Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PLA2G10 Gene

Aliases for PLA2G10 Gene

  • Phospholipase A2, Group X 2 3
  • Phosphatidylcholine 2-Acylhydrolase 10 3 4
  • Group X Secretory Phospholipase A2 3 4
  • GX SPLA2 3 4
  • GXSPLA2 3 6
  • SPLA2-X 3 4
  • SPLA2 3 6
  • Group 10 Secretory Phospholipase A2 3
  • EC 3.1.1.4 4
  • GXPLA2 3

External Ids for PLA2G10 Gene

Previous GeneCards Identifiers for PLA2G10 Gene

  • GC16M014715
  • GC16P017772
  • GC16M014732
  • GC16M014673
  • GC16M014767

Summaries for PLA2G10 Gene

GeneCards Summary for PLA2G10 Gene

PLA2G10 (Phospholipase A2, Group X) is a Protein Coding gene. Diseases associated with PLA2G10 include acute chest syndrome and meconium aspiration syndrome. Among its related pathways are Ras signaling pathway and PAK Pathway. GO annotations related to this gene include calcium ion binding and phospholipase activity. An important paralog of this gene is PLA2G2D.

UniProtKB/Swiss-Prot for PLA2G10 Gene

  • PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine

Tocris Summary for PLA2G10 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+ concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLA2G10 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G10 Gene

Genomics for PLA2G10 Gene

Regulatory Elements for PLA2G10 Gene

Genomic Location for PLA2G10 Gene

Start:
14,672,545 bp from pter
End:
14,702,763 bp from pter
Size:
30,219 bases
Orientation:
Minus strand

Genomic View for PLA2G10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLA2G10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G10 Gene

Proteins for PLA2G10 Gene

  • Protein details for PLA2G10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15496-PA2GX_HUMAN
    Recommended name:
    Group 10 secretory phospholipase A2
    Protein Accession:
    O15496
    Secondary Accessions:
    • Q14DU3
    • Q6NT23

    Protein attributes for PLA2G10 Gene

    Size:
    165 amino acids
    Molecular mass:
    18153 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PLA2G10 Gene

neXtProt entry for PLA2G10 Gene

Proteomics data for PLA2G10 Gene at MOPED

Post-translational modifications for PLA2G10 Gene

Other Protein References for PLA2G10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PLA2G10 Gene

Domains for PLA2G10 Gene

Gene Families for PLA2G10 Gene

Protein Domains for PLA2G10 Gene

Suggested Antigen Peptide Sequences for PLA2G10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15496

UniProtKB/Swiss-Prot:

PA2GX_HUMAN :
  • O15496
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G10: view

Function for PLA2G10 Gene

Molecular function for PLA2G10 Gene

GENATLAS Biochemistry: phospholipase A2,group X,Ca2+ dependent,secreted,mainly expressed in spleen,thymus,peripheral blood lymphocytes (15kb transcript) pancreas,lung,colon (0.8kb),likely involved in the inflammatory process
UniProtKB/Swiss-Prot CatalyticActivity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine

Enzyme Numbers (IUBMB) for PLA2G10 Gene

Gene Ontology (GO) - Molecular Function for PLA2G10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity ISS 20844270
GO:0004623 phospholipase A2 activity IEA --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PLA2G10: view
genes like me logo Genes that share phenotypes with PLA2G10: view

Animal Models for PLA2G10 Gene

MGI Knock Outs for PLA2G10:

Animal Model Products

miRNA for PLA2G10 Gene

miRTarBase miRNAs that target PLA2G10

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLA2G10

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for PLA2G10 Gene

Localization for PLA2G10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G10 Gene COMPARTMENTS Subcellular localization image for PLA2G10 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PLA2G10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with PLA2G10: view

Pathways for PLA2G10 Gene

genes like me logo Genes that share pathways with PLA2G10: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PLA2G10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0007411 axon guidance IDA 15927955
GO:0010744 positive regulation of macrophage derived foam cell differentiation IC 18511424
GO:0010884 positive regulation of lipid storage IMP 18511424
genes like me logo Genes that share ontologies with PLA2G10: view

Compounds for PLA2G10 Gene

(5) Tocris Compounds for PLA2G10 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor [83373-60-8]
m-3M3FBS Phospholipase C activator [200933-14-8]
U 73343 Inactive analog of U 73122 (Cat. No. 1268) [142878-12-4]
VU 0155069 Potent and selective PLD1 inhibitor [1130067-06-9]
VU 0364739 hydrochloride Potent and selective PLD2 inhibitor [1244640-48-9]

(2264) HMDB Compounds for PLA2G10 Gene

Compound Synonyms Cas Number PubMed IDs
Alpha-Linolenic acid
  • (9,12,15)-linolenate
463-40-1
Arachidic acid
  • Arachate
506-30-9
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1
Calcium
  • Ca
7440-70-2
Heptadecanoic acid
  • Heptadecanoate
506-12-7

(16) Novoseek inferred chemical compound relationships for PLA2G10 Gene

Compound -log(P) Hits PubMed IDs
arachidonic acid 60.4 18
phosphatidylcholine 59.3 9
phosphatidylethanolamine 51.8 2
phospholipid 51.6 8
phosphatidylserine 51.3 1
genes like me logo Genes that share compounds with PLA2G10: view

Transcripts for PLA2G10 Gene

mRNA/cDNA for PLA2G10 Gene

(6) Additional mRNA sequences :
(9) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLA2G10 Gene

Phospholipase A2, group X:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLA2G10

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PLA2G10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for PLA2G10 Gene

GeneLoc Exon Structure for
PLA2G10
ECgene alternative splicing isoforms for
PLA2G10

Expression for PLA2G10 Gene

mRNA expression in normal human tissues for PLA2G10 Gene

mRNA differential expression in normal tissues according to GTEx for PLA2G10 Gene

This gene is overexpressed in Colon - Transverse (18.5), Stomach (7.7), and Pancreas (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PLA2G10 Gene

SOURCE GeneReport for Unigene cluster for PLA2G10 Gene Hs.567366

mRNA Expression by UniProt/SwissProt for PLA2G10 Gene

O15496-PA2GX_HUMAN
Tissue specificity: Found in spleen, thymus, peripheral blood leukocytes, pancreas, lung, and colon
genes like me logo Genes that share expressions with PLA2G10: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PLA2G10 Gene

Orthologs for PLA2G10 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G10 35
  • 98.28 (n)
  • 97.06 (a)
PLA2G10 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLA2G10 35
  • 76.33 (n)
  • 68.12 (a)
PLA2G10 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLA2G10 35
  • 82.15 (n)
  • 78.74 (a)
PLA2G10 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pla2g10 35
  • 76.12 (n)
  • 70.9 (a)
Pla2g10 16
Pla2g10 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLA2G10 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
OneToMany
-- 36
  • 36 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pla2g10 35
  • 76.37 (n)
  • 69.4 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 44 (a)
OneToMany
PLA2G10 35
  • 57.6 (n)
  • 51.2 (a)
PLA2G10 36
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia PLA2G10 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492785 35
  • 55.56 (n)
  • 48.41 (a)
zebrafish
(Danio rerio)
Actinopterygii PLA2G10 36
  • 42 (a)
OneToOne
zgc:92162 35
  • 51.88 (n)
  • 48.87 (a)
worm
(Caenorhabditis elegans)
Secernentea C07E3.9 36
  • 27 (a)
OneToMany
Species with no ortholog for PLA2G10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLA2G10 Gene

ENSEMBL:
Gene Tree for PLA2G10 (if available)
TreeFam:
Gene Tree for PLA2G10 (if available)

Paralogs for PLA2G10 Gene

Paralogs for PLA2G10 Gene

Selected SIMAP similar genes for PLA2G10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PLA2G10: view

Variants for PLA2G10 Gene

Sequence variations from dbSNP and Humsavar for PLA2G10 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1141184 -- 14,677,460(+) ctcct(G/T)ggttc intron-variant
rs1965689 -- 14,676,547(-) catgc(A/C/G)ccacc intron-variant
rs3900822 -- 14,676,589(-) cgatt(C/T)tcctg intron-variant
rs4003232 -- 14,690,768(+) ttcct(A/G)gctgt intron-variant
rs4780753 -- 14,679,428(-) cgcct(C/T)ggcct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2G10 Gene

Variant ID Type Subtype PubMed ID
dgv810e1 CNV Complex 17122850
dgv811e1 CNV Complex 17122850
nsv833144 CNV Gain 17160897
nsv905356 CNV Gain 21882294
nsv1740 CNV Loss 18451855
essv16469 CNV CNV 17122850
dgv812e1 CNV Complex 17122850
nsv905357 CNV Gain 21882294
nsv821150 CNV Deletion 20802225
esv1008243 CNV Gain 20482838
esv28787 CNV Gain+Loss 19812545
nsv9353 CNV Gain+Loss 18304495

Relevant External Links for PLA2G10 Gene

HapMap Linkage Disequilibrium report
PLA2G10
Human Gene Mutation Database (HGMD)
PLA2G10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G10 Gene

Disorders for PLA2G10 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for PLA2G10 Gene including...

Search for PLA2G10 Gene in MalaCards »

(3) University of Copenhagen DISEASES for PLA2G10 Gene

(10) Novoseek inferred disease relationships for PLA2G10 Gene

Disease -log(P) Hits PubMed IDs
embolism fat 49.9 1
atherosclerosis 31.7 4
sickle cell disease 29.3 1
inflammation 27.6 9
rheumatoid arthritis 26.4 3

Relevant External Links for PLA2G10

Genetic Association Database (GAD)
PLA2G10
Human Genome Epidemiology (HuGE) Navigator
PLA2G10
genes like me logo Genes that share disorders with PLA2G10: view

No data available for UniProtKB/Swiss-Prot for PLA2G10 Gene

Publications for PLA2G10 Gene

  1. Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2. (PMID: 9188469) Cupillard L. … Lambeau G. (J. Biol. Chem. 1997) 2 3 4 23
  2. Phase composition of lipoprotein SM/cholesterol/PtdCho affects FA specificity of sPLA2s. (PMID: 18587072) Kuksis A. … Pruzanski W. (J. Lipid Res. 2008) 3 23
  3. Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis. (PMID: 11741884) Degousee N. … Rubin B.B. (J. Biol. Chem. 2002) 3 23
  4. Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. (PMID: 19336475) Drenos F. … Hingorani A.D. (Hum. Mol. Genet. 2009) 3 48
  5. Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes. (PMID: 12161451) Pan Y.H. … Bahnson B.J. (J. Biol. Chem. 2002) 3 4

Products for PLA2G10 Gene

  • antibodies-online proteins for PLA2G10
  • antibodies-online antibodies for PLA2G10
  • antibodies-online kits for PLA2G10

Sources for PLA2G10 Gene

Back to Top

Content