Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC25A11 Gene

Aliases for SLC25A11 Gene

  • Solute Carrier Family 25 Member 11 2 3 4 5
  • Solute Carrier Family 25 (Mitochondrial Carrier; Oxoglutarate Carrier), Member 11 2 3
  • SLC20A4 3 4
  • OGCP 3 4
  • Solute Carrier Family 20 (Oxoglutarate Carrier), Member 4 3
  • Mitochondrial 2-Oxoglutarate/Malate Carrier Protein 3
  • OGC 3

External Ids for SLC25A11 Gene

Previous HGNC Symbols for SLC25A11 Gene

  • SLC20A4

Previous GeneCards Identifiers for SLC25A11 Gene

  • GC17M005260
  • GC17M004785
  • GC17M005041
  • GC17M004782
  • GC17M004840

Summaries for SLC25A11 Gene

Entrez Gene Summary for SLC25A11 Gene

  • The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992 [PubMed 1457818]).[supplied by OMIM, Jan 2011]

GeneCards Summary for SLC25A11 Gene

SLC25A11 (Solute Carrier Family 25 Member 11) is a Protein Coding gene. Diseases associated with SLC25A11 include Breast Leiomyosarcoma and Oculogyric Crisis. Among its related pathways are Metabolism and Glucose metabolism. GO annotations related to this gene include poly(A) RNA binding and oxoglutarate:malate antiporter activity. An important paralog of this gene is ENSG00000262660.

UniProtKB/Swiss-Prot for SLC25A11 Gene

  • Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.

Gene Wiki entry for SLC25A11 Gene

Additional gene information for SLC25A11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A11 Gene

Genomics for SLC25A11 Gene

Regulatory Elements for SLC25A11 Gene

Enhancers for SLC25A11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H004965 1.4 ENCODE dbSUPER 12.3 -28.4 -28366 5.4 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 SPAG7 ZNF232 NUP88 INCA1 CHRNE KIF1C MIS12 CAMTA2 RNF167 SLC25A11
GH17H004852 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +86.6 86616 3.3 NFIA NFIB CBFB ZIC2 ZFHX2 NFIC POLR2A KLF16 ZNF547 EED CHRNE MINK1 PLD2 ZMYND15 CXCL16 RNF167 SLC25A11 SPAG7 ENO3 PFN1
GH17H004856 1.4 Ensembl ENCODE dbSUPER 10.8 +81.5 81476 5.3 ELF3 ZBTB40 RAD21 ETS1 EGR1 FOS MIXL1 THAP11 EGR2 SP5 CHRNE C17orf107 ZFP3 MINK1 PLD2 ARRB2 LOC101559451 PELP1 RPS12P29 ZMYND15
GH17H004996 1.1 ENCODE 11.8 -58.6 -58596 4.2 HDGF MLX ARID4B SIN3A DMAP1 YBX1 YY1 ZNF766 GLIS2 ELK1 NUP88 CHRNE ZNF232 MIS12 ZZEF1 CAMTA2 DERL2 ENSG00000234203 SPAG7 RNF167
GH17H004837 1.1 ENCODE dbSUPER 10.5 +101.1 101143 3.9 HDAC1 TBP HDGF PKNOX1 TBL1XR1 ARNT ZSCAN4 ZBTB40 TCF12 GATA2 CHRNE ENO3 SPAG7 PLD2 GLTPD2 VMO1 ZMYND15 CXCL16 ENSG00000234203 PFN1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A11 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SLC25A11 Gene

Genomic Locations for SLC25A11 Gene
chr17:4,937,130-4,940,251
(GRCh38/hg38)
Size:
3,122 bases
Orientation:
Minus strand
chr17:4,840,425-4,843,546
(GRCh37/hg19)

Genomic View for SLC25A11 Gene

Genes around SLC25A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A11 Gene

Proteins for SLC25A11 Gene

  • Protein details for SLC25A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02978-M2OM_HUMAN
    Recommended name:
    Mitochondrial 2-oxoglutarate/malate carrier protein
    Protein Accession:
    Q02978
    Secondary Accessions:
    • F5GY65
    • O75537
    • Q969P7

    Protein attributes for SLC25A11 Gene

    Size:
    314 amino acids
    Molecular mass:
    34062 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A11 Gene

Post-translational modifications for SLC25A11 Gene

  • Ubiquitination at Lys57, isoforms=62, Lys73, and isoforms=2162
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC25A11 Gene

No data available for DME Specific Peptides for SLC25A11 Gene

Domains & Families for SLC25A11 Gene

Gene Families for SLC25A11 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC25A11 Gene

Graphical View of Domain Structure for InterPro Entry

Q02978

UniProtKB/Swiss-Prot:

M2OM_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A11: view

Function for SLC25A11 Gene

Molecular function for SLC25A11 Gene

GENATLAS Biochemistry:
solute carrier family 25 mitochondrial member 11,inner mitochondrial membrane,catalyzing the transport of 2-oxoglutarate for malate and other dicarboxylic acids,involved in malate-aspartate shuttle,oxoglutarate-isocitrate shuttle,gluco neogenesis and nitrogen metabolism
UniProtKB/Swiss-Prot Function:
Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.

Phenotypes From GWAS Catalog for SLC25A11 Gene

Gene Ontology (GO) - Molecular Function for SLC25A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0015367 oxoglutarate:malate antiporter activity TAS --
genes like me logo Genes that share ontologies with SLC25A11: view
genes like me logo Genes that share phenotypes with SLC25A11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A11 Gene

Localization for SLC25A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A11 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A11 gene
Compartment Confidence
mitochondrion 5
nucleus 5
plasma membrane 4
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC25A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA,IEA 20833797
GO:0005743 mitochondrial inner membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1457818
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC25A11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC25A11 Gene

Pathways & Interactions for SLC25A11 Gene

genes like me logo Genes that share pathways with SLC25A11: view

Pathways by source for SLC25A11 Gene

Gene Ontology (GO) - Biological Process for SLC25A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006094 gluconeogenesis TAS --
GO:0006810 transport IEA,TAS 1457818
GO:0006839 mitochondrial transport IBA --
GO:0015742 alpha-ketoglutarate transport IEA --
genes like me logo Genes that share ontologies with SLC25A11: view

No data available for SIGNOR curated interactions for SLC25A11 Gene

Drugs & Compounds for SLC25A11 Gene

(2) Additional Compounds for SLC25A11 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Oxoglutaric acid
  • 2-Ketoglutarate
  • 2-Ketoglutaric acid
  • 2-Oxo-1,5-pentanedioate
  • 2-Oxo-1,5-pentanedioic acid
  • 2-Oxoglutarate
328-50-7
genes like me logo Genes that share compounds with SLC25A11: view

Transcripts for SLC25A11 Gene

Unigene Clusters for SLC25A11 Gene

Solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for SLC25A11 Gene

GeneLoc Exon Structure for
SLC25A11
ECgene alternative splicing isoforms for
SLC25A11

Expression for SLC25A11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A11 Gene

This gene is overexpressed in Nasal epithelium (19.5) and Heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A11 Gene



Protein tissue co-expression partners for SLC25A11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC25A11 Gene:

SLC25A11

SOURCE GeneReport for Unigene cluster for SLC25A11 Gene:

Hs.184877

Evidence on tissue expression from TISSUES for SLC25A11 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Muscle(4.4)
  • Lung(2.3)
  • Intestine(2.2)
  • Kidney(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with SLC25A11: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A11 Gene

Orthologs for SLC25A11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A11 33 34
  • 99.68 (n)
cow
(Bos Taurus)
Mammalia SLC25A11 33 34
  • 92.25 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A11 34
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A11 34
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A11 33 34
  • 91.61 (n)
mouse
(Mus musculus)
Mammalia Slc25a11 33 16 34
  • 90.32 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a11 33
  • 89.33 (n)
lizard
(Anolis carolinensis)
Reptilia SLC25A11 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a11 33
  • 78.18 (n)
Str.8212 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.13480 33
zebrafish
(Danio rerio)
Actinopterygii slc25a11 33 34
  • 73.8 (n)
wufa07h09 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11128 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012097 33
  • 63.6 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1907 35 33 34
  • 62.98 (n)
CG18418 35 34
  • 54 (a)
CG7514 35 34
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea B0432.4 35
  • 72 (a)
misc-1 33 34
  • 63.05 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIC1 34
  • 37 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G19760 33
  • 51.02 (n)
rice
(Oryza sativa)
Liliopsida Os11g0432400 33
  • 52.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7200 34
  • 75 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU10732 33
  • 50.66 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.987 33
Species where no ortholog for SLC25A11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A11 Gene

ENSEMBL:
Gene Tree for SLC25A11 (if available)
TreeFam:
Gene Tree for SLC25A11 (if available)

Paralogs for SLC25A11 Gene

(11) SIMAP similar genes for SLC25A11 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC25A11: view

Variants for SLC25A11 Gene

Sequence variations from dbSNP and Humsavar for SLC25A11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000580299 -- 4,937,142(+) TTTTC(C/T)GGCCC utr-variant-3-prime
rs1001333628 -- 4,939,520(+) GACTC(C/T)AGGTA intron-variant, upstream-variant-2KB
rs1001935294 -- 4,940,684(+) ACCAG(A/G)AAAGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1002984190 -- 4,941,730(+) TGGCC(A/G)ACATG intron-variant, upstream-variant-2KB
rs1003134444 -- 4,937,351(+) GAGGG(A/G)GAGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC25A11 Gene

Variant ID Type Subtype PubMed ID
nsv833350 CNV loss 17160897
nsv833349 CNV loss 17160897
nsv833347 CNV loss 17160897
nsv574275 CNV gain 21841781
nsv574273 CNV gain 21841781
esv3572365 CNV gain 25503493
dgv3088n100 CNV gain 25217958

Variation tolerance for SLC25A11 Gene

Residual Variation Intolerance Score: 16.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A11 Gene

Disorders for SLC25A11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC25A11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
breast leiomyosarcoma
  • leiomyosarcoma of the breast
oculogyric crisis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC25A11

Genetic Association Database (GAD)
SLC25A11
Human Genome Epidemiology (HuGE) Navigator
SLC25A11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A11
genes like me logo Genes that share disorders with SLC25A11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A11 Gene

Publications for SLC25A11 Gene

  1. Assignment of the oxoglutarate carrier gene (SLC20A4) to human chromosome 17p13.3. (PMID: 10072597) Piccininni S … Palmieri F (Cytogenetics and cell genetics 1998) 2 3 22 60
  2. Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier. (PMID: 1457818) Iacobazzi V … Walker JE (DNA sequence : the journal of DNA sequencing and mapping 1992) 2 3 4 60
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  5. Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier. (PMID: 16920706) Kabe Y … Handa H (The Journal of biological chemistry 2006) 3 22 60

Products for SLC25A11 Gene

Sources for SLC25A11 Gene

Content
Loading form....