Free for academic non-profit institutions. Other users need a Commercial license

Aliases for STX7 Gene

Aliases for STX7 Gene

  • Syntaxin 7 2 3
  • Syntaxin-7 3

External Ids for STX7 Gene

Summaries for STX7 Gene

GeneCards Summary for STX7 Gene

STX7 (Syntaxin 7) is a Protein Coding gene. Among its related pathways are Disease and Transmission across Chemical Synapses. GO annotations related to this gene include SNAP receptor activity and SNARE binding. An important paralog of this gene is STX12.

UniProtKB/Swiss-Prot for STX7 Gene

  • May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes

Gene Wiki entry for STX7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX7 Gene

Genomics for STX7 Gene

Genomic Location for STX7 Gene

Start:
132,445,867 bp from pter
End:
132,513,198 bp from pter
Size:
67,332 bases
Orientation:
Minus strand

Genomic View for STX7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STX7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX7 Gene

Regulatory Elements for STX7 Gene

Proteins for STX7 Gene

  • Protein details for STX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15400-STX7_HUMAN
    Recommended name:
    Syntaxin-7
    Protein Accession:
    O15400
    Secondary Accessions:
    • E1P579
    • Q5SZW2
    • Q96ES9

    Protein attributes for STX7 Gene

    Size:
    261 amino acids
    Molecular mass:
    29816 Da
    Quaternary structure:
    • Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes (By similarity). Interacts with VPS11, VPS16 and VPS18. Interacts with VPS33A.

    Alternative splice isoforms for STX7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STX7 Gene

Proteomics data for STX7 Gene at MOPED

Post-translational modifications for STX7 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys24 and Lys71

Other Protein References for STX7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STX7 Gene

Domains for STX7 Gene

Protein Domains for STX7 Gene

UniProtKB/Swiss-Prot:

STX7_HUMAN
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.:
    • O15400
Family:
  • Belongs to the syntaxin family.:
    • O15400
genes like me logo Genes that share domains with STX7: view

No data available for Gene Families for STX7 Gene

Function for STX7 Gene

Molecular function for STX7 Gene

UniProtKB/Swiss-Prot Function: May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes

Gene Ontology (GO) - Molecular Function for STX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IDA 24550300
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 21516116
GO:0019869 chloride channel inhibitor activity IDA 18570918
GO:0019905 syntaxin binding IPI 10564279
genes like me logo Genes that share ontologies with STX7: view

miRNA for STX7 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for STX7 Gene

Localization for STX7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX7 Gene

Early endosome membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STX7 Gene COMPARTMENTS Subcellular localization image for STX7 gene
Compartment Confidence
endosome 5
cytosol 3
lysosome 2
plasma membrane 2
vacuole 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for STX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 21438968
GO:0005764 lysosome IDA 18980942
GO:0005765 lysosomal membrane IDA 17897319
GO:0005768 endosome IDA 10564279
GO:0005769 early endosome IDA 10564279
genes like me logo Genes that share ontologies with STX7: view

Pathways for STX7 Gene

genes like me logo Genes that share pathways with STX7: view

Pathways by source for STX7 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for STX7 Gene
2 Reactome pathways for STX7 Gene

Gene Ontology (GO) - Biological Process for STX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001916 positive regulation of T cell mediated cytotoxicity IMP 21438968
GO:0006886 intracellular protein transport IBA --
GO:0006892 post-Golgi vesicle-mediated transport --
GO:0006906 vesicle fusion IBA --
GO:0016079 synaptic vesicle exocytosis --
genes like me logo Genes that share ontologies with STX7: view

Transcripts for STX7 Gene

Unigene Clusters for STX7 Gene

Syntaxin 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STX7 Gene

No ASD Table

Relevant External Links for STX7 Gene

GeneLoc Exon Structure for
STX7
ECgene alternative splicing isoforms for
STX7

Expression for STX7 Gene

mRNA expression in normal human tissues for STX7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX7 Gene

SOURCE GeneReport for Unigene cluster for STX7 Gene Hs.593148

mRNA Expression by UniProt/SwissProt for STX7 Gene

O15400-STX7_HUMAN
Tissue specificity: Highest expression is found in placenta followed by heart, skeletal muscle, kidney and brain. Low expression is found in pancreas, lung and liver
genes like me logo Genes that share expressions with STX7: view

Orthologs for STX7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STX7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STX7 36
  • 99.62 (n)
  • 99.62 (a)
STX7 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STX7 36
  • 92.79 (n)
  • 95.37 (a)
STX7 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC483987 36
  • 92.47 (n)
  • 95.82 (a)
STX7 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stx7 36
  • 87.64 (n)
  • 94.98 (a)
Stx7 16
Stx7 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STX7 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STX7 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stx7 36
  • 85.84 (n)
  • 93.44 (a)
chicken
(Gallus gallus)
Aves STX7 36
  • 79.97 (n)
  • 82.21 (a)
STX7 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STX7 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53161 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17638 36
stx7 36
  • 68.37 (n)
  • 69.41 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.334 36
zebrafish
(Danio rerio)
Actinopterygii stx7l 36
  • 61.54 (n)
  • 59.92 (a)
stx7l 37
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005543 36
  • 50.77 (n)
  • 44.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syx7 36
  • 50.37 (n)
  • 47.09 (a)
Syx7 37
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea syx-7 37
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP12 37
  • 20 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons VAM3 36
  • 44.15 (n)
  • 34.21 (a)
rice
(Oryza sativa)
Liliopsida Os01g0254900 36
  • 43.75 (n)
  • 34.37 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8310 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 34 (a)
OneToMany
Species with no ortholog for STX7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX7 Gene

ENSEMBL:
Gene Tree for STX7 (if available)
TreeFam:
Gene Tree for STX7 (if available)

Paralogs for STX7 Gene

Paralogs for STX7 Gene

Selected SIMAP similar genes for STX7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STX7: view

Variants for STX7 Gene

Sequence variations from dbSNP and Humsavar for STX7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs9239 -- 132,459,629(+) ACCGA(A/G)CTGCT utr-variant-3-prime
rs10612 -- 132,458,280(+) CCATG(C/G)CTGTC utr-variant-3-prime
rs14012 -- 132,458,617(+) ACCTT(A/C)ACTTT utr-variant-3-prime
rs1002799 -- 132,480,736(+) ATCCC(A/G)AACAG intron-variant
rs1044057 -- 132,503,497(-) ACCCC(A/G)CCCAG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for STX7 Gene

Variant ID Type Subtype PubMed ID
nsv830811 CNV Gain 17160897
nsv819019 CNV Loss 19587683

Relevant External Links for STX7 Gene

HapMap Linkage Disequilibrium report
STX7

Disorders for STX7 Gene

Relevant External Links for STX7

Genetic Association Database (GAD)
STX7
Human Genome Epidemiology (HuGE) Navigator
STX7
genes like me logo Genes that share disorders with STX7: view

No data available for UniProtKB/Swiss-Prot for STX7 Gene

Publications for STX7 Gene

  1. Human syntaxin 7: a Pep12p/Vps6p homologue implicated in vesicle trafficking to lysosomes. (PMID: 9358037) Wang H. … Pevsner J. (Gene 1997) 2 3 4 23
  2. Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking. (PMID: 10564279) Prekeris R. … Scheller R.H. (Mol. Biol. Cell 1999) 3 4 23
  3. Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7. (PMID: 11382755) Kim B.Y. … Akazawa C. (J. Biol. Chem. 2001) 3 4 23
  4. Involvement of syntaxin 7 in human gastric epithelial cell vacuolation induced by the Helicobacter pylori-produced cytotoxin VacA. (PMID: 12730232) Suzuki J. … Mashima H. (J. Biol. Chem. 2003) 3 23
  5. Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling. (PMID: 17255364) Lapierre L.A. … Goldenring J.R. (Am. J. Physiol. Gastrointest. Liver Physiol. 2007) 3 23

Products for STX7 Gene

  • Addgene plasmids for STX7

Sources for STX7 Gene

Back to Top

Content