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Aliases for EEA1 Gene

Aliases for EEA1 Gene

  • Early Endosome Antigen 1 2 3
  • Zinc Finger FYVE Domain-Containing Protein 2 3 4
  • Endosome-Associated Protein P162 3 4
  • Early Endosome Antigen 1, 162kD 2 3
  • ZFYVE2 3 4
  • Early Endosome-Associated Protein 3
  • MSTP105 3
  • MST105 3

External Ids for EEA1 Gene

Previous GeneCards Identifiers for EEA1 Gene

  • GC12M092561
  • GC12M093628
  • GC12M093102
  • GC12M091671
  • GC12M091668
  • GC12M090233

Summaries for EEA1 Gene

GeneCards Summary for EEA1 Gene

EEA1 (Early Endosome Antigen 1) is a Protein Coding gene. Among its related pathways are Endocytosis and Cytoskeletal Signaling. GO annotations related to this gene include protein homodimerization activity and 1-phosphatidylinositol binding. An important paralog of this gene is FYCO1.

UniProtKB/Swiss-Prot for EEA1 Gene

  • Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEA1 Gene

Genomics for EEA1 Gene

Regulatory Elements for EEA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EEA1 Gene

Start:
92,770,637 bp from pter
End:
92,929,331 bp from pter
Size:
158,695 bases
Orientation:
Minus strand

Genomic View for EEA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EEA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEA1 Gene

Proteins for EEA1 Gene

  • Protein details for EEA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15075-EEA1_HUMAN
    Recommended name:
    Early endosome antigen 1
    Protein Accession:
    Q15075
    Secondary Accessions:
    • Q14221

    Protein attributes for EEA1 Gene

    Size:
    1411 amino acids
    Molecular mass:
    162466 Da
    Quaternary structure:
    • Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding. Interacts with RAB31. Interacts with ERBB2. May interact with PLEKHF2.
    Miscellaneous:
    • Antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus and other autoimmune diseases

    Three dimensional structures from OCA and Proteopedia for EEA1 Gene

neXtProt entry for EEA1 Gene

Proteomics data for EEA1 Gene at MOPED

Post-translational modifications for EEA1 Gene

  • Ubiquitination at Lys58
  • Modification sites at PhosphoSitePlus

Other Protein References for EEA1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EEA1 (EEA1)

No data available for DME Specific Peptides for EEA1 Gene

Domains for EEA1 Gene

Gene Families for EEA1 Gene

HGNC:
  • ZFYVE :Zinc fingers, FYVE domain containing

Protein Domains for EEA1 Gene

Suggested Antigen Peptide Sequences for EEA1 Gene

Graphical View of Domain Structure for InterPro Entry

Q15075

UniProtKB/Swiss-Prot:

EEA1_HUMAN :
  • Q15075
Domain:
  • The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions.
Similarity:
  • Contains 1 C2H2-type zinc finger.
  • Contains 1 FYVE-type zinc finger.
genes like me logo Genes that share domains with EEA1: view

Function for EEA1 Gene

Molecular function for EEA1 Gene

UniProtKB/Swiss-Prot Function: Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking

Gene Ontology (GO) - Molecular Function for EEA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10491193
GO:0005516 calmodulin binding NAS 11741531
GO:0005545 1-phosphatidylinositol binding IDA 11256955
GO:0008270 zinc ion binding TAS 11741531
GO:0030742 GTP-dependent protein binding IDA 10491193
genes like me logo Genes that share ontologies with EEA1: view

Phenotypes for EEA1 Gene

GenomeRNAi human phenotypes for EEA1:
genes like me logo Genes that share phenotypes with EEA1: view

Animal Model Products

CRISPR Products

miRNA for EEA1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EEA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EEA1 Gene

Localization for EEA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EEA1 Gene

Cytoplasm. Early endosome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EEA1 Gene COMPARTMENTS Subcellular localization image for EEA1 gene
Compartment Confidence
cytosol 5
endosome 5
plasma membrane 5
lysosome 3
nucleus 3
vacuole 3
cytoskeleton 2
golgi apparatus 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for EEA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 7768953
GO:0005768 endosome --
GO:0005769 early endosome IDA 11741531
GO:0005829 cytosol IDA 7768953
GO:0005969 serine-pyruvate aminotransferase complex IEA --
genes like me logo Genes that share ontologies with EEA1: view

Pathways for EEA1 Gene

genes like me logo Genes that share pathways with EEA1: view

Pathways by source for EEA1 Gene

1 Cell Signaling Technology pathway for EEA1 Gene
1 Reactome pathway for EEA1 Gene

Gene Ontology (GO) - Biological Process for EEA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IMP 21081650
GO:0006906 vesicle fusion IMP 9697774
GO:0016189 synaptic vesicle to endosome fusion TAS 11741531
GO:0045022 early endosome to late endosome transport NAS 7768953
genes like me logo Genes that share ontologies with EEA1: view

Compounds for EEA1 Gene

(1) HMDB Compounds for EEA1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(1) Drugbank Compounds for EEA1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Inositol 1,3-Bisphosphate
target

(14) Novoseek inferred chemical compound relationships for EEA1 Gene

Compound -log(P) Hits PubMed IDs
phosphatidylinositol 3-phosphate 92 21
ptdins(3)p 83.4 15
wortmannin 62.7 2
phosphatidylinositol 58.5 8
phosphoinositide 50.2 1
genes like me logo Genes that share compounds with EEA1: view

Transcripts for EEA1 Gene

Unigene Clusters for EEA1 Gene

Early endosome antigen 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EEA1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for EEA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EEA1 Gene

No ASD Table

Relevant External Links for EEA1 Gene

GeneLoc Exon Structure for
EEA1
ECgene alternative splicing isoforms for
EEA1

Expression for EEA1 Gene

mRNA expression in normal human tissues for EEA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EEA1 Gene

SOURCE GeneReport for Unigene cluster for EEA1 Gene Hs.567367

genes like me logo Genes that share expressions with EEA1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EEA1 Gene

Orthologs for EEA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for EEA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EEA1 35
  • 99.74 (n)
  • 99.65 (a)
EEA1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EEA1 35
  • 91.02 (n)
  • 91.63 (a)
EEA1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EEA1 35
  • 91.44 (n)
  • 91.53 (a)
EEA1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eea1 35
  • 84.53 (n)
  • 85.97 (a)
Eea1 16
Eea1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EEA1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EEA1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eea1 35
  • 84.9 (n)
  • 85.54 (a)
chicken
(Gallus gallus)
Aves EEA1 35
  • 74.69 (n)
  • 76.01 (a)
EEA1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EEA1 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eea1 35
  • 67.29 (n)
  • 66.52 (a)
zebrafish
(Danio rerio)
Actinopterygii eea1 36
  • 58 (a)
OneToOne
LOC562943 35
  • 60.46 (n)
  • 58.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3493 37
  • 20 (a)
worm
(Caenorhabditis elegans)
Secernentea eea-1 36
  • 21 (a)
OneToOne
R07G3.3a 37
  • 20 (a)
C02F12.7 37
  • 22 (a)
T10G3.5 37
  • 21 (a)
hcp-2 37
  • 20 (a)
R07G3.3b 37
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToOne
Species with no ortholog for EEA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEA1 Gene

ENSEMBL:
Gene Tree for EEA1 (if available)
TreeFam:
Gene Tree for EEA1 (if available)

Paralogs for EEA1 Gene

Paralogs for EEA1 Gene

genes like me logo Genes that share paralogs with EEA1: view

Variants for EEA1 Gene

Sequence variations from dbSNP and Humsavar for EEA1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs731799 -- 92,858,127(+) AAGGG(A/C)ACATT intron-variant
rs813778 -- 92,804,405(+) catct(C/T)tacta intron-variant
rs924325 -- 92,811,868(-) ATTTT(A/T)TTTTT intron-variant
rs924327 -- 92,854,954(+) TTCTC(C/T)CCCTT intron-variant
rs924328 -- 92,857,732(+) ACTGT(C/T)AAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EEA1 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
nsv455691 CNV Gain 19166990
nsv899438 CNV Loss 21882294
nsv520865 CNV Loss 19592680
esv21874 CNV Loss 19812545
esv2665205 CNV Deletion 23128226

Relevant External Links for EEA1 Gene

HapMap Linkage Disequilibrium report
EEA1
Human Gene Mutation Database (HGMD)
EEA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEA1 Gene

Disorders for EEA1 Gene

(3) Novoseek inferred disease relationships for EEA1 Gene

Disease -log(P) Hits PubMed IDs
neurological disorders 30.1 4
wegeners granulomatosis 22 1
tuberculosis 0 1

Relevant External Links for EEA1

Genetic Association Database (GAD)
EEA1
Human Genome Epidemiology (HuGE) Navigator
EEA1
genes like me logo Genes that share disorders with EEA1: view

No data available for UniProtKB/Swiss-Prot for EEA1 Gene

Publications for EEA1 Gene

  1. EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. (PMID: 9697774) Simonsen A. … Stenmark H. (Nature 1998) 2 3 4 23
  2. Direct interaction of EEA1 with Rab5b. (PMID: 10491193) Callaghan J.M. … Stenmark H. (Eur. J. Biochem. 1999) 3 4 23
  3. The Rab5 effector EEA1 interacts directly with syntaxin-6. (PMID: 10506127) Simonsen A. … Stenmark H. (J. Biol. Chem. 1999) 3 4 23
  4. Structural mechanism of endosome docking by the FYVE domain. (PMID: 11230696) Kutateladze T.G. … Overduin M. (Science 2001) 3 4 23
  5. EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine 'fingers' and contains a calmodulin-binding IQ motif. (PMID: 7768953) Mu F.-T. … Toh B.-H. (J. Biol. Chem. 1995) 2 3 4

Products for EEA1 Gene

  • Addgene plasmids for EEA1

Sources for EEA1 Gene

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