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Aliases for SLC25A11 Gene

Aliases for SLC25A11 Gene

  • Solute Carrier Family 25 (Mitochondrial Carrier; Oxoglutarate Carrier), Member 11 2 3
  • Solute Carrier Family 25 Member 11 3 4
  • SLC20A4 3 4
  • OGCP 3 4
  • Solute Carrier Family 20 (Oxoglutarate Carrier), Member 4 3
  • Mitochondrial 2-Oxoglutarate/Malate Carrier Protein 3
  • Oxoglutarate Carrier) 6
  • Member 11 6
  • OGC 3

External Ids for SLC25A11 Gene

Previous Symbols for SLC25A11 Gene

  • SLC20A4

Summaries for SLC25A11 Gene

Entrez Gene Summary for SLC25A11 Gene

  • The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992 [PubMed 1457818]).[supplied by OMIM, Jan 2011]

GeneCards Summary for SLC25A11 Gene

SLC25A11 (Solute Carrier Family 25 (Mitochondrial Carrier; Oxoglutarate Carrier), Member 11) is a Protein Coding gene. Among its related pathways are Metabolism and MPS VI - Maroteaux-Lamy syndrome. GO annotations related to this gene include oxoglutarate:malate antiporter activity. An important paralog of this gene is SLC25A30.

UniProtKB/Swiss-Prot for SLC25A11 Gene

  • Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism

Gene Wiki entry for SLC25A11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A11 Gene

Genomics for SLC25A11 Gene

Genomic Location for SLC25A11 Gene

Start:
4,937,130 bp from pter
End:
4,940,251 bp from pter
Size:
3,122 bases
Orientation:
Minus strand

Genomic View for SLC25A11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A11 Gene

Regulatory Elements for SLC25A11 Gene

Proteins for SLC25A11 Gene

  • Protein details for SLC25A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02978-M2OM_HUMAN
    Recommended name:
    Mitochondrial 2-oxoglutarate/malate carrier protein
    Protein Accession:
    Q02978
    Secondary Accessions:
    • F5GY65
    • O75537
    • Q969P7

    Protein attributes for SLC25A11 Gene

    Size:
    314 amino acids
    Molecular mass:
    34062 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A11 Gene

Proteomics data for SLC25A11 Gene at MOPED

Post-translational modifications for SLC25A11 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys15, Lys57, Lys62, Lys73, and Lys162

Other Protein References for SLC25A11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A11 Gene

Domains for SLC25A11 Gene

Gene Families for SLC25A11 Gene

Protein Domains for SLC25A11 Gene

UniProtKB/Swiss-Prot:

M2OM_HUMAN
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.:
    • Q02978
Similarity:
  • Contains 3 Solcar repeats.:
    • Q02978
genes like me logo Genes that share domains with SLC25A11: view

Function for SLC25A11 Gene

Molecular function for SLC25A11 Gene

GENATLAS Biochemistry: solute carrier family 25 mitochondrial member 11,inner mitochondrial membrane,catalyzing the transport of 2-oxoglutarate for malate and other dicarboxylic acids,involved in malate-aspartate shuttle,oxoglutarate-isocitrate shuttle,gluco neogenesis and nitrogen metabolism
UniProtKB/Swiss-Prot Function: Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism

Gene Ontology (GO) - Molecular Function for SLC25A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015367 oxoglutarate:malate antiporter activity TAS --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with SLC25A11: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC25A11 Gene

Localization for SLC25A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A11 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A11 Gene COMPARTMENTS Subcellular localization image for SLC25A11 gene
Compartment Confidence
mitochondrion 5
plasma membrane 4
cytosol 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC25A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA 20833797
GO:0005743 mitochondrial inner membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1457818
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC25A11: view

Pathways for SLC25A11 Gene

genes like me logo Genes that share pathways with SLC25A11: view

Pathways by source for SLC25A11 Gene

Gene Ontology (GO) - Biological Process for SLC25A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006006 glucose metabolic process TAS --
GO:0006094 gluconeogenesis TAS --
GO:0006810 transport TAS 1457818
GO:0015742 alpha-ketoglutarate transport TAS 1457818
genes like me logo Genes that share ontologies with SLC25A11: view

Compounds for SLC25A11 Gene

(1) HMDB Compounds for SLC25A11 Gene

Compound Synonyms Cas Number PubMed IDs
Oxoglutaric acid
  • 2-Ketoglutarate
328-50-7

(1) Novoseek inferred chemical compound relationships for SLC25A11 Gene

Compound -log(P) Hits PubMed IDs
alpha-ketoglutarate 82.7 8
genes like me logo Genes that share compounds with SLC25A11: view

Transcripts for SLC25A11 Gene

Unigene Clusters for SLC25A11 Gene

Solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for SLC25A11 Gene

GeneLoc Exon Structure for
SLC25A11
ECgene alternative splicing isoforms for
SLC25A11

Expression for SLC25A11 Gene

mRNA expression in normal human tissues for SLC25A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A11 Gene

SOURCE GeneReport for Unigene cluster for SLC25A11 Gene Hs.184877

genes like me logo Genes that share expressions with SLC25A11: view

Orthologs for SLC25A11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A11 36
  • 99.68 (n)
  • 100 (a)
SLC25A11 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC25A11 36
  • 92.25 (n)
  • 96.18 (a)
SLC25A11 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A11 36
  • 91.61 (n)
  • 97.13 (a)
SLC25A11 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a11 36
  • 90.32 (n)
  • 97.03 (a)
Slc25a11 16
Slc25a11 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC25A11 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A11 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a11 36
  • 89.33 (n)
  • 97.02 (a)
lizard
(Anolis carolinensis)
Reptilia SLC25A11 37
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13480 36
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a11 36
  • 78.18 (n)
  • 89.7 (a)
Str.8212 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11128 36
zebrafish
(Danio rerio)
Actinopterygii slc25a11 36
  • 73.8 (n)
  • 88.63 (a)
slc25a11 37
  • 87 (a)
OneToOne
wufa07h09 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012097 36
  • 63.6 (n)
  • 62.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18418 37
  • 52 (a)
OneToMany
CG1907 36
  • 62.98 (n)
  • 59.4 (a)
CG1907 37
  • 56 (a)
OneToMany
CG7514 37
  • 53 (a)
OneToMany
CG18418 38
  • 54 (a)
CG1907 38
  • 59 (a)
CG7514 38
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea misc-1 36
  • 63.05 (n)
  • 73.08 (a)
misc-1 37
  • 69 (a)
OneToOne
B0432.4 38
  • 72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIC1 37
  • 37 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G19760 36
  • 51.02 (n)
  • 46.57 (a)
rice
(Oryza sativa)
Liliopsida Os11g0432400 36
  • 52.65 (n)
  • 49.12 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU10732 36
  • 50.66 (n)
  • 40.86 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.987 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7200 37
  • 75 (a)
OneToOne
Species with no ortholog for SLC25A11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A11 Gene

ENSEMBL:
Gene Tree for SLC25A11 (if available)
TreeFam:
Gene Tree for SLC25A11 (if available)

Paralogs for SLC25A11 Gene

Selected SIMAP similar genes for SLC25A11 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC25A11: view

Variants for SLC25A11 Gene

Sequence variations from dbSNP and Humsavar for SLC25A11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs400688 -- 4,936,635(+) TACAC(A/G)GAGGC downstream-variant-500B
rs1060431 -- 4,937,573(-) CTGCT(C/T)GTCCT utr-variant-3-prime
rs2243107 -- 4,937,082(+) GCATC(A/G)GTGGC downstream-variant-500B
rs3213653 -- 4,937,169(+) ATGAC(A/C)GATTT utr-variant-3-prime
rs3216966 -- 4,937,514(+) CTCAG(-/G)AAGTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC25A11 Gene

Variant ID Type Subtype PubMed ID
nsv833347 CNV Loss 17160897
nsv833349 CNV Loss 17160897
nsv907619 CNV Loss 21882294
nsv907620 CNV Loss 21882294
nsv833350 CNV Loss 17160897
nsv907621 CNV Loss 21882294

Relevant External Links for SLC25A11 Gene

HapMap Linkage Disequilibrium report
SLC25A11

Disorders for SLC25A11 Gene

(1) University of Copenhagen DISEASES for SLC25A11 Gene

Relevant External Links for SLC25A11

Genetic Association Database (GAD)
SLC25A11
Human Genome Epidemiology (HuGE) Navigator
SLC25A11
genes like me logo Genes that share disorders with SLC25A11: view

No data available for UniProtKB/Swiss-Prot for SLC25A11 Gene

Publications for SLC25A11 Gene

  1. Assignment of the oxoglutarate carrier gene (SLC20A4) to human chromosome 17p13.3. (PMID: 10072597) Piccininni S. … Palmieri F. (Cytogenet. Cell Genet. 1998) 2 3 23
  2. Sequences of the human and bovine genes for the mitochondrial 2- oxoglutarate carrier. (PMID: 1457818) Iacobazzi V. … Walker J.E. (DNA Seq. 1992) 2 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  4. The formation of a disulfide cross-link between the two subunits demonstrates the dimeric structure of the mitochondrial oxoglutarate carrier. (PMID: 8597574) Bisaccia F. … Palmieri F. (Biochim. Biophys. Acta 1996) 3 23
  5. Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier. (PMID: 16920706) Kabe Y. … Handa H. (J. Biol. Chem. 2006) 3 23

Products for SLC25A11 Gene

Sources for SLC25A11 Gene

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