Aliases for BCL2L12 Gene
External Ids for BCL2L12 Gene
Previous GeneCards Identifiers for BCL2L12 Gene
This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for BCL2L12 Gene
BCL2L12 (BCL2 Like 12) is a Protein Coding gene. Among its related pathways are Regulation of Apoptosis by Parathyroid Hormone-related Protein. GO annotations related to this gene include p53 binding.