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Aliases for DRC7 Gene

Aliases for DRC7 Gene

  • Dynein Regulatory Complex Subunit 7 2 3
  • Coiled-Coil Domain-Containing Protein Lobo Homolog 3 4
  • Coiled-Coil Domain-Containing Protein 135 3 4
  • Coiled-Coil Domain Containing 135 2 3
  • C16orf50 3 4
  • CCDC135 3 4
  • Chromosome 16 Open Reading Frame 50 2
  • CFAP50 3
  • FAP50 3

External Ids for DRC7 Gene

Previous HGNC Symbols for DRC7 Gene

  • C16orf50
  • CCDC135

Summaries for DRC7 Gene

GeneCards Summary for DRC7 Gene

DRC7 (Dynein Regulatory Complex Subunit 7) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DRC7 Gene

  • Key component of the nexin-dynein regulatory complex (N-DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility.

Gene Wiki entry for DRC7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRC7 Gene

Genomics for DRC7 Gene

Genomic Location for DRC7 Gene

57,694,793 bp from pter
57,731,805 bp from pter
37,013 bases
Plus strand

Genomic View for DRC7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DRC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRC7 Gene

No data available for Regulatory Elements for DRC7 Gene

Proteins for DRC7 Gene

  • Protein details for DRC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dynein regulatory complex subunit 7
    Protein Accession:
    Secondary Accessions:
    • A8K943
    • Q8NAA0
    • Q9H080

    Protein attributes for DRC7 Gene

    874 amino acids
    Molecular mass:
    103497 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DRC7 Gene


neXtProt entry for DRC7 Gene

Proteomics data for DRC7 Gene at MOPED

Post-translational modifications for DRC7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DRC7 Gene

Domains for DRC7 Gene

Protein Domains for DRC7 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q8IY82
  • Belongs to the DRC7 family.
genes like me logo Genes that share domains with DRC7: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for DRC7 Gene

Function for DRC7 Gene

Molecular function for DRC7 Gene

UniProtKB/Swiss-Prot Function: Key component of the nexin-dynein regulatory complex (N-DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility.

Gene Ontology (GO) - Molecular Function for DRC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24407287
genes like me logo Genes that share ontologies with DRC7: view

Phenotypes for DRC7 Gene

genes like me logo Genes that share phenotypes with DRC7: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DRC7 Gene

Localization for DRC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRC7 Gene

Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme. Note=Associated with the outer doublet microtubules (OD). {ECO:0000250 UniProtKB:A8JAM0}.

Gene Ontology (GO) - Cellular Components for DRC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005856 cytoskeleton IEA --
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with DRC7: view

No data available for Subcellular locations from COMPARTMENTS for DRC7 Gene

Pathways for DRC7 Gene

SuperPathways for DRC7 Gene

No Data Available

Interacting Proteins for DRC7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000353942 Q8IY82-DRC7_HUMAN for DRC7 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for DRC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis --
GO:0030154 cell differentiation --
genes like me logo Genes that share ontologies with DRC7: view

No data available for Pathways by source for DRC7 Gene

Transcripts for DRC7 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DRC7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DRC7
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRC7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20
SP1: -
SP2: - -

Relevant External Links for DRC7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DRC7 Gene

mRNA expression in normal human tissues for DRC7 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DRC7 Gene

genes like me logo Genes that share expressions with DRC7: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DRC7 Gene

Orthologs for DRC7 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRC7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC135 35
  • 94.28 (n)
  • 92.92 (a)
CCDC135 36
  • 99 (a)
(Bos Taurus)
Mammalia CCDC135 35
  • 87.77 (n)
  • 87.04 (a)
CCDC135 36
  • 87 (a)
(Canis familiaris)
Mammalia CCDC135 35
  • 86.84 (n)
  • 85.11 (a)
CCDC135 36
  • 85 (a)
(Mus musculus)
Mammalia Ccdc135 35
  • 83.56 (n)
  • 83.18 (a)
Ccdc135 16
Ccdc135 36
  • 83 (a)
(Monodelphis domestica)
Mammalia CCDC135 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC135 36
  • 68 (a)
(Rattus norvegicus)
Mammalia Ccdc135 35
  • 83.66 (n)
  • 84.19 (a)
(Gallus gallus)
Aves CCDC135 35
  • 64.25 (n)
  • 58.16 (a)
CCDC135 36
  • 56 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
-- 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc135 35
  • 60.15 (n)
  • 57.26 (a)
Str.5324 35
(Danio rerio)
Actinopterygii ccdc135 36
  • 47 (a)
LOC555782 35
  • 54.63 (n)
  • 47.44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002677 35
  • 49.75 (n)
  • 34.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta lobo 35
  • 45.55 (n)
  • 31.48 (a)
lobo 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
Species with no ortholog for DRC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DRC7 Gene

Gene Tree for DRC7 (if available)
Gene Tree for DRC7 (if available)

Paralogs for DRC7 Gene

No data available for Paralogs for DRC7 Gene

Variants for DRC7 Gene

Sequence variations from dbSNP and Humsavar for DRC7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1463236 -- 57,715,868(+) GGCTC(C/T)GAGGT intron-variant
rs1542259 -- 57,717,335(+) AATCA(A/T)GTGAT intron-variant
rs1562791 -- 57,707,384(+) CCCAG(C/T)CCCAG intron-variant
rs2077612 -- 57,693,052(+) GCGCC(A/G)GGGTG upstream-variant-2KB
rs2078553 -- 57,693,068(-) TTGGA(C/T)GGATA upstream-variant-2KB

Relevant External Links for DRC7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DRC7 Gene

Disorders for DRC7 Gene

No disorders were found for DRC7 Gene.

No data available for UniProtKB/Swiss-Prot for DRC7 Gene

Publications for DRC7 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Regulation of flagellar motility by the conserved flagellar protein CG34110/Ccdc135/FAP50. (PMID: 21289096) Yang Y. … Lu X. (Mol. Biol. Cell 2011) 2 3
  4. Novel transglutaminase-like peptidase and C2 domains elucidate the structure, biogenesis and evolution of the ciliary compartment. (PMID: 22983010) Zhang D. … Aravind L. (Cell Cycle 2012) 2 3
  5. Promyelocytic Leukemia protein (PML) interacts with ASC to limit Inflammasome Activation. (PMID: 24407287) Dowling J.K. … O'Neill L.A. (J. Biol. Chem. 2014) 3

Products for DRC7 Gene

Sources for DRC7 Gene

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