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Aliases for HIST1H4G Gene

Aliases for HIST1H4G Gene

  • Histone Cluster 1 H4 Family Member G 2 3 5
  • H4 Histone Family, Member L 2 3
  • Histone Cluster 1, H4g 2 3
  • Histone 1, H4g 2 3
  • H4/L 3 4
  • H4FL 3 4
  • Histone H4-Like Protein Type G 3

External Ids for HIST1H4G Gene

Previous HGNC Symbols for HIST1H4G Gene

  • H4FL

Previous GeneCards Identifiers for HIST1H4G Gene

  • GC06M026305
  • GC06M026354
  • GC06M026248
  • GC06M026189
  • GC06M026249
  • GC06M026263
  • GC06M026300
  • GC06M026409
  • GC06M026438
  • GC06M026421
  • GC06M026463
  • GC06M026484
  • GC06M026503
  • GC06M026530

Summaries for HIST1H4G Gene

Entrez Gene Summary for HIST1H4G Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H4G Gene

HIST1H4G (Histone Cluster 1 H4 Family Member G) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST1H4D.

UniProtKB/Swiss-Prot for HIST1H4G Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).

Gene Wiki entry for HIST1H4G Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H4G Gene

Genomics for HIST1H4G Gene

Regulatory Elements for HIST1H4G Gene

Enhancers for HIST1H4G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G026309 1.7 Ensembl ENCODE dbSUPER 10 -64.9 -64864 4.9 CREB3L1 MLX DMAP1 FEZF1 YBX1 YY1 ZNF143 NFYC TBX21 MEF2D BTN3A2 HIST1H4H ABT1 HIST1H3E GUSBP2 ZNF322 HIST1H2APS4 HIST1H3G TRIM38 HIST1H2APS3
GH06G026303 1.6 Ensembl ENCODE dbSUPER 10.3 -57.8 -57770 2.8 HDGF PKNOX1 CREB3L1 MLX ARNT ARID4B SIN3A ZNF766 ZNF143 FOS ABT1 HIST1H3E HIST1H2APS4 HIST1H3G TRIM38 HIST1H2APS3 HIST1H4G HIST1H2BE LARP1P1 BTN1A1
GH06G026294 1.6 Ensembl ENCODE dbSUPER 10 -49.4 -49448 3.2 HDGF HNRNPUL1 FOXA2 PKNOX1 CREB3L1 MLX ARNT ARID4B SIN3A DMAP1 HMGN4 HIST1H3E HIST1H2APS4 HIST1H3G HIST1H2BH HIST1H2BD HIST1H1E HIST1H4G HIST1H2BE LARP1P1
GH06G026193 1.5 ENCODE dbSUPER 10.6 +46.2 46186 14.6 CREB3L1 MLX AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ABT1 BTN3A2 HIST1H3E HMGN4 HIST1H2AE HIST1H2BE LARP1P1 HIST1H2APS3 HIST1H1E HIST1H2BD
GH06G026299 1 ENCODE dbSUPER 9.7 -52.3 -52251 0.2 CBX3 CEBPG RBBP5 EGR1 ADNP MAZ ZNF197 ZNF740 E2F5 USF2 HIST1H2APS4 HIST1H3G HIST1H1E HIST1H2BD HIST1H4G HMGN4 HIST1H2BE LARP1P1 BTN1A1 GC06P026813
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HIST1H4G on UCSC Golden Path with GeneCards custom track

Genomic Location for HIST1H4G Gene

Chromosome:
6
Start:
26,246,611 bp from pter
End:
26,246,977 bp from pter
Size:
367 bases
Orientation:
Minus strand

Genomic View for HIST1H4G Gene

Genes around HIST1H4G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H4G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H4G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H4G Gene

Proteins for HIST1H4G Gene

  • Protein details for HIST1H4G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99525-H4G_HUMAN
    Recommended name:
    Histone H4-like protein type G
    Protein Accession:
    Q99525

    Protein attributes for HIST1H4G Gene

    Size:
    98 amino acids
    Molecular mass:
    11009 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).

neXtProt entry for HIST1H4G Gene

Post-translational modifications for HIST1H4G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HIST1H4G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H4G Gene

Domains & Families for HIST1H4G Gene

Gene Families for HIST1H4G Gene

Protein Domains for HIST1H4G Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HIST1H4G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99525

UniProtKB/Swiss-Prot:

H4G_HUMAN :
  • Belongs to the histone H4 family.
Family:
  • Belongs to the histone H4 family.
genes like me logo Genes that share domains with HIST1H4G: view

Function for HIST1H4G Gene

Molecular function for HIST1H4G Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).

Gene Ontology (GO) - Molecular Function for HIST1H4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0042393 histone binding IBA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST1H4G: view
genes like me logo Genes that share phenotypes with HIST1H4G: view

Animal Model Products

miRNA for HIST1H4G Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H4G Gene

Localization for HIST1H4G Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H4G Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIST1H4G gene
Compartment Confidence
nucleus 5
extracellular 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HIST1H4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000788 nuclear nucleosome IBA --
GO:0005634 nucleus IDA 21630459
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with HIST1H4G: view

Pathways & Interactions for HIST1H4G Gene

genes like me logo Genes that share pathways with HIST1H4G: view

Pathways by source for HIST1H4G Gene

1 BioSystems pathway for HIST1H4G Gene

Interacting Proteins for HIST1H4G Gene

Gene Ontology (GO) - Biological Process for HIST1H4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HIST1H4G: view

No data available for SIGNOR curated interactions for HIST1H4G Gene

Transcripts for HIST1H4G Gene

mRNA/cDNA for HIST1H4G Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H4G Gene

No ASD Table

Relevant External Links for HIST1H4G Gene

GeneLoc Exon Structure for
HIST1H4G
ECgene alternative splicing isoforms for
HIST1H4G

Expression for HIST1H4G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST1H4G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HIST1H4G Gene

This gene is overexpressed in Plasma (39.7) and Pancreas (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HIST1H4G Gene



NURSA nuclear receptor signaling pathways regulating expression of HIST1H4G Gene:

HIST1H4G

SOURCE GeneReport for Unigene cluster for HIST1H4G Gene:

Hs.553507
genes like me logo Genes that share expression patterns with HIST1H4G: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H4G Gene

Orthologs for HIST1H4G Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for HIST1H4G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC472229 34
  • 97.28 (n)
Species where no ortholog for HIST1H4G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIST1H4G Gene

ENSEMBL:
Gene Tree for HIST1H4G (if available)
TreeFam:
Gene Tree for HIST1H4G (if available)

Paralogs for HIST1H4G Gene

(14) SIMAP similar genes for HIST1H4G Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIST1H4G: view

Variants for HIST1H4G Gene

Sequence variations from dbSNP and Humsavar for HIST1H4G Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1002316739 -- 26,246,276(+) AAGTC(A/G)GGTTA downstream-variant-500B
rs1003351870 -- 26,248,016(+) TAGTA(C/G)AGACC upstream-variant-2KB
rs1003486567 -- 26,248,303(+) AAAAA(A/G)GATAA upstream-variant-2KB
rs1004131048 -- 26,247,994(+) CTCCC(A/G)GCTCA upstream-variant-2KB
rs1005159557 -- 26,246,301(+) CTACA(A/G)TTTTA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HIST1H4G Gene

Variant ID Type Subtype PubMed ID
dgv5926n100 CNV gain 25217958
nsv1023453 CNV gain 25217958
nsv428137 CNV loss 18775914
nsv601173 CNV loss 21841781

Variation tolerance for HIST1H4G Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST1H4G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST1H4G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H4G Gene

Disorders for HIST1H4G Gene

Relevant External Links for HIST1H4G

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H4G

No disorders were found for HIST1H4G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H4G Gene

Publications for HIST1H4G Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
  2. Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 2 3 4 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PMID: 22412018) Roux K.J. … Burke B. (J. Cell Biol. 2012) 3 64
  5. A conserved function for the H2A.Z C terminus. (PMID: 22493515) Wratting D. … Millar C.B. (J. Biol. Chem. 2012) 3 64

Products for HIST1H4G Gene

Sources for HIST1H4G Gene

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