Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MXD3 Gene

Aliases for MXD3 Gene

  • MAX Dimerization Protein 3 2 3 5
  • Max-Interacting Transcriptional Repressor MAD3 3 4
  • Class C Basic Helix-Loop-Helix Protein 13 3 4
  • Max-Associated Protein 3 3 4
  • Max Dimerizer 3 3 4
  • BHLHC13 3 4
  • MAD3 3 4
  • MYX 3 4

External Ids for MXD3 Gene

Previous GeneCards Identifiers for MXD3 Gene

  • GC05M177575
  • GC05M176668
  • GC05M176713
  • GC05M176715
  • GC05M176665
  • GC05M176666
  • GC05M176732
  • GC05M171653
  • GC05M176733
  • GC05M176744

Summaries for MXD3 Gene

Entrez Gene Summary for MXD3 Gene

  • This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]

GeneCards Summary for MXD3 Gene

MXD3 (MAX Dimerization Protein 3) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is MXI1.

UniProtKB/Swiss-Prot for MXD3 Gene

  • Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5-CAC[GA]TG-3. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MXD3 Gene

Genomics for MXD3 Gene

Regulatory Elements for MXD3 Gene

Enhancers for MXD3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MXD3 on UCSC Golden Path with GeneCards custom track

Promoters for MXD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MXD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MXD3 Gene

Chromosome:
5
Start:
177,301,461 bp from pter
End:
177,312,757 bp from pter
Size:
11,297 bases
Orientation:
Minus strand

Genomic View for MXD3 Gene

Genes around MXD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MXD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MXD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MXD3 Gene

Proteins for MXD3 Gene

  • Protein details for MXD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW11-MAD3_HUMAN
    Recommended name:
    Max dimerization protein 3
    Protein Accession:
    Q9BW11
    Secondary Accessions:
    • B4E0J1
    • Q53HK1
    • Q7Z4Y0
    • Q8NDJ7
    • Q96ME3

    Protein attributes for MXD3 Gene

    Size:
    206 amino acids
    Molecular mass:
    23477 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17 (By similarity).

    Alternative splice isoforms for MXD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MXD3 Gene

Proteomics data for MXD3 Gene at MOPED

Post-translational modifications for MXD3 Gene

  • Ubiquitination at Lys 81 and Lys 108
  • Modification sites at PhosphoSitePlus

Other Protein References for MXD3 Gene

No data available for DME Specific Peptides for MXD3 Gene

Domains & Families for MXD3 Gene

Protein Domains for MXD3 Gene

Suggested Antigen Peptide Sequences for MXD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BW11

UniProtKB/Swiss-Prot:

MAD3_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with MXD3: view

Function for MXD3 Gene

Molecular function for MXD3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5-CAC[GA]TG-3. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).

Gene Ontology (GO) - Molecular Function for MXD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with MXD3: view
genes like me logo Genes that share phenotypes with MXD3: view

Animal Models for MXD3 Gene

MGI Knock Outs for MXD3:

Animal Model Products

miRNA for MXD3 Gene

miRTarBase miRNAs that target MXD3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MXD3 Gene

Localization for MXD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MXD3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MXD3 Gene COMPARTMENTS Subcellular localization image for MXD3 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for MXD3 Gene

Pathways & Interactions for MXD3 Gene

SuperPathways for MXD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MXD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MXD3: view

No data available for Pathways by source and SIGNOR curated interactions for MXD3 Gene

Drugs & Compounds for MXD3 Gene

No Compound Related Data Available

Transcripts for MXD3 Gene

Unigene Clusters for MXD3 Gene

MAX dimerization protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MXD3 Gene

No ASD Table

Relevant External Links for MXD3 Gene

GeneLoc Exon Structure for
MXD3
ECgene alternative splicing isoforms for
MXD3

Expression for MXD3 Gene

mRNA expression in normal human tissues for MXD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MXD3 Gene

This gene is overexpressed in Whole Blood (x4.7).

SOURCE GeneReport for Unigene cluster for MXD3 Gene Hs.743332

genes like me logo Genes that share expression patterns with MXD3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MXD3 Gene

Orthologs for MXD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MXD3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MXD3 35
  • 89.97 (n)
  • 91.75 (a)
MXD3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MXD3 35
  • 87.7 (n)
  • 87.38 (a)
MXD3 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mxd3 35
  • 84.79 (n)
  • 83.98 (a)
Mxd3 16
Mxd3 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MXD3 35
  • 89.33 (n)
  • 87.19 (a)
MXD3 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mxd3 35
  • 82.36 (n)
  • 81.07 (a)
oppossum
(Monodelphis domestica)
Mammalia MXD3 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves MXD3 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MXD3 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mxd3 35
  • 58.96 (n)
  • 63.82 (a)
zebrafish
(Danio rerio)
Actinopterygii mxd3 35
  • 60.5 (n)
  • 56 (a)
mxd3 36
  • 58 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mdl-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2549 36
  • 32 (a)
OneToMany
Species with no ortholog for MXD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MXD3 Gene

ENSEMBL:
Gene Tree for MXD3 (if available)
TreeFam:
Gene Tree for MXD3 (if available)

Paralogs for MXD3 Gene

Paralogs for MXD3 Gene

(4) SIMAP similar genes for MXD3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MXD3: view

Variants for MXD3 Gene

Sequence variations from dbSNP and Humsavar for MXD3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs35691394 - 177,307,944(-) GAGCA(G/T)CGGGC reference, missense
rs4568379 -- 177,307,854(+) CGCTC(A/C/G/T)GCCGC reference, synonymous-codon
rs6885410 -- 177,313,995(+) GAATT(A/C)TAGAC upstream-variant-2KB
rs7725769 -- 177,314,179(+) GAGCC(A/G)CAAGG upstream-variant-2KB
rs6886181 -- 177,314,185(+) CAAGG(C/G)TTGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MXD3 Gene

Variant ID Type Subtype PubMed ID
dgv1878e1 CNV Complex 17122850
nsv428132 CNV Gain 18775914
dgv6379n71 CNV Loss 21882294
nsv883159 CNV Loss 21882294
nsv509103 CNV Insertion 20534489
nsv471057 CNV Loss 18288195

Variation tolerance for MXD3 Gene

Residual Variation Intolerance Score: 58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MXD3 Gene

HapMap Linkage Disequilibrium report
MXD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MXD3 Gene

Disorders for MXD3 Gene

Relevant External Links for MXD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MXD3

No disorders were found for MXD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MXD3 Gene

Publications for MXD3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? (PMID: 10918583) Meroni G. … Reymond A. (Oncogene 2000) 3 23
  3. Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells. (PMID: 25554682) Barisone G.A. … DI^az E. (Blood Cells Mol. Dis. 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. MXD3 regulation of DAOY cell proliferation dictated by time course of activation. (PMID: 25053245) Ngo T. … DI^az E. (BMC Cell Biol. 2014) 3

Products for MXD3 Gene

Sources for MXD3 Gene

Content