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Aliases for SLC25A31 Gene

Aliases for SLC25A31 Gene

  • Solute Carrier Family 25 Member 31 2 3 4 5
  • Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 31 2 3
  • Sperm Flagellar Energy Carrier Protein 3 4
  • Adenine Nucleotide Translocator 4 3 4
  • ADP,ATP Carrier Protein 4 3 4
  • ANT 4 3 4
  • AAC4 3 4
  • ANT4 3 4
  • Adenine Nucleotide Translocase 4 3
  • ADP/ATP Translocase 4 3
  • SFEC35kDa 3
  • SFEC 4

External Ids for SLC25A31 Gene

Previous GeneCards Identifiers for SLC25A31 Gene

  • GC04P129010
  • GC04P128871
  • GC04P128651
  • GC04P124379

Summaries for SLC25A31 Gene

Entrez Gene Summary for SLC25A31 Gene

  • The protein encoded by this gene is a member of the ADP/ATP carrier family of proteins that exchange cytosolic ADP for matrix ATP in the mitochondria. Cells over-expressing this gene have been shown to display an anti-apoptotic phenotype. This protein is also thought to play a role in spermatogenesis, where it is believed to associate with a part of the flagellar cytoskeleton and with glycolytic enzymes. Male mice with mutations in the mouse ortholog of this gene are sterile and spermatocytes display an early meiotic arrest phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for SLC25A31 Gene

SLC25A31 (Solute Carrier Family 25 Member 31) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and HTLV-I infection. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLC25A4.

UniProtKB/Swiss-Prot for SLC25A31 Gene

  • Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility.

Gene Wiki entry for SLC25A31 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A31 Gene

Genomics for SLC25A31 Gene

Regulatory Elements for SLC25A31 Gene

Enhancers for SLC25A31 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G127781 1.4 ENCODE dbSUPER 10.2 +52.8 52844 4.3 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZHX2 JUNB SLC25A31 INTU HSPA4L ABHD18 ENSG00000282855
GH04G127698 1.1 Ensembl ENCODE 11.3 -31.5 -31493 1.0 PKNOX1 BMI1 CBX5 FOS RELB IKZF2 CREM CBFB JUNB CEBPB SLC25A31 INTU LOC105377413
GH04G127632 1.1 ENCODE 10.7 -97.2 -97154 1.9 PKNOX1 ARNT ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 ZNF263 ZHX2 INTU SLC25A31 LOC105377413
GH04G127708 0.9 Ensembl ENCODE 11.2 -21.0 -20964 1.8 TAF1 NFIA JUN ATF2 FOXA1 MAFF JUND SCRT2 FOS PRDM10 SLC25A31 LOC105377413
GH04G127634 0.2 ENCODE 10.7 -96.0 -95985 0.2 SLC25A31 LOC105377413
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A31 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A31 Gene

Chromosome:
4
Start:
127,730,375 bp from pter
End:
127,774,299 bp from pter
Size:
43,925 bases
Orientation:
Plus strand

Genomic View for SLC25A31 Gene

Genes around SLC25A31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A31 Gene

Proteins for SLC25A31 Gene

  • Protein details for SLC25A31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0C2-ADT4_HUMAN
    Recommended name:
    ADP/ATP translocase 4
    Protein Accession:
    Q9H0C2

    Protein attributes for SLC25A31 Gene

    Size:
    315 amino acids
    Molecular mass:
    35022 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC25A31 Gene

Post-translational modifications for SLC25A31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A31 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A31 Gene

Domains & Families for SLC25A31 Gene

Gene Families for SLC25A31 Gene

Suggested Antigen Peptide Sequences for SLC25A31 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0C2

UniProtKB/Swiss-Prot:

ADT4_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A31: view

Function for SLC25A31 Gene

Molecular function for SLC25A31 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility.

Gene Ontology (GO) - Molecular Function for SLC25A31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A31: view

Phenotypes for SLC25A31 Gene

genes like me logo Genes that share phenotypes with SLC25A31: view

Animal Models for SLC25A31 Gene

MGI Knock Outs for SLC25A31:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A31

CRISPR Products

miRNA for SLC25A31 Gene

miRTarBase miRNAs that target SLC25A31

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC25A31 Gene

Localization for SLC25A31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A31 Gene

Mitochondrion inner membrane; Multi-pass membrane protein. Cell projection, cilium, flagellum. Note=In sperm flagellum this protein is located in the fibrous sheath, a non-mitochondrial region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A31 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC25A31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IBA --
GO:0005929 cilium IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC25A31: view

Pathways & Interactions for SLC25A31 Gene

genes like me logo Genes that share pathways with SLC25A31: view

Pathways by source for SLC25A31 Gene

Gene Ontology (GO) - Biological Process for SLC25A31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006839 mitochondrial transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A31: view

No data available for SIGNOR curated interactions for SLC25A31 Gene

Drugs & Compounds for SLC25A31 Gene

(3) Drugs for SLC25A31 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atenolol Approved Pharma Antagonist 104
Hydrochlorothiazide Approved, Vet_approved Pharma Inhibition, Inhibitor 413
Metoprolol Approved, Investigational Pharma Antagonist 212
genes like me logo Genes that share compounds with SLC25A31: view

Transcripts for SLC25A31 Gene

mRNA/cDNA for SLC25A31 Gene

Unigene Clusters for SLC25A31 Gene

Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A31 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: - -

Relevant External Links for SLC25A31 Gene

GeneLoc Exon Structure for
SLC25A31
ECgene alternative splicing isoforms for
SLC25A31

Expression for SLC25A31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A31 Gene

This gene is overexpressed in Testis (x49.9).

Protein differential expression in normal tissues from HIPED for SLC25A31 Gene

This gene is overexpressed in Brain (38.7), Heart (11.3), and Testis (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A31 Gene



Protein tissue co-expression partners for SLC25A31 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC25A31 Gene:

SLC25A31

SOURCE GeneReport for Unigene cluster for SLC25A31 Gene:

Hs.149030

mRNA Expression by UniProt/SwissProt for SLC25A31 Gene:

Q9H0C2-ADT4_HUMAN
Tissue specificity: Expressed in brain, liver, sperm and testis.

Evidence on tissue expression from TISSUES for SLC25A31 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with SLC25A31: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A31 Gene

Orthologs for SLC25A31 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A31 34 35
  • 99.58 (n)
cow
(Bos Taurus)
Mammalia SLC25A31 34 35
  • 91.72 (n)
dog
(Canis familiaris)
Mammalia SLC25A31 34 35
  • 91.72 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A31 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a31 34 16 35
  • 85.46 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a31 34
  • 83.97 (n)
lizard
(Anolis carolinensis)
Reptilia SLC25A31 35
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sesB 35
  • 69 (a)
ManyToMany
Ant2 35
  • 67 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea R07E3.4 35
  • 43 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAC1 35
  • 50 (a)
ManyToMany
AAC3 35
  • 50 (a)
ManyToMany
PET9 35 37
  • 50 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G56450 34
  • 55.59 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1260 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 70 (a)
OneToMany
CSA.10315 35
  • 70 (a)
OneToMany
CSA.11146 35
  • 68 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
Species where no ortholog for SLC25A31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC25A31 Gene

ENSEMBL:
Gene Tree for SLC25A31 (if available)
TreeFam:
Gene Tree for SLC25A31 (if available)

Paralogs for SLC25A31 Gene

Paralogs for SLC25A31 Gene

(5) SIMAP similar genes for SLC25A31 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC25A31: view

Variants for SLC25A31 Gene

Sequence variations from dbSNP and Humsavar for SLC25A31 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000068326 -- 127,770,712(+) ACAGA(A/C)AAAAA intron-variant
rs1000082321 -- 127,750,391(+) GGAAG(G/T)CCAAA intron-variant
rs1000118941 -- 127,730,299(+) GCATC(C/T)AGGAG upstream-variant-2KB
rs1000172586 -- 127,730,264(+) AGGCT(C/T)CGCTC upstream-variant-2KB
rs1000180708 -- 127,763,589(+) CTTCA(A/G)TAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A31 Gene

Variant ID Type Subtype PubMed ID
nsv290569 CNV deletion 16902084
nsv437935 CNV loss 16468122
nsv830056 CNV loss 17160897
nsv830057 CNV loss 17160897

Variation tolerance for SLC25A31 Gene

Residual Variation Intolerance Score: 75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A31 Gene

Disorders for SLC25A31 Gene

Relevant External Links for SLC25A31

Genetic Association Database (GAD)
SLC25A31
Human Genome Epidemiology (HuGE) Navigator
SLC25A31
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A31

No disorders were found for SLC25A31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A31 Gene

Publications for SLC25A31 Gene

  1. A fourth ADP/ATP carrier isoform in man: identification, bacterial expression, functional characterization and tissue distribution. (PMID: 15670820) Dolce V. … Palmieri F. (FEBS Lett. 2005) 2 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Compartmentalization of a unique ADP/ATP carrier protein SFEC (sperm flagellar energy carrier, AAC4) with glycolytic enzymes in the fibrous sheath of the human sperm flagellar principal piece. (PMID: 17137571) Kim Y.-H. … Herr J.C. (Dev. Biol. 2007) 3 4 64
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  5. Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas. (PMID: 25787250) Cromer M.K. … Lifton R.P. (Proc. Natl. Acad. Sci. U.S.A. 2015) 4 64

Products for SLC25A31 Gene

Sources for SLC25A31 Gene

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