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Aliases for DDX59 Gene

Aliases for DDX59 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 59 2 3
  • Zinc Finger HIT Domain-Containing Protein 5 3 4
  • DEAD Box Protein 59 3 4
  • ZNHIT5 3 4
  • OFD5 3 6
  • Probable ATP-Dependent RNA Helicase DDX59 3
  • EC 3.6.4.13 4
  • EC 3.6.1 64

External Ids for DDX59 Gene

Summaries for DDX59 Gene

GeneCards Summary for DDX59 Gene

DDX59 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 59) is a Protein Coding gene. Diseases associated with DDX59 include orofaciodigital syndrome v and orofaciodigital syndrome. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity. An important paralog of this gene is DDX23.

Gene Wiki entry for DDX59 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX59 Gene

Genomics for DDX59 Gene

Genomic Location for DDX59 Gene

Start:
200,623,896 bp from pter
End:
200,669,998 bp from pter
Size:
46,103 bases
Orientation:
Minus strand

Genomic View for DDX59 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX59 Gene

Regulatory Elements for DDX59 Gene

Proteins for DDX59 Gene

  • Protein details for DDX59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T1V6-DDX59_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX59
    Protein Accession:
    Q5T1V6
    Secondary Accessions:
    • Q6PJL2
    • Q8IVW3
    • Q9H0W3

    Protein attributes for DDX59 Gene

    Size:
    619 amino acids
    Molecular mass:
    68810 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH14183.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 433.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DDX59 Gene

    Alternative splice isoforms for DDX59 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX59 Gene

Proteomics data for DDX59 Gene at MOPED

Selected DME Specific Peptides for DDX59 Gene

Post-translational modifications for DDX59 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for DDX59 Gene

Gene Families for DDX59 Gene

HGNC:
  • DDX :DEAD-boxes
  • ZNHIT :Zinc fingers, HIT-type

UniProtKB/Swiss-Prot:

DDX59_HUMAN
Domain:
  • The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis:
    • Q5T1V6
  • Contains 1 helicase ATP-binding domain.:
    • Q5T1V6
  • Contains 1 helicase C-terminal domain.:
    • Q5T1V6
Family:
  • Belongs to the DEAD box helicase family. DDX59 subfamily.:
    • Q5T1V6
Similarity:
  • Contains 1 HIT-type zinc finger.:
    • Q5T1V6
genes like me logo Genes that share domains with DDX59: view

Function for DDX59 Gene

Molecular function for DDX59 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate

Enzyme Numbers (IUBMB) for DDX59 Gene

Gene Ontology (GO) - Molecular Function for DDX59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX59: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DDX59 Gene

Localization for DDX59 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX59 Gene

Cytoplasm. Nucleus. Note=Exhibits granular localization in the nucleus, as well as in the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX59 Gene COMPARTMENTS Subcellular localization image for DDX59 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for DDX59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus --
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DDX59: view

Pathways for DDX59 Gene

SuperPathways for DDX59 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX59: view

No data available for Pathways by source for DDX59 Gene

Transcripts for DDX59 Gene

Unigene Clusters for DDX59 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 59:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX59 Gene

No ASD Table

Relevant External Links for DDX59 Gene

GeneLoc Exon Structure for
DDX59
ECgene alternative splicing isoforms for
DDX59

Expression for DDX59 Gene

mRNA expression in normal human tissues for DDX59 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX59 Gene

SOURCE GeneReport for Unigene cluster for DDX59 Gene Hs.497332

mRNA Expression by UniProt/SwissProt for DDX59 Gene

Q5T1V6-DDX59_HUMAN
Tissue specificity: Expressed in fibroblasts (at protein level).
genes like me logo Genes that share expressions with DDX59: view

Orthologs for DDX59 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX59 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX59 36
  • 99.19 (n)
  • 99.03 (a)
DDX59 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDX59 36
  • 74.26 (n)
  • 77.22 (a)
DDX59 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX59 36
  • 88.42 (n)
  • 89.98 (a)
DDX59 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx59 36
  • 81.53 (n)
  • 83.68 (a)
Ddx59 16
Ddx59 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDX59 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX59 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx59 36
  • 81.5 (n)
  • 84.14 (a)
chicken
(Gallus gallus)
Aves DDX59 36
  • 72.34 (n)
  • 74.07 (a)
DDX59 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDX59 37
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3767 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx59 36
  • 65.69 (n)
  • 65.18 (a)
Str.16783 36
zebrafish
(Danio rerio)
Actinopterygii ddx59 36
  • 62 (n)
  • 64.08 (a)
ddx59 37
  • 61 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP28 37
  • 24 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G02065 36
  • 52.48 (n)
  • 47.17 (a)
Species with no ortholog for DDX59:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDX59 Gene

ENSEMBL:
Gene Tree for DDX59 (if available)
TreeFam:
Gene Tree for DDX59 (if available)

Paralogs for DDX59 Gene

Paralogs for DDX59 Gene

genes like me logo Genes that share paralogs with DDX59: view

Variants for DDX59 Gene

Sequence variations from dbSNP and Humsavar for DDX59 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1132058 -- 200,650,449(-) AAAAA(A/G)AAAAA synonymous-codon, reference, intron-variant
rs1134343 -- 200,651,560(-) tttcc(C/T)acagt intron-variant
rs2808230 -- 200,650,350(+) AATCT(A/C)AAAAT intron-variant
rs2808231 -- 200,653,908(+) CTGCC(A/G)TATCG intron-variant
rs2808232 -- 200,657,736(+) agagc(A/G)agact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX59 Gene

Variant ID Type Subtype PubMed ID
nsv873095 CNV Gain 21882294

Relevant External Links for DDX59 Gene

HapMap Linkage Disequilibrium report
DDX59
Human Gene Mutation Database (HGMD)
DDX59

Disorders for DDX59 Gene

(1) OMIM Diseases for DDX59 Gene (615464)

UniProtKB/Swiss-Prot

DDX59_HUMAN
  • Orofaciodigital syndrome 5 (OFD5) [MIM:174300]: A form of orofaciodigital syndrome, a group of heterogeneous disorders characterized by malformations of the oral cavity, face and digits, and associated phenotypic abnormalities that lead to the delineation of various subtypes. OFD5 patients show the core features of cleft palate, lobulated tongue, and polydactyly. Additional features include frontal bossing and intellectual disability. {ECO:0000269 PubMed:23972372}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DDX59

Genetic Association Database (GAD)
DDX59
genes like me logo Genes that share disorders with DDX59: view

Publications for DDX59 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Mutations in DDX59 implicate RNA helicase in the pathogenesis of orofaciodigital syndrome. (PMID: 23972372) Shamseldin H.E. … Alkuraya F.S. (Am. J. Hum. Genet. 2013) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for DDX59 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate DDX59
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for DDX59
    • Block miRNA regulation of DDX59 using miScript Target Protectors

    Sources for DDX59 Gene

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