Aliases for CARD11 Gene
External Ids for CARD11 Gene
Previous GeneCards Identifiers for CARD11 Gene
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]
GeneCards Summary for CARD11 Gene
CARD11 (Caspase Recruitment Domain Family, Member 11) is a Protein Coding gene. Diseases associated with CARD11 include severe combined immunodeficiency due to card11 deficiency and persistent polyclonal b-cell lymphocytosis. Among its related pathways are Immune System and Downstream signaling events of B Cell Receptor (BCR). GO annotations related to this gene include guanylate kinase activity and CARD domain binding. An important paralog of this gene is CARD10.
UniProtKB/Swiss-Prot for CARD11 Gene
Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10