Free for academic non-profit institutions. Other users need a Commercial license

Aliases for STK40 Gene

Aliases for STK40 Gene

  • Serine/Threonine Kinase 40 2 3
  • SHIK 3 4 6
  • SINK-Homologous Serine/Threonine-Protein Kinase 3 4
  • Sugen Kinase 495 3 4
  • EC 2.7.11.1 4 64
  • SgK495 3 4
  • Serine/Threonine-Protein Kinase 40 3
  • Ser/Thr-Like Kinase 3
  • EC 2.7.11 64

External Ids for STK40 Gene

Summaries for STK40 Gene

GeneCards Summary for STK40 Gene

STK40 (Serine/Threonine Kinase 40) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is NUAK1.

UniProtKB/Swiss-Prot for STK40 Gene

  • May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.

Gene Wiki entry for STK40 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK40 Gene

Genomics for STK40 Gene

Genomic Location for STK40 Gene

Start:
36,339,619 bp from pter
End:
36,385,927 bp from pter
Size:
46,309 bases
Orientation:
Minus strand

Genomic View for STK40 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STK40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK40 Gene

Regulatory Elements for STK40 Gene

Proteins for STK40 Gene

  • Protein details for STK40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2I9-STK40_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 40
    Protein Accession:
    Q8N2I9
    Secondary Accessions:
    • D3DPS8
    • Q5VTK8
    • Q5VTK9
    • Q6ZMN1
    • Q8N2J8
    • Q8N3I6
    • Q96HN6
    • Q96I44
    • Q9BSA3
    • Q9H7H6

    Protein attributes for STK40 Gene

    Size:
    435 amino acids
    Molecular mass:
    49001 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH08344.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15794.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11361.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for STK40 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK40 Gene

Proteomics data for STK40 Gene at MOPED

Post-translational modifications for STK40 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STK40 Gene

Domains for STK40 Gene

Gene Families for STK40 Gene

UniProtKB/Swiss-Prot:

STK40_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q8N2I9
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.:
    • Q8N2I9
genes like me logo Genes that share domains with STK40: view

Function for STK40 Gene

Molecular function for STK40 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.

Enzyme Numbers (IUBMB) for STK40 Gene

Gene Ontology (GO) - Molecular Function for STK40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 21784977
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with STK40: view
genes like me logo Genes that share phenotypes with STK40: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for STK40 Gene

Localization for STK40 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK40 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK40 Gene COMPARTMENTS Subcellular localization image for STK40 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for STK40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with STK40: view

Pathways for STK40 Gene

SuperPathways for STK40 Gene

No Data Available

Interacting Proteins for STK40 Gene

Gene Ontology (GO) - Biological Process for STK40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003016 respiratory system process IEA --
GO:0005977 glycogen metabolic process IEA --
GO:0006468 protein phosphorylation IEA --
GO:0010468 regulation of gene expression IEA --
GO:0030324 lung development --
genes like me logo Genes that share ontologies with STK40: view

No data available for Pathways by source for STK40 Gene

Transcripts for STK40 Gene

Unigene Clusters for STK40 Gene

Serine/threonine kinase 40:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STK40 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e ^ 13a · 13b ^ 14a · 14b ^ 15a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: - -
SP7: -
SP8: - - - - - - -
SP9: - - - - -
SP10: -
SP11:
SP12:
SP13: - - - - - - - - -
SP14:
SP15:

ExUns: 15b ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11: -
SP12:
SP13:
SP14:
SP15:

Relevant External Links for STK40 Gene

GeneLoc Exon Structure for
STK40
ECgene alternative splicing isoforms for
STK40

Expression for STK40 Gene

mRNA expression in normal human tissues for STK40 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STK40 Gene

This gene is overexpressed in Whole Blood (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for STK40 Gene

SOURCE GeneReport for Unigene cluster for STK40 Gene Hs.471768

mRNA Expression by UniProt/SwissProt for STK40 Gene

Q8N2I9-STK40_HUMAN
Tissue specificity: Strongly expressed in heart, brain, placenta, lung, skeletal muscle, kidney, spleen, thymus, prostate, liver, pancreas, testis, ovary, small intestine, colon and peripheral blood leukocytes.
genes like me logo Genes that share expressions with STK40: view

Orthologs for STK40 Gene

This gene was present in the common ancestor of animals.

Orthologs for STK40 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK40 36
  • 99.16 (n)
  • 99.49 (a)
STK40 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STK40 36
  • 91.19 (n)
  • 96.55 (a)
STK40 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STK40 36
  • 91.03 (n)
  • 97.7 (a)
STK40 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk40 36
  • 89.81 (n)
  • 97.24 (a)
Stk40 16
Stk40 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STK40 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STK40 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk40 36
  • 89.5 (n)
  • 97.24 (a)
chicken
(Gallus gallus)
Aves STK40 36
  • 81.69 (n)
  • 89.89 (a)
STK40 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STK40 37
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398681 36
tropical clawed frog
(Silurana tropicalis)
Amphibia stk40 36
  • 75.08 (n)
  • 86.81 (a)
zebrafish
(Danio rerio)
Actinopterygii stk40 36
  • 76.45 (n)
  • 85.05 (a)
STK40 37
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008948 36
  • 56.81 (n)
  • 51.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta trbl 37
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nipi-3 37
  • 9 (a)
OneToMany
Species with no ortholog for STK40:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK40 Gene

ENSEMBL:
Gene Tree for STK40 (if available)
TreeFam:
Gene Tree for STK40 (if available)

Paralogs for STK40 Gene

Paralogs for STK40 Gene

genes like me logo Genes that share paralogs with STK40: view

Variants for STK40 Gene

Sequence variations from dbSNP and Humsavar for STK40 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1128665 -- 36,339,711(-) AAGTC(A/C)CAAAA utr-variant-3-prime
rs2002808 -- 36,384,276(-) gaggc(A/G)ggcgg intron-variant
rs3007220 -- 36,376,248(-) TTTCA(C/G)TGGTG intron-variant
rs3795496 -- 36,358,720(-) ATGGG(A/G)GTGAG intron-variant
rs3795497 -- 36,344,096(-) GGGGT(A/G)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK40 Gene

Variant ID Type Subtype PubMed ID
dgv47e1 CNV Complex 17122850
nsv834702 CNV Loss 17160897
nsv524394 CNV Loss 19592680
esv2676376 CNV Deletion 23128226

Relevant External Links for STK40 Gene

HapMap Linkage Disequilibrium report
STK40

Disorders for STK40 Gene

Relevant External Links for STK40

Genetic Association Database (GAD)
STK40
Human Genome Epidemiology (HuGE) Navigator
STK40
genes like me logo Genes that share disorders with STK40: view

No data available for UniProtKB/Swiss-Prot for STK40 Gene

Publications for STK40 Gene

  1. Identification of a novel serine/threonine kinase that inhibits TNF- induced NF-kappaB activation and p53-induced transcription. (PMID: 13679039) Huang J. … Shu H.-B. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for STK40 Gene

  • Addgene plasmids for STK40

Sources for STK40 Gene

Back to Top

Content