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Aliases for NIFK Gene

Aliases for NIFK Gene

  • Nucleolar Protein Interacting With The FHA Domain Of MKI67 2 3 5
  • Nucleolar Protein Interacting With The FHA Domain Of PKi-67 2 3
  • MKI67 (FHA Domain) Interacting Nucleolar Phosphoprotein 2 3
  • Nucleolar Phosphoprotein Nopp34 3 4
  • MKI67IP 3 4
  • Nopp34 3 4
  • HNIFK 3 4
  • Nucleolar Protein Interacting With The FHA Domain Of PKI-67 4

External Ids for NIFK Gene

Previous HGNC Symbols for NIFK Gene

  • MKI67IP

Previous GeneCards Identifiers for NIFK Gene

  • GC02M122485

Summaries for NIFK Gene

Entrez Gene Summary for NIFK Gene

  • This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encoded protein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple pseudogenes exist on chromosomes 5, 10, 12, 15, and 19.[provided by RefSeq, Jan 2009]

GeneCards Summary for NIFK Gene

NIFK (Nucleolar Protein Interacting With The FHA Domain Of MKI67) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding.

Gene Wiki entry for NIFK Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NIFK Gene

Genomics for NIFK Gene

Regulatory Elements for NIFK Gene

Promoters for NIFK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NIFK on UCSC Golden Path with GeneCards custom track

Genomic Location for NIFK Gene

Chromosome:
2
Start:
121,726,945 bp from pter
End:
121,736,927 bp from pter
Size:
9,983 bases
Orientation:
Minus strand

Genomic View for NIFK Gene

Genes around NIFK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NIFK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NIFK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIFK Gene

Proteins for NIFK Gene

  • Protein details for NIFK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYG3-MK67I_HUMAN
    Recommended name:
    MKI67 FHA domain-interacting nucleolar phosphoprotein
    Protein Accession:
    Q9BYG3
    Secondary Accessions:
    • A8K788
    • Q8TB66
    • Q96ED4

    Protein attributes for NIFK Gene

    Size:
    293 amino acids
    Molecular mass:
    34222 Da
    Quaternary structure:
    • Binds to the FHA domain of MKI67; this interaction is enhanced in mitosis.

    Three dimensional structures from OCA and Proteopedia for NIFK Gene

neXtProt entry for NIFK Gene

Proteomics data for NIFK Gene at MOPED

Post-translational modifications for NIFK Gene

  • Sequentially phosphorylated on Thr-238, Thr-234 and Ser-230. Thr-234 is phosphorylated only when Thr-238 is phosphorylated. Likewise, phosphorylation at Ser-230 requires that Thr-234 and Thr-238 are phosphorylated. Phosphorylation enhances MKI67 binding.
  • Ubiquitination at Lys 139
  • Modification sites at PhosphoSitePlus

Other Protein References for NIFK Gene

No data available for DME Specific Peptides for NIFK Gene

Domains & Families for NIFK Gene

Gene Families for NIFK Gene

Suggested Antigen Peptide Sequences for NIFK Gene

Graphical View of Domain Structure for InterPro Entry

Q9BYG3

UniProtKB/Swiss-Prot:

MK67I_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with NIFK: view

Function for NIFK Gene

Gene Ontology (GO) - Molecular Function for NIFK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with NIFK: view
genes like me logo Genes that share phenotypes with NIFK: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NIFK Gene

Localization for NIFK Gene

Subcellular locations from UniProtKB/Swiss-Prot for NIFK Gene

Nucleus, nucleolus. Chromosome. Note=Localizes to mitotic chromosomes in conjunction with MKI67.

Gene Ontology (GO) - Cellular Components for NIFK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA 11342549
GO:0005737 cytoplasm IDA 11342549
genes like me logo Genes that share ontologies with NIFK: view

No data available for Subcellular locations from COMPARTMENTS for NIFK Gene

Pathways & Interactions for NIFK Gene

SuperPathways for NIFK Gene

No Data Available

Gene Ontology (GO) - Biological Process for NIFK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009303 rRNA transcription NAS 11342549
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with NIFK: view

No data available for Pathways by source and SIGNOR curated interactions for NIFK Gene

Drugs & Compounds for NIFK Gene

No Compound Related Data Available

Transcripts for NIFK Gene

Alternative Splicing Database (ASD) splice patterns (SP) for NIFK Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2:
SP3: -

Relevant External Links for NIFK Gene

GeneLoc Exon Structure for
NIFK
ECgene alternative splicing isoforms for
NIFK

Expression for NIFK Gene

mRNA expression in normal human tissues for NIFK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NIFK Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.3) and CD8 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NIFK Gene



genes like me logo Genes that share expression patterns with NIFK: view

Protein tissue co-expression partners for NIFK Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NIFK Gene

Orthologs for NIFK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NIFK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MKI67IP 35
  • 99.43 (n)
  • 98.98 (a)
MKI67IP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MKI67IP 36
  • 73 (a)
OneToOne
NIFK 35
  • 82.82 (n)
  • 74.4 (a)
dog
(Canis familiaris)
Mammalia MKI67IP 35
  • 82.37 (n)
  • 74.74 (a)
NIFK 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mki67ip 36
  • 56 (a)
OneToOne
Nifk 35
  • 70.02 (n)
  • 62.85 (a)
Nifk 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NIFK 36
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nifk 35
  • 72.45 (n)
  • 64.15 (a)
chicken
(Gallus gallus)
Aves NIFK 36
  • 51 (a)
OneToOne
MKI67IP 35
  • 60.19 (n)
  • 56.75 (a)
lizard
(Anolis carolinensis)
Reptilia NIFK 36
  • 53 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398645 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nifk 35
  • 57.98 (n)
  • 57.14 (a)
Str.1406 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11192 35
zebrafish
(Danio rerio)
Actinopterygii mki67ipl 35
nifk 35
  • 60.66 (n)
  • 54.1 (a)
nifk 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6937 36
  • 22 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T04A8.6 36
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP15 36
  • 23 (a)
OneToOne
NOP15 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G04600 35
  • 48.15 (n)
  • 38.89 (a)
rice
(Oryza sativa)
Liliopsida Os08g0412200 35
  • 51.37 (n)
  • 41.1 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10558 36
  • 29 (a)
OneToOne
Species with no ortholog for NIFK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NIFK Gene

ENSEMBL:
Gene Tree for NIFK (if available)
TreeFam:
Gene Tree for NIFK (if available)

Paralogs for NIFK Gene

genes like me logo Genes that share paralogs with NIFK: view

No data available for Paralogs for NIFK Gene

Variants for NIFK Gene

Sequence variations from dbSNP and Humsavar for NIFK Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs17852212 - 121,731,026(+) CTGAT(G/T)GATAT reference, missense
rs287800 -- 121,732,576(+) TGTCA(A/G)TAACA intron-variant
rs287801 -- 121,730,400(+) gtggc(A/G)catgc intron-variant
rs287802 -- 121,730,413(+) gtaat(C/G)ccagc intron-variant
rs3860375 -- 121,734,110(+) cagtg(A/T)ttagt intron-variant

Variation tolerance for NIFK Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 48.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NIFK Gene

HapMap Linkage Disequilibrium report
NIFK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NIFK Gene

Disorders for NIFK Gene

Relevant External Links for NIFK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NIFK

No disorders were found for NIFK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NIFK Gene

Publications for NIFK Gene

  1. A novel nucleolar protein, NIFK, interacts with the forkhead associated domain of Ki-67 antigen in mitosis. (PMID: 11342549) Takagi M. … Yoneda Y. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67. (PMID: 16244663) Byeon I.-J. … Tsai M.-D. (Nat. Struct. Mol. Biol. 2005) 2 3
  3. Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions. (PMID: 14659764) Li H. … Tsai M.-D. (J. Mol. Biol. 2004) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for NIFK Gene

Sources for NIFK Gene

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