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Aliases for NR0B2 Gene

Aliases for NR0B2 Gene

  • Nuclear Receptor Subfamily 0, Group B, Member 2 2 3
  • SHP 3 4 6
  • Orphan Nuclear Receptor SHP 3 4
  • Small Heterodimer Partner 3 4
  • Nuclear Receptor Subfamily 0 Group B Member 2 3
  • Nuclear Receptor SHP 3
  • SHP1 3

External Ids for NR0B2 Gene

Summaries for NR0B2 Gene

Entrez Gene Summary for NR0B2 Gene

  • The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]

GeneCards Summary for NR0B2 Gene

NR0B2 (Nuclear Receptor Subfamily 0, Group B, Member 2) is a Protein Coding gene. Diseases associated with NR0B2 include obesity and hepatopulmonary syndrome. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is NR0B1.

UniProtKB/Swiss-Prot for NR0B2 Gene

  • Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.

Gene Wiki entry for NR0B2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR0B2 Gene

Genomics for NR0B2 Gene

Genomic Location for NR0B2 Gene

Start:
26,911,484 bp from pter
End:
26,914,076 bp from pter
Size:
2,593 bases
Orientation:
Minus strand

Genomic View for NR0B2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NR0B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR0B2 Gene

Regulatory Elements for NR0B2 Gene

Proteins for NR0B2 Gene

  • Protein details for NR0B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15466-NR0B2_HUMAN
    Recommended name:
    Nuclear receptor subfamily 0 group B member 2
    Protein Accession:
    Q15466
    Secondary Accessions:
    • F1D8P5
    • Q5QP36

    Protein attributes for NR0B2 Gene

    Size:
    257 amino acids
    Molecular mass:
    28058 Da
    Quaternary structure:
    • Interacts with RARA, RXRA, THRB, NR5A1, NR5A2, NR1I3, PPARA, PPARG and EID1. May also interact with HNF4A (By similarity). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein. Interacts (via N-terminus) with NEUROD1 (via N-terminus an C-terminus). Interacts with ID2.

    Three dimensional structures from OCA and Proteopedia for NR0B2 Gene

neXtProt entry for NR0B2 Gene

Proteomics data for NR0B2 Gene at MOPED

Post-translational modifications for NR0B2 Gene

  • Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NR0B2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NR0B2 Gene

Domains for NR0B2 Gene

Gene Families for NR0B2 Gene

HGNC:
  • NR :Nuclear hormone receptors
IUPHAR :

Protein Domains for NR0B2 Gene

UniProtKB/Swiss-Prot:

NR0B2_HUMAN
Family:
  • Belongs to the nuclear hormone receptor family. NR0 subfamily.:
    • Q15466
genes like me logo Genes that share domains with NR0B2: view

Function for NR0B2 Gene

Molecular function for NR0B2 Gene

GENATLAS Biochemistry: orphan nuclear (steroid/thyroid/retinoid) receptor,subfamily 0,group B,member 2,orphan specifically expressed in fetal liver and adrenal gland,adult spleen and small intestine,heterodimerizing with many members of receptor superfamily including RARs,RRXs,small heterodimer partner interacting with PPARx,potential negative regulator of receptor dependent signaling pathways
UniProtKB/Swiss-Prot Function: Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.

Gene Ontology (GO) - Molecular Function for NR0B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0003707 steroid hormone receptor activity IEA --
GO:0003714 transcription corepressor activity IDA 14752053
GO:0005515 protein binding IPI 14752053
genes like me logo Genes that share ontologies with NR0B2: view
genes like me logo Genes that share phenotypes with NR0B2: view

Animal Models for NR0B2 Gene

MGI Knock Outs for NR0B2:

miRNA for NR0B2 Gene

miRTarBase miRNAs that target NR0B2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NR0B2 Gene

Localization for NR0B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR0B2 Gene

Nucleus. Cytoplasm. Note=Colocalizes with NEUROD1 in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NR0B2 Gene COMPARTMENTS Subcellular localization image for NR0B2 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NR0B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 14752053
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 14752053
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with NR0B2: view

Pathways for NR0B2 Gene

genes like me logo Genes that share pathways with NR0B2: view

Pathways by source for NR0B2 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for NR0B2 Gene
1 BioSystems pathway for NR0B2 Gene
1 KEGG pathway for NR0B2 Gene

Gene Ontology (GO) - Biological Process for NR0B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0008203 cholesterol metabolic process TAS 11030331
GO:0009749 response to glucose IEA --
genes like me logo Genes that share ontologies with NR0B2: view

Compounds for NR0B2 Gene

(13) Novoseek inferred chemical compound relationships for NR0B2 Gene

Compound -log(P) Hits PubMed IDs
gw 4064 75.6 3
chenodeoxycholic acid 69.9 2
phosphoenolpyruvate 61.5 2
androstane 51.8 1
tyrosine 46 16
genes like me logo Genes that share compounds with NR0B2: view

Transcripts for NR0B2 Gene

mRNA/cDNA for NR0B2 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(39) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NR0B2 Gene

Nuclear receptor subfamily 0, group B, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NR0B2 Gene

No ASD Table

Relevant External Links for NR0B2 Gene

GeneLoc Exon Structure for
NR0B2
ECgene alternative splicing isoforms for
NR0B2

Expression for NR0B2 Gene

mRNA expression in normal human tissues for NR0B2 Gene

mRNA differential expression in normal tissues according to GTEx for NR0B2 Gene

This gene is overexpressed in Liver (26.1), Pancreas (6.0), Stomach (5.1), and Adrenal Gland (4.3).

SOURCE GeneReport for Unigene cluster for NR0B2 Gene Hs.427055

mRNA Expression by UniProt/SwissProt for NR0B2 Gene

Q15466-NR0B2_HUMAN
Tissue specificity: Liver. Low levels of expression were detected in heart and pancreas.
genes like me logo Genes that share expressions with NR0B2: view

Orthologs for NR0B2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NR0B2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NR0B2 36
  • 99.09 (n)
  • 99.22 (a)
NR0B2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NR0B2 36
  • 84.64 (n)
  • 80.86 (a)
NR0B2 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NR0B2 36
  • 85.55 (n)
  • 85.16 (a)
NR0B2 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nr0b2 36
  • 80.93 (n)
  • 78.99 (a)
Nr0b2 16
Nr0b2 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NR0B2 37
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NR0B2 37
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nr0b2 36
  • 80.8 (n)
  • 78.6 (a)
chicken
(Gallus gallus)
Aves NR0B2 36
  • 65.7 (n)
  • 58.92 (a)
NR0B2 37
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NR0B2 37
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nr0b2 36
  • 49.53 (n)
  • 41.37 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.11590 36
nr0b2a 36
  • 57.28 (n)
  • 54.69 (a)
nr0b2a 37
  • 50 (a)
OneToMany
nr0b2b 37
  • 38 (a)
OneToMany
Species with no ortholog for NR0B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NR0B2 Gene

ENSEMBL:
Gene Tree for NR0B2 (if available)
TreeFam:
Gene Tree for NR0B2 (if available)

Paralogs for NR0B2 Gene

Paralogs for NR0B2 Gene

Selected SIMAP similar genes for NR0B2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NR0B2: view

Variants for NR0B2 Gene

Sequence variations from dbSNP and Humsavar for NR0B2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7504 -- 26,911,659(+) CTGGA(A/G)CACTG utr-variant-3-prime
rs6659176 - 26,913,429(+) TGGTC(C/G)CTTTC missense, reference
rs11278723 -- 26,914,999(+) TATAT(G/T)TATAT upstream-variant-2KB
rs11581460 -- 26,915,518(+) GTGTG(A/G)CAAGC upstream-variant-2KB
rs12027292 -- 26,915,013(+) tatgt(A/G)tattt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NR0B2 Gene

Variant ID Type Subtype PubMed ID
nsv834524 CNV Gain+Loss 17160897
nsv508689 CNV Loss 20534489

Relevant External Links for NR0B2 Gene

HapMap Linkage Disequilibrium report
NR0B2
Human Gene Mutation Database (HGMD)
NR0B2

Disorders for NR0B2 Gene

(1) OMIM Diseases for NR0B2 Gene (604630)

UniProtKB/Swiss-Prot

NR0B2_HUMAN
  • Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. {ECO:0000269 PubMed:11136233}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for NR0B2 Gene

(5) Novoseek inferred disease relationships for NR0B2 Gene

Disease -log(P) Hits PubMed IDs
cholestasis 46.2 1
insulin resistance 0 1
breast cancer 0 2
tumors 0 2
obesity 0 4

Relevant External Links for NR0B2

Genetic Association Database (GAD)
NR0B2
Human Genome Epidemiology (HuGE) Navigator
NR0B2
genes like me logo Genes that share disorders with NR0B2: view

Publications for NR0B2 Gene

  1. Structure and expression of the orphan nuclear receptor SHP gene. (PMID: 9603951) Lee H.-K. … Choi H.-S. (J. Biol. Chem. 1998) 2 3 4 23
  2. Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects. (PMID: 11136233) Nishigori H. … Takeda J. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4 23 49
  3. Mutation analysis of NR0B2 among 1545 Danish men identifies a novel c.278G>A (p.G93D) variant with reduced functional activity. (PMID: 15459958) Echwald S.M. … Pedersen O. (Hum. Mutat. 2004) 3 23 49
  4. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. (PMID: 11030331) Lu T.T. … Mangelsdorf D.J. (Mol. Cell 2000) 3 23
  5. The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression. (PMID: 10594021) Lee Y.K. … Moore D.D. (Mol. Cell. Biol. 2000) 3 23

Products for NR0B2 Gene

Sources for NR0B2 Gene

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