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Aliases for PUS7L Gene

Aliases for PUS7L Gene

  • Pseudouridylate Synthase 7 Homolog (S. Cerevisiae)-Like 2 3
  • EC 5.4.99.- 4

External Ids for PUS7L Gene

Previous GeneCards Identifiers for PUS7L Gene

  • GC12M042409
  • GC12M044122
  • GC12M041149

Summaries for PUS7L Gene

GeneCards Summary for PUS7L Gene

PUS7L (Pseudouridylate Synthase 7 Homolog (S. Cerevisiae)-Like) is a Protein Coding gene. GO annotations related to this gene include RNA binding and pseudouridine synthase activity. An important paralog of this gene is PUS7.

Gene Wiki entry for PUS7L Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PUS7L Gene

Genomics for PUS7L Gene

Regulatory Elements for PUS7L Gene

Genomic Location for PUS7L Gene

Start:
43,728,025 bp from pter
End:
43,758,817 bp from pter
Size:
30,793 bases
Orientation:
Minus strand

Genomic View for PUS7L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PUS7L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PUS7L Gene

Proteins for PUS7L Gene

  • Protein details for PUS7L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0K6-PUS7L_HUMAN
    Recommended name:
    Pseudouridylate synthase 7 homolog-like protein
    Protein Accession:
    Q9H0K6
    Secondary Accessions:
    • B3KUJ1
    • Q05CU0
    • Q6AHZ3
    • Q6NUP2

    Protein attributes for PUS7L Gene

    Size:
    701 amino acids
    Molecular mass:
    80700 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH20781.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for PUS7L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PUS7L Gene

Proteomics data for PUS7L Gene at MOPED

Post-translational modifications for PUS7L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PUS7L Gene

Domains for PUS7L Gene

Suggested Antigen Peptide Sequences for PUS7L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0K6

UniProtKB/Swiss-Prot:

PUS7L_HUMAN :
  • Q9H0K6
Domain:
  • Contains 1 TRUD domain.
Family:
  • Belongs to the pseudouridine synthase TruD family.
genes like me logo Genes that share domains with PUS7L: view

No data available for Gene Families for PUS7L Gene

Function for PUS7L Gene

Molecular function for PUS7L Gene

UniProtKB/Swiss-Prot CatalyticActivity: tRNA uridine = tRNA pseudouridine

Enzyme Numbers (IUBMB) for PUS7L Gene

Gene Ontology (GO) - Molecular Function for PUS7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0009982 pseudouridine synthase activity IEA --
genes like me logo Genes that share ontologies with PUS7L: view

Phenotypes for PUS7L Gene

MGI mutant phenotypes for PUS7L:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with PUS7L: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PUS7L Gene

Localization for PUS7L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PUS7L Gene COMPARTMENTS Subcellular localization image for PUS7L gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PUS7L Gene

Pathways for PUS7L Gene

SuperPathways for PUS7L Gene

No Data Available

Gene Ontology (GO) - Biological Process for PUS7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001522 pseudouridine synthesis IEA --
GO:0008033 tRNA processing IEA --
GO:0009451 RNA modification --
genes like me logo Genes that share ontologies with PUS7L: view

No data available for Pathways by source for PUS7L Gene

Compounds for PUS7L Gene

(1) HMDB Compounds for PUS7L Gene

Compound Synonyms Cas Number PubMed IDs
Pseudouridine
  • 5-(b-D-Ribofuranosyl)uracil
1445-07-4
genes like me logo Genes that share compounds with PUS7L: view

Transcripts for PUS7L Gene

Unigene Clusters for PUS7L Gene

Pseudouridylate synthase 7 homolog (S. cerevisiae)-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PUS7L Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1: - - - - -
SP2: -
SP3:
SP4: - -
SP5: - - -
SP6: -

Relevant External Links for PUS7L Gene

GeneLoc Exon Structure for
PUS7L
ECgene alternative splicing isoforms for
PUS7L

Expression for PUS7L Gene

mRNA expression in normal human tissues for PUS7L Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PUS7L Gene

SOURCE GeneReport for Unigene cluster for PUS7L Gene Hs.445814

genes like me logo Genes that share expressions with PUS7L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PUS7L Gene

Orthologs for PUS7L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PUS7L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PUS7L 35
  • 99.43 (n)
  • 98.86 (a)
PUS7L 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PUS7L 35
  • 87.14 (n)
  • 83.29 (a)
PUS7L 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PUS7L 35
  • 87.66 (n)
  • 84.65 (a)
PUS7L 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pus7l 35
  • 76.89 (n)
  • 72.21 (a)
Pus7l 16
Pus7l 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pus7l 35
  • 76.46 (n)
  • 72.64 (a)
chicken
(Gallus gallus)
Aves PUS7L 35
  • 62.35 (n)
  • 57.53 (a)
PUS7L 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PUS7L 36
  • 54 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13328 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pus7l 35
  • 61.85 (n)
  • 54.55 (a)
zebrafish
(Danio rerio)
Actinopterygii pus7l 35
  • 58.2 (n)
  • 54.03 (a)
pus7l 36
  • 47 (a)
OneToOne
wufi64f08 35
worm
(Caenorhabditis elegans)
Secernentea B0024.11 36
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUS7 36
  • 20 (a)
OneToMany
Species with no ortholog for PUS7L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PUS7L Gene

ENSEMBL:
Gene Tree for PUS7L (if available)
TreeFam:
Gene Tree for PUS7L (if available)

Paralogs for PUS7L Gene

Paralogs for PUS7L Gene

Selected SIMAP similar genes for PUS7L Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with PUS7L: view

Variants for PUS7L Gene

Sequence variations from dbSNP and Humsavar for PUS7L Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs471049 -- 43,743,952(-) TTTGT(G/T)TCAAG intron-variant
rs473049 -- 43,743,931(-) TCTGT(G/T)ATAAA intron-variant
rs474072 -- 43,743,793(-) GTACT(C/T)ATTCT intron-variant
rs487640 -- 43,740,853(-) ACTAT(C/T)TGTGG intron-variant
rs528605 -- 43,743,736(-) accca(C/G)gctgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PUS7L Gene

Variant ID Type Subtype PubMed ID
esv270667 CNV Insertion 20981092

Relevant External Links for PUS7L Gene

HapMap Linkage Disequilibrium report
PUS7L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PUS7L Gene

Disorders for PUS7L Gene

Relevant External Links for PUS7L

Genetic Association Database (GAD)
PUS7L
Human Genome Epidemiology (HuGE) Navigator
PUS7L
genes like me logo Genes that share disorders with PUS7L: view

No data available for UniProtKB/Swiss-Prot for PUS7L Gene

Publications for PUS7L Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for PUS7L Gene

Sources for PUS7L Gene

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