Aliases for LOXL4 Gene
External Ids for LOXL4 Gene
Previous GeneCards Identifiers for LOXL4 Gene
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
GeneCards Summary for LOXL4 Gene
LOXL4 (Lysyl Oxidase-Like 4) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Elastic fibre formation. GO annotations related to this gene include copper ion binding and protein-lysine 6-oxidase activity. An important paralog of this gene is LOXL1.
UniProtKB/Swiss-Prot for LOXL4 Gene
May modulate the formation of a collagenous extracellular matrix