Aliases for NUDT12 Gene
External Ids for NUDT12 Gene
Previous GeneCards Identifiers for NUDT12 Gene
Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003 [PubMed 12790796]).[supplied by OMIM, Mar 2008]
GeneCards Summary for NUDT12 Gene
NUDT12 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 12) is a Protein Coding gene. Among its related pathways are Nicotinate and nicotinamide metabolism and Nicotinate and nicotinamide metabolism. GO annotations related to this gene include NADH pyrophosphatase activity and NAD+ diphosphatase activity. An important paralog of this gene is NUDT13.
UniProtKB/Swiss-Prot for NUDT12 Gene
Hydrolyzes NAD(P)H to NMNH and AMP (2,5-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle.