Aliases for MXD3 Gene
External Ids for MXD3 Gene
Previous GeneCards Identifiers for MXD3 Gene
This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]
GeneCards Summary for MXD3 Gene
MXD3 (MAX Dimerization Protein 3) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is MXI1.
UniProtKB/Swiss-Prot for MXD3 Gene
Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5-CAC[GA]TG-3. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).