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Aliases for PLA2G10 Gene

Aliases for PLA2G10 Gene

  • Phospholipase A2 Group X 2 3 5
  • Phosphatidylcholine 2-Acylhydrolase 10 3 4
  • Group X Secretory Phospholipase A2 3 4
  • SPLA2-X 3 4
  • Group 10 Secretory Phospholipase A2 3
  • Phospholipase A2, Group X 2
  • EC 3.1.1.4 4
  • GX SPLA2 4
  • GXSPLA2 3
  • GXPLA2 3
  • SPLA2 3

External Ids for PLA2G10 Gene

Previous GeneCards Identifiers for PLA2G10 Gene

  • GC16M014715
  • GC16P017772
  • GC16M014732
  • GC16M014673
  • GC16M014767

Summaries for PLA2G10 Gene

Entrez Gene Summary for PLA2G10 Gene

  • This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015]

GeneCards Summary for PLA2G10 Gene

PLA2G10 (Phospholipase A2 Group X) is a Protein Coding gene. Diseases associated with PLA2G10 include Acute Chest Syndrome and Potter's Syndrome. Among its related pathways are Phospholipase-C Pathway and Metabolism. GO annotations related to this gene include calcium ion binding and phospholipase activity. An important paralog of this gene is PLA2G2D.

UniProtKB/Swiss-Prot for PLA2G10 Gene

  • PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.

Tocris Summary for PLA2G10 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G10 Gene

Additional gene information for PLA2G10 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G10 Gene

Genomics for PLA2G10 Gene

Regulatory Elements for PLA2G10 Gene

Enhancers for PLA2G10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H013955 1.7 FANTOM5 Ensembl ENCODE 5.8 +737.3 737282 3 PKNOX1 FOXA2 ARNT SIN3A FEZF1 ZNF2 SLC30A9 FOS JUNB REST ERCC4 PARN ENSG00000183458 NPIPA1 NPIPA3 ENSG00000242307 NPIPA2 PLA2G10 MKL2 ENSG00000263234
GH16H015481 1.5 Ensembl ENCODE dbSUPER 5.3 -787.9 -787889 1 FOXA2 ARID4B SIN3A DMAP1 YY1 TCF12 SLC30A9 ZNF143 FOS NFYC PARN ABCC1 C16orf45 BFAR PLA2G10 LOC105371102
GH16H013993 1.2 FANTOM5 ENCODE 4.7 +700.0 700000 1 SOX13 FOXA2 FEZF1 ZNF644 RAD21 RARA YY1 TEAD3 LCORL HNF4G ENSG00000261819 PLA2G10 LINC02185 ENSG00000263234
GH16H013959 0.8 ENCODE 4.5 +734.0 733957 2 ELF3 FOXA2 NFIB SAP130 ZFP64 FEZF1 RARA ZNF366 SCRT2 ZBTB20 ERCC4 ENSG00000242307 PLA2G10 ENSG00000263234 LINC02185
GH16H014655 1.1 FANTOM5 ENCODE 0.3 +37.4 37389 3 ELF3 TBP SOX13 PKNOX1 ESRRA ATF1 FOXA2 MAX CTBP1 POLR2A LOC100505915 GC16P014643 PLA2G10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLA2G10 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLA2G10 Gene

Chromosome:
16
Start:
14,672,545 bp from pter
End:
14,694,669 bp from pter
Size:
22,125 bases
Orientation:
Minus strand

Genomic View for PLA2G10 Gene

Genes around PLA2G10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G10 Gene

Proteins for PLA2G10 Gene

  • Protein details for PLA2G10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15496-PA2GX_HUMAN
    Recommended name:
    Group 10 secretory phospholipase A2
    Protein Accession:
    O15496
    Secondary Accessions:
    • Q14DU3
    • Q6NT23

    Protein attributes for PLA2G10 Gene

    Size:
    165 amino acids
    Molecular mass:
    18153 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PLA2G10 Gene

neXtProt entry for PLA2G10 Gene

Post-translational modifications for PLA2G10 Gene

Other Protein References for PLA2G10 Gene

Antibody Products

No data available for DME Specific Peptides for PLA2G10 Gene

Domains & Families for PLA2G10 Gene

Gene Families for PLA2G10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for PLA2G10 Gene

Suggested Antigen Peptide Sequences for PLA2G10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15496

UniProtKB/Swiss-Prot:

PA2GX_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G10: view

Function for PLA2G10 Gene

Molecular function for PLA2G10 Gene

GENATLAS Biochemistry:
phospholipase A2,group X,Ca2+ dependent,secreted,mainly expressed in spleen,thymus,peripheral blood lymphocytes (15kb transcript) pancreas,lung,colon (0.8kb),likely involved in the inflammatory process
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.

Enzyme Numbers (IUBMB) for PLA2G10 Gene

Gene Ontology (GO) - Molecular Function for PLA2G10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity ISS 20844270
GO:0004623 phospholipase A2 activity IEA,TAS --
GO:0005509 calcium ion binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PLA2G10: view
genes like me logo Genes that share phenotypes with PLA2G10: view

Animal Models for PLA2G10 Gene

MGI Knock Outs for PLA2G10:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLA2G10

CRISPR Products

miRNA for PLA2G10 Gene

miRTarBase miRNAs that target PLA2G10

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PLA2G10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G10 Gene

Localization for PLA2G10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G10 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytosol 2

Gene Ontology (GO) - Cellular Components for PLA2G10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005615 extracellular space IDA 21805676
genes like me logo Genes that share ontologies with PLA2G10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLA2G10 Gene

Pathways & Interactions for PLA2G10 Gene

genes like me logo Genes that share pathways with PLA2G10: view

Gene Ontology (GO) - Biological Process for PLA2G10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IEA --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0007411 axon guidance IDA 15927955
GO:0010744 positive regulation of macrophage derived foam cell differentiation IC 18511424
genes like me logo Genes that share ontologies with PLA2G10: view

No data available for SIGNOR curated interactions for PLA2G10 Gene

Drugs & Compounds for PLA2G10 Gene

(18) Drugs for PLA2G10 Gene - From: DrugBank, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
arachidonic acid Experimental Nutra Activator 32
Myristic acid Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22

(177) Additional Compounds for PLA2G10 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
LysoPC(14:1(9Z))
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)

(5) Tocris Compounds for PLA2G10 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
U 73343 Analog of U 73122 (Cat. No. 1268) 142878-12-4
VU 0155069 Potent and selective PLD1 inhibitor 1130067-06-9
VU 0364739 hydrochloride Potent and selective PLD2 inhibitor 1244640-48-9
genes like me logo Genes that share compounds with PLA2G10: view

Transcripts for PLA2G10 Gene

mRNA/cDNA for PLA2G10 Gene

(5) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLA2G10 Gene

Phospholipase A2, group X:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PLA2G10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for PLA2G10 Gene

GeneLoc Exon Structure for
PLA2G10
ECgene alternative splicing isoforms for
PLA2G10

Expression for PLA2G10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLA2G10 Gene

mRNA differential expression in normal tissues according to GTEx for PLA2G10 Gene

This gene is overexpressed in Colon - Transverse (x18.5), Stomach (x7.7), and Pancreas (x4.3).

Protein differential expression in normal tissues from HIPED for PLA2G10 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLA2G10 Gene



Protein tissue co-expression partners for PLA2G10 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLA2G10 Gene:

PLA2G10

SOURCE GeneReport for Unigene cluster for PLA2G10 Gene:

Hs.567366

mRNA Expression by UniProt/SwissProt for PLA2G10 Gene:

O15496-PA2GX_HUMAN
Tissue specificity: Found in spleen, thymus, peripheral blood leukocytes, pancreas, lung, and colon.

Evidence on tissue expression from TISSUES for PLA2G10 Gene

  • Lung(4.4)
  • Intestine(2.3)
  • Nervous system(2.3)
  • Muscle(2.1)
  • Blood(2)
  • Heart(2)
  • Liver(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with PLA2G10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G10 Gene

Orthologs for PLA2G10 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G10 34 33
  • 98.28 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PLA2G10 33 34
  • 82.15 (n)
rat
(Rattus norvegicus)
Mammalia Pla2g10 33
  • 76.37 (n)
cow
(Bos Taurus)
Mammalia PLA2G10 34 33
  • 76.33 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pla2g10 34 16 33
  • 76.12 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLA2G10 34
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 46 (a)
OneToMany
-- 34
  • 41 (a)
OneToMany
-- 34
  • 39 (a)
OneToMany
-- 34
  • 39 (a)
OneToMany
-- 34
  • 36 (a)
OneToMany
chicken
(Gallus gallus)
Aves PLA2G10 34 33
  • 57.6 (n)
OneToMany
-- 34
  • 44 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia PLA2G10 34
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492785 33
  • 55.56 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:92162 33
  • 51.88 (n)
PLA2G10 34
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C07E3.9 34
  • 27 (a)
OneToMany
Species where no ortholog for PLA2G10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLA2G10 Gene

ENSEMBL:
Gene Tree for PLA2G10 (if available)
TreeFam:
Gene Tree for PLA2G10 (if available)

Paralogs for PLA2G10 Gene

(6) SIMAP similar genes for PLA2G10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PLA2G10: view

Variants for PLA2G10 Gene

Sequence variations from dbSNP and Humsavar for PLA2G10 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000193000 -- 14,675,183(+) AAAAA(A/C)AAAAC intron-variant
rs1000203027 -- 14,674,753(+) TCAAA(C/T)TATGC intron-variant
rs1000400172 -- 14,674,645(+) GCAGT(A/G)AGCTG intron-variant
rs1000468568 -- 14,680,943(+) GATCC(C/G)TTGAG intron-variant
rs1000675982 -- 14,686,790(+) GCACC(C/T)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2G10 Gene

Variant ID Type Subtype PubMed ID
dgv2738n100 CNV gain 25217958
dgv2740n100 CNV loss 25217958
dgv4916n54 CNV loss 21841781
dgv4917n54 CNV loss 21841781
esv1008243 CNV gain 20482838
esv2758632 CNV gain+loss 17122850
esv28787 CNV gain+loss 19812545
esv3638012 CNV loss 21293372
nsv1143811 CNV deletion 24896259
nsv1160344 CNV deletion 26073780
nsv1740 CNV deletion 18451855
nsv571511 CNV loss 21841781
nsv821150 CNV deletion 20802225
nsv833144 CNV gain 17160897
nsv9353 CNV gain+loss 18304495
nsv952927 CNV deletion 24416366
nsv984262 CNV duplication 23825009

Variation tolerance for PLA2G10 Gene

Gene Damage Index Score: 0.04; 1.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G10 Gene

Human Gene Mutation Database (HGMD)
PLA2G10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G10 Gene

Disorders for PLA2G10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PLA2G10 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
acute chest syndrome
  • acute chest syndrome in sickle cell disease
potter's syndrome
  • potter syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLA2G10

Genetic Association Database (GAD)
PLA2G10
Human Genome Epidemiology (HuGE) Navigator
PLA2G10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G10
genes like me logo Genes that share disorders with PLA2G10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G10 Gene

Publications for PLA2G10 Gene

  1. Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2. (PMID: 9188469) Cupillard L … Lambeau G (The Journal of biological chemistry 1997) 2 3 4 22 60
  2. Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. (PMID: 19336475) Drenos F … Hingorani AD (Human molecular genetics 2009) 3 45 60
  3. Phase composition of lipoprotein SM/cholesterol/PtdCho affects FA specificity of sPLA2s. (PMID: 18587072) Kuksis A … Pruzanski W (Journal of lipid research 2008) 3 22 60
  4. Lp-PLA2 activity and PLA2G7 A379V genotype in patients with diabetes mellitus. (PMID: 16438975) Wootton PT … Talmud PJ (Atherosclerosis 2006) 3 45 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for PLA2G10 Gene

Sources for PLA2G10 Gene

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