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Aliases for ZNF644 Gene

Aliases for ZNF644 Gene

  • Zinc Finger Protein 644 2 3
  • ZEP-2 3 4
  • MYP21 3 6
  • Zinc Finger Motif Enhancer Binding Protein 2 3
  • Zinc Finger Motif Enhancer-Binding Protein 2 4
  • KIAA1221 4
  • BM-005 3
  • NatF 3
  • ZEP2 4

External Ids for ZNF644 Gene

Previous GeneCards Identifiers for ZNF644 Gene

  • GC01M091093
  • GC01M091153
  • GC01M091380
  • GC01M089499

Summaries for ZNF644 Gene

Entrez Gene Summary for ZNF644 Gene

  • The protein encoded by this gene is a zinc finger transcription factor that may play a role in eye development. Defects in this gene have been associated with high myopia. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for ZNF644 Gene

ZNF644 (Zinc Finger Protein 644) is a Protein Coding gene. Diseases associated with ZNF644 include myopia 21, autosomal dominant and myopia. An important paralog of this gene is WIZ.

UniProtKB/Swiss-Prot for ZNF644 Gene

  • May be involved in transcriptional regulation

Gene Wiki entry for ZNF644 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF644 Gene

Genomics for ZNF644 Gene

Regulatory Elements for ZNF644 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF644 Gene

90,915,298 bp from pter
91,022,272 bp from pter
106,975 bases
Minus strand

Genomic View for ZNF644 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF644 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF644 Gene

Proteins for ZNF644 Gene

  • Protein details for ZNF644 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 644
    Protein Accession:
    Secondary Accessions:
    • A2RU71
    • Q2TAM0
    • Q5TCC0
    • Q6BEP7
    • Q6P446
    • Q6PI06
    • Q7LG67
    • Q9ULJ9

    Protein attributes for ZNF644 Gene

    1327 amino acids
    Molecular mass:
    149565 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF644 Gene


neXtProt entry for ZNF644 Gene

Proteomics data for ZNF644 Gene at MOPED

Post-translational modifications for ZNF644 Gene

  • Ubiquitination at Lys843 and Lys1110
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF644 Gene

No data available for DME Specific Peptides for ZNF644 Gene

Domains for ZNF644 Gene

Protein Domains for ZNF644 Gene

Suggested Antigen Peptide Sequences for ZNF644 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9H582
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF644: view

No data available for Gene Families for ZNF644 Gene

Function for ZNF644 Gene

Molecular function for ZNF644 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF644 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF644: view

Animal Model Products

CRISPR Products

miRNA for ZNF644 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF644

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF644 Gene

Localization for ZNF644 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF644 Gene

Subcellular locations from

Jensen Localization Image for ZNF644 Gene COMPARTMENTS Subcellular localization image for ZNF644 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF644 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF644: view

Pathways for ZNF644 Gene

SuperPathways for ZNF644 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF644 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF644: view

No data available for Pathways by source for ZNF644 Gene

Transcripts for ZNF644 Gene

Unigene Clusters for ZNF644 Gene

Zinc finger protein 644:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF644

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF644

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF644 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b
SP1: - - - - -
SP2: - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - -
SP7: -
SP8: - - -
SP9: - - - - -

Relevant External Links for ZNF644 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF644 Gene

mRNA expression in normal human tissues for ZNF644 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF644 Gene

SOURCE GeneReport for Unigene cluster for ZNF644 Gene Hs.173001

mRNA Expression by UniProt/SwissProt for ZNF644 Gene

Tissue specificity: Expressed in liver, placenta, retina and retinal pigment epithelium.
genes like me logo Genes that share expressions with ZNF644: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZNF644 Gene

Orthologs for ZNF644 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF644 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF644 35
  • 99.45 (n)
  • 99.4 (a)
ZNF644 36
  • 100 (a)
(Bos Taurus)
Mammalia ZNF644 35
  • 93.42 (n)
  • 92.54 (a)
ZNF644 36
  • 93 (a)
(Canis familiaris)
Mammalia ZNF644 35
  • 93.44 (n)
  • 93.82 (a)
ZNF644 36
  • 95 (a)
(Mus musculus)
Mammalia Zfp644 35
  • 86.26 (n)
  • 85.13 (a)
Zfp644 16
Zfp644 36
  • 84 (a)
(Monodelphis domestica)
Mammalia ZNF644 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF644 36
  • 80 (a)
(Rattus norvegicus)
Mammalia Zfp644 35
  • 82.8 (n)
  • 81.82 (a)
(Gallus gallus)
Aves ZNF644 35
  • 80.78 (n)
  • 81.12 (a)
ZNF644 36
  • 79 (a)
(Anolis carolinensis)
Reptilia ZNF644 36
  • 71 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8927 35
tropical clawed frog
(Silurana tropicalis)
Amphibia znf644 35
  • 68.43 (n)
  • 61.27 (a)
(Danio rerio)
Actinopterygii znf644b 36
  • 28 (a)
Species with no ortholog for ZNF644:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF644 Gene

Gene Tree for ZNF644 (if available)
Gene Tree for ZNF644 (if available)

Paralogs for ZNF644 Gene

Paralogs for ZNF644 Gene

genes like me logo Genes that share paralogs with ZNF644: view

Variants for ZNF644 Gene

Sequence variations from dbSNP and Humsavar for ZNF644 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13368 -- 90,915,589(+) AAAAA(A/T)TTTTA utr-variant-3-prime
rs100694 -- 90,982,628(-) TTTTT(A/T)AAAAA intron-variant
rs165156 -- 91,017,180(+) AGATA(C/T)ACATA intron-variant
rs165157 -- 91,017,269(+) TTAAG(C/T)TTCAA intron-variant
rs165158 -- 91,018,085(+) GGGAA(C/G)TTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF644 Gene

Variant ID Type Subtype PubMed ID
nsv159370 CNV Loss 16902084

Relevant External Links for ZNF644 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF644 Gene

Disorders for ZNF644 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ZNF644 Gene including...

Search for ZNF644 Gene in MalaCards »

(1) OMIM Diseases for ZNF644 Gene (614159)


  • Myopia 21, autosomal dominant (MYP21) [MIM:614167]: A refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far. {ECO:0000269 PubMed:21695231}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for ZNF644 Gene

genes like me logo Genes that share disorders with ZNF644: view

Publications for ZNF644 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Exome sequencing identifies ZNF644 mutations in high myopia. (PMID: 21695231) Shi Y. … Yang Z. (PLoS Genet. 2011) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ZNF644 Gene

Sources for ZNF644 Gene

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