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Aliases for LCOR Gene

Aliases for LCOR Gene

  • Ligand Dependent Nuclear Receptor Corepressor 2 3
  • MLR2 3 4 6
  • Mblk1-Related Protein 2 3 4
  • KIAA1795 4 6
  • Ligand-Dependent Corepressor 3
  • LCoR 4

External Ids for LCOR Gene

Previous GeneCards Identifiers for LCOR Gene

  • GC10P098583
  • GC10P092221

Summaries for LCOR Gene

Entrez Gene Summary for LCOR Gene

  • LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008]

GeneCards Summary for LCOR Gene

LCOR (Ligand Dependent Nuclear Receptor Corepressor) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is LCORL.

UniProtKB/Swiss-Prot for LCOR Gene

  • May act as transcription activator that binds DNA elements with the sequence 5-CCCTATCGATCGATCTCTACCT-3 (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.

Gene Wiki entry for LCOR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCOR Gene

Genomics for LCOR Gene

Regulatory Elements for LCOR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LCOR Gene

Start:
96,832,260 bp from pter
End:
96,981,043 bp from pter
Size:
148,784 bases
Orientation:
Plus strand

Genomic View for LCOR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LCOR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCOR Gene

Proteins for LCOR Gene

  • Protein details for LCOR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JN0-LCOR_HUMAN
    Recommended name:
    Ligand-dependent corepressor
    Protein Accession:
    Q96JN0
    Secondary Accessions:
    • D3DR47
    • Q5VW16
    • Q7Z723
    • Q86T32
    • Q86T33
    • Q8N3L6

    Protein attributes for LCOR Gene

    Size:
    433 amino acids
    Molecular mass:
    47007 Da
    Quaternary structure:
    • Interacts with ESR1 and ESR2 in the presence of estradiol. Interacts with CTBP1, HDAC3 and HDAC6. Component of a large corepressor complex that contains about 20 proteins, including CTBP1, CTBP2, HDAC1 and HDAC2.
    SequenceCaution:
    • Sequence=BAB47424.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LCOR Gene

    Alternative splice isoforms for LCOR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LCOR Gene

Proteomics data for LCOR Gene at MOPED

Post-translational modifications for LCOR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LCOR Gene

No data available for DME Specific Peptides for LCOR Gene

Domains for LCOR Gene

Protein Domains for LCOR Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LCOR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96JN0

UniProtKB/Swiss-Prot:

LCOR_HUMAN :
  • Q96JN0
Domain:
  • Contains 1 HTH psq-type DNA-binding domain.
genes like me logo Genes that share domains with LCOR: view

No data available for Gene Families for LCOR Gene

Function for LCOR Gene

Molecular function for LCOR Gene

UniProtKB/Swiss-Prot Function: May act as transcription activator that binds DNA elements with the sequence 5-CCCTATCGATCGATCTCTACCT-3 (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.

Gene Ontology (GO) - Molecular Function for LCOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with LCOR: view

Phenotypes for LCOR Gene

GenomeRNAi human phenotypes for LCOR:
genes like me logo Genes that share phenotypes with LCOR: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LCOR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for LCOR Gene

Localization for LCOR Gene

Subcellular locations from UniProtKB/Swiss-Prot for LCOR Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LCOR Gene COMPARTMENTS Subcellular localization image for LCOR gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for LCOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with LCOR: view

Pathways for LCOR Gene

SuperPathways for LCOR Gene

No Data Available

Gene Ontology (GO) - Biological Process for LCOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with LCOR: view

No data available for Pathways by source for LCOR Gene

Transcripts for LCOR Gene

Unigene Clusters for LCOR Gene

Ligand dependent nuclear receptor corepressor:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LCOR

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for LCOR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LCOR Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12
SP1: - - - - - - -
SP2: - -
SP3: - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: - - - -
SP7:

Relevant External Links for LCOR Gene

GeneLoc Exon Structure for
LCOR
ECgene alternative splicing isoforms for
LCOR

Expression for LCOR Gene

mRNA expression in normal human tissues for LCOR Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LCOR Gene

SOURCE GeneReport for Unigene cluster for LCOR Gene Hs.745068

mRNA Expression by UniProt/SwissProt for LCOR Gene

Q96JN0-LCOR_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with LCOR: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LCOR Gene

Orthologs for LCOR Gene

This gene was present in the common ancestor of animals.

Orthologs for LCOR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C10H10ORF12 36
  • 100 (a)
OneToOne
LCOR 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia LCOR 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LCOR 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lcor 35
  • 96.84 (n)
  • 97.92 (a)
Lcor 16
Lcor 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LCOR 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LCOR 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves LCOR 35
  • 91.84 (n)
  • 93.76 (a)
LCOR 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LCOR 36
  • 90 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii lcor 35
  • 64.54 (n)
  • 64.13 (a)
lcor 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Eip93F 36
  • 2 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mbr-1 36
  • 8 (a)
OneToMany
Species with no ortholog for LCOR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LCOR Gene

ENSEMBL:
Gene Tree for LCOR (if available)
TreeFam:
Gene Tree for LCOR (if available)

Paralogs for LCOR Gene

Paralogs for LCOR Gene

Selected SIMAP similar genes for LCOR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LCOR: view

Variants for LCOR Gene

Sequence variations from dbSNP and Humsavar for LCOR Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1129468 -- 96,963,228(+) AAAAG(C/T)GCATA utr-variant-3-prime
rs1129473 -- 96,964,298(+) TGTAA(A/G)ATTTA utr-variant-3-prime
rs1410900 -- 96,904,367(-) TACCA(C/G)ACCTT intron-variant
rs1986845 -- 96,945,940(+) tttaa(A/G)aaatt intron-variant
rs2104785 -- 96,850,837(-) TGTCA(C/T)CAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LCOR Gene

Variant ID Type Subtype PubMed ID
nsv895910 CNV Gain 21882294
nsv825532 CNV Gain 20364138
nsv527351 CNV Loss 19592680
esv2401890 CNV Deletion 18987734
esv2588205 CNV Deletion 19546169
nsv831951 CNV Gain 17160897

Relevant External Links for LCOR Gene

HapMap Linkage Disequilibrium report
LCOR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCOR Gene

Disorders for LCOR Gene

Relevant External Links for LCOR

Genetic Association Database (GAD)
LCOR
Human Genome Epidemiology (HuGE) Navigator
LCOR
genes like me logo Genes that share disorders with LCOR: view

No data available for UniProtKB/Swiss-Prot for LCOR Gene

Publications for LCOR Gene

  1. Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms. (PMID: 12535528) Fernandes I. … White J.H. (Mol. Cell 2003) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  3. Coordinated histone modifications mediated by a CtBP co-repressor complex. (PMID: 12700765) Shi Y. … Shi Y. (Nature 2003) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  5. Corepressor recruitment by agonist-bound nuclear receptors. (PMID: 15193453) White J.H. … Yang X.J. (Vitam. Horm. 2004) 2 3

Products for LCOR Gene

Sources for LCOR Gene

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