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Aliases for NUDT12 Gene

Aliases for NUDT12 Gene

  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 12 2 3
  • EC 3.6.1.22 4 63
  • Nucleoside Diphosphate Linked Moiety X-Type Motif 12 2
  • Nucleoside Diphosphate-Linked Moiety X Motif 12 4
  • Nudix Motif 12 4

External Ids for NUDT12 Gene

Previous GeneCards Identifiers for NUDT12 Gene

  • GC05M102544
  • GC05M103315
  • GC05M102915
  • GC05M102960
  • GC05M102912
  • GC05M098066
  • GC05M102884

Summaries for NUDT12 Gene

Entrez Gene Summary for NUDT12 Gene

  • Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003 [PubMed 12790796]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NUDT12 Gene

NUDT12 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 12) is a Protein Coding gene. Among its related pathways are NAD metabolism and Peroxisome. GO annotations related to this gene include hydrolase activity and NAD+ diphosphatase activity. An important paralog of this gene is NUDT13.

UniProtKB/Swiss-Prot for NUDT12 Gene

  • Hydrolyzes NAD(P)H to NMNH and AMP (2,5-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle.

Gene Wiki entry for NUDT12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT12 Gene

Genomics for NUDT12 Gene

Regulatory Elements for NUDT12 Gene

Genomic Location for NUDT12 Gene

Chromosome:
5
Start:
103,548,855 bp from pter
End:
103,562,804 bp from pter
Size:
13,950 bases
Orientation:
Minus strand

Genomic View for NUDT12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUDT12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT12 Gene

Proteins for NUDT12 Gene

  • Protein details for NUDT12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQG2-NUD12_HUMAN
    Recommended name:
    Peroxisomal NADH pyrophosphatase NUDT12
    Protein Accession:
    Q9BQG2
    Secondary Accessions:
    • B3KUW2
    • Q8TAL7

    Protein attributes for NUDT12 Gene

    Size:
    462 amino acids
    Molecular mass:
    52076 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for NUDT12 Gene

Proteomics data for NUDT12 Gene at MOPED

Post-translational modifications for NUDT12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for NUDT12 Gene

Suggested Antigen Peptide Sequences for NUDT12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQG2

UniProtKB/Swiss-Prot:

NUD12_HUMAN :
  • Contains 1 nudix hydrolase domain.
  • Belongs to the Nudix hydrolase family. NudC subfamily.
  • Contains 3 ANK repeats.
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the Nudix hydrolase family. NudC subfamily.
Similarity:
  • Contains 3 ANK repeats.
genes like me logo Genes that share domains with NUDT12: view

Function for NUDT12 Gene

Molecular function for NUDT12 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=11 uM for NADH {ECO:0000269 PubMed:12790796}; KM=16 uM for NADPH {ECO:0000269 PubMed:12790796}; KM=190 uM for NAD {ECO:0000269 PubMed:12790796}; pH dependence: Optimum pH is 8-9. {ECO:0000269 PubMed:12790796};
UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + H(2)O = AMP + NMN.
UniProtKB/Swiss-Prot Function:
Hydrolyzes NAD(P)H to NMNH and AMP (2,5-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle.

Enzyme Numbers (IUBMB) for NUDT12 Gene

Gene Ontology (GO) - Molecular Function for NUDT12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000210 NAD+ diphosphatase activity IDA 12790796
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity --
GO:0035529 NADH pyrophosphatase activity IDA 12790796
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NUDT12: view

Phenotypes for NUDT12 Gene

genes like me logo Genes that share phenotypes with NUDT12: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUDT12

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT12 Gene

Localization for NUDT12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT12 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDT12 Gene COMPARTMENTS Subcellular localization image for NUDT12 gene
Compartment Confidence
peroxisome 5
nucleus 4

Gene Ontology (GO) - Cellular Components for NUDT12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm --
GO:0005777 peroxisome IDA 12790796
genes like me logo Genes that share ontologies with NUDT12: view

Pathways & Interactions for NUDT12 Gene

genes like me logo Genes that share pathways with NUDT12: view

Pathways by source for NUDT12 Gene

2 KEGG pathways for NUDT12 Gene
1 GeneGo (Thomson Reuters) pathway for NUDT12 Gene

Gene Ontology (GO) - Biological Process for NUDT12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006742 NADP catabolic process IDA 12790796
GO:0008152 metabolic process --
GO:0019677 NAD catabolic process IDA 12790796
genes like me logo Genes that share ontologies with NUDT12: view

No data available for SIGNOR curated interactions for NUDT12 Gene

Drugs & Compounds for NUDT12 Gene

(5) Drugs for NUDT12 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Manganese Pharma 30
NAD Pharma Agonist, Activator 0
Magnesium Nutra 0
NADH Nutra 0

(6) Additional Compounds for NUDT12 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
beta-nicotinamide D-ribonucleotide
Nicotinamide ribotide
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium hydroxide inner salt
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium inner salt
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-beta-delta-ribofuranosyl)-Pyridinium hydroxide inner salt
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-beta-delta-ribofuranosyl)-Pyridinium inner salt
  • 3-Carbamoyl-1-b-D-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
1094-61-7
nicotinate beta-D-ribonucleotide
Nicotinic acid adenine dinucleotide
  • Deamido-NAD+
  • Deamidonicotinamide adenine dinucleoetide
  • Deamino-nad+
  • NAAD
  • NaADN
6450-77-7
Nicotinic acid mononucleotide
  • 3-Carboxy-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium inner salt
  • 3-Carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)-Pyridinium inner salt
  • 3-Carboxy-1-(5-O-phosphono-beta-delta-ribofuranosyl)-Pyridinium inner salt
  • 3-Carboxy-1-beta-D-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
  • 3-Carboxy-1-beta-delta-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
321-02-8
genes like me logo Genes that share compounds with NUDT12: view

Transcripts for NUDT12 Gene

Unigene Clusters for NUDT12 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 12:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUDT12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT12 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5: -
SP6:
SP7:

Relevant External Links for NUDT12 Gene

GeneLoc Exon Structure for
NUDT12
ECgene alternative splicing isoforms for
NUDT12

Expression for NUDT12 Gene

mRNA expression in normal human tissues for NUDT12 Gene

Protein differential expression in normal tissues from HIPED for NUDT12 Gene

This gene is overexpressed in Platelet (41.3) and Urine (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUDT12 Gene



SOURCE GeneReport for Unigene cluster for NUDT12 Gene Hs.434289

genes like me logo Genes that share expression patterns with NUDT12: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NUDT12 Gene

Orthologs for NUDT12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUDT12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUDT12 35
  • 92.57 (n)
  • 93.92 (a)
NUDT12 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUDT12 35
  • 92.25 (n)
  • 91.96 (a)
NUDT12 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt12 35
  • 84.13 (n)
  • 87.88 (a)
Nudt12 16
Nudt12 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUDT12 35
  • 99.35 (n)
  • 99.57 (a)
NUDT12 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nudt12 35
  • 83.98 (n)
  • 87.66 (a)
oppossum
(Monodelphis domestica)
Mammalia NUDT12 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDT12 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDT12 35
  • 75.9 (n)
  • 75.54 (a)
NUDT12 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDT12 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt12 35
  • 68.21 (n)
  • 66.3 (a)
zebrafish
(Danio rerio)
Actinopterygii nudt12 35
  • 58.26 (n)
  • 54.67 (a)
nudt12 36
  • 54 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03146g 35
  • 44.84 (n)
  • 33.63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPY1 35
  • 46.12 (n)
  • 33.53 (a)
NPY1 36
  • 26 (a)
OneToMany
NPY1 38
soybean
(Glycine max)
eudicotyledons Gma.1733 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00293 35
  • 45.92 (n)
  • 41.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1778.03c 35
  • 48.52 (n)
  • 40.37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3106 36
  • 42 (a)
OneToOne
Species with no ortholog for NUDT12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDT12 Gene

ENSEMBL:
Gene Tree for NUDT12 (if available)
TreeFam:
Gene Tree for NUDT12 (if available)

Paralogs for NUDT12 Gene

Paralogs for NUDT12 Gene

(1) SIMAP similar genes for NUDT12 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NUDT12: view

Variants for NUDT12 Gene

Sequence variations from dbSNP and Humsavar for NUDT12 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_034157 -
VAR_034158 -

Structural Variations from Database of Genomic Variants (DGV) for NUDT12 Gene

Variant ID Type Subtype PubMed ID
nsv882523 CNV Gain 21882294

Variation tolerance for NUDT12 Gene

Residual Variation Intolerance Score: 37.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDT12 Gene

HapMap Linkage Disequilibrium report
NUDT12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT12 Gene

Disorders for NUDT12 Gene

Relevant External Links for NUDT12

Genetic Association Database (GAD)
NUDT12
Human Genome Epidemiology (HuGE) Navigator
NUDT12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDT12
genes like me logo Genes that share disorders with NUDT12: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT12 Gene

Publications for NUDT12 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. (PMID: 24529757) Xie T. … Xu R. (Neurobiol. Aging 2014) 67
  5. A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels. (PMID: 25240745) LA^pez S. … Soria J.M. (Mitochondrion 2014) 67

Products for NUDT12 Gene

Sources for NUDT12 Gene

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