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Aliases for MINDY4 Gene

Aliases for MINDY4 Gene

  • MINDY Lysine 48 Deubiquitinase 4 2 3 5
  • Family With Sequence Similarity 188 Member B 2 3
  • Probable Deubiquitinating Enzyme MINDY-4 3 4
  • MINDY Deubiquitinase 4 2 3
  • C7orf67 3 4
  • FAM188B 3 4
  • Probable Ubiquitin Carboxyl-Terminal Hydrolase FAM188B 3
  • Probable Ubiquitin Carboxyl-Terminal Hydrolase MINDY-4 3
  • Family With Sequence Similarity 188, Member B 2
  • Chromosome 7 Open Reading Frame 67 2
  • Protein FAM188B 3
  • EC 3.4.19.12 4

External Ids for MINDY4 Gene

Previous HGNC Symbols for MINDY4 Gene

  • C7orf67
  • FAM188B

Summaries for MINDY4 Gene

GeneCards Summary for MINDY4 Gene

MINDY4 (MINDY Lysine 48 Deubiquitinase 4) is a Protein Coding gene. An important paralog of this gene is MINDY4B.

UniProtKB/Swiss-Prot for MINDY4 Gene

  • Probable hydrolase that can remove Lys-48-linked conjugated ubiquitin from proteins.

Gene Wiki entry for MINDY4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MINDY4 Gene

Genomics for MINDY4 Gene

Regulatory Elements for MINDY4 Gene

Enhancers for MINDY4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G030798 1.4 Ensembl ENCODE dbSUPER 29.9 +28.9 28919 3.2 FOXA2 INSM2 KLF17 BMI1 RAD21 GLIS2 GATA2 SCRT2 ZNF143 FOS MINDY4 ENSG00000250424 AQP1 ENSG00000229263 INMT
GH07G030794 1.1 Ensembl ENCODE dbSUPER 31.4 +25.1 25064 4.0 JUN ZBTB7B ZKSCAN1 JUND CTBP1 ZNF585B NR2F6 FOS HNF4A MINDY4 ENSG00000250424 AQP1 ENSG00000229263 INMT ZNRF2
GH07G030748 1.2 Ensembl ENCODE dbSUPER 28.6 -20.3 -20252 5.8 CTCF CBX3 FOXA2 ZBTB21 CEBPG RAD21 CBX5 ADNP ZSCAN5C SCRT2 MINDY4 CRHR2 INMT ENSG00000244480 INMT-MINDY4 ENSG00000223419
GH07G030760 1.3 ENCODE dbSUPER 20.4 -9.8 -9837 1.8 PKNOX1 CREB3L1 ARNT YY1 ZNF766 REST SMARCB1 ZNF592 MEF2D SMARCA4 MINDY4 INMT-MINDY4
GH07G030788 1.1 Ensembl ENCODE dbSUPER 24.1 +18.1 18068 1.3 ATF3 IKZF1 JUN SCRT2 FOS CEBPG MINDY4 ENSG00000229263
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MINDY4 on UCSC Golden Path with GeneCards custom track

Promoters for MINDY4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000210395 283 1401 HDGF ATF1 CREB3L1 SIN3A YY1 ETS1 GLIS2 ZNF143 SP3 ZHX2

Genomic Location for MINDY4 Gene

Chromosome:
7
Start:
30,771,417 bp from pter
End:
30,892,387 bp from pter
Size:
120,971 bases
Orientation:
Plus strand

Genomic View for MINDY4 Gene

Genes around MINDY4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MINDY4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MINDY4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MINDY4 Gene

Proteins for MINDY4 Gene

  • Protein details for MINDY4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0A6-MINY4_HUMAN
    Recommended name:
    Probable ubiquitin carboxyl-terminal hydrolase MINDY-4
    Protein Accession:
    Q4G0A6
    Secondary Accessions:
    • Q71AZ7
    • Q9H6D2

    Protein attributes for MINDY4 Gene

    Size:
    757 amino acids
    Molecular mass:
    84372 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ10898.1; Type=Frameshift; Positions=617; Evidence={ECO:0000305}; Sequence=BAB15327.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for MINDY4 Gene

Post-translational modifications for MINDY4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MINDY4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MINDY4 Gene

Domains & Families for MINDY4 Gene

Gene Families for MINDY4 Gene

Protein Domains for MINDY4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MINDY4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4G0A6

UniProtKB/Swiss-Prot:

MINY4_HUMAN :
  • Belongs to the peptidase MINDY family. FAM188 subfamily.
Family:
  • Belongs to the peptidase MINDY family. FAM188 subfamily.
genes like me logo Genes that share domains with MINDY4: view

Function for MINDY4 Gene

Molecular function for MINDY4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Probable hydrolase that can remove Lys-48-linked conjugated ubiquitin from proteins.

Enzyme Numbers (IUBMB) for MINDY4 Gene

Gene Ontology (GO) - Molecular Function for MINDY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with MINDY4: view

Animal Model Products

miRNA for MINDY4 Gene

miRTarBase miRNAs that target MINDY4

Inhibitory RNA Products

Clone Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MINDY4 Gene

Localization for MINDY4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MINDY4 Gene

Pathways & Interactions for MINDY4 Gene

SuperPathways for MINDY4 Gene

No Data Available

Interacting Proteins for MINDY4 Gene

Selected Interacting proteins: Q4G0A6-MINY4_HUMAN for MINDY4 Gene via IID

Gene Ontology (GO) - Biological Process for MINDY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with MINDY4: view

No data available for Pathways by source and SIGNOR curated interactions for MINDY4 Gene

Drugs & Compounds for MINDY4 Gene

No Compound Related Data Available

Transcripts for MINDY4 Gene

mRNA/cDNA for MINDY4 Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MINDY4 Gene

No ASD Table

Relevant External Links for MINDY4 Gene

GeneLoc Exon Structure for
MINDY4
ECgene alternative splicing isoforms for
MINDY4

Expression for MINDY4 Gene

NURSA nuclear receptor signaling pathways regulating expression of MINDY4 Gene:

MINDY4

Evidence on tissue expression from TISSUES for MINDY4 Gene

  • Nervous system(4)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MINDY4 Gene

Orthologs for MINDY4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MINDY4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM188B 34 35
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia FAM188B 34 35
  • 85.28 (n)
cow
(Bos Taurus)
Mammalia FAM188B 34 35
  • 82.32 (n)
mouse
(Mus musculus)
Mammalia Fam188b 34 16 35
  • 80.8 (n)
rat
(Rattus norvegicus)
Mammalia Fam188b 34
  • 79.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM188B 35
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM188B 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM188B 34 35
  • 61.72 (n)
lizard
(Anolis carolinensis)
Reptilia FAM188B 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam188b 34
  • 57.93 (n)
Str.11231 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14505 34
zebrafish
(Danio rerio)
Actinopterygii si:dkey-30h22.11 34
  • 55.59 (n)
FAM188B 35
  • 43 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13006 34
Species where no ortholog for MINDY4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MINDY4 Gene

ENSEMBL:
Gene Tree for MINDY4 (if available)
TreeFam:
Gene Tree for MINDY4 (if available)

Paralogs for MINDY4 Gene

Paralogs for MINDY4 Gene

genes like me logo Genes that share paralogs with MINDY4: view

Variants for MINDY4 Gene

Sequence variations from dbSNP and Humsavar for MINDY4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000036169 -- 30,840,470(+) AACCT(A/G)TGGTG intron-variant
rs1000075121 -- 30,826,106(+) TTCTT(A/G)TAATT intron-variant
rs1000108453 -- 30,847,607(+) AGAGG(A/G)TATAA intron-variant
rs1000113570 -- 30,884,144(+) TCCAG(A/G)GGGCA intron-variant
rs1000133574 -- 30,776,941(+) CAAGG(C/G)CACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MINDY4 Gene

Variant ID Type Subtype PubMed ID
dgv1879e212 CNV loss 25503493
dgv6316n100 CNV gain 25217958
esv22626 CNV gain 19812545
esv2390406 CNV deletion 18987734
esv2678492 CNV deletion 23128226
esv2678752 CNV deletion 23128226
esv2734203 CNV deletion 23290073
esv2734204 CNV deletion 23290073
esv2761316 CNV gain 21179565
esv3305464 CNV mobile element insertion 20981092
esv3356059 CNV insertion 20981092
esv3541409 CNV deletion 23714750
esv3571725 CNV loss 25503493
esv3612714 CNV loss 21293372
esv5109 CNV loss 18987735
esv5499 CNV loss 19470904
esv993279 CNV deletion 20482838
nsv1025945 CNV loss 25217958
nsv1068321 OTHER inversion 25765185
nsv1074084 CNV deletion 25765185
nsv1146524 CNV deletion 26484159
nsv1148830 OTHER inversion 26484159
nsv436557 CNV deletion 17901297
nsv464416 CNV loss 19166990
nsv526591 CNV loss 19592680
nsv527038 CNV gain 19592680
nsv606507 CNV loss 21841781
nsv606508 CNV loss 21841781
nsv606509 CNV loss 21841781
nsv830938 CNV gain 17160897
nsv830939 CNV loss 17160897
nsv955992 CNV deletion 24416366

Variation tolerance for MINDY4 Gene

Residual Variation Intolerance Score: 98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.83; 73.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MINDY4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MINDY4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MINDY4 Gene

Disorders for MINDY4 Gene

Relevant External Links for MINDY4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MINDY4

No disorders were found for MINDY4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MINDY4 Gene

Publications for MINDY4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1. (PMID: 22396660) Urabe Y. … Matsuda K. (PLoS Genet. 2012) 3 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 64
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3 64

Products for MINDY4 Gene

Sources for MINDY4 Gene

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