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Aliases for STX7 Gene

Aliases for STX7 Gene

  • Syntaxin 7 2 3 5
  • Syntaxin-7 3

External Ids for STX7 Gene

Previous GeneCards Identifiers for STX7 Gene

  • GC06M132624
  • GC06M132761
  • GC06M132822
  • GC06M130353
  • GC06M132767

Summaries for STX7 Gene

Entrez Gene Summary for STX7 Gene

  • The protein encoded by this gene is a syntaxin family membrane receptor involved in vesicle transport. The encoded protein binds alpha-SNAP, an important regulator of transport vesicle fusion. Along with syntaxin 13, this protein plays a role in the ordered fusion of endosomes and lysosomes with the phagosome. [provided by RefSeq, May 2016]

GeneCards Summary for STX7 Gene

STX7 (Syntaxin 7) is a Protein Coding gene. Diseases associated with STX7 include Leukodystrophy, Hypomyelinating, 6 and Hemophagocytic Lymphohistiocytosis, Familial, 4. Among its related pathways are wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF) and Phagosome. GO annotations related to this gene include syntaxin binding and SNAP receptor activity. An important paralog of this gene is STX12.

UniProtKB/Swiss-Prot for STX7 Gene

  • May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.

Gene Wiki entry for STX7 Gene

Additional gene information for STX7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX7 Gene

Genomics for STX7 Gene

Regulatory Elements for STX7 Gene

Enhancers for STX7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H132489 1.4 FANTOM5 Ensembl ENCODE dbSUPER 20.1 +22.3 22345 2 NFIC PKNOX1 POLR2A NFYB FOXP2 STX7 MOXD1 VNN1 TAAR6 VNN2 TAAR5 SLC18B1
GH06H132510 1.7 FANTOM5 ENCODE dbSUPER 13.7 +0.4 442 4 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 MED23 STX7 SNORA33 LOC100421775 ENPP1 VNN2 VNN1 MOXD1
GH06H132493 1.3 Ensembl ENCODE dbSUPER 9.5 +15.8 15800 7 HDGF PKNOX1 TBL1XR1 RB1 BMI1 BATF ZNF207 ATF7 RUNX3 CREM MOXD1 STX7 ENPP1
GH06H132484 0.9 ENCODE dbSUPER 11.6 +28.8 28842 0 SCRT1 CTCF ZNF654 TRIM22 ZFP37 MAX RAD21 ZNF121 SCRT2 ZNF143 STX7 MOXD1
GH06H132748 1.4 FANTOM5 Ensembl ENCODE 6.2 -236.0 -235969 1 ELF3 ETV1 MAX CEBPG ZNF644 RAD21 YY1 TRIM24 GATAD2A KLF6 VNN2 VNN3 STX7 SLC18B1 ENSG00000234484
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STX7 on UCSC Golden Path with GeneCards custom track

Promoters for STX7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000202992 598 2401 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9

Genomic Location for STX7 Gene

Chromosome:
6
Start:
132,445,867 bp from pter
End:
132,513,198 bp from pter
Size:
67,332 bases
Orientation:
Minus strand

Genomic View for STX7 Gene

Genes around STX7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX7 Gene

Proteins for STX7 Gene

  • Protein details for STX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15400-STX7_HUMAN
    Recommended name:
    Syntaxin-7
    Protein Accession:
    O15400
    Secondary Accessions:
    • E1P579
    • Q5SZW2
    • Q96ES9

    Protein attributes for STX7 Gene

    Size:
    261 amino acids
    Molecular mass:
    29816 Da
    Quaternary structure:
    • Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes (By similarity). Interacts with VPS11, VPS16 and VPS18. Interacts with VPS33A.

    Alternative splice isoforms for STX7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STX7 Gene

Post-translational modifications for STX7 Gene

  • Ubiquitination at Lys24 and Lys71
  • Modification sites at PhosphoSitePlus

Other Protein References for STX7 Gene

No data available for DME Specific Peptides for STX7 Gene

Domains & Families for STX7 Gene

Gene Families for STX7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for STX7 Gene

Suggested Antigen Peptide Sequences for STX7 Gene

Graphical View of Domain Structure for InterPro Entry

O15400

UniProtKB/Swiss-Prot:

STX7_HUMAN :
  • Belongs to the syntaxin family.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX7: view

Function for STX7 Gene

Molecular function for STX7 Gene

UniProtKB/Swiss-Prot Function:
May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.

Phenotypes From GWAS Catalog for STX7 Gene

Gene Ontology (GO) - Molecular Function for STX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IDA 24550300
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 11382755
GO:0019869 chloride channel inhibitor activity IDA 18570918
GO:0019905 syntaxin binding IPI 10564279
genes like me logo Genes that share ontologies with STX7: view

Phenotypes for STX7 Gene

genes like me logo Genes that share phenotypes with STX7: view

Animal Model Products

CRISPR Products

miRNA for STX7 Gene

miRTarBase miRNAs that target STX7

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for STX7
  • Applied Biological Materials Clones for STX7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STX7 Gene

Localization for STX7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX7 Gene

Early endosome membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STX7 gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 5
endosome 5
cytosol 3
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 21438968
GO:0005764 lysosome IDA 18980942
GO:0005765 lysosomal membrane IDA 17897319
GO:0005768 endosome IDA,IEA 10564279
GO:0005769 early endosome IDA 10564279
genes like me logo Genes that share ontologies with STX7: view

Pathways & Interactions for STX7 Gene

genes like me logo Genes that share pathways with STX7: view

Pathways by source for STX7 Gene

1 GeneGo (Thomson Reuters) pathway for STX7 Gene

Gene Ontology (GO) - Biological Process for STX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001916 positive regulation of T cell mediated cytotoxicity IMP 21438968
GO:0006886 intracellular protein transport IBA --
GO:0006906 vesicle fusion IBA --
GO:0016192 vesicle-mediated transport IEA --
GO:0048278 vesicle docking IBA --
genes like me logo Genes that share ontologies with STX7: view

No data available for SIGNOR curated interactions for STX7 Gene

Drugs & Compounds for STX7 Gene

No Compound Related Data Available

Transcripts for STX7 Gene

Unigene Clusters for STX7 Gene

Syntaxin 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for STX7
  • Applied Biological Materials Clones for STX7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for STX7 Gene

No ASD Table

Relevant External Links for STX7 Gene

GeneLoc Exon Structure for
STX7
ECgene alternative splicing isoforms for
STX7

Expression for STX7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STX7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STX7 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STX7 Gene



Protein tissue co-expression partners for STX7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STX7 Gene:

STX7

SOURCE GeneReport for Unigene cluster for STX7 Gene:

Hs.593148

mRNA Expression by UniProt/SwissProt for STX7 Gene:

O15400-STX7_HUMAN
Tissue specificity: Highest expression is found in placenta followed by heart, skeletal muscle, kidney and brain. Low expression is found in pancreas, lung and liver.

Evidence on tissue expression from TISSUES for STX7 Gene

  • Nervous system(4.9)
  • Blood(4.3)
  • Liver(4.2)
  • Intestine(2)
  • Kidney(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with STX7: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STX7 Gene

Orthologs for STX7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STX7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STX7 33 34
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia STX7 34
  • 93 (a)
OneToOne
LOC483987 33
  • 92.47 (n)
cow
(Bos Taurus)
Mammalia STX7 33 34
  • 92.79 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STX7 34
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STX7 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stx7 33 16 34
  • 87.64 (n)
rat
(Rattus norvegicus)
Mammalia Stx7 33
  • 85.84 (n)
chicken
(Gallus gallus)
Aves STX7 33 34
  • 79.97 (n)
lizard
(Anolis carolinensis)
Reptilia STX7 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stx7 33
  • 68.37 (n)
Str.17638 33
African clawed frog
(Xenopus laevis)
Amphibia MGC53161 33
zebrafish
(Danio rerio)
Actinopterygii stx7l 33 34
  • 61.54 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.334 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005543 33
  • 50.77 (n)
fruit fly
(Drosophila melanogaster)
Insecta Syx7 33 34
  • 50.37 (n)
worm
(Caenorhabditis elegans)
Secernentea syx-7 34
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP12 34
  • 20 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons VAM3 33
  • 44.15 (n)
rice
(Oryza sativa)
Liliopsida Os01g0254900 33
  • 43.75 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8310 33
Species where no ortholog for STX7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX7 Gene

ENSEMBL:
Gene Tree for STX7 (if available)
TreeFam:
Gene Tree for STX7 (if available)

Paralogs for STX7 Gene

Paralogs for STX7 Gene

(2) SIMAP similar genes for STX7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STX7: view

Variants for STX7 Gene

Sequence variations from dbSNP and Humsavar for STX7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs864309676 Likely pathogenic 132,472,372(-) AGGCA(A/C)CAGAA nc-transcript-variant, reference, missense
rs1000006324 -- 132,473,023(+) GTGTG(A/G)TGGAG intron-variant
rs1000006471 -- 132,471,108(+) TAATC(C/G)AGGAG intron-variant
rs1000153264 -- 132,474,222(+) GATCC(C/T)GTCTC intron-variant
rs1000154141 -- 132,513,051(+) TCACC(C/T)ACCTA intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for STX7 Gene

Variant ID Type Subtype PubMed ID
nsv819019 CNV loss 19587683
nsv830811 CNV gain 17160897

Variation tolerance for STX7 Gene

Residual Variation Intolerance Score: 29.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STX7 Gene

Human Gene Mutation Database (HGMD)
STX7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STX7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX7 Gene

Disorders for STX7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for STX7 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
leukodystrophy, hypomyelinating, 6
  • hld
hemophagocytic lymphohistiocytosis, familial, 4
  • familial hemophagocytic lymphohistiocytosis 4
- elite association - COSMIC cancer census association via MalaCards
Search STX7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for STX7

Genetic Association Database (GAD)
STX7
Human Genome Epidemiology (HuGE) Navigator
STX7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STX7
genes like me logo Genes that share disorders with STX7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STX7 Gene

Publications for STX7 Gene

  1. Human syntaxin 7: a Pep12p/Vps6p homologue implicated in vesicle trafficking to lysosomes. (PMID: 9358037) Wang H … Pevsner J (Gene 1997) 2 3 4 22 60
  2. Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7. (PMID: 11382755) Kim BY … Akazawa C (The Journal of biological chemistry 2001) 3 4 22 60
  3. Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking. (PMID: 10564279) Prekeris R … Scheller RH (Molecular biology of the cell 1999) 3 4 22 60
  4. Intracellular location of syntaxin 7 in human neutrophils. (PMID: 20170677) Xie LX … Mollinedo F (Immunology letters 2010) 3 22 60
  5. Selective expression of Syntaxin-7 protein in benign melanocytes and malignant melanoma. (PMID: 19714869) Strömberg S … Ponten F (Journal of proteome research 2009) 3 22 60

Products for STX7 Gene

  • Addgene plasmids for STX7

Sources for STX7 Gene

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