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Aliases for HIST2H2BE Gene

Aliases for HIST2H2BE Gene

  • Histone Cluster 2, H2be 2 3 5
  • H2B Histone Family, Member Q 2 3
  • Histone H2B-GL105 3 4
  • Histone 2, H2be 2 3
  • Histone H2B.Q 3 4
  • H2BFQ 3 4
  • H2BGL105 3
  • H2B.1 3
  • GL105 3
  • H2B/Q 4
  • H2BQ 3
  • H2B 3

External Ids for HIST2H2BE Gene

Previous HGNC Symbols for HIST2H2BE Gene

  • H2B
  • H2BFQ

Previous GeneCards Identifiers for HIST2H2BE Gene

  • GC01M145598
  • GC01M146631
  • GC01M147072
  • GC01M146669
  • GC01M148122
  • GC01M148082
  • GC01M149856
  • GC01M121237

Summaries for HIST2H2BE Gene

Entrez Gene Summary for HIST2H2BE Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. The protein has antibacterial and antifungal antimicrobial activity. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST2H2BE Gene

HIST2H2BE (Histone Cluster 2, H2be) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Viral carcinogenesis. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BH.

UniProtKB/Swiss-Prot for HIST2H2BE Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

  • Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.

Gene Wiki entry for HIST2H2BE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H2BE Gene

Genomics for HIST2H2BE Gene

Regulatory Elements for HIST2H2BE Gene

Enhancers for HIST2H2BE Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HIST2H2BE on UCSC Golden Path with GeneCards custom track

Promoters for HIST2H2BE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HIST2H2BE on UCSC Golden Path with GeneCards custom track

Genomic Location for HIST2H2BE Gene

Chromosome:
1
Start:
149,842,204 bp from pter
End:
149,886,682 bp from pter
Size:
44,479 bases
Orientation:
Minus strand

Genomic View for HIST2H2BE Gene

Genes around HIST2H2BE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST2H2BE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST2H2BE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST2H2BE Gene

Proteins for HIST2H2BE Gene

  • Protein details for HIST2H2BE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16778-H2B2E_HUMAN
    Recommended name:
    Histone H2B type 2-E
    Protein Accession:
    Q16778
    Secondary Accessions:
    • A3KMC7
    • A8K110
    • Q4KMY1
    • Q5QNX0
    • Q9UE88

    Protein attributes for HIST2H2BE Gene

    Size:
    126 amino acids
    Molecular mass:
    13920 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

    Three dimensional structures from OCA and Proteopedia for HIST2H2BE Gene

neXtProt entry for HIST2H2BE Gene

Proteomics data for HIST2H2BE Gene at MOPED

Post-translational modifications for HIST2H2BE Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Ubiquitination at Lys 121
  • Glycosylation at Ser 113
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST2H2BE Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for HIST2H2BE

No data available for DME Specific Peptides for HIST2H2BE Gene

Domains & Families for HIST2H2BE Gene

Gene Families for HIST2H2BE Gene

Protein Domains for HIST2H2BE Gene

Suggested Antigen Peptide Sequences for HIST2H2BE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16778

UniProtKB/Swiss-Prot:

H2B2E_HUMAN :
  • Belongs to the histone H2B family.
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST2H2BE: view

Function for HIST2H2BE Gene

Molecular function for HIST2H2BE Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
UniProtKB/Swiss-Prot Function:
Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.

Phenotypes for HIST2H2BE Gene

genes like me logo Genes that share phenotypes with HIST2H2BE: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST2H2BE Gene

Localization for HIST2H2BE Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST2H2BE Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST2H2BE Gene COMPARTMENTS Subcellular localization image for HIST2H2BE gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for HIST2H2BE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with HIST2H2BE: view

Pathways & Interactions for HIST2H2BE Gene

SuperPathways for HIST2H2BE Gene

Superpath Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence
4 Chromosome Maintenance
5 Packaging Of Telomere Ends
genes like me logo Genes that share pathways with HIST2H2BE: view

Gene Ontology (GO) - Biological Process for HIST2H2BE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019731 antibacterial humoral response IDA 12860195
GO:0050830 defense response to Gram-positive bacterium IDA 12860195
genes like me logo Genes that share ontologies with HIST2H2BE: view

No data available for SIGNOR curated interactions for HIST2H2BE Gene

Drugs & Compounds for HIST2H2BE Gene

(1) Drugs for HIST2H2BE Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for HIST2H2BE Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HIST2H2BE: view

Transcripts for HIST2H2BE Gene

mRNA/cDNA for HIST2H2BE Gene

Unigene Clusters for HIST2H2BE Gene

Histone cluster 2, H2be:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST2H2BE Gene

No ASD Table

Relevant External Links for HIST2H2BE Gene

GeneLoc Exon Structure for
HIST2H2BE
ECgene alternative splicing isoforms for
HIST2H2BE

Expression for HIST2H2BE Gene

mRNA expression in normal human tissues for HIST2H2BE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST2H2BE Gene

This gene is overexpressed in Whole Blood (x5.8).

Protein differential expression in normal tissues from HIPED for HIST2H2BE Gene

This gene is overexpressed in Saliva (53.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST2H2BE Gene



SOURCE GeneReport for Unigene cluster for HIST2H2BE Gene Hs.2178

genes like me logo Genes that share expression patterns with HIST2H2BE: view

Protein tissue co-expression partners for HIST2H2BE Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HIST2H2BE Gene

Orthologs for HIST2H2BE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST2H2BE Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC512612 35
  • 88.62 (n)
  • 94.44 (a)
H2B 36
  • 99 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC483170 35
  • 94.71 (n)
  • 100 (a)
-- 36
  • 79 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia HIST1H2BD 35
  • 99.47 (n)
  • 100 (a)
HIST2H2BE 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HIST2H2BE 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HIST2H2BE 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves H2B-I 36
  • 97 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 94 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1950 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
ano9a 36
  • 88 (a)
ManyToMany
ano9a 36
  • 94 (a)
ManyToMany
CABZ01086354.1 36
  • 86 (a)
ManyToMany
wu:fe11b02 36
  • 89 (a)
ManyToMany
wu:fe11b02 36
  • 89 (a)
ManyToMany
wu:fe11b02 36
  • 88 (a)
ManyToMany
wu:fe11b02 36
  • 89 (a)
ManyToMany
wu:fe11b02 36
  • 94 (a)
ManyToMany
wu:fe11b02 36
  • 94 (a)
ManyToMany
wu:fe11b02 36
  • 89 (a)
ManyToMany
wu:fe11b02 36
  • 87 (a)
ManyToMany
zgc:171759 36
  • 89 (a)
ManyToMany
zgc:171759 36
  • 90 (a)
ManyToMany
zgc:173587 36
  • 87 (a)
ManyToMany
zgc:194989 36
  • 94 (a)
ManyToMany
zgc:171759 36
  • 88 (a)
ManyToMany
zgc:171759 36
  • 88 (a)
ManyToMany
zgc:171759 36
  • 85 (a)
ManyToMany
zgc:171759 36
  • 87 (a)
ManyToMany
zgc:171759 36
  • 47 (a)
ManyToMany
zgc:171759 36
  • 94 (a)
ManyToMany
zgc:171759 36
  • 87 (a)
ManyToMany
zgc:171759 36
  • 88 (a)
ManyToMany
zgc:112234 36
  • 94 (a)
ManyToMany
zgc:112234 36
  • 94 (a)
ManyToMany
zgc:112234 36
  • 94 (a)
ManyToMany
zgc:112234 36
  • 94 (a)
ManyToMany
zgc:112234 36
  • 87 (a)
ManyToMany
si:dkey-261m9.6 36
  • 87 (a)
ManyToMany
si:dkey-261m9.19 36
  • 87 (a)
ManyToMany
LOC560748 35
  • 85.22 (n)
  • 95.16 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11306 35
rice
(Oryza sativa)
Liliopsida Os.47714 35
wheat
(Triticum aestivum)
Liliopsida Ta.27708 35
Species with no ortholog for HIST2H2BE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for HIST2H2BE Gene

ENSEMBL:
Gene Tree for HIST2H2BE (if available)
TreeFam:
Gene Tree for HIST2H2BE (if available)

Paralogs for HIST2H2BE Gene

genes like me logo Genes that share paralogs with HIST2H2BE: view

Variants for HIST2H2BE Gene

Sequence variations from dbSNP and Humsavar for HIST2H2BE Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs15931 -- 149,884,800(+) TTGGC(C/T)TCATT utr-variant-3-prime
rs16841820 -- 149,884,597(+) CATCA(A/G)CTCCA utr-variant-3-prime
rs79555758 -- 149,884,354(+) ATCCC(C/T)CAGAT downstream-variant-500B
rs141705609 -- 149,884,357(+) CCCCA(C/G)ATCAG downstream-variant-500B
rs148278594 -- 149,884,173(+) GCTCC(A/G)TAGGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HIST2H2BE Gene

Variant ID Type Subtype PubMed ID
dgv117e1 CNV Complex 17122850
nsv428235 CNV Gain 18775914
esv2750807 CNV Gain 17911159
dgv123e1 CNV Complex 17122850
dgv125e1 CNV Complex 17122850
nsv831525 CNV Gain 17160897
essv23032 CNV CNV 17122850
nsv7182 OTHER Inversion 18451855
nsv831537 CNV Loss 17160897

Variation tolerance for HIST2H2BE Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST2H2BE Gene

HapMap Linkage Disequilibrium report
HIST2H2BE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST2H2BE Gene

Disorders for HIST2H2BE Gene

Relevant External Links for HIST2H2BE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST2H2BE

No disorders were found for HIST2H2BE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST2H2BE Gene

Publications for HIST2H2BE Gene

  1. A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing. (PMID: 1469070) Collart D. … Stein G.S. (J. Cell. Biochem. 1992) 2 3 4 23 67
  2. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. (PMID: 18206972) Zhao Y. … Devys D. (Mol. Cell 2008) 3 23
  3. Characterization of histones H2A and H2B variants and their post- translational modifications by mass spectrometry. (PMID: 16319397) Bonenfant D. … van Oostrum J. (Mol. Cell. Proteomics 2006) 3 23
  4. Gene-specific characterization of human histone H2B by electron capture dissociation. (PMID: 16457587) Siuti N. … Pesavento J.J. (J. Proteome Res. 2006) 3 23
  5. Quantitative proteomic analysis of post-translational modifications of human histones. (PMID: 16627869) Beck H.C. … Jensen O.N. (Mol. Cell. Proteomics 2006) 3 23

Products for HIST2H2BE Gene

Sources for HIST2H2BE Gene

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