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Aliases for HVCN1 Gene

Aliases for HVCN1 Gene

  • Hydrogen Voltage Gated Channel 1 2 3
  • Voltage Sensor Domain-Only Protein 2 3 4
  • Hydrogen Voltage-Gated Channel 1 2 3 4
  • VSOP 3 4 6
  • HV1 3 4 6
  • Voltage-Gated Hydrogen Channel 1 3

External Ids for HVCN1 Gene

Previous GeneCards Identifiers for HVCN1 Gene

  • GC12M109570
  • GC12M111086
  • GC12M108104

Summaries for HVCN1 Gene

Entrez Gene Summary for HVCN1 Gene

  • This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for HVCN1 Gene

HVCN1 (Hydrogen Voltage Gated Channel 1) is a Protein Coding gene. Among its related pathways are Reproduction and Reproduction. GO annotations related to this gene include voltage-gated cation channel activity and voltage-gated proton channel activity. An important paralog of this gene is C15orf27.

UniProtKB/Swiss-Prot for HVCN1 Gene

  • Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.

Gene Wiki entry for HVCN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HVCN1 Gene

Genomics for HVCN1 Gene

Regulatory Elements for HVCN1 Gene

Genomic Location for HVCN1 Gene

Start:
110,627,841 bp from pter
End:
110,704,950 bp from pter
Size:
77,110 bases
Orientation:
Minus strand

Genomic View for HVCN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HVCN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HVCN1 Gene

Proteins for HVCN1 Gene

  • Protein details for HVCN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96D96-HVCN1_HUMAN
    Recommended name:
    Voltage-gated hydrogen channel 1
    Protein Accession:
    Q96D96
    Secondary Accessions:
    • A8MQ37
    • B4DEB3
    • F8WCH5
    • Q6UW11
    • Q96IS5

    Protein attributes for HVCN1 Gene

    Size:
    273 amino acids
    Molecular mass:
    31683 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAQ89413.1; Type=Frameshift; Positions=164, 175; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HVCN1 Gene

    Alternative splice isoforms for HVCN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HVCN1 Gene

Proteomics data for HVCN1 Gene at MOPED

Post-translational modifications for HVCN1 Gene

Other Protein References for HVCN1 Gene

Antibody Products

No data available for DME Specific Peptides for HVCN1 Gene

Domains for HVCN1 Gene

Gene Families for HVCN1 Gene

HGNC:
  • HVCN :Voltage-gated ion channels / Hydrogen voltage-gated channel
IUPHAR :

Protein Domains for HVCN1 Gene

Suggested Antigen Peptide Sequences for HVCN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96D96

UniProtKB/Swiss-Prot:

HVCN1_HUMAN :
  • Q96D96
Domain:
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Unlike other voltage-gated ion channels it lacks the pore domain.
  • The C-terminal coiled coil region mediates homodimerization and cooperative channel gating. It is essential for normal subcellular localization.
Family:
  • Belongs to the hydrogen channel family.
genes like me logo Genes that share domains with HVCN1: view

Function for HVCN1 Gene

Molecular function for HVCN1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
The dimers display cooperative channel gating (By similarity). The channel activity is inhibited by zinc ions.
UniProtKB/Swiss-Prot Function:
Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.

Gene Ontology (GO) - Molecular Function for HVCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0022843 voltage-gated cation channel activity TAS --
GO:0030171 voltage-gated proton channel activity ISS 16556803
genes like me logo Genes that share ontologies with HVCN1: view

Phenotypes for HVCN1 Gene

genes like me logo Genes that share phenotypes with HVCN1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HVCN1 Gene

Localization for HVCN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HVCN1 Gene

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Detected mainly at intracellular membranes upon overexpression in HeLa cells (PuMed:20147290), but not in other cell types.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HVCN1 Gene COMPARTMENTS Subcellular localization image for HVCN1 gene
Compartment Confidence
mitochondrion 3
plasma membrane 3
peroxisome 2
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HVCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 22020278
GO:0016020 membrane --
GO:0016021 integral component of membrane IDA 16554753
genes like me logo Genes that share ontologies with HVCN1: view

Pathways for HVCN1 Gene

SuperPathways for HVCN1 Gene

Superpath Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with HVCN1: view

Pathways by source for HVCN1 Gene

3 Reactome pathways for HVCN1 Gene

Interacting Proteins for HVCN1 Gene

Gene Ontology (GO) - Biological Process for HVCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0007338 single fertilization TAS --
GO:0009268 response to pH ISS 16556803
GO:0010043 response to zinc ion ISS 16556803
GO:0015992 proton transport ISS 16556803
genes like me logo Genes that share ontologies with HVCN1: view

Compounds for HVCN1 Gene

(1) HMDB Compounds for HVCN1 Gene

Compound Synonyms Cas Number PubMed IDs
Hydrogen
  • Hydrogen cation
1333-74-0

(2) IUPHAR Ligand for HVCN1 Gene

Ligand Type Action Affinity Pubmed IDs
Zn2+ Channel blocker None 6
Cd2+ Channel blocker None
genes like me logo Genes that share compounds with HVCN1: view

Transcripts for HVCN1 Gene

Unigene Clusters for HVCN1 Gene

Hydrogen voltage-gated channel 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HVCN1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HVCN1 Gene

No ASD Table

Relevant External Links for HVCN1 Gene

GeneLoc Exon Structure for
HVCN1
ECgene alternative splicing isoforms for
HVCN1

Expression for HVCN1 Gene

mRNA expression in normal human tissues for HVCN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HVCN1 Gene

This gene is overexpressed in Whole Blood (5.1).

Protein differential expression in normal tissues for HVCN1 Gene

This gene is overexpressed in Nasal epithelium (39.3) and Blymphocyte (8.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for HVCN1 Gene

SOURCE GeneReport for Unigene cluster for HVCN1 Gene Hs.334637

mRNA Expression by UniProt/SwissProt for HVCN1 Gene

Q96D96-HVCN1_HUMAN
Tissue specificity: Enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes and spleen.
genes like me logo Genes that share expressions with HVCN1: view

Expression partners for HVCN1 Gene

In Situ Assay Products

Orthologs for HVCN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HVCN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HVCN1 35
  • 86.35 (n)
  • 86.35 (a)
HVCN1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HVCN1 35
  • 85.45 (n)
  • 85.45 (a)
HVCN1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hvcn1 35
  • 79.93 (n)
  • 78.81 (a)
Hvcn1 16
Hvcn1 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hvcn1 35
  • 79.55 (n)
  • 75.84 (a)
oppossum
(Monodelphis domestica)
Mammalia HVCN1 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HVCN1 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HVCN1 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves HVCN1 35
  • 66.95 (n)
  • 62.23 (a)
HVCN1 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HVCN1 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hvcn1 35
  • 58.89 (n)
  • 54.71 (a)
zebrafish
(Danio rerio)
Actinopterygii hvcn1 35
  • 52.65 (n)
  • 46.78 (a)
hvcn1 36
  • 46 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10149 36
  • 25 (a)
OneToOne
Species with no ortholog for HVCN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HVCN1 Gene

ENSEMBL:
Gene Tree for HVCN1 (if available)
TreeFam:
Gene Tree for HVCN1 (if available)

Paralogs for HVCN1 Gene

Paralogs for HVCN1 Gene

genes like me logo Genes that share paralogs with HVCN1: view

Variants for HVCN1 Gene

Sequence variations from dbSNP and Humsavar for HVCN1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs871921 -- 110,677,308(-) GGGGA(C/G)AGAGG intron-variant
rs871922 -- 110,677,137(-) gcctc(A/G)acatt intron-variant
rs1018133 -- 110,683,497(-) GAAAG(C/G)CTATG intron-variant
rs1018134 -- 110,683,314(-) CAAGG(C/T)AGATG intron-variant
rs1573820 -- 110,678,438(+) CTAtt(C/T)ctttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HVCN1 Gene

Variant ID Type Subtype PubMed ID
esv2746356 CNV Deletion 23290073

Relevant External Links for HVCN1 Gene

HapMap Linkage Disequilibrium report
HVCN1
Human Gene Mutation Database (HGMD)
HVCN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HVCN1 Gene

Disorders for HVCN1 Gene

No disorders were found for HVCN1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for HVCN1 Gene

Publications for HVCN1 Gene

  1. Aspartatea88112 is the selectivity filter of the human voltage-gated proton channel. (PMID: 22020278) Musset B. … Decoursey T.E. (Nature 2011) 2 3 4
  2. Identification of Thr29 as a critical phosphorylation site that activates the human proton channel Hvcn1 in leukocytes. (PMID: 20037153) Musset B. … DeCoursey T.E. (J. Biol. Chem. 2010) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. A voltage-gated proton-selective channel lacking the pore domain. (PMID: 16554753) Ramsey I.S. … Clapham D.E. (Nature 2006) 3 4
  5. A voltage sensor-domain protein is a voltage-gated proton channel. (PMID: 16556803) Sasaki M. … Okamura Y. (Science 2006) 2 3

Products for HVCN1 Gene

  • Addgene plasmids for HVCN1

Sources for HVCN1 Gene

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