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Aliases for PUS7L Gene

Aliases for PUS7L Gene

  • Pseudouridylate Synthase 7 Like 2 3
  • Pseudouridylate Synthase 7-Like 2 5
  • Pseudouridylate Synthase 7 Homolog (S. Cerevisiae)-Like 2
  • EC 5.4.99.- 4

External Ids for PUS7L Gene

Previous GeneCards Identifiers for PUS7L Gene

  • GC12M042409
  • GC12M044122
  • GC12M041149

Summaries for PUS7L Gene

GeneCards Summary for PUS7L Gene

PUS7L (Pseudouridylate Synthase 7 Like) is a Protein Coding gene. GO annotations related to this gene include RNA binding and pseudouridine synthase activity. An important paralog of this gene is PUS7.

Gene Wiki entry for PUS7L Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PUS7L Gene

Genomics for PUS7L Gene

Regulatory Elements for PUS7L Gene

Enhancers for PUS7L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PUS7L on UCSC Golden Path with GeneCards custom track

Promoters for PUS7L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PUS7L on UCSC Golden Path with GeneCards custom track

Genomic Location for PUS7L Gene

Chromosome:
12
Start:
43,718,993 bp from pter
End:
43,758,817 bp from pter
Size:
39,825 bases
Orientation:
Minus strand

Genomic View for PUS7L Gene

Genes around PUS7L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PUS7L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PUS7L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PUS7L Gene

Proteins for PUS7L Gene

  • Protein details for PUS7L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0K6-PUS7L_HUMAN
    Recommended name:
    Pseudouridylate synthase 7 homolog-like protein
    Protein Accession:
    Q9H0K6
    Secondary Accessions:
    • B3KUJ1
    • Q05CU0
    • Q6AHZ3
    • Q6NUP2

    Protein attributes for PUS7L Gene

    Size:
    701 amino acids
    Molecular mass:
    80700 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH20781.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for PUS7L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PUS7L Gene

Proteomics data for PUS7L Gene at MOPED

Post-translational modifications for PUS7L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PUS7L Gene

Domains & Families for PUS7L Gene

Suggested Antigen Peptide Sequences for PUS7L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0K6

UniProtKB/Swiss-Prot:

PUS7L_HUMAN :
  • Contains 1 TRUD domain.
  • Belongs to the pseudouridine synthase TruD family.
Domain:
  • Contains 1 TRUD domain.
Family:
  • Belongs to the pseudouridine synthase TruD family.
genes like me logo Genes that share domains with PUS7L: view

No data available for Gene Families for PUS7L Gene

Function for PUS7L Gene

Molecular function for PUS7L Gene

UniProtKB/Swiss-Prot CatalyticActivity:
tRNA uridine = tRNA pseudouridine.

Enzyme Numbers (IUBMB) for PUS7L Gene

Gene Ontology (GO) - Molecular Function for PUS7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009982 pseudouridine synthase activity IEA,IBA --
genes like me logo Genes that share ontologies with PUS7L: view
genes like me logo Genes that share phenotypes with PUS7L: view

Animal Models for PUS7L Gene

MGI Knock Outs for PUS7L:

Animal Model Products

miRNA for PUS7L Gene

miRTarBase miRNAs that target PUS7L

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PUS7L Gene

Localization for PUS7L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PUS7L Gene COMPARTMENTS Subcellular localization image for PUS7L gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PUS7L Gene

Pathways & Interactions for PUS7L Gene

SuperPathways for PUS7L Gene

No Data Available

Gene Ontology (GO) - Biological Process for PUS7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009451 RNA modification IEA --
genes like me logo Genes that share ontologies with PUS7L: view

No data available for Pathways by source and SIGNOR curated interactions for PUS7L Gene

Drugs & Compounds for PUS7L Gene

(1) Additional Compounds for PUS7L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pseudouridine
  • 5-(b-D-Ribofuranosyl)uracil
  • 5-(b-delta-Ribofuranosyl)uracil
  • 5-b-D-Ribofuranosyl-Uracil
  • 5-beta-delta-Ribofuranosyl-Uracil
  • 5-Ribosyluracil
1445-07-4
genes like me logo Genes that share compounds with PUS7L: view

Transcripts for PUS7L Gene

Unigene Clusters for PUS7L Gene

Pseudouridylate synthase 7 homolog (S. cerevisiae)-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PUS7L Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1: - - - - -
SP2: -
SP3:
SP4: - -
SP5: - - -
SP6: -

Relevant External Links for PUS7L Gene

GeneLoc Exon Structure for
PUS7L
ECgene alternative splicing isoforms for
PUS7L

Expression for PUS7L Gene

mRNA expression in normal human tissues for PUS7L Gene

Protein differential expression in normal tissues from HIPED for PUS7L Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (48.1) and Brain (19.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PUS7L Gene



SOURCE GeneReport for Unigene cluster for PUS7L Gene Hs.445814

genes like me logo Genes that share expression patterns with PUS7L: view

Protein tissue co-expression partners for PUS7L Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PUS7L Gene

Orthologs for PUS7L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PUS7L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PUS7L 35
  • 87.14 (n)
  • 83.29 (a)
PUS7L 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PUS7L 35
  • 87.66 (n)
  • 84.65 (a)
PUS7L 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pus7l 35
  • 76.89 (n)
  • 72.21 (a)
Pus7l 16
Pus7l 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PUS7L 35
  • 99.43 (n)
  • 98.86 (a)
PUS7L 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pus7l 35
  • 76.46 (n)
  • 72.64 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
chicken
(Gallus gallus)
Aves PUS7L 35
  • 62.35 (n)
  • 57.53 (a)
PUS7L 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PUS7L 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pus7l 35
  • 61.85 (n)
  • 54.55 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13328 35
zebrafish
(Danio rerio)
Actinopterygii pus7l 35
  • 58.2 (n)
  • 54.03 (a)
wufi64f08 35
pus7l 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0024.11 36
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUS7 36
  • 20 (a)
OneToMany
Species with no ortholog for PUS7L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PUS7L Gene

ENSEMBL:
Gene Tree for PUS7L (if available)
TreeFam:
Gene Tree for PUS7L (if available)

Paralogs for PUS7L Gene

Paralogs for PUS7L Gene

(1) SIMAP similar genes for PUS7L Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with PUS7L: view

Variants for PUS7L Gene

Sequence variations from dbSNP and Humsavar for PUS7L Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs33999797 - 43,754,970(+) TACTT(A/C)ATCAA intron-variant, nc-transcript-variant, reference, missense
rs1057190 - 43,754,456(-) TTTCT(A/C/G)AAATG intron-variant, nc-transcript-variant, reference, missense
rs34668377 - 43,748,493(+) GGTGA(C/T)GGCTT nc-transcript-variant, reference, missense
rs1973138 -- 43,742,784(-) CTGAC(C/G)TATTT intron-variant
rs471049 -- 43,743,952(-) TTTGT(G/T)TCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PUS7L Gene

Variant ID Type Subtype PubMed ID
esv270667 CNV Insertion 20981092

Variation tolerance for PUS7L Gene

Residual Variation Intolerance Score: 98.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.56; 82.46% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PUS7L Gene

Disorders for PUS7L Gene

Relevant External Links for PUS7L

Genetic Association Database (GAD)
PUS7L
Human Genome Epidemiology (HuGE) Navigator
PUS7L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PUS7L

No disorders were found for PUS7L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PUS7L Gene

Publications for PUS7L Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3
  5. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PMID: 22610502) Kennedy R.B. … Poland G.A. (Hum. Genet. 2012) 3

Products for PUS7L Gene

Sources for PUS7L Gene

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