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Aliases for CASP7 Gene

Aliases for CASP7 Gene

  • Caspase 7 2 3 5
  • Caspase 7, Apoptosis-Related Cysteine Peptidase 2 3
  • Caspase 7, Apoptosis-Related Cysteine Protease 2 3
  • ICE-Like Apoptotic Protease 3 3 4
  • ICE-LAP3 3 4
  • CASP-7 3 4
  • CMH-1 3 4
  • MCH3 3 4
  • Apoptotic Protease MCH-3 3
  • Apoptotic Protease Mch-3 4
  • EC 3.4.22.60 4
  • EC 3.4.22 63
  • LICE2 3

External Ids for CASP7 Gene

Previous GeneCards Identifiers for CASP7 Gene

  • GC10P114346
  • GC10P114672
  • GC10P115570
  • GC10P115103
  • GC10P115428
  • GC10P109065

Summaries for CASP7 Gene

Entrez Gene Summary for CASP7 Gene

  • This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for CASP7 Gene

CASP7 (Caspase 7) is a Protein Coding gene. Diseases associated with CASP7 include breast adenocarcinoma and colorectal cancer. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include cysteine-type endopeptidase activity and aspartic-type endopeptidase activity. An important paralog of this gene is CASP1.

UniProtKB/Swiss-Prot for CASP7 Gene

  • Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a 216-Asp- -Gly-217 bond. Overexpression promotes programmed cell death.

Tocris Summary for CASP7 Gene

  • Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules.

Gene Wiki entry for CASP7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASP7 Gene

Genomics for CASP7 Gene

Regulatory Elements for CASP7 Gene

Promoters for CASP7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CASP7 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CASP7 gene promoter:

Genomic Location for CASP7 Gene

Chromosome:
10
Start:
113,679,162 bp from pter
End:
113,730,909 bp from pter
Size:
51,748 bases
Orientation:
Plus strand

Genomic View for CASP7 Gene

Genes around CASP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASP7 Gene

Proteins for CASP7 Gene

  • Protein details for CASP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55210-CASP7_HUMAN
    Recommended name:
    Caspase-7
    Protein Accession:
    P55210
    Secondary Accessions:
    • B4DQU7
    • B5BU45
    • D3DRB8
    • Q13364
    • Q53YD5
    • Q5SVL0
    • Q5SVL3
    • Q96BA0

    Protein attributes for CASP7 Gene

    Size:
    303 amino acids
    Molecular mass:
    34277 Da
    Quaternary structure:
    • Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce.

    Three dimensional structures from OCA and Proteopedia for CASP7 Gene

    Alternative splice isoforms for CASP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CASP7 Gene

Proteomics data for CASP7 Gene at MOPED

Selected DME Specific Peptides for CASP7 Gene

Post-translational modifications for CASP7 Gene

  • Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CASP7 Gene

Gene Families for CASP7 Gene

HGNC:
IUPHAR :

Suggested Antigen Peptide Sequences for CASP7 Gene

Graphical View of Domain Structure for InterPro Entry

P55210

UniProtKB/Swiss-Prot:

CASP7_HUMAN :
  • Belongs to the peptidase C14A family.
Family:
  • Belongs to the peptidase C14A family.
genes like me logo Genes that share domains with CASP7: view

Function for CASP7 Gene

Molecular function for CASP7 Gene

GENATLAS Biochemistry:
caspase 7,effector,cysteine containing aspartate-specific protease,CASP3 subfamily,stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli,promoting apoptosis,H3,isoform alpha,interacting with calpain during B cell clonal deletion by apoptosis
UniProtKB/Swiss-Prot CatalyticActivity:
Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp- -.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by isatin sulfonamides.
UniProtKB/Swiss-Prot Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a 216-Asp- -Gly-217 bond. Overexpression promotes programmed cell death.

Enzyme Numbers (IUBMB) for CASP7 Gene

Gene Ontology (GO) - Molecular Function for CASP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IEA,TAS --
GO:0008234 cysteine-type peptidase activity IEA,TAS 8567622
genes like me logo Genes that share ontologies with CASP7: view
genes like me logo Genes that share phenotypes with CASP7: view

Animal Models for CASP7 Gene

MGI Knock Outs for CASP7:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CASP7 Gene

Localization for CASP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CASP7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CASP7 Gene COMPARTMENTS Subcellular localization image for CASP7 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 3
endoplasmic reticulum 2
extracellular 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CASP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8576161
genes like me logo Genes that share ontologies with CASP7: view

Pathways & Interactions for CASP7 Gene

genes like me logo Genes that share pathways with CASP7: view

SIGNOR curated interactions for CASP7 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CASP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IDA 12888622
GO:0006915 apoptotic process IEA,TAS 8567622
GO:0009411 response to UV IEA --
GO:0012501 programmed cell death TAS --
GO:0016485 protein processing IEA --
genes like me logo Genes that share ontologies with CASP7: view

Drugs & Compounds for CASP7 Gene

(45) Drugs for CASP7 Gene - From: Novoseek, ApexBio, DrugBank, PharmGKB, DGIdb, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1844
Paclitaxel Approved Pharma Tubulin and Bcl2 inhibitor, Taxanes 2621
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1881
Vinorelbine Approved, Investigational Pharma 352
Fica Experimental Pharma Target 0

(26) Additional Compounds for CASP7 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
MG 132
133407-82-6
Calpeptin
117591-20-5
N-Acetyl-L-leucyl-L-leucyl-L-methional
136632-32-1
PD 150606
179528-45-1

(5) Tocris Compounds for CASP7 Gene

Compound Action Cas Number
Calpeptin Calpain and cathepsin L inhibitor 117591-20-5
MDL 28170 Potent, selective calpain and cathepsin B inhibitor 88191-84-8
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation 133407-82-6
N-Acetyl-L-leucyl-L-leucyl-L-methional Cathepsin inhibitor 136632-32-1
PD 150606 Cell permeable calpain inhibitor 179528-45-1

(2) ApexBio Compounds for CASP7 Gene

Compound Action Cas Number
Caspase-3/7 Inhibitor I Caspase-3/7 inhibitor 220509-74-0
Z-VAD-FMK Cell-permeable, irreversible pan-caspase inhibitor 187389-52-2
genes like me logo Genes that share compounds with CASP7: view

Drug Products

Transcripts for CASP7 Gene

Unigene Clusters for CASP7 Gene

Caspase 7, apoptosis-related cysteine peptidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CASP7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1: - - - - - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - -
SP8: - -
SP9:

Relevant External Links for CASP7 Gene

GeneLoc Exon Structure for
CASP7
ECgene alternative splicing isoforms for
CASP7

Expression for CASP7 Gene

mRNA expression in normal human tissues for CASP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CASP7 Gene

This gene is overexpressed in Colon - Transverse (x4.1).

Protein differential expression in normal tissues from HIPED for CASP7 Gene

This gene is overexpressed in Skin (14.9) and Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CASP7 Gene



SOURCE GeneReport for Unigene cluster for CASP7 Gene Hs.9216

mRNA Expression by UniProt/SwissProt for CASP7 Gene

P55210-CASP7_HUMAN
Tissue specificity: Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.
genes like me logo Genes that share expression patterns with CASP7: view

Protein tissue co-expression partners for CASP7 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CASP7 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASP7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CASP7 35
  • 87.04 (n)
  • 89.37 (a)
CASP7 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CASP7 35
  • 86.38 (n)
  • 87.38 (a)
CASP7 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Casp7 35
  • 81.74 (n)
  • 82.18 (a)
Casp7 16
Casp7 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CASP7 35
  • 99.4 (n)
  • 99.7 (a)
CASP7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Casp7 35
  • 82.29 (n)
  • 85.15 (a)
oppossum
(Monodelphis domestica)
Mammalia CASP7 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CASP7 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves CASP7 35
  • 68.33 (n)
  • 73 (a)
CASP7 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CASP7 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia casp7 35
  • 67.49 (n)
  • 67.49 (a)
Str.16573 35
African clawed frog
(Xenopus laevis)
Amphibia xCaspase-7 35
zebrafish
(Danio rerio)
Actinopterygii casp7 35
  • 65.65 (n)
  • 68.03 (a)
casp7 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dcp-1 37
  • 44 (a)
decay 37
  • 32 (a)
Ice 37
  • 43 (a)
Dcp-1 35
  • 51.6 (n)
  • 46.44 (a)
Dcp-1 36
  • 34 (a)
ManyToMany
decay 36
  • 30 (a)
ManyToMany
Ice 36
  • 34 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta CASPS7 35
  • 50.93 (n)
  • 42.86 (a)
worm
(Caenorhabditis elegans)
Secernentea ced-3 37
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
Species with no ortholog for CASP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CASP7 Gene

ENSEMBL:
Gene Tree for CASP7 (if available)
TreeFam:
Gene Tree for CASP7 (if available)

Paralogs for CASP7 Gene

Paralogs for CASP7 Gene

genes like me logo Genes that share paralogs with CASP7: view

Variants for CASP7 Gene

Sequence variations from dbSNP and Humsavar for CASP7 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_048617 -
rs2227310 - 113,729,393(+) AAAGA(C/G)CTGGA reference, missense
rs1127684 -- 113,729,321(+) TACTC(A/G)TGGAG reference, synonymous-codon, missense
rs1127685 -- 113,729,871(+) GGTGG(C/T)AACAG utr-variant-3-prime
rs1127686 -- 113,729,880(+) AGTGG(C/T)AGAGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CASP7 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
esv2741073 CNV Deletion 23290073

Variation tolerance for CASP7 Gene

Residual Variation Intolerance Score: 77.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.24; 81.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CASP7 Gene

HapMap Linkage Disequilibrium report
CASP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASP7 Gene

Disorders for CASP7 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CASP7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast adenocarcinoma
  • adenocarcinoma of breast
colorectal cancer
  • colorectal cancer, somatic
pancreatic cancer
  • pancreatic carcinoma, somatic
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search CASP7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CASP7

Genetic Association Database (GAD)
CASP7
Human Genome Epidemiology (HuGE) Navigator
CASP7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CASP7
genes like me logo Genes that share disorders with CASP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CASP7 Gene

Publications for CASP7 Gene

  1. ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis. (PMID: 8576161) Duan H. … Dixit V.M. (J. Biol. Chem. 1996) 2 3 4 67
  2. Human caspase 7 is positively controlled by SREBP-1 and SREBP-2. (PMID: 19323650) Gibot L. … Le Jossic-Corcos C. (Biochem. J. 2009) 3 23
  3. Polymorphisms and haplotypes in the caspase-3, caspase-7, and caspase-8 genes and risk for endometrial cancer: a population-based, case-control study in a Chinese population. (PMID: 19531679) Xu H.L. … Shu X.O. (Cancer Epidemiol. Biomarkers Prev. 2009) 3 23
  4. Dissecting an allosteric switch in caspase-7 using chemical and mutational probes. (PMID: 19581639) Hardy J.A. … Wells J.A. (J. Biol. Chem. 2009) 3 23
  5. Calpain-1 cleaves and activates caspase-7. (PMID: 19617626) Gafni J. … Ellerby L.M. (J. Biol. Chem. 2009) 3 23

Products for CASP7 Gene

Sources for CASP7 Gene

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