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Aliases for SARNP Gene

Aliases for SARNP Gene

  • SAP Domain Containing Ribonucleoprotein 2 3
  • HCC1 3 4 6
  • Proliferation-Associated Cytokine-Inducible Protein CIP29 3 4
  • Cytokine-Induced Protein Of 29 KDa 3 4
  • Cytokine Induced Protein 29 KDa 2 3
  • Hepatocellular Carcinoma 1 2 3
  • Nuclear Protein Hcc-1 3 4
  • HSPC316 3 6
  • CIP29 3 6
  • Proliferation Associated Cytokine-Inducible Protein CIP29 3
  • SAP Domain-Containing Ribonucleoprotein 3
  • THO1 3

External Ids for SARNP Gene

Summaries for SARNP Gene

Entrez Gene Summary for SARNP Gene

  • This gene encodes a protein that is upregulated in response to various cytokines. The encoded protein may play a role in cell cycle progression. A translocation between this gene and the myeloid/lymphoid leukemia gene, resulting in expression of a chimeric protein, has been associated with acute myelomonocytic leukemia. Pseudogenes exist on chromosomes 7 and 8. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

GeneCards Summary for SARNP Gene

SARNP (SAP Domain Containing Ribonucleoprotein) is a Protein Coding gene. Diseases associated with SARNP include hepatocellular carcinoma and acute myelomonocytic leukemia. GO annotations related to this gene include RNA binding and nucleic acid binding.

UniProtKB/Swiss-Prot for SARNP Gene

  • Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5 end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposis sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

Gene Wiki entry for SARNP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SARNP Gene

Genomics for SARNP Gene

Genomic Location for SARNP Gene

Start:
55,752,463 bp from pter
End:
55,817,756 bp from pter
Size:
65,294 bases
Orientation:
Minus strand

Genomic View for SARNP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SARNP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SARNP Gene

Regulatory Elements for SARNP Gene

Proteins for SARNP Gene

  • Protein details for SARNP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82979-SARNP_HUMAN
    Recommended name:
    SAP domain-containing ribonucleoprotein
    Protein Accession:
    P82979
    Secondary Accessions:
    • A8K393
    • Q9P066

    Protein attributes for SARNP Gene

    Size:
    210 amino acids
    Molecular mass:
    23671 Da
    Quaternary structure:
    • Interacts with DDX39A. Interacts with FUS. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have dynamic structure involving ATP-dependent remodeling; in the complex interacts directly with DDX39B in a ATP-dependent manner which bridges it to ALYREF/THOC4.
    SequenceCaution:
    • Sequence=AAF28994.1; Type=Frameshift; Positions=134, 149; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SARNP Gene

neXtProt entry for SARNP Gene

Proteomics data for SARNP Gene at MOPED

Post-translational modifications for SARNP Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys92 and Lys135

Other Protein References for SARNP Gene

No data available for DME Specific Peptides for SARNP Gene

Domains for SARNP Gene

Protein Domains for SARNP Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

SARNP_HUMAN
Domain:
  • Contains 1 SAP domain.:
    • P82979
genes like me logo Genes that share domains with SARNP: view

No data available for Gene Families for SARNP Gene

Function for SARNP Gene

Molecular function for SARNP Gene

UniProtKB/Swiss-Prot Function: Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5 end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposis sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.
UniProtKB/Swiss-Prot Induction: By EPO/erythropoietin

Gene Ontology (GO) - Molecular Function for SARNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SARNP: view

Phenotypes for SARNP Gene

GenomeRNAi human phenotypes for SARNP:
genes like me logo Genes that share phenotypes with SARNP: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SARNP Gene

Localization for SARNP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SARNP Gene

Nucleus. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SARNP Gene COMPARTMENTS Subcellular localization image for SARNP gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SARNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000346 transcription export complex IDA 20844015
GO:0005634 nucleus NAS 11356193
GO:0005654 nucleoplasm IDA --
GO:0016607 nuclear speck IDA 20844015
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with SARNP: view

Pathways for SARNP Gene

SuperPathways for SARNP Gene

No Data Available

Gene Ontology (GO) - Biological Process for SARNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006406 mRNA export from nucleus IDA 20844015
GO:0006417 regulation of translation IEA --
genes like me logo Genes that share ontologies with SARNP: view

No data available for Pathways by source for SARNP Gene

Transcripts for SARNP Gene

Unigene Clusters for SARNP Gene

SAP domain containing ribonucleoprotein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SARNP Gene

No ASD Table

Relevant External Links for SARNP Gene

GeneLoc Exon Structure for
SARNP
ECgene alternative splicing isoforms for
SARNP

Expression for SARNP Gene

mRNA expression in normal human tissues for SARNP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SARNP Gene

SOURCE GeneReport for Unigene cluster for SARNP Gene Hs.505676

mRNA Expression by UniProt/SwissProt for SARNP Gene

P82979-SARNP_HUMAN
Tissue specificity: Low expression in spleen, liver, pancreas, testis, thymus, heart, and kidney. Increased levels are seen in hepatocellular carcinoma and pancreatic adenocarcinoma.
genes like me logo Genes that share expressions with SARNP: view

Orthologs for SARNP Gene

This gene was present in the common ancestor of chordates.

Orthologs for SARNP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC14 37
  • 100 (a)
OneToOne
SARNP 36
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 96 (a)
OneToMany
CIP29 37
  • 97 (a)
OneToMany
SARNP 36
  • 93.17 (n)
  • 97.14 (a)
dog
(Canis familiaris)
Mammalia SARNP 36
  • 93.17 (n)
  • 96.67 (a)
SARNP 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm6563 37
  • 96 (a)
OneToMany
Sarnp 36
  • 89.52 (n)
  • 95.71 (a)
Sarnp 16
Sarnp 37
  • 96 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SARNP 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SARNP 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sarnp 36
  • 90.48 (n)
  • 96.67 (a)
chicken
(Gallus gallus)
Aves SARNP 36
  • 78.15 (n)
  • 85.17 (a)
SARNP 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SARNP 37
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sarnp 36
  • 70.26 (n)
  • 75.49 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12479 36
zebrafish
(Danio rerio)
Actinopterygii sarnp 36
  • 61.5 (n)
  • 61.5 (a)
sarnp 37
  • 61 (a)
OneToOne
Species with no ortholog for SARNP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SARNP Gene

ENSEMBL:
Gene Tree for SARNP (if available)
TreeFam:
Gene Tree for SARNP (if available)

Paralogs for SARNP Gene

Selected SIMAP similar genes for SARNP Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SARNP Gene

genes like me logo Genes that share paralogs with SARNP: view

No data available for Paralogs for SARNP Gene

Variants for SARNP Gene

Sequence variations from dbSNP and Humsavar for SARNP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs705709 -- 55,772,483(-) AGGAG(G/T)GGGGG intron-variant
rs772259 -- 55,784,371(+) CGCTA(A/C/T)GTAGC intron-variant
rs772260 -- 55,784,632(-) TTTAT(C/G)AGACC intron-variant
rs772261 -- 55,780,362(+) ggcag(A/G)agaat intron-variant
rs772262 -- 55,769,950(+) ACATA(A/G)CCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SARNP Gene

Variant ID Type Subtype PubMed ID
nsv832423 CNV Gain 17160897
nsv469410 CNV Loss 19166990
esv2672374 CNV Deletion 23128226
nsv507644 CNV Insertion 20534489
esv22731 CNV Loss 19812545

Relevant External Links for SARNP Gene

HapMap Linkage Disequilibrium report
SARNP

Disorders for SARNP Gene

genes like me logo Genes that share disorders with SARNP: view

No data available for UniProtKB/Swiss-Prot for SARNP Gene

Publications for SARNP Gene

  1. Cloning and characterization of a proliferation-associated cytokine- inducible protein, CIP29. (PMID: 11922608) Fukuda S. … Pelus L.M. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 23
  2. An integrated approach in the discovery and characterization of a novel nuclear protein over-expressed in liver and pancreatic tumors. (PMID: 11356193) Choong M.L. … Chung M.C.M. (FEBS Lett. 2001) 2 3 4
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function. (PMID: 15338056) Leaw C.L. … Choong M.L. (Cell. Mol. Life Sci. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SARNP Gene

  • Addgene plasmids for SARNP

Sources for SARNP Gene

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