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Aliases for NIFK Gene

Aliases for NIFK Gene

  • Nucleolar Protein Interacting With The FHA Domain Of MKI67 2 3 5
  • Nucleolar Protein Interacting With The FHA Domain Of PKi-67 2 3 4
  • Nucleolar Phosphoprotein Nopp34 3 4
  • MKI67IP 3 4
  • Nopp34 3 4
  • HNIFK 3 4
  • MKI67 (FHA Domain) Interacting Nucleolar Phosphoprotein 2
  • MKI67 FHA Domain-Interacting Nucleolar Phosphoprotein 3

External Ids for NIFK Gene

Previous HGNC Symbols for NIFK Gene

  • MKI67IP

Previous GeneCards Identifiers for NIFK Gene

  • GC02M122485

Summaries for NIFK Gene

Entrez Gene Summary for NIFK Gene

  • This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encoded protein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple pseudogenes exist on chromosomes 5, 10, 12, 15, and 19.[provided by RefSeq, Jan 2009]

GeneCards Summary for NIFK Gene

NIFK (Nucleolar Protein Interacting With The FHA Domain Of MKI67) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding.

Gene Wiki entry for NIFK Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NIFK Gene

Genomics for NIFK Gene

Regulatory Elements for NIFK Gene

Enhancers for NIFK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G120892 1.4 Ensembl ENCODE 13.5 +843.1 843052 3.0 HDGF PKNOX1 CREB3L1 MLX ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 NIFK GLI2 ENSG00000271709 ENSG00000201584 GC02M121041
GH02G121524 1.7 Ensembl ENCODE dbSUPER 10.5 +207.9 207888 9.2 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NIFK TSN LINC01823 CLASP1 ENSG00000265451 GC02M121346
GH02G120932 1.6 Ensembl ENCODE dbSUPER 10.7 +800.2 800179 8.8 PKNOX1 FOXA2 MLX ZFP64 SIN3A FEZF1 ZNF766 FOS SP5 ZHX2 NIFK GLI2 ENSG00000271709 ENSG00000201584 GC02M121041
GH02G121706 1.1 Ensembl ENCODE 11.8 +28.9 28943 2.5 ELF3 INSM2 ARID4B FEZF1 RARA SLC30A9 ZNF366 ZSCAN5C THAP11 HMG20B NIFK TSN NPM1P32 ENSG00000279721
GH02G120772 1.2 dbSUPER 9.7 +963.4 963427 1.1 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TMEM185B NIFK GC02P120736 PIR37537
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NIFK on UCSC Golden Path with GeneCards custom track

Promoters for NIFK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000122679 227 2201 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207

Genomic Location for NIFK Gene

Chromosome:
2
Start:
121,726,945 bp from pter
End:
121,736,927 bp from pter
Size:
9,983 bases
Orientation:
Minus strand

Genomic View for NIFK Gene

Genes around NIFK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NIFK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NIFK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIFK Gene

Proteins for NIFK Gene

  • Protein details for NIFK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYG3-MK67I_HUMAN
    Recommended name:
    MKI67 FHA domain-interacting nucleolar phosphoprotein
    Protein Accession:
    Q9BYG3
    Secondary Accessions:
    • A8K788
    • Q8TB66
    • Q96ED4

    Protein attributes for NIFK Gene

    Size:
    293 amino acids
    Molecular mass:
    34222 Da
    Quaternary structure:
    • Binds to the FHA domain of MKI67; this interaction is enhanced in mitosis.

    Three dimensional structures from OCA and Proteopedia for NIFK Gene

neXtProt entry for NIFK Gene

Post-translational modifications for NIFK Gene

  • Sequentially phosphorylated on Thr-238, Thr-234 and Ser-230. Thr-234 is phosphorylated only when Thr-238 is phosphorylated. Likewise, phosphorylation at Ser-230 requires that Thr-234 and Thr-238 are phosphorylated. Phosphorylation enhances MKI67 binding.
  • Ubiquitination at posLast=139139
  • Modification sites at PhosphoSitePlus

Other Protein References for NIFK Gene

No data available for DME Specific Peptides for NIFK Gene

Domains & Families for NIFK Gene

Gene Families for NIFK Gene

Suggested Antigen Peptide Sequences for NIFK Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NIFK: view

No data available for UniProtKB/Swiss-Prot for NIFK Gene

Function for NIFK Gene

Gene Ontology (GO) - Molecular Function for NIFK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,IEA 11342549
GO:0005515 protein binding IPI 11342549
genes like me logo Genes that share ontologies with NIFK: view
genes like me logo Genes that share phenotypes with NIFK: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NIFK Gene

Localization for NIFK Gene

Subcellular locations from UniProtKB/Swiss-Prot for NIFK Gene

Nucleus, nucleolus. Chromosome. Note=Localizes to mitotic chromosomes in conjunction with MKI67.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NIFK gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for NIFK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000794 condensed nuclear chromosome IDA 11342549
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA 11342549
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA 11342549
genes like me logo Genes that share ontologies with NIFK: view

Pathways & Interactions for NIFK Gene

No Data Available

Gene Ontology (GO) - Biological Process for NIFK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly NAS 11342549
GO:0009303 rRNA transcription NAS 11342549
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0016072 rRNA metabolic process NAS 11342549
genes like me logo Genes that share ontologies with NIFK: view

No data available for Pathways by source and SIGNOR curated interactions for NIFK Gene

Transcripts for NIFK Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NIFK Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2:
SP3: -

Relevant External Links for NIFK Gene

GeneLoc Exon Structure for
NIFK
ECgene alternative splicing isoforms for
NIFK

Expression for NIFK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NIFK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NIFK Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.3) and CD8 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NIFK Gene



Protein tissue co-expression partners for NIFK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NIFK Gene:

NIFK

Evidence on tissue expression from TISSUES for NIFK Gene

  • Nervous system(4.7)
  • Lung(4.2)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with NIFK: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NIFK Gene

Orthologs for NIFK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NIFK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MKI67IP 35 34
  • 99.43 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NIFK 34
  • 82.82 (n)
MKI67IP 35
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MKI67IP 34
  • 82.37 (n)
NIFK 35
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nifk 34
  • 72.45 (n)
mouse
(Mus musculus)
Mammalia Nifk 34 16
  • 70.02 (n)
Mki67ip 35
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 61 (a)
OneToMany
-- 35
  • 54 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NIFK 35
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves MKI67IP 34
  • 60.19 (n)
NIFK 35
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NIFK 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nifk 34
  • 57.98 (n)
Str.1406 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398645 34
zebrafish
(Danio rerio)
Actinopterygii nifk 34 35
  • 60.66 (n)
mki67ipl 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11192 34
fruit fly
(Drosophila melanogaster)
Insecta CG6937 35
  • 22 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T04A8.6 35
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP15 35 37
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G04600 34
  • 48.15 (n)
rice
(Oryza sativa)
Liliopsida Os08g0412200 34
  • 51.37 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10558 35
  • 29 (a)
OneToOne
Species where no ortholog for NIFK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NIFK Gene

ENSEMBL:
Gene Tree for NIFK (if available)
TreeFam:
Gene Tree for NIFK (if available)

Paralogs for NIFK Gene

No data available for Paralogs for NIFK Gene

Variants for NIFK Gene

Sequence variations from dbSNP and Humsavar for NIFK Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000500782 -- 121,727,465(+) AGAGC(C/T)ATGAA intron-variant, utr-variant-3-prime
rs1000526848 -- 121,737,477(+) CCAGG(A/C)TGGAG upstream-variant-2KB
rs1000813779 -- 121,737,760(+) CCGGC(C/G)CTAAT upstream-variant-2KB
rs1001079870 -- 121,726,528(+) TTTTT(-/G)TTTTT intron-variant, downstream-variant-500B
rs1001153569 -- 121,737,135(+) GGCGT(C/G)AGTCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NIFK Gene

Variant ID Type Subtype PubMed ID
esv3592209 CNV gain 21293372
esv3592217 CNV gain 21293372
nsv1011665 CNV gain 25217958
nsv459163 CNV gain 19166990
nsv582808 CNV gain 21841781
nsv834351 CNV loss 17160897
nsv961503 CNV duplication 23825009

Variation tolerance for NIFK Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 48.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NIFK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NIFK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NIFK Gene

Disorders for NIFK Gene

Relevant External Links for NIFK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NIFK

No disorders were found for NIFK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NIFK Gene

Publications for NIFK Gene

  1. A novel nucleolar protein, NIFK, interacts with the forkhead associated domain of Ki-67 antigen in mitosis. (PMID: 11342549) Takagi M. … Yoneda Y. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67. (PMID: 16244663) Byeon I.-J. … Tsai M.-D. (Nat. Struct. Mol. Biol. 2005) 2 3 4 64
  3. Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions. (PMID: 14659764) Li H. … Tsai M.-D. (J. Mol. Biol. 2004) 2 3 4 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for NIFK Gene

Sources for NIFK Gene

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