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Aliases for DDX59 Gene

Aliases for DDX59 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 59 2 3
  • Zinc Finger HIT Domain-Containing Protein 5 3 4
  • DEAD Box Protein 59 3 4
  • ZNHIT5 3 4
  • OFD5 3 6
  • Probable ATP-Dependent RNA Helicase DDX59 3
  • EC 4
  • EC 3.6.1 63

External Ids for DDX59 Gene

Previous GeneCards Identifiers for DDX59 Gene

  • GC01M197325
  • GC01M198859
  • GC01M171779

Summaries for DDX59 Gene

GeneCards Summary for DDX59 Gene

DDX59 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 59) is a Protein Coding gene. Diseases associated with DDX59 include orofaciodigital syndrome v and orofaciodigital syndrome xiv. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity. An important paralog of this gene is DDX23.

Gene Wiki entry for DDX59 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX59 Gene

Genomics for DDX59 Gene

Regulatory Elements for DDX59 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DDX59 Gene

200,623,896 bp from pter
200,669,998 bp from pter
46,103 bases
Minus strand

Genomic View for DDX59 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX59 Gene

Proteins for DDX59 Gene

  • Protein details for DDX59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DDX59
    Protein Accession:
    Secondary Accessions:
    • Q6PJL2
    • Q8IVW3
    • Q9H0W3

    Protein attributes for DDX59 Gene

    619 amino acids
    Molecular mass:
    68810 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH14183.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 433.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DDX59 Gene

    Alternative splice isoforms for DDX59 Gene


neXtProt entry for DDX59 Gene

Proteomics data for DDX59 Gene at MOPED

Selected DME Specific Peptides for DDX59 Gene

Post-translational modifications for DDX59 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains for DDX59 Gene

Gene Families for DDX59 Gene

  • DDX :DEAD-boxes
  • ZNHIT :Zinc fingers, HIT-type

Graphical View of Domain Structure for InterPro Entry



  • Q5T1V6
  • The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DDX59 subfamily.
  • Contains 1 HIT-type zinc finger.
genes like me logo Genes that share domains with DDX59: view

Function for DDX59 Gene

Molecular function for DDX59 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate

Enzyme Numbers (IUBMB) for DDX59 Gene

Gene Ontology (GO) - Molecular Function for DDX59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX59: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX59

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DDX59 Gene

Localization for DDX59 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX59 Gene

Cytoplasm. Nucleus. Note=Exhibits granular localization in the nucleus, as well as in the cytoplasm.

Subcellular locations from

Jensen Localization Image for DDX59 Gene COMPARTMENTS Subcellular localization image for DDX59 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for DDX59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus --
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DDX59: view

Pathways for DDX59 Gene

SuperPathways for DDX59 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX59: view

No data available for Pathways by source for DDX59 Gene

Transcripts for DDX59 Gene

Unigene Clusters for DDX59 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 59:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX59

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX59 Gene

No ASD Table

Relevant External Links for DDX59 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX59 Gene

mRNA expression in normal human tissues for DDX59 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DDX59 Gene

This gene is overexpressed in Testis (42.8), Placenta (8.9), and Lymph node (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX59 Gene

SOURCE GeneReport for Unigene cluster for DDX59 Gene Hs.497332

mRNA Expression by UniProt/SwissProt for DDX59 Gene

Tissue specificity: Expressed in fibroblasts (at protein level).
genes like me logo Genes that share expressions with DDX59: view

Expression partners for DDX59 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DDX59 Gene

Orthologs for DDX59 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX59 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DDX59 35
  • 74.26 (n)
  • 77.22 (a)
DDX59 36
  • 76 (a)
(Canis familiaris)
Mammalia DDX59 35
  • 88.42 (n)
  • 89.98 (a)
DDX59 36
  • 84 (a)
(Mus musculus)
Mammalia Ddx59 35
  • 81.53 (n)
  • 83.68 (a)
Ddx59 16
Ddx59 36
  • 84 (a)
(Pan troglodytes)
Mammalia DDX59 35
  • 99.19 (n)
  • 99.03 (a)
DDX59 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ddx59 35
  • 81.5 (n)
  • 84.14 (a)
(Monodelphis domestica)
Mammalia DDX59 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia DDX59 36
  • 72 (a)
(Gallus gallus)
Aves DDX59 35
  • 72.34 (n)
  • 74.07 (a)
DDX59 36
  • 57 (a)
(Anolis carolinensis)
Reptilia DDX59 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx59 35
  • 65.69 (n)
  • 65.18 (a)
Str.16783 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3767 35
(Danio rerio)
Actinopterygii ddx59 35
  • 62 (n)
  • 64.08 (a)
ddx59 36
  • 61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP28 36
  • 24 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G02065 35
  • 52.48 (n)
  • 47.17 (a)
Species with no ortholog for DDX59:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDX59 Gene

Gene Tree for DDX59 (if available)
Gene Tree for DDX59 (if available)

Paralogs for DDX59 Gene

Paralogs for DDX59 Gene

genes like me logo Genes that share paralogs with DDX59: view

Variants for DDX59 Gene

Sequence variations from dbSNP and Humsavar for DDX59 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1132058 -- 200,650,449(-) AAAAA(A/G)AAAAA synonymous-codon, reference, intron-variant
rs1134343 -- 200,651,560(-) tttcc(C/T)acagt intron-variant
rs2808230 -- 200,650,350(+) AATCT(A/C)AAAAT intron-variant
rs2808231 -- 200,653,908(+) CTGCC(A/G)TATCG intron-variant
rs2808232 -- 200,657,736(+) agagc(A/G)agact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX59 Gene

Variant ID Type Subtype PubMed ID
nsv873095 CNV Gain 21882294

Relevant External Links for DDX59 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX59 Gene

Disorders for DDX59 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DDX59 Gene in MalaCards »

(3) Diseases for DDX59 Gene including...

(1) OMIM Diseases for DDX59 Gene (615464)


  • Orofaciodigital syndrome 5 (OFD5) [MIM:174300]: A form of orofaciodigital syndrome, a group of heterogeneous disorders characterized by malformations of the oral cavity, face and digits, and associated phenotypic abnormalities that lead to the delineation of various subtypes. OFD5 patients show the core features of cleft palate, lobulated tongue, and polydactyly. Additional features include frontal bossing and intellectual disability. {ECO:0000269 PubMed:23972372}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DDX59

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with DDX59: view

No data available for University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DDX59 Gene

Publications for DDX59 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Mutations in DDX59 implicate RNA helicase in the pathogenesis of orofaciodigital syndrome. (PMID: 23972372) Shamseldin H.E. … Alkuraya F.S. (Am. J. Hum. Genet. 2013) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for DDX59 Gene

Sources for DDX59 Gene

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