Aliases for MAD1L1 Gene
External Ids for MAD1L1 Gene
Previous GeneCards Identifiers for MAD1L1 Gene
MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
GeneCards Summary for MAD1L1 Gene
MAD1L1 (MAD1 Mitotic Arrest Deficient-Like 1 (Yeast)) is a Protein Coding gene. Diseases associated with MAD1L1 include prostate cancer and breast cancer. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases.
UniProtKB/Swiss-Prot for MAD1L1 Gene
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.