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Aliases for CASP3 Gene

Aliases for CASP3 Gene

  • Caspase 3, Apoptosis-Related Cysteine Peptidase 2 3
  • Caspase 3, Apoptosis-Related Cysteine Protease 2 3
  • SREBP Cleavage Activity 1 3 4
  • Cysteine Protease CPP32 3 4
  • Protein Yama 3 4
  • EC 3.4.22.56 4 63
  • Apopain 3 4
  • CASP-3 3 4
  • CPP-32 3 4
  • CPP32 3 4
  • SCA-1 3 4
  • PARP Cleavage Protease 3
  • Procaspase3 3
  • EC 3.4.22 63
  • CPP32B 3

External Ids for CASP3 Gene

Previous GeneCards Identifiers for CASP3 Gene

  • GC04M186576
  • GC04M186228
  • GC04M186133
  • GC04M186244
  • GC04M185924
  • GC04M185785
  • GC04M185548
  • GC04M181303

Summaries for CASP3 Gene

Entrez Gene Summary for CASP3 Gene

  • This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for CASP3 Gene

CASP3 (Caspase 3, Apoptosis-Related Cysteine Peptidase) is a Protein Coding gene. Diseases associated with CASP3 include pharynx squamous cell carcinoma and nutmeg liver. Among its related pathways are MAPK signaling pathway and Signaling by GPCR. GO annotations related to this gene include peptidase activity and cysteine-type peptidase activity. An important paralog of this gene is CASP1.

UniProtKB/Swiss-Prot for CASP3 Gene

  • Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a 216-Asp- -Gly-217 bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

Tocris Summary for CASP3 Gene

  • Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules.

Gene Wiki entry for CASP3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASP3 Gene

Genomics for CASP3 Gene

Regulatory Elements for CASP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CASP3 Gene

Chromosome:
4
Start:
184,627,696 bp from pter
End:
184,649,509 bp from pter
Size:
21,814 bases
Orientation:
Minus strand

Genomic View for CASP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CASP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASP3 Gene

Proteins for CASP3 Gene

  • Protein details for CASP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42574-CASP3_HUMAN
    Recommended name:
    Caspase-3
    Protein Accession:
    P42574
    Secondary Accessions:
    • A8K5M2
    • D3DP53
    • Q96AN1
    • Q96KP2

    Protein attributes for CASP3 Gene

    Size:
    277 amino acids
    Molecular mass:
    31608 Da
    Quaternary structure:
    • Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce.

    Three dimensional structures from OCA and Proteopedia for CASP3 Gene

neXtProt entry for CASP3 Gene

Proteomics data for CASP3 Gene at MOPED

Post-translational modifications for CASP3 Gene

  • Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa
  • S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol.
  • Ubiquitination at Lys 229
  • Modification sites at PhosphoSitePlus

Other Protein References for CASP3 Gene

Assay Products

  • Enzo Life Sciences assays for CASP3
  • Cloud-Clone Corp Assay Kits for CASP3

Domains & Families for CASP3 Gene

Gene Families for CASP3 Gene

HGNC:
IUPHAR :

Suggested Antigen Peptide Sequences for CASP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P42574

UniProtKB/Swiss-Prot:

CASP3_HUMAN :
  • Belongs to the peptidase C14A family.
Family:
  • Belongs to the peptidase C14A family.
genes like me logo Genes that share domains with CASP3: view

Function for CASP3 Gene

Molecular function for CASP3 Gene

GENATLAS Biochemistry:
caspase 3,effector,cysteine containing aspartate-specific protease CPP32,activated by CASP9,cleaving specifically CDKN1A,alpha-fodrin (SPTAN1), gelsolin (GSN),stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli,promoting CD95/APO1/fas mediated apoptosis,homolog to C elegans Ced-3 and mammalian interleukin 1 beta convertase (IL1BC),including two isoforms alpha and beta
UniProtKB/Swiss-Prot CatalyticActivity:
Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp- - with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by isatin sulfonamides
UniProtKB/Swiss-Prot Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a 216-Asp- -Gly-217 bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

Enzyme Numbers (IUBMB) for CASP3 Gene

Gene Ontology (GO) - Molecular Function for CASP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IEA --
GO:0004190 aspartic-type endopeptidase activity EXP --
GO:0004197 cysteine-type endopeptidase activity TAS --
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IEA --
GO:0005123 death receptor binding IEA --
genes like me logo Genes that share ontologies with CASP3: view
genes like me logo Genes that share phenotypes with CASP3: view

Animal Models for CASP3 Gene

MGI Knock Outs for CASP3:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CASP3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CASP3 Gene

Localization for CASP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CASP3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CASP3 Gene COMPARTMENTS Subcellular localization image for CASP3 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 4
plasma membrane 4
cytoskeleton 3
endoplasmic reticulum 3
extracellular 3
lysosome 2
vacuole 2
endosome 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CASP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17167422
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with CASP3: view

Pathways & Interactions for CASP3 Gene

genes like me logo Genes that share pathways with CASP3: view

PCR Array Products

SIGNOR curated interactions for CASP3 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CASP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001782 B cell homeostasis IEA --
GO:0006309 apoptotic DNA fragmentation TAS --
GO:0006508 proteolysis IDA 12888622
GO:0006915 apoptotic process TAS --
genes like me logo Genes that share ontologies with CASP3: view

Drugs & Compounds for CASP3 Gene

(75) Drugs for CASP3 Gene - From: NovoSeek, DrugBank, IUPHAR, DGIdb, Tocris, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Minocycline Approved, Investigational Pharma Target, negative modulator 162
Bortezomib Approved, Experimental, Investigational Pharma Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 758
Celecoxib Approved, Investigational Pharma Inhibition, Inhibitor Selective cyclooxygenase-2 (COX-2) inhibitor 395
Cytarabine Approved, Investigational Pharma 995

(81) Additional Compounds for CASP3 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1 methyl 4 phenylpyridinium
15-deoxy-delta-12,14-prostaglandin j2
87893-55-8
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
3-(4,5-Dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium
4,6-diamidino-2-phenylindole
genes like me logo Genes that share compounds with CASP3: view

Drug Products

Transcripts for CASP3 Gene

Unigene Clusters for CASP3 Gene

Caspase 3, apoptosis-related cysteine peptidase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CASP3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CASP3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b
SP1: -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for CASP3 Gene

GeneLoc Exon Structure for
CASP3
ECgene alternative splicing isoforms for
CASP3

Expression for CASP3 Gene

mRNA expression in normal human tissues for CASP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CASP3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.2) and Nasal epithelium (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CASP3 Gene



SOURCE GeneReport for Unigene cluster for CASP3 Gene Hs.141125

mRNA Expression by UniProt/SwissProt for CASP3 Gene

P42574-CASP3_HUMAN
Tissue specificity: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system
genes like me logo Genes that share expression patterns with CASP3: view

Protein tissue co-expression partners for CASP3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CASP3 Gene

Orthologs for CASP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CASP3 35
  • 86.3 (n)
  • 84 (a)
CASP3 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CASP3 35
  • 89.53 (n)
  • 89.17 (a)
CASP3 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Casp3 35
  • 83.63 (n)
  • 86.64 (a)
Casp3 16
Casp3 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CASP3 35
  • 99.52 (n)
  • 99.64 (a)
CASP3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Casp3 35
  • 84.84 (n)
  • 89.17 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CASP3 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves CASP3 35
  • 70.76 (n)
  • 66.91 (a)
CASP3 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia casp3 35
  • 66.67 (n)
  • 63.07 (a)
zebrafish
(Danio rerio)
Actinopterygii casp3 35
casp3a 36
  • 55 (a)
OneToMany
casp3b 36
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Dcp-1 37
  • 39 (a)
decay 37
  • 37 (a)
Ice 37
  • 42 (a)
Dcp-1 36
  • 30 (a)
ManyToMany
decay 36
  • 30 (a)
ManyToMany
Ice 36
  • 32 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta CASPS8 35
  • 45.94 (n)
  • 37.08 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
Species with no ortholog for CASP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CASP3 Gene

ENSEMBL:
Gene Tree for CASP3 (if available)
TreeFam:
Gene Tree for CASP3 (if available)

Paralogs for CASP3 Gene

(6) SIMAP similar genes for CASP3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CASP3 Gene

genes like me logo Genes that share paralogs with CASP3: view

Variants for CASP3 Gene

Sequence variations from dbSNP and Humsavar for CASP3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_001401 -
VAR_048616 -

Structural Variations from Database of Genomic Variants (DGV) for CASP3 Gene

Variant ID Type Subtype PubMed ID
nsv830168 CNV Loss 17160897

Variation tolerance for CASP3 Gene

Residual Variation Intolerance Score: 53.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CASP3 Gene

HapMap Linkage Disequilibrium report
CASP3
Human Gene Mutation Database (HGMD)
CASP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASP3 Gene

Disorders for CASP3 Gene

MalaCards: The human disease database

(80) MalaCards diseases for CASP3 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
pharynx squamous cell carcinoma
nutmeg liver
  • chronic passive congestion of liver
primary effusion lymphoma
  • aids-related lymphoma
chronic myelocytic leukemia
  • cml
cowpox
  • yaba
- elite association
Search CASP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CASP3

Genetic Association Database (GAD)
CASP3
Human Genome Epidemiology (HuGE) Navigator
CASP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CASP3
genes like me logo Genes that share disorders with CASP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CASP3 Gene

Publications for CASP3 Gene

  1. Caspase-3 and -9 are activated in human myeloid HL-60 cells by calcium signal. (PMID: 19626422) GonzA!lez D. … Pariente J.A. (Mol. Cell. Biochem. 2010) 23 67
  2. The pharmacological NFkappaB inhibitors BAY117082 and MG132 induce cell arrest and apoptosis in leukemia cells through ROS-mitochondria pathway activation. (PMID: 19646807) Zanotto-Filho A. … Moreira J.C. (Cancer Lett. 2010) 23 67
  3. Combination treatment with resveratrol and sulforaphane induces apoptosis in human U251 glioma cells. (PMID: 19685289) Jiang H. … Chopp M. (Neurochem. Res. 2010) 23 67
  4. MG-132 inhibits carcinoid growth and alters the neuroendocrine phenotype. (PMID: 19765735) Chen J.Y. … Chen H. (J. Surg. Res. 2010) 23 67
  5. CCL2 is induced by chemotherapy and protects prostate cancer cells from docetaxel-induced cytotoxicity. (PMID: 19866475) Qian D.Z. … Beer T.M. (Prostate 2010) 23 67

Products for CASP3 Gene

  • Addgene plasmids for CASP3

Sources for CASP3 Gene

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