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Aliases for CDCA3 Gene

Aliases for CDCA3 Gene

  • Cell Division Cycle Associated 3 2 3
  • Trigger Of Mitotic Entry Protein 1 3 4
  • Gene-Rich Cluster Protein C8 3 4
  • Trigger Of Mitotic Entry 1 2 3
  • TOME-1 3 4
  • GRCC8 3 4
  • Cell Division Cycle-Associated Protein 3 3
  • Gene Rich Cluster, C8 3
  • TOME1 4
  • C8 4

External Ids for CDCA3 Gene

Previous GeneCards Identifiers for CDCA3 Gene

  • GC12U990228
  • GC12M006833
  • GC12M006828
  • GC12M006959
  • GC12M006960

Summaries for CDCA3 Gene

GeneCards Summary for CDCA3 Gene

CDCA3 (Cell Division Cycle Associated 3) is a Protein Coding gene. Diseases associated with CDCA3 include clonorchiasis. Among its related pathways are Cell cycle_Role of APC in cell cycle regulation.

UniProtKB/Swiss-Prot for CDCA3 Gene

  • F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity).

Gene Wiki entry for CDCA3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDCA3 Gene

Genomics for CDCA3 Gene

Regulatory Elements for CDCA3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDCA3 Gene

Start:
6,844,793 bp from pter
End:
6,852,066 bp from pter
Size:
7,274 bases
Orientation:
Minus strand

Genomic View for CDCA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDCA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDCA3 Gene

Proteins for CDCA3 Gene

  • Protein details for CDCA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99618-CDCA3_HUMAN
    Recommended name:
    Cell division cycle-associated protein 3
    Protein Accession:
    Q99618
    Secondary Accessions:
    • A8K5V6
    • D3DUS6

    Protein attributes for CDCA3 Gene

    Size:
    268 amino acids
    Molecular mass:
    28998 Da
    Quaternary structure:
    • Interacts with SKP1. Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity).

neXtProt entry for CDCA3 Gene

Proteomics data for CDCA3 Gene at MOPED

Post-translational modifications for CDCA3 Gene

No data available for DME Specific Peptides for CDCA3 Gene

Domains for CDCA3 Gene

Protein Domains for CDCA3 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CDCA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99618

UniProtKB/Swiss-Prot:

CDCA3_HUMAN :
  • Q99618
Domain:
  • The KEN box is required for the association with the APC/C-Cdh1 complex.
genes like me logo Genes that share domains with CDCA3: view

No data available for Gene Families for CDCA3 Gene

Function for CDCA3 Gene

Molecular function for CDCA3 Gene

UniProtKB/Swiss-Prot Function: F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity).

Gene Ontology (GO) - Molecular Function for CDCA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CDCA3: view
genes like me logo Genes that share phenotypes with CDCA3: view

Animal Model Products

CRISPR Products

miRNA for CDCA3 Gene

miRTarBase miRNAs that target CDCA3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDCA3 Gene

Localization for CDCA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDCA3 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDCA3 Gene COMPARTMENTS Subcellular localization image for CDCA3 gene
Compartment Confidence
cytosol 2
mitochondrion 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CDCA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with CDCA3: view

Pathways for CDCA3 Gene

genes like me logo Genes that share pathways with CDCA3: view

Pathways by source for CDCA3 Gene

1 GeneGo (Thomson Reuters) pathway for CDCA3 Gene

UniProtKB/Swiss-Prot Q99618-CDCA3_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for CDCA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0008150 biological_process ND --
GO:0016567 protein ubiquitination IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CDCA3: view

Transcripts for CDCA3 Gene

Unigene Clusters for CDCA3 Gene

Cell division cycle associated 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDCA3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDCA3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - -
SP2: - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - - -
SP6: - - - -
SP7:
SP8: - -
SP9:
SP10:

Relevant External Links for CDCA3 Gene

GeneLoc Exon Structure for
CDCA3
ECgene alternative splicing isoforms for
CDCA3

Expression for CDCA3 Gene

mRNA expression in normal human tissues for CDCA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDCA3 Gene

This gene is overexpressed in Testis (9.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CDCA3 Gene

SOURCE GeneReport for Unigene cluster for CDCA3 Gene Hs.524216

genes like me logo Genes that share expressions with CDCA3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CDCA3 Gene

Orthologs for CDCA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDCA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDCA3 35
  • 99.75 (n)
  • 99.25 (a)
CDCA3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDCA3 35
  • 85.41 (n)
  • 81.13 (a)
CDCA3 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDCA3 35
  • 88.51 (n)
  • 83.9 (a)
CDCA3 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdca3 35
  • 81.45 (n)
  • 73.31 (a)
Cdca3 16
Cdca3 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDCA3 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDCA3 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdca3 35
  • 80.83 (n)
  • 73.68 (a)
chicken
(Gallus gallus)
Aves CDCA3 35
  • 54.65 (n)
  • 48.65 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cdca3 35
  • 48.07 (n)
  • 40.62 (a)
Species with no ortholog for CDCA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CDCA3 Gene

ENSEMBL:
Gene Tree for CDCA3 (if available)
TreeFam:
Gene Tree for CDCA3 (if available)

Paralogs for CDCA3 Gene

Pseudogenes.org Pseudogenes for CDCA3 Gene

genes like me logo Genes that share paralogs with CDCA3: view

No data available for Paralogs for CDCA3 Gene

Variants for CDCA3 Gene

Sequence variations from dbSNP and Humsavar for CDCA3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs3180416 -- 6,848,827(-) AGGTA(A/T)ATGTA utr-variant-3-prime, intron-variant, nc-transcript-variant, downstream-variant-500B
rs5796254 -- 6,849,932(-) CCTGG(-/G)TTTCT intron-variant
rs7979180 -- 6,847,982(+) gaagg(A/T)tctct intron-variant
rs11064428 -- 6,849,097(+) CCTTG(C/T)TCCCA synonymous-codon, reference, intron-variant, utr-variant-3-prime, nc-transcript-variant
rs11064429 -- 6,849,924(+) AAACA(C/T)ACAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDCA3 Gene

Variant ID Type Subtype PubMed ID
nsv832323 CNV Loss 17160897
nsv832324 CNV Loss 17160897
dgv1353n71 CNV Loss 21882294
nsv898641 CNV Loss 21882294

Relevant External Links for CDCA3 Gene

HapMap Linkage Disequilibrium report
CDCA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDCA3 Gene

Disorders for CDCA3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CDCA3 Gene including...

Search for CDCA3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CDCA3 Gene

Relevant External Links for CDCA3

Genetic Association Database (GAD)
CDCA3
Human Genome Epidemiology (HuGE) Navigator
CDCA3
genes like me logo Genes that share disorders with CDCA3: view

No data available for UniProtKB/Swiss-Prot for CDCA3 Gene

Publications for CDCA3 Gene

  1. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. (PMID: 9074930) Ansari-Lari M.A. … Gibbs R.A. (Genome Res. 1997) 2 3 4
  2. Drug target discovery by gene expression analysis: cell cycle genes. (PMID: 12188893) Walker M.G. (Curr. Cancer Drug Targets 2001) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban H.J. … Park K.J. (BMC Genet. 2010) 3 48
  5. Interplay between Cdh1 and JNK activity during the cell cycle. (PMID: 20581839) Gutierrez G.J. … Ronai Z.A. (Nat. Cell Biol. 2010) 3

Products for CDCA3 Gene

Sources for CDCA3 Gene

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