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Aliases for HIST2H2BE Gene

Aliases for HIST2H2BE Gene

  • Histone Cluster 2, H2be 2 3
  • H2B Histone Family, Member Q 2 3
  • Histone H2B-GL105 3 4
  • Histone 2, H2be 2 3
  • Histone H2B.Q 3 4
  • H2BFQ 3 4
  • H2B 3 6
  • Histone H2B Type 2-E 3
  • H2BGL105 3
  • GL105 3
  • H2B.1 3
  • H2B/Q 4
  • H2BQ 3

External Ids for HIST2H2BE Gene

Previous HGNC Symbols for HIST2H2BE Gene

  • H2B
  • H2BFQ

Previous GeneCards Identifiers for HIST2H2BE Gene

  • GC01M145598
  • GC01M146631
  • GC01M147072
  • GC01M146669
  • GC01M148122
  • GC01M148082
  • GC01M149856
  • GC01M121237

Summaries for HIST2H2BE Gene

Entrez Gene Summary for HIST2H2BE Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. The protein has antibacterial and antifungal antimicrobial activity. [provided by RefSeq, Dec 2014]

GeneCards Summary for HIST2H2BE Gene

HIST2H2BE (Histone Cluster 2, H2be) is a Protein Coding gene. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST1H2BN.

UniProtKB/Swiss-Prot for HIST2H2BE Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

  • Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

Gene Wiki entry for HIST2H2BE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H2BE Gene

Genomics for HIST2H2BE Gene

Regulatory Elements for HIST2H2BE Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HIST2H2BE Gene

Start:
149,842,204 bp from pter
End:
149,886,682 bp from pter
Size:
44,479 bases
Orientation:
Minus strand

Genomic View for HIST2H2BE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST2H2BE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST2H2BE Gene

Proteins for HIST2H2BE Gene

  • Protein details for HIST2H2BE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16778-H2B2E_HUMAN
    Recommended name:
    Histone H2B type 2-E
    Protein Accession:
    Q16778
    Secondary Accessions:
    • A3KMC7
    • A8K110
    • Q4KMY1
    • Q5QNX0
    • Q9UE88

    Protein attributes for HIST2H2BE Gene

    Size:
    126 amino acids
    Molecular mass:
    13920 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

    Three dimensional structures from OCA and Proteopedia for HIST2H2BE Gene

neXtProt entry for HIST2H2BE Gene

Proteomics data for HIST2H2BE Gene at MOPED

Post-translational modifications for HIST2H2BE Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Ubiquitination at Lys6, Lys44, Lys47, Lys58, Lys109, Lys117, and Lys121
  • Glycosylation at Ser113
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST2H2BE Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST2H2BE Gene

Domains for HIST2H2BE Gene

Gene Families for HIST2H2BE Gene

HGNC:
  • HIST :Histones / Replication-dependent

Protein Domains for HIST2H2BE Gene

Suggested Antigen Peptide Sequences for HIST2H2BE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16778

UniProtKB/Swiss-Prot:

H2B2E_HUMAN :
  • Q16778
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST2H2BE: view

Function for HIST2H2BE Gene

Molecular function for HIST2H2BE Gene

UniProtKB/Swiss-Prot Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
UniProtKB/Swiss-Prot Function: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

Gene Ontology (GO) - Molecular Function for HIST2H2BE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 1469070
GO:0043565 sequence-specific DNA binding --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST2H2BE: view

Phenotypes for HIST2H2BE Gene

genes like me logo Genes that share phenotypes with HIST2H2BE: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST2H2BE

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HIST2H2BE Gene

Localization for HIST2H2BE Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST2H2BE Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST2H2BE Gene COMPARTMENTS Subcellular localization image for HIST2H2BE gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HIST2H2BE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome NAS 1469070
GO:0000788 nuclear nucleosome IBA --
GO:0005615 extracellular space IDA 12860195
GO:0005622 intracellular --
GO:0005634 nucleus IDA 16319397
genes like me logo Genes that share ontologies with HIST2H2BE: view

Pathways for HIST2H2BE Gene

genes like me logo Genes that share pathways with HIST2H2BE: view

Pathways by source for HIST2H2BE Gene

29 Reactome pathways for HIST2H2BE Gene
3 KEGG pathways for HIST2H2BE Gene
1 GeneGo (Thomson Reuters) pathway for HIST2H2BE Gene

Gene Ontology (GO) - Biological Process for HIST2H2BE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002227 innate immune response in mucosa IDA 12860195
GO:0006325 chromatin organization TAS --
GO:0006334 nucleosome assembly NAS 1469070
GO:0019731 antibacterial humoral response IDA 12860195
GO:0050830 defense response to Gram-positive bacterium IDA 12860195
genes like me logo Genes that share ontologies with HIST2H2BE: view

Compounds for HIST2H2BE Gene

(4) Novoseek inferred chemical compound relationships for HIST2H2BE Gene

Compound -log(P) Hits PubMed IDs
lactacystin 39.6 1
adpribose 27.5 1
butyrate 14.5 1
atp 0 2
genes like me logo Genes that share compounds with HIST2H2BE: view

Transcripts for HIST2H2BE Gene

mRNA/cDNA for HIST2H2BE Gene

(254) Selected AceView cDNA sequences:
(10) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST2H2BE Gene

Histone cluster 2, H2be:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST2H2BE

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST2H2BE Gene

No ASD Table

Relevant External Links for HIST2H2BE Gene

GeneLoc Exon Structure for
HIST2H2BE
ECgene alternative splicing isoforms for
HIST2H2BE

Expression for HIST2H2BE Gene

mRNA expression in normal human tissues for HIST2H2BE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST2H2BE Gene

This gene is overexpressed in Whole Blood (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST2H2BE Gene

SOURCE GeneReport for Unigene cluster for HIST2H2BE Gene Hs.2178

genes like me logo Genes that share expressions with HIST2H2BE: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HIST2H2BE Gene

Orthologs for HIST2H2BE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST2H2BE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIST1H2BD 35
  • 99.47 (n)
  • 100 (a)
HIST2H2BE 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia H2B 36
  • 99 (a)
ManyToMany
LOC512612 35
  • 88.62 (n)
  • 94.44 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
LOC483170 35
  • 94.71 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Hist2h2be 16
oppossum
(Monodelphis domestica)
Mammalia HIST2H2BE 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HIST2H2BE 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves H2B-I 36
  • 97 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 94 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1950 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
ano9a 36
  • 88 (a)
ManyToMany
ano9a 36
  • 94 (a)
ManyToMany
CABZ01086354.1 36
  • 86 (a)
ManyToMany
LOC560748 35
  • 85.22 (n)
  • 95.16 (a)
si:dkey-261m9.19 36
  • 87 (a)
ManyToMany
si:dkey-261m9.6 36
  • 87 (a)
ManyToMany
wu:fe11b02 36
  • 89 (a)
ManyToMany
wu:fe11b02 36
  • 89 (a)
ManyToMany
wu:fe11b02 36
  • 88 (a)
ManyToMany
wu:fe11b02 36
  • 89 (a)
ManyToMany
wu:fe11b02 36
  • 94 (a)
ManyToMany
wu:fe11b02 36
  • 94 (a)
ManyToMany
wu:fe11b02 36
  • 89 (a)
ManyToMany
wu:fe11b02 36
  • 87 (a)
ManyToMany
zgc:112234 36
  • 87 (a)
ManyToMany
zgc:112234 36
  • 94 (a)
ManyToMany
zgc:112234 36
  • 94 (a)
ManyToMany
zgc:112234 36
  • 94 (a)
ManyToMany
zgc:112234 36
  • 94 (a)
ManyToMany
zgc:171759 36
  • 88 (a)
ManyToMany
zgc:171759 36
  • 87 (a)
ManyToMany
zgc:171759 36
  • 94 (a)
ManyToMany
zgc:171759 36
  • 47 (a)
ManyToMany
zgc:171759 36
  • 87 (a)
ManyToMany
zgc:171759 36
  • 85 (a)
ManyToMany
zgc:171759 36
  • 88 (a)
ManyToMany
zgc:171759 36
  • 88 (a)
ManyToMany
zgc:171759 36
  • 89 (a)
ManyToMany
zgc:171759 36
  • 90 (a)
ManyToMany
zgc:173587 36
  • 87 (a)
ManyToMany
zgc:194989 36
  • 94 (a)
ManyToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11306 35
rice
(Oryza sativa)
Liliopsida Os.47714 35
wheat
(Triticum aestivum)
Liliopsida Ta.27708 35
Species with no ortholog for HIST2H2BE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for HIST2H2BE Gene

ENSEMBL:
Gene Tree for HIST2H2BE (if available)
TreeFam:
Gene Tree for HIST2H2BE (if available)

Paralogs for HIST2H2BE Gene

genes like me logo Genes that share paralogs with HIST2H2BE: view

Variants for HIST2H2BE Gene

Sequence variations from dbSNP and Humsavar for HIST2H2BE Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13672 -- 149,884,629(-) GAGTG(A/G)TTCAG utr-variant-3-prime
rs15931 -- 149,884,800(+) TTGGC(C/T)TCATT utr-variant-3-prime
rs16841820 -- 149,884,597(+) CATCA(A/G)CTCCA utr-variant-3-prime
rs59956612 -- 149,884,184(+) GTTAG(C/T)TTAAC downstream-variant-500B
rs74488507 -- 149,884,518(+) ACACA(C/T)ATGTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HIST2H2BE Gene

Variant ID Type Subtype PubMed ID
dgv117e1 CNV Complex 17122850
nsv428235 CNV Gain 18775914
esv2750807 CNV Gain 17911159
dgv123e1 CNV Complex 17122850
dgv125e1 CNV Complex 17122850
nsv831525 CNV Gain 17160897
essv23032 CNV CNV 17122850
nsv7182 OTHER Inversion 18451855
nsv831537 CNV Loss 17160897

Relevant External Links for HIST2H2BE Gene

HapMap Linkage Disequilibrium report
HIST2H2BE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST2H2BE Gene

Disorders for HIST2H2BE Gene

(1) Novoseek inferred disease relationships for HIST2H2BE Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2
genes like me logo Genes that share disorders with HIST2H2BE: view

No data available for UniProtKB/Swiss-Prot for HIST2H2BE Gene

Publications for HIST2H2BE Gene

  1. A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing. (PMID: 1469070) Collart D. … Stein G.S. (J. Cell. Biochem. 1992) 2 3 4 23
  2. Gene-specific characterization of human histone H2B by electron capture dissociation. (PMID: 16457587) Siuti N. … Pesavento J.J. (J. Proteome Res. 2006) 3 4 23
  3. Quantitative proteomic analysis of post-translational modifications of human histones. (PMID: 16627869) Beck H.C. … Jensen O.N. (Mol. Cell. Proteomics 2006) 3 4 23
  4. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
  5. Characterization of histones H2A and H2B variants and their post- translational modifications by mass spectrometry. (PMID: 16319397) Bonenfant D. … van Oostrum J. (Mol. Cell. Proteomics 2006) 3 23

Products for HIST2H2BE Gene

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  • antibodies-online antibodies for HIST2H2BE
  • antibodies-online kits for HIST2H2BE

Sources for HIST2H2BE Gene

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