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Aliases for SLC25A31 Gene

Aliases for SLC25A31 Gene

  • Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 31 2 3
  • AAC4 3 4 6
  • ANT4 3 4 6
  • Sperm Flagellar Energy Carrier Protein 3 4
  • Solute Carrier Family 25 Member 31 3 4
  • Adenine Nucleotide Translocator 4 3 4
  • ADP,ATP Carrier Protein 4 3 4
  • ANT 4 3 4
  • Adenine Nucleotide Translocase 4 3
  • ADP/ATP Translocase 4 3
  • SFEC35kDa 3
  • SFEC 4

External Ids for SLC25A31 Gene

Previous GeneCards Identifiers for SLC25A31 Gene

  • GC04P129010
  • GC04P128871
  • GC04P128651
  • GC04P124379

Summaries for SLC25A31 Gene

Entrez Gene Summary for SLC25A31 Gene

  • Mitochondrial ADP/ATP carriers, such as SLC25A31, are nuclear-coded mitochondrial proteins that catalyze the exchange of ATP generated in mitochondria by ATP synthase (see MIM 108729) against ADP produced in cytosol by most energy-consuming reactions (Dolce et al., 2005 [PubMed 15670820]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A31 Gene

SLC25A31 (Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 31) is a Protein Coding gene. Among its related pathways are Calcium signaling pathway and HTLV-I infection. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLC25A5.

UniProtKB/Swiss-Prot for SLC25A31 Gene

  • Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility.

Gene Wiki entry for SLC25A31 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A31 Gene

Genomics for SLC25A31 Gene

Regulatory Elements for SLC25A31 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC25A31 Gene

Start:
127,730,378 bp from pter
End:
127,774,299 bp from pter
Size:
43,922 bases
Orientation:
Plus strand

Genomic View for SLC25A31 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A31 Gene

Proteins for SLC25A31 Gene

  • Protein details for SLC25A31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0C2-ADT4_HUMAN
    Recommended name:
    ADP/ATP translocase 4
    Protein Accession:
    Q9H0C2
    Secondary Accessions:

    Protein attributes for SLC25A31 Gene

    Size:
    315 amino acids
    Molecular mass:
    35022 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC25A31 Gene

Proteomics data for SLC25A31 Gene at MOPED

Post-translational modifications for SLC25A31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A31 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A31 Gene

Domains for SLC25A31 Gene

Gene Families for SLC25A31 Gene

Suggested Antigen Peptide Sequences for SLC25A31 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0C2

UniProtKB/Swiss-Prot:

ADT4_HUMAN :
  • Q9H0C2
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A31: view

Function for SLC25A31 Gene

Molecular function for SLC25A31 Gene

UniProtKB/Swiss-Prot Function: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility.

Gene Ontology (GO) - Molecular Function for SLC25A31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
genes like me logo Genes that share ontologies with SLC25A31: view

Phenotypes for SLC25A31 Gene

genes like me logo Genes that share phenotypes with SLC25A31: view

Animal Model Products

CRISPR Products

miRNA for SLC25A31 Gene

miRTarBase miRNAs that target SLC25A31

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC25A31

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC25A31 Gene

Localization for SLC25A31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A31 Gene

Mitochondrion inner membrane; Multi-pass membrane protein. Cell projection, cilium, flagellum. Note=In sperm flagellum this protein is located in the fibrous sheath, a non-mitochondrial region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A31 Gene COMPARTMENTS Subcellular localization image for SLC25A31 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC25A31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with SLC25A31: view

Pathways for SLC25A31 Gene

genes like me logo Genes that share pathways with SLC25A31: view

Pathways by source for SLC25A31 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SLC25A31 Gene

Gene Ontology (GO) - Biological Process for SLC25A31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A31: view

Transcripts for SLC25A31 Gene

mRNA/cDNA for SLC25A31 Gene

Unigene Clusters for SLC25A31 Gene

Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC25A31

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC25A31
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A31 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: - -

Relevant External Links for SLC25A31 Gene

GeneLoc Exon Structure for
SLC25A31
ECgene alternative splicing isoforms for
SLC25A31

Expression for SLC25A31 Gene

mRNA expression in normal human tissues for SLC25A31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A31 Gene

This gene is overexpressed in Testis (49.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A31 Gene

SOURCE GeneReport for Unigene cluster for SLC25A31 Gene Hs.149030

mRNA Expression by UniProt/SwissProt for SLC25A31 Gene

Q9H0C2-ADT4_HUMAN
Tissue specificity: Expressed in brain, liver, sperm and testis.
genes like me logo Genes that share expressions with SLC25A31: view

In Situ Assay Products

Orthologs for SLC25A31 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A31 35
  • 99.58 (n)
  • 99.68 (a)
SLC25A31 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC25A31 35
  • 91.72 (n)
  • 92.04 (a)
SLC25A31 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A31 35
  • 91.72 (n)
  • 92.04 (a)
SLC25A31 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a31 35
  • 85.46 (n)
  • 89.17 (a)
Slc25a31 16
Slc25a31 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC25A31 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a31 35
  • 83.97 (n)
  • 86.31 (a)
lizard
(Anolis carolinensis)
Reptilia SLC25A31 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ant2 36
  • 67 (a)
ManyToMany
sesB 36
  • 69 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea R07E3.4 36
  • 43 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAC1 36
  • 50 (a)
ManyToMany
AAC3 36
  • 50 (a)
ManyToMany
PET9 36
  • 50 (a)
ManyToMany
PET9 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1260 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G56450 35
  • 55.59 (n)
  • 50.17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
CSA.10315 36
  • 70 (a)
OneToMany
CSA.11146 36
  • 68 (a)
OneToMany
Species with no ortholog for SLC25A31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC25A31 Gene

ENSEMBL:
Gene Tree for SLC25A31 (if available)
TreeFam:
Gene Tree for SLC25A31 (if available)

Paralogs for SLC25A31 Gene

Paralogs for SLC25A31 Gene

Selected SIMAP similar genes for SLC25A31 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC25A31: view

Variants for SLC25A31 Gene

Sequence variations from dbSNP and Humsavar for SLC25A31 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs769293 -- 127,744,826(-) GGAAG(A/G)AAAAA intron-variant
rs1459048 -- 127,761,698(-) ATTCA(C/T)GGATC intron-variant
rs1580227 -- 127,739,750(-) agaaa(A/T)ataag intron-variant
rs1585311 -- 127,758,405(-) gcaaa(C/G)tatgc intron-variant
rs1585312 -- 127,758,258(-) caaac(A/G)tatga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A31 Gene

Variant ID Type Subtype PubMed ID
nsv879915 CNV Gain 21882294
nsv879916 CNV Loss 21882294
dgv5711n71 CNV Loss 21882294
nsv830056 CNV Loss 17160897
dgv5712n71 CNV Loss 21882294
nsv879921 CNV Loss 21882294
nsv879923 CNV Loss 21882294
nsv879925 CNV Loss 21882294
nsv830057 CNV Loss 17160897
dgv5713n71 CNV Loss 21882294
nsv290569 CNV Loss 16902084
nsv437935 CNV Loss 16468122

Relevant External Links for SLC25A31 Gene

HapMap Linkage Disequilibrium report
SLC25A31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A31 Gene

Disorders for SLC25A31 Gene

(1) University of Copenhagen DISEASES for SLC25A31 Gene

Relevant External Links for SLC25A31

Genetic Association Database (GAD)
SLC25A31
Human Genome Epidemiology (HuGE) Navigator
SLC25A31
genes like me logo Genes that share disorders with SLC25A31: view

No data available for UniProtKB/Swiss-Prot for SLC25A31 Gene

Publications for SLC25A31 Gene

  1. A fourth ADP/ATP carrier isoform in man: identification, bacterial expression, functional characterization and tissue distribution. (PMID: 15670820) Dolce V. … Palmieri F. (FEBS Lett. 2005) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Compartmentalization of a unique ADP/ATP carrier protein SFEC (sperm flagellar energy carrier, AAC4) with glycolytic enzymes in the fibrous sheath of the human sperm flagellar principal piece. (PMID: 17137571) Kim Y.-H. … Herr J.C. (Dev. Biol. 2007) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for SLC25A31 Gene

Sources for SLC25A31 Gene

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