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Aliases for SOX14 Gene

Aliases for SOX14 Gene

  • SRY (Sex Determining Region Y)-Box 14 2 3
  • HMG Box Transcription Factor SOX-14 2 3
  • SRY-Box 14 2 3
  • SOX28 3 4
  • Transcription Factor SOX-14 3
  • Protein SOX-28 4

External Ids for SOX14 Gene

Previous GeneCards Identifiers for SOX14 Gene

  • GC03P134468
  • GC03P138275
  • GC03P138765
  • GC03P138804
  • GC03P138966
  • GC03P137483
  • GC03P134858

Summaries for SOX14 Gene

Entrez Gene Summary for SOX14 Gene

  • This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene are suggested to be responsible for the limb defects associated with blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) and Mobius syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOX14 Gene

SOX14 (SRY (Sex Determining Region Y)-Box 14) is a Protein Coding gene. Among its related pathways are ERK Signaling. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is SOX3.

UniProtKB/Swiss-Prot for SOX14 Gene

  • Acts as a negative regulator of transcription.

Gene Wiki entry for SOX14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOX14 Gene

Genomics for SOX14 Gene

Regulatory Elements for SOX14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SOX14 Gene

137,764,284 bp from pter
137,766,338 bp from pter
2,055 bases
Plus strand

Genomic View for SOX14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SOX14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOX14 Gene

Proteins for SOX14 Gene

  • Protein details for SOX14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor SOX-14
    Protein Accession:
    Secondary Accessions:
    • B2RAC0
    • Q3KPH7

    Protein attributes for SOX14 Gene

    240 amino acids
    Molecular mass:
    26485 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SOX14 Gene

Proteomics data for SOX14 Gene at MOPED

Post-translational modifications for SOX14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOX14 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SOX14 Gene

Domains for SOX14 Gene

Gene Families for SOX14 Gene

  • SOX :SRY (sex determining region Y)-boxes

Protein Domains for SOX14 Gene


Suggested Antigen Peptide Sequences for SOX14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O95416
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with SOX14: view

Function for SOX14 Gene

Molecular function for SOX14 Gene

GENATLAS Biochemistry:
SRY related HMG box gene 14,predominantly expressed in fetal brain,spinal cord,thymus,potentially involved in regulation of nervous system development,modulator of LINE retroposons promoter activity
UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of transcription.

Gene Ontology (GO) - Molecular Function for SOX14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IEA --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding ISS --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with SOX14: view

Phenotypes for SOX14 Gene

genes like me logo Genes that share phenotypes with SOX14: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SOX14 Gene

Localization for SOX14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOX14 Gene

Subcellular locations from

Jensen Localization Image for SOX14 Gene COMPARTMENTS Subcellular localization image for SOX14 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for SOX14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0044798 nuclear transcription factor complex IEA --
genes like me logo Genes that share ontologies with SOX14: view

Pathways for SOX14 Gene

SuperPathways for SOX14 Gene

Superpath Contained pathways
1 ERK Signaling
genes like me logo Genes that share pathways with SOX14: view

Pathways by source for SOX14 Gene

1 Qiagen pathway for SOX14 Gene

Interacting Proteins for SOX14 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000305343 O95416-SOX14_HUMAN for SOX14 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for SOX14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007399 nervous system development TAS 9925951
GO:0007601 visual perception IEA --
GO:0009649 entrainment of circadian clock IEA --
genes like me logo Genes that share ontologies with SOX14: view

Transcripts for SOX14 Gene

mRNA/cDNA for SOX14 Gene

(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOX14 Gene

SRY (sex determining region Y)-box 14:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SOX14

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOX14 Gene

No ASD Table

Relevant External Links for SOX14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SOX14 Gene

mRNA expression in normal human tissues for SOX14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOX14 Gene

This gene is overexpressed in Brain - Hypothalamus (23.7), Brain - Substantia nigra (14.9), and Prostate (8.2).

Protein differential expression in normal tissues for SOX14 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SOX14 Gene

SOURCE GeneReport for Unigene cluster for SOX14 Gene Hs.248184

genes like me logo Genes that share expressions with SOX14: view

Expression partners for SOX14 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SOX14 Gene

Orthologs for SOX14 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOX14 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SOX14 35
  • 96.67 (n)
  • 100 (a)
(Canis familiaris)
Mammalia SOX14 35
  • 96.25 (n)
  • 100 (a)
(Mus musculus)
Mammalia Sox14 35
  • 95.42 (n)
  • 99.58 (a)
Sox14 16
Sox14 36
  • 100 (a)
(Pan troglodytes)
Mammalia SOX14 35
  • 99.72 (n)
  • 100 (a)
(Rattus norvegicus)
Mammalia Sox14 35
  • 95.42 (n)
  • 99.58 (a)
(Monodelphis domestica)
Mammalia SOX14 36
  • 95 (a)
(Gallus gallus)
Aves SOX14 35
  • 84.44 (n)
  • 96.25 (a)
SOX14 36
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sox14 35
  • 77.13 (n)
  • 89.12 (a)
(Danio rerio)
Actinopterygii -- 35
sox14 35
  • 77.73 (n)
  • 91.18 (a)
sox14 36
  • 91 (a)
fruit fly
(Drosophila melanogaster)
Insecta D 37
  • 87 (a)
Sox21a 37
  • 90 (a)
Sox21b 37
  • 88 (a)
Sox21a 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea sox-3 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for SOX14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOX14 Gene

Gene Tree for SOX14 (if available)
Gene Tree for SOX14 (if available)

Paralogs for SOX14 Gene

Selected SIMAP similar genes for SOX14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SOX14: view

Variants for SOX14 Gene

Sequence variations from dbSNP and Humsavar for SOX14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs149863 -- 137,763,521(+) ATAAC(A/G)TAAAT upstream-variant-2KB
rs157281 -- 137,763,401(+) CCGCT(C/G)TAGGG upstream-variant-2KB
rs201718 -- 137,764,520(+) CTGGT(G/T)CCTGA utr-variant-5-prime
rs2016242 -- 137,766,653(-) TCGGC(C/T)TTTGA downstream-variant-500B
rs11717337 -- 137,762,668(+) CGCAG(A/G)ATCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SOX14 Gene

Variant ID Type Subtype PubMed ID
nsv428422 CNV Gain+Loss 18775914

Relevant External Links for SOX14 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOX14 Gene

Disorders for SOX14 Gene

Relevant External Links for SOX14

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SOX14: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for SOX14 Gene

Publications for SOX14 Gene

  1. Characterisation and mapping of the human SOX14 gene. (PMID: 9925951) Arsic N. … Stevanovic M. (Cytogenet. Cell Genet. 1998) 2 3 4
  2. Fine mapping of the neurally expressed gene SOX14 to human 3q23, relative to three congenital diseases. (PMID: 10830911) Hargrave M. … Koopman P. (Hum. Genet. 2000) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3. (PMID: 10441749) Malas S. … Episkopou V. (Mamm. Genome 1999) 3 4
  5. Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT. (PMID: 20797317) Kim H.Y. … Kim H. (BMB Rep 2010) 3 48

Products for SOX14 Gene

Sources for SOX14 Gene

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