is a Protein Coding gene. Among its related pathways are Protein Stability and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is CUL1.

UniProtKB/Swiss-Prot for CUL4A Gene

  • Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL.

Gene Wiki entry for CUL4A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUL4A Gene

Genomics for CUL4A Gene

Genomic Location for CUL4A Gene

Start:
113,208,193 bp from pter
End:
113,267,108 bp from pter
Size:
58,916 bases
Orientation:
Plus strand

Genomic View for CUL4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CUL4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUL4A Gene

Regulatory Elements for CUL4A Gene

Proteins for CUL4A Gene

  • Protein details for CUL4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13619-CUL4A_HUMAN
    Recommended name:
    Cullin-4A
    Protein Accession:
    Q13619
    Secondary Accessions:
    • A2A2W2
    • O75834
    • Q589T6
    • Q5TC62
    • Q6UP08
    • Q9UP17

    Protein attributes for CUL4A Gene

    Size:
    759 amino acids
    Molecular mass:
    87680 Da
    Quaternary structure:
    • Component of multiple DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes that seem to consist of DDB1, CUL4A or CUL4B, RBX1 and a variable substrate recognition component which seems to belong to a protein family described as DCAF (Ddb1- and Cul4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins. Component of the CSA complex (DCX(ERCC8) complex) containing ERCC8, RBX1, DDB1 and CUL4A; the CSA complex interacts with RNA polymerase II; upon UV irradiation it interacts with the COP9 signalosome and preferentially with the hyperphosphorylated form of RNA polymerase II. Component of the DCX(DET1-COP1) complex with the substrate recognition component DET1 and COP1. Component of the DCX(DDB2) complex with the substrate recognition component DDB2. Component of the DCX(DTL) complex with the putative substrate recognition component DTL. Interacts with DDB1, RBX1, RNF7, CTD1, TIP120A/CAND1, SKP2, CDKN1B, MDM2, TP53 and HOXA9. Interacts with DDB2; the interactions with DDB2 and CAND1 are mutually exclusive. Interacts with VPRBP, DTL, DDA1, DCAF6, DCAF4, DCAF16, DCAF17, DET1, WDTC1, DCAF5, DCAF11, WDR24A, RFWD2, PAFAH1B1, ERCC8, GRWD1, FBXW5, RBBP7, GNB2, WSB1, WSB2, NUP43, PWP1, FBXW8, ATG16L1, KATNB1, RBBP4, RBBP5, LRWD1 and DCAF8. May interact with WDR26, WDR51B, SNRNP40, WDR61, WDR76, WDR5. Can self-associate. Interacts with Epstein-Barr virus BPLF1.

    Three dimensional structures from OCA and Proteopedia for CUL4A Gene

    Alternative splice isoforms for CUL4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CUL4A Gene

Proteomics data for CUL4A Gene at MOPED

Post-translational modifications for CUL4A Gene

  • Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (By similarity). Deneddylated by Epstein-Barr virus BPLF1 leading to a S-phase-like environment that is required for efficient replication of the viral genome.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys33, Lys104, and Lys496

No data available for DME Specific Peptides for CUL4A Gene

Domains for CUL4A Gene

UniProtKB/Swiss-Prot:

CUL4A_HUMAN
Family:
  • Belongs to the cullin family.:
    • Q13619
genes like me logo Genes that share domains with CUL4A: view

No data available for Gene Families for CUL4A Gene

Function for CUL4A Gene

Molecular function for CUL4A Gene

UniProtKB/Swiss-Prot Function: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL.

Gene Ontology (GO) - Molecular Function for CUL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12504025
GO:0031625 ubiquitin protein ligase binding IEA --
genes like me logo Genes that share ontologies with CUL4A: view
genes like me logo Genes that share phenotypes with CUL4A: view

Animal Models for CUL4A Gene

MGI Knock Outs for CUL4A:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CUL4A Gene

Localization for CUL4A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CUL4A Gene COMPARTMENTS Subcellular localization image for CUL4A gene
Compartment Confidence
cytosol 3
golgi apparatus 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CUL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0031461 cullin-RING ubiquitin ligase complex --
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex IDA 12732143
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 18381890
genes like me logo Genes that share ontologies with CUL4A: view

Pathways for CUL4A Gene

genes like me logo Genes that share pathways with CUL4A: view

Pathways by source for CUL4A Gene

1 Cell Signaling Technology pathway for CUL4A Gene

UniProtKB/Swiss-Prot Q13619-CUL4A_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for CUL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS 8681378
GO:0006281 DNA repair TAS --
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0007050 cell cycle arrest TAS 8681378
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with CUL4A: view

Transcripts for CUL4A Gene

Unigene Clusters for CUL4A Gene

Cullin 4A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CUL4A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a ·
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - -
SP6: - - - -
SP7:
SP8: - - - - - -
SP9: - - - - -
SP10: - - -
SP11: - - -
SP12: - - - -
SP13: -

ExUns: 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b · 26c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for CUL4A Gene

GeneLoc Exon Structure for
CUL4A
ECgene alternative splicing isoforms for
CUL4A

Expression for CUL4A Gene

mRNA expression in normal human tissues for CUL4A Gene

mRNA differential expression in normal tissues according to GTEx for CUL4A Gene

This gene is overexpressed in Muscle - Skeletal (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CUL4A Gene

SOURCE GeneReport for Unigene cluster for CUL4A Gene Hs.339735

genes like me logo Genes that share expressions with CUL4A: view

Orthologs for CUL4A Gene

This gene was present in the common ancestor of animals.

Orthologs for CUL4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CUL4A 36
  • 99.65 (n)
  • 100 (a)
CUL4A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CUL4A 36
  • 83.88 (n)
  • 92.68 (a)
CUL4A 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CUL4A 36
  • 87.83 (n)
  • 95.13 (a)
CUL4A 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cul4a 36
  • 86.21 (n)
  • 95.13 (a)
Cul4a 16
Cul4a 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CUL4A 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CUL4A 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cul4a 36
  • 86.17 (n)
  • 94.99 (a)
chicken
(Gallus gallus)
Aves CUL4A 36
  • 80.68 (n)
  • 91.04 (a)
CUL4A 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CUL4A 37
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cul4a 36
  • 75.08 (n)
  • 84.2 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6469 36
zebrafish
(Danio rerio)
Actinopterygii cul4a 37
  • 79 (a)
OneToOne
zgc64071 36
fruit fly
(Drosophila melanogaster)
Insecta Cul-4 37
  • 60 (a)
OneToMany
cul-4 38
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea cul-4 37
  • 29 (a)
OneToMany
cul-4 38
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9784 37
  • 54 (a)
OneToMany
Species with no ortholog for CUL4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CUL4A Gene

ENSEMBL:
Gene Tree for CUL4A (if available)
TreeFam:
Gene Tree for CUL4A (if available)

Paralogs for CUL4A Gene

Paralogs for CUL4A Gene

Selected SIMAP similar genes for CUL4A Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CUL4A Gene

genes like me logo Genes that share paralogs with CUL4A: view

Variants for CUL4A Gene

Sequence variations from dbSNP and Humsavar for CUL4A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs9994 -- 113,229,987(+) AGGGG(C/T)TCTGG intron-variant
rs912012 -- 113,231,838(-) GGCCT(C/T)TCCTG intron-variant
rs1053933 -- 113,230,150(+) GTCTT(G/T)TTCTC intron-variant
rs1053934 -- 113,230,153(+) TTGTT(C/T)TCTGT intron-variant
rs1053935 -- 113,230,155(+) GTTCT(C/T)TGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CUL4A Gene

Variant ID Type Subtype PubMed ID
nsv901039 CNV Loss 21882294
dgv1797n71 CNV Loss 21882294
nsv901049 CNV Loss 21882294
nsv518044 CNV Gain 19592680
esv25141 CNV Loss 19812545
esv2748266 CNV Deletion 23290073
esv2748267 CNV Deletion 23290073
nsv509520 CNV Insertion 20534489
esv2748268 CNV Deletion 23290073
esv1282521 CNV Insertion 17803354
esv2748269 CNV Deletion 23290073
esv2748270 CNV Deletion 23290073
esv1654591 CNV Insertion 17803354
esv2748271 CNV Deletion 23290073
nsv1194 CNV Insertion 18451855
dgv1802n71 CNV Loss 21882294
esv1087624 CNV Insertion 17803354
esv1574408 CNV Insertion 17803354

Relevant External Links for CUL4A Gene

HapMap Linkage Disequilibrium report
CUL4A

Disorders for CUL4A Gene

(1) University of Copenhagen DISEASES for CUL4A Gene

(2) Novoseek inferred disease relationships for CUL4A Gene

Disease -log(P) Hits PubMed IDs
xeroderma pigmentosum 79.9 1
tumors 0 1

Relevant External Links for CUL4A

Genetic Association Database (GAD)
CUL4A
Human Genome Epidemiology (HuGE) Navigator
CUL4A
genes like me logo Genes that share disorders with CUL4A: view

No data available for UniProtKB/Swiss-Prot for CUL4A Gene

Publications for CUL4A Gene

  1. Covalent modification of all members of human cullin family proteins by NEDD8. (PMID: 10597293) Hori T. … Tanaka K. (Oncogene 1999) 3 4 23
  2. A new NEDD8-ligating system for cullin-4A. (PMID: 9694792) Osaka F. … Kato S. (Genes Dev. 1998) 3 4 23
  3. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PMID: 12732143) Groisman R. … Nakatani Y. (Cell 2003) 3 4 23
  4. Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. (PMID: 14739464) Wertz I.E. … Dixit V.M. (Science 2004) 3 4 23
  5. Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. (PMID: 15448697) Hu J. … Xiong Y. (Nat. Cell Biol. 2004) 3 4 23

Products for CUL4A Gene

  • Addgene plasmids for CUL4A

Sources for CUL4A Gene

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