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Aliases for HIST1H4G Gene

Aliases for HIST1H4G Gene

  • Histone Cluster 1, H4g 2 3 5
  • H4 Histone Family, Member L 2 3
  • Histone 1, H4g 2 3
  • H4/L 3 4
  • H4FL 3 4

External Ids for HIST1H4G Gene

Previous HGNC Symbols for HIST1H4G Gene

  • H4FL

Previous GeneCards Identifiers for HIST1H4G Gene

  • GC06M026305
  • GC06M026354
  • GC06M026248
  • GC06M026189
  • GC06M026249
  • GC06M026263
  • GC06M026300
  • GC06M026409
  • GC06M026438
  • GC06M026421
  • GC06M026463

Summaries for HIST1H4G Gene

Entrez Gene Summary for HIST1H4G Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H4G Gene

HIST1H4G (Histone Cluster 1, H4g) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Viral carcinogenesis. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST1H4C.

UniProtKB/Swiss-Prot for HIST1H4G Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).

Gene Wiki entry for HIST1H4G Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H4G Gene

Genomics for HIST1H4G Gene

Regulatory Elements for HIST1H4G Gene

Genomic Location for HIST1H4G Gene

Chromosome:
6
Start:
26,246,611 bp from pter
End:
26,246,977 bp from pter
Size:
367 bases
Orientation:
Minus strand

Genomic View for HIST1H4G Gene

Genes around HIST1H4G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H4G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H4G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H4G Gene

Proteins for HIST1H4G Gene

  • Protein details for HIST1H4G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99525-H4G_HUMAN
    Recommended name:
    Histone H4-like protein type G
    Protein Accession:
    Q99525

    Protein attributes for HIST1H4G Gene

    Size:
    98 amino acids
    Molecular mass:
    11009 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).

neXtProt entry for HIST1H4G Gene

Proteomics data for HIST1H4G Gene at MOPED

Post-translational modifications for HIST1H4G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HIST1H4G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H4G Gene

Domains & Families for HIST1H4G Gene

Gene Families for HIST1H4G Gene

Protein Domains for HIST1H4G Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HIST1H4G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99525

UniProtKB/Swiss-Prot:

H4G_HUMAN :
  • Belongs to the histone H4 family.
Family:
  • Belongs to the histone H4 family.
genes like me logo Genes that share domains with HIST1H4G: view

Function for HIST1H4G Gene

Molecular function for HIST1H4G Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).

Gene Ontology (GO) - Molecular Function for HIST1H4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST1H4G: view
genes like me logo Genes that share phenotypes with HIST1H4G: view

miRNA for HIST1H4G Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H4G Gene

Localization for HIST1H4G Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H4G Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H4G Gene COMPARTMENTS Subcellular localization image for HIST1H4G gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for HIST1H4G Gene

Pathways & Interactions for HIST1H4G Gene

genes like me logo Genes that share pathways with HIST1H4G: view

Pathways by source for HIST1H4G Gene

Interacting Proteins for HIST1H4G Gene

Selected Interacting proteins: Q99525-H4G_HUMAN for HIST1H4G Gene via UniProtKB

Symbol External ID(s) Details
AGTRAP

Gene Ontology (GO) - Biological Process for HIST1H4G Gene

None

No data available for SIGNOR curated interactions for HIST1H4G Gene

Drugs & Compounds for HIST1H4G Gene

No Compound Related Data Available

Transcripts for HIST1H4G Gene

mRNA/cDNA for HIST1H4G Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H4G Gene

No ASD Table

Relevant External Links for HIST1H4G Gene

GeneLoc Exon Structure for
HIST1H4G
ECgene alternative splicing isoforms for
HIST1H4G

Expression for HIST1H4G Gene

mRNA expression in normal human tissues for HIST1H4G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HIST1H4G Gene

This gene is overexpressed in Plasma (39.7) and Pancreas (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HIST1H4G Gene



SOURCE GeneReport for Unigene cluster for HIST1H4G Gene Hs.553507

genes like me logo Genes that share expression patterns with HIST1H4G: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HIST1H4G Gene

Orthologs for HIST1H4G Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for HIST1H4G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC472229 35
  • 97.28 (n)
  • 94.9 (a)
Species with no ortholog for HIST1H4G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIST1H4G Gene

ENSEMBL:
Gene Tree for HIST1H4G (if available)
TreeFam:
Gene Tree for HIST1H4G (if available)

Paralogs for HIST1H4G Gene

(14) SIMAP similar genes for HIST1H4G Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIST1H4G: view

Variants for HIST1H4G Gene

Sequence variations from dbSNP and Humsavar for HIST1H4G Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs768119 -- 26,247,901(-) GGGCA(C/G)AGATT upstream-variant-2KB
rs6919866 -- 26,247,279(+) GGCGC(A/G)GTGGC upstream-variant-2KB
rs6924863 -- 26,247,862(+) agttt(C/T)gctct upstream-variant-2KB
rs6930351 -- 26,248,598(+) CAGTT(A/T)CGATG upstream-variant-2KB
rs9467693 -- 26,246,556(+) TTGCT(C/G)AGTGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HIST1H4G Gene

Variant ID Type Subtype PubMed ID
nsv428137 CNV Loss 18775914

Variation tolerance for HIST1H4G Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST1H4G Gene

HapMap Linkage Disequilibrium report
HIST1H4G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H4G Gene

Disorders for HIST1H4G Gene

Relevant External Links for HIST1H4G

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H4G

No disorders were found for HIST1H4G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H4G Gene

Publications for HIST1H4G Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 67
  2. Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PMID: 22412018) Roux K.J. … Burke B. (J. Cell Biol. 2012) 3
  5. A conserved function for the H2A.Z C terminus. (PMID: 22493515) Wratting D. … Millar C.B. (J. Biol. Chem. 2012) 3

Products for HIST1H4G Gene

Sources for HIST1H4G Gene

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